EKS-CAJ-00080

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAJ-00080

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Musk	620.9	6.0E-187	490	770	281

Status

Unreviewed

Ensembl Protein

ENSCJAP00000032174

UniProt Accession

F7FYI7;

Protein Name

Protein Synonyms/Alias

Gene Name

MUSK

Gene Synonyms/Alias

MUSK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCJAG00000017434	ENSCJAP00000032181	ENSCJAT00000034019
ENSCJAG00000017434	ENSCJAP00000032174	ENSCJAT00000034010

Organism

Callithrix jacchus

Functional Description

Protein Length

784

Protein Sequence
(FASTA)

MRELVNIPLV HILTLVAFSR TEKLPKAPVI TTPLETVDAL VEEVATFMCA VESYPQPEIS 60

WTRNKILIKL FDTRYSIREN GQLLTILSVE DSDDGIYCCT ANNGVGGAVE SCGALQVKMK 120

PKITRPPINV KIIEGLKAVL PCTTMGNPKP SVSWIKGDSP LRENSRIAVL ESGSLRIHNV 180

QKEDAGQYRC VAKNSLGTAY SKVVKLEVEE EREPEQDTKV FARILRAPES HNVTFGSFVT 240

LHCTATGIPV PTITWIENGN AVSSGSIQES VKDRVIDSRL QLFITKPGLY TCIATNKHGE 300

KFSTSKAAAT ISIAEHFREY CLAVKELFCA KEWLAMEEKT HRGLYRSEMH LLSVPECSKL 360

PSMHWDPMAC ARLPHLAFPP MTSSKPSVDI PNLPSSSSSS FSVSPTYSMT VIISIMSSFA 420

IFVLLTITTL YCCRRRKQWK NKKRESATVT LTTLPSELLL DRLHPNPMYQ RMPLLLNPKL 480

LSLEYPRNNI EYVRDIGEGA FGRVFQARAP GLLPHEPFTM VAVKMLKEEA SADMQADFQR 540

EAALMAEFDN PNIVKLLGVC AVGKPMCLLF EYMAYGDLNE FLRSMSPHTV CSLSHSDLSM 600

RAQVSSPGPP LLSCAEQLCI ARQVAAGMAY LSERKFVHRD LATRNCLVGE NMVVKIADFG 660

LSRNIYSADY YKANENDAIP IRWMPPESIF YNRYTTESDV WAYGVVLWEI FSYGLQPYYG 720

MAHEEVIYYV RDGNILSCPE NCPMELYNLM RLCWSKLPTD RPSFASIHRI LERMCERAEG 780

TVSV 784

Nucleotide Sequence
(FASTA)

