EKS-CAJ-00301

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAJ-00301

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/IKK	435.7	1.5E-130	16	289	274

Status

Unreviewed

Ensembl Protein

ENSCJAP00000031759

UniProt Accession

F7HRZ1;

Protein Name

Protein Synonyms/Alias

Gene Name

CHUK

Gene Synonyms/Alias

CHUK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCJAG00000017244	ENSCJAP00000031747	ENSCJAT00000033558
ENSCJAG00000017244	ENSCJAP00000031759	ENSCJAT00000033570

Organism

Callithrix jacchus

Functional Description

Protein Length

746

Protein Sequence
(FASTA)

LEQRRNLRPL SLPPHWEMRE RLGTGGFGNV CLYQHRELDL KIAIKSCRLE LSTKNRERWC 60

HEIQIMKKLN HANVVKACDV PEELNVLIHD VPLLAMEYCS GGDLRKLLNK PENCCGLKES 120

QILSLLSDIG SGIRYLHENK IIHRDLKPEN IVLQDAGGKI IHKIIDLGYA KDVDQGSLCT 180

SFVGTLQYLA PELFENKPYT ATVDYWSFGT MVFECIAGYR PFLHHLQPFT WHEKIKKKDP 240

KCIFACEEMS GEVRFSSHLP QPNSLCSLIV EPMENWLQLM LNWDPQQRGG PVDLTLKQPR 300

CFVLMDHILN LKIVHILNMT SAKIISFLLP PDESLHSLQS RIERETGINT GSQELLSETG 360

ISLDPRKPAS QCVLDGVRGC DSYMVYLFDK SKTVYEGPFA SRSLSECVNY IVRDSKIQLP 420

VIQLRKVWAE AVHYVSGLKE DYSRLFQGQR AAMLSLLRYN ANLTKMKNTL ISASQQLKAK 480

LEFFHKSIQL DLERYSEQMT YGISSEKMLK AWKEMEEKAI HYAEVGVIGY LEDQIMSLHA 540

EIMELQKSPY GRRQGDLMES LEQRAIDLYK QLKHRPSDHS YSDSTEMVKI IVHTVQSQDR 600

VLKELFGHLT SCWGCKQKII DLLPKVEVAL SNIKEADNTV MFMQGKRQKE IWHLLKIACT 660

QSSARSLVGS SLEGAVTPQT SAWLPPTSTE HNHSLSCVVT PQDGWVHFVA IDSGIHCKGK 720

LISIITQMRE EQGSSMMSLD WSWLTE 746

Nucleotide Sequence
(FASTA)

