EKS-CAJ-00167

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAJ-00167

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/RSKb	448.1	1.9E-134	368	628	261

Status

Unreviewed

Ensembl Protein

ENSCJAP00000032899

UniProt Accession

F7HGG0;

Protein Name

Ribosomal protein S6 kinase

Protein Synonyms/Alias

Gene Name

RPS6KA5

Gene Synonyms/Alias

RPS6KA5;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCJAG00000017801	ENSCJAP00000032899	ENSCJAT00000034768
ENSCJAG00000017801	ENSCJAP00000032888	ENSCJAT00000034757

Organism

Callithrix jacchus

Functional Description

Protein Length

740

Protein Sequence
(FASTA)

YGKVFLVRKI SGHDTGKLYA MKVLKKATIV QKAKTTEHTR TERQVLEHIR QSPFLVTLHY 60

AFQTETKLHL ILGYAWGGEL FTHLSQRERF TEHEVQIYVG EIVLALEHLH KLGIIYRDIK 120

LENILLDSNG HVVLTDFGLS KEFVADETER AYSFCGTIEY MAPDIVRGGD SGHDKAVDWW 180

SLGVLMYELL TGASPFTVDG EKNSQAEISR RILKSEPPYP QEMSALAKDL IQRLLMKDPK 240

KRLGCGPRDA DEIKEHLFFQ KINWDDLAAK KVPAPFKPVI RDELDVSNFA EEFTEMDPTY 300

SPAALPQSSE KLFQGYSFVA PSILFKRNAA VVDPLQFHVG VERPGVTNVA RSAMMKDSPF 360

YQHYDLDLKD KPLGEGSFSI CRKCVHKKSN QAFAVKIISK RMEANTQKEI TALKLCEGHP 420

NIVKLHEVFH DQLHTFLVME LLNGGELFER IKKKKHFSET EASYIMRKLV SAVSHMHDVG 480

VVHRDLKPEN LLFTDENDNL EIKVIDFGFA RLKPPDNQPL KTPCFTLHYA APELLNQNGY 540

DESCDLWSLG VILYTMLSGQ VPFQSHDRSL TCTSAVEIMK KIKKGDFSFE GEAWKNVSQE 600

AKDLIQGLLT VDPNKRLKMS GLRYNEWLQD GSQLSSNPLM TPDILGSSGA AVHTCVKATF 660

HAFNKYKREG FCLQNVDKAP LAKRRKMKKT STSTETRSSS SESSHSSSSH SHGKTTPTKT 720

LQPSNPADSN NPETLFQFSD 740

Nucleotide Sequence
(FASTA)

TATGGAAAAG TATTTCTAGT TCGTAAAATA AGTGGACATG ATACTGGAAA GCTGTATGCC 60

ATGAAAGTTT TGAAAAAGGC AACAATAGTT CAAAAGGCCA AAACCACAGA GCATACAAGG 120

ACAGAACGGC AAGTCCTGGA GCACATCAGG CAGTCGCCGT TTTTGGTGAC ATTACATTAT 180

GCTTTCCAAA CAGAAACCAA ACTTCATCTC ATTTTAGGTT ATGCTTGGGG TGGAGAACTT