ATGAGAGAGC TCGTCAACAT TCCACTGGTA CATATTCTTA CTCTGGTCGC CTTCAGCAGA 60

ACCGAGAAAC TTCCAAAAGC TCCTGTCATC ACCACTCCTC TTGAAACAGT GGATGCCTTA 120

GTTGAAGAAG TGGCTACTTT CATGTGTGCA GTGGAATCCT ACCCCCAACC TGAGATTTCC 180

TGGACTAGAA ATAAAATTCT CATTAAGCTC TTTGACACCC GGTACAGCAT CCGGGAGAAT 240

GGGCAGCTCC TCACCATCCT GAGTGTGGAA GACAGTGATG ATGGCATTTA CTGCTGCACA 300

GCCAACAATG GTGTGGGAGG AGCTGTGGAG AGTTGTGGAG CCCTGCAAGT GAAGATGAAA 360

CCTAAAATAA CTCGTCCTCC TATAAATGTG AAAATAATAG AAGGATTAAA AGCAGTCCTA 420

CCATGTACTA CAATGGGCAA TCCCAAACCA TCAGTGTCTT GGATAAAGGG AGACAGCCCT 480

CTCAGGGAAA ACTCCCGAAT TGCAGTTCTT GAATCTGGGA GCTTGAGGAT TCATAATGTA 540

CAAAAGGAAG ATGCAGGACA GTATCGGTGT GTGGCAAAAA ACAGCCTCGG GACAGCATAT 600

TCCAAAGTGG TGAAGCTGGA AGTTGAGGAA GAAAGGGAAC CTGAACAAGA TACTAAAGTT 660

TTTGCCAGGA TCCTGCGGGC TCCTGAATCC CACAATGTCA CCTTTGGCTC CTTTGTGACC 720

CTGCACTGTA CAGCAACAGG AATTCCTGTC CCCACCATCA CCTGGATTGA AAACGGAAAT 780

GCTGTTTCTT CTGGGTCCAT TCAAGAGAGT GTGAAAGACC GAGTGATTGA CTCAAGACTG 840

CAACTGTTTA TCACCAAGCC AGGACTCTAC ACATGTATAG CTACCAATAA GCATGGAGAG 900

AAGTTCAGTA CTTCCAAGGC TGCCGCCACC ATCAGCATAG CAGAACATTT TAGAGAGTAC 960

TGCTTGGCAG TAAAGGAGCT CTTCTGTGCA AAAGAATGGC TGGCAATGGA AGAGAAGACC 1020

CACAGAGGAC TCTACAGATC CGAGATGCAT TTGCTGTCTG TACCAGAATG CAGCAAGCTT 1080

CCCAGCATGC ACTGGGATCC CATGGCCTGT GCCAGACTGC CACATCTAGC ATTCCCACCA 1140

ATGACATCCT CAAAGCCAAG TGTGGACATT CCAAATTTGC CTTCCTCCTC CTCTTCTTCC 1200

TTCTCTGTCT CACCTACATA CTCCATGACT GTAATAATCT CCATCATGTC CAGCTTTGCA 1260

ATATTTGTGC TTCTTACCAT AACTACTCTC TATTGCTGCC GAAGAAGAAA ACAATGGAAA 1320

AATAAGAAAC GAGAATCAGC AACAGTAACC CTCACCACAC TGCCTTCTGA GCTCTTGCTA 1380

GACAGACTTC ATCCCAATCC CATGTACCAG AGGATGCCGC TCCTTCTGAA CCCTAAATTG 1440

CTCAGCCTGG AGTATCCAAG GAATAACATT GAATACGTGA GAGACATCGG AGAGGGAGCG 1500

TTTGGAAGGG TGTTTCAAGC AAGGGCACCA GGCTTACTTC CCCATGAACC TTTCACTATG 1560

GTGGCGGTAA AGATGCTCAA AGAAGAAGCC TCGGCAGATA TGCAAGCGGA CTTTCAGAGG 1620

GAGGCAGCCC TCATGGCAGA ATTTGACAAT CCTAACATTG TGAAACTCTT AGGCGTGTGT 1680

GCTGTCGGGA AGCCGATGTG CCTGCTCTTT GAATACATGG CCTATGGAGA CCTCAATGAG 1740

TTCCTCCGCA GCATGTCCCC TCACACTGTG TGCAGCCTCA GTCACAGTGA CTTGTCTATG 1800

AGGGCTCAGG TCTCCAGTCC CGGACCCCCA CTGCTGTCCT GTGCTGAGCA GCTTTGCATT 1860

GCCAGGCAGG TGGCCGCTGG CATGGCTTAC CTCTCAGAAC GTAAGTTTGT TCACCGAGAT 1920

TTAGCCACCA GGAACTGCCT GGTGGGTGAG AACATGGTGG TGAAAATTGC CGACTTTGGC 1980

CTCTCCAGAA ACATCTACTC AGCCGACTAC TACAAAGCTA ATGAAAACGA TGCTATCCCT 2040

ATCCGTTGGA TGCCACCAGA GTCCATTTTT TATAACCGCT ATACTACAGA GTCTGATGTG 2100

TGGGCCTATG GCGTGGTCCT TTGGGAGATC TTCTCCTATG GCCTGCAGCC CTACTATGGG 2160

ATGGCCCATG AGGAGGTCAT TTACTACGTG CGAGACGGCA ACATCCTCTC CTGCCCTGAG 2220

AACTGCCCCA TGGAACTGTA CAATCTAATG CGTCTGTGTT GGAGCAAGCT GCCTACAGAC 2280

AGACCCAGTT TCGCCAGTAT TCACCGAATT CTGGAACGCA TGTGTGAGAG GGCAGAGGGA 2340

ACTGTGAGTG TCTAA 2355

Domain Profile

S: 1     ieyvrdlgegafgrvfqarapgllpyeefllvavkmlkeeasadmqadfereaallaefd  60

         ieyvrd+gegafgrvfqarapgllp+e+f++vavkmlkeeasadmqadf+reaal+aefd

Q: 490   IEYVRDIGEGAFGRVFQARAPGLLPHEPFTMVAVKMLKEEASADMQADFQREAALMAEFD  549

         89**********************************************************

S: 61    npnivkllgvcavgkpmcllfeymaygdlneflrslspytvcslshsdlslraqvsspdr  120

         npnivkllgvcavgkpmcllfeymaygdlneflrs+sp+tvcslshsdls+raqvssp++

Q: 550   NPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSMRAQVSSPGP  609

         ************************************************************

S: 121   lplseaellciarqvaagmaylserkfvhrdlatrnclvgetmvvkiadfglsrkiysad  180

         + ls+ae+lciarqvaagmaylserkfvhrdlatrnclvge+mvvkiadfglsr+iysad

Q: 610   PLLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSRNIYSAD  669

         ************************************************************

S: 181   yykadendaipirwmplesilynrytlesdvwaygvvlweifsyalqpyyglaheeviky  240

         yyka+endaipirwmp+esi+ynryt+esdvwaygvvlweifsy+lqpyyg+aheevi+y

Q: 670   YYKANENDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGLQPYYGMAHEEVIYY  729

         ************************************************************

S: 241   vrdgnilacpentplelyalmrlcwsklpadrpsfasihri  281

         vrdgnil+cpen+p+ely+lmrlcwsklp+drpsfasihri

Q: 730   VRDGNILSCPENCPMELYNLMRLCWSKLPTDRPSFASIHRI  770

         ***************************************98

Domain Sequence
(FASTA)

IEYVRDIGEG AFGRVFQARA PGLLPHEPFT MVAVKMLKEE ASADMQADFQ REAALMAEFD 60

NPNIVKLLGV CAVGKPMCLL FEYMAYGDLN EFLRSMSPHT VCSLSHSDLS MRAQVSSPGP 120

PLLSCAEQLC IARQVAAGMA YLSERKFVHR DLATRNCLVG ENMVVKIADF GLSRNIYSAD 180

YYKANENDAI PIRWMPPESI FYNRYTTESD VWAYGVVLWE IFSYGLQPYY GMAHEEVIYY 240

VRDGNILSCP ENCPMELYNL MRLCWSKLPT DRPSFASIHR I 281

Keyword

ATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR020067	; Frizzled_dom.
IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003598	; Ig_sub2.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF01392	; Fz; 1.
PF07679	; I-set; 2.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00408	; IGc2; 3.
SM00219	; TyrKc; 1.

Prosites

PS50038	; FZ; 1.
PS50835	; IG_LIKE; 3.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013