TTGGAACAAC GGCGAAATCT GAGGCCGCTT TCCCTCCCGC CCCATTGGGA GATGCGGGAG 60

CGGCTGGGCA CCGGCGGCTT CGGGAACGTC TGTCTGTACC AGCATCGGGA ACTTGATCTC 120

AAAATAGCAA TTAAGTCTTG TCGCCTAGAG CTAAGTACCA AAAACAGAGA ACGGTGGTGC 180

CACGAAATCC AGATTATGAA GAAGTTGAAC CATGCCAATG TTGTAAAGGC CTGTGATGTT 240

CCTGAAGAAT TGAATGTTTT GATTCATGAT GTGCCTCTTC TAGCAATGGA ATACTGTTCT 300

GGAGGAGATC TCCGAAAGCT GCTCAACAAA CCAGAAAATT GTTGTGGACT TAAAGAAAGC 360

CAGATACTTT CTTTACTAAG TGATATAGGG TCTGGGATTC GATATTTGCA TGAAAACAAA 420

ATTATACATC GAGATCTAAA ACCTGAAAAC ATAGTTCTTC AGGACGCTGG TGGAAAGATA 480

ATACATAAAA TAATTGATCT AGGATATGCC AAAGATGTTG ATCAAGGAAG TCTGTGTACA 540

TCTTTTGTGG GAACACTGCA GTATCTGGCC CCAGAGCTCT TTGAGAATAA GCCTTACACA 600

GCCACTGTTG ATTATTGGAG CTTTGGGACC ATGGTATTTG AATGTATTGC TGGATATAGG 660

CCTTTTTTGC ATCATCTGCA GCCATTTACC TGGCATGAGA AGATTAAGAA GAAGGATCCA 720

AAGTGTATAT TTGCATGTGA AGAGATGTCA GGAGAAGTTC GGTTTAGTAG CCATTTACCT 780

CAACCAAATA GCCTTTGTAG TTTAATAGTA GAACCCATGG AAAACTGGCT ACAGTTGATG 840

TTGAATTGGG ACCCTCAGCA GAGAGGAGGA CCTGTTGACC TTACTTTGAA GCAGCCAAGA 900

TGTTTTGTAT TAATGGATCA CATTTTGAAT TTGAAGATAG TACACATCCT AAATATGACT 960

TCTGCAAAGA TAATTTCTTT TCTGTTACCA CCTGATGAAA GTCTTCATTC ACTACAGTCT 1020

CGTATTGAGC GTGAAACCGG AATAAATACT GGTTCTCAGG AGCTTCTTTC AGAGACAGGA 1080

ATTTCTCTGG ATCCTCGGAA ACCAGCCTCT CAGTGTGTTC TAGATGGAGT TAGAGGCTGT 1140

GATAGCTATA TGGTTTATTT GTTTGATAAA AGTAAAACTG TATATGAAGG GCCATTTGCT 1200

TCCAGAAGTT TATCTGAATG TGTAAATTAT ATCGTACGGG ACAGTAAAAT ACAGCTTCCA 1260

GTTATACAGC TGCGTAAAGT ATGGGCTGAA GCTGTGCACT ATGTGTCTGG ACTAAAAGAA 1320

GACTACAGCA GGCTCTTTCA GGGACAAAGA GCAGCAATGT TAAGTCTTCT TAGATATAAT 1380

GCTAACTTAA CAAAAATGAA GAACACTTTA ATCTCAGCAT CACAACAACT GAAAGCTAAA 1440

TTGGAGTTTT TTCACAAAAG CATTCAGCTT GACTTGGAGA GATATAGCGA GCAGATGACT 1500

TATGGGATAT CTTCAGAAAA AATGCTAAAA GCATGGAAAG AAATGGAAGA AAAGGCCATC 1560

CACTATGCTG AGGTTGGTGT CATTGGATAC CTGGAGGATC AGATTATGTC TTTGCATGCT 1620

GAAATCATGG AGCTACAGAA GAGCCCCTAT GGAAGACGTC AGGGAGACTT GATGGAATCT 1680

CTGGAACAGC GTGCCATTGA TCTATATAAG CAGTTAAAAC ACAGACCTTC AGATCACTCC 1740

TACAGTGACA GCACAGAGAT GGTGAAAATC ATTGTGCACA CTGTGCAGAG TCAGGACCGT 1800

GTGCTCAAGG AGCTGTTTGG TCATTTGACA AGTTGTTGGG GCTGTAAGCA GAAGATTATT 1860

GATCTACTCC CTAAGGTGGA AGTGGCCCTC AGTAACATCA AAGAAGCTGA CAATACTGTA 1920

ATGTTCATGC AGGGAAAAAG GCAGAAAGAA ATATGGCATC TCCTTAAAAT TGCCTGTACA 1980

CAAAGTTCTG CCCGGTCCCT TGTGGGATCC AGTCTAGAAG GTGCAGTAAC CCCTCAGACA 2040

TCAGCATGGC TGCCCCCAAC TTCAACAGAA CATAATCATT CTTTGTCATG TGTGGTAACT 2100

CCTCAAGATG GGTGGGTTCA CTTTGTAGCA ATAGATAGTG GAATACACTG TAAAGGAAAA 2160

TTGATTTCAA TCATAACTCA AATGAGGGAG GAACAGGGCA GTAGTATGAT GAGTCTTGAT 2220

TGGAGTTGGT TAACAGAATG A 2241

Domain Profile

S: 1     WelkelLGeGafgnvikarnkktgekiavkvikeesslrprevqvrelevlrklnhkniv  60

         We++e+LG+G+fgnv+ +++++ + kia+k+++ e+s+++re++++e+++++klnh+n+v

Q: 16    WEMRERLGTGGFGNVCLYQHRELDLKIAIKSCRLELSTKNRERWCHEIQIMKKLNHANVV  75

         ************************************************************

S: 61    klvdveeelnlasarlkvlvleyCsgGdlrkvLeepenayGLkesevlvvLsdvvaglry  120

         k++dv+eeln++ +++++l++eyCsgGdlrk+L++pen++GLkes++l++Lsd+ +g+ry

Q: 76    KACDVPEELNVLIHDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQILSLLSDIGSGIRY  135

         ************************************************************

S: 121   LrenkivhRDlkPenivllkgedgksiykltDlGaareldddekvvslvGteeYlaPely  180

         L+enki+hRDlkPenivl+++ +gk i+k++DlG+a+++d++++++s+vGt++YlaPel+

Q: 136   LHENKIIHRDLKPENIVLQDA-GGKIIHKIIDLGYAKDVDQGSLCTSFVGTLQYLAPELF  194

         ********************9.**************************************

S: 181   eqkkytatvDlWsiGvllyeaitGslPflpfegprrlykkitkkpakaiagtekangeve  240

         e+k ytatvD+Ws+G++++e+i+G++Pfl++ +p+++++ki+kk++k+i+++e+++gev+

Q: 195   ENKPYTATVDYWSFGTMVFECIAGYRPFLHHLQPFTWHEKIKKKDPKCIFACEEMSGEVR  254

         ************************************************************

S: 241   fssslPlsaslssglqeklekllanllevdeekrw  275

         fss+lP+++sl+s+++e +e++l+++l++d+++r+

Q: 255   FSSHLPQPNSLCSLIVEPMENWLQLMLNWDPQQRG  289

         ********************************986

Domain Sequence
(FASTA)

WEMRERLGTG GFGNVCLYQH RELDLKIAIK SCRLELSTKN RERWCHEIQI MKKLNHANVV 60

KACDVPEELN VLIHDVPLLA MEYCSGGDLR KLLNKPENCC GLKESQILSL LSDIGSGIRY 120

LHENKIIHRD LKPENIVLQD AGGKIIHKII DLGYAKDVDQ GSLCTSFVGT LQYLAPELFE 180

NKPYTATVDY WSFGTMVFEC IAGYRPFLHH LQPFTWHEKI KKKDPKCIFA CEEMSGEVRF 240

SSHLPQPNSL CSLIVEPMEN WLQLMLNWDP QQRG 274

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0008384	; F:IkappaB kinase activity
GO:0007252	; P:I-kappaB phosphorylation

KEGG

InterPros

IPR022007	; IKKbetaNEMObind.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF12179	; IKKbetaNEMObind; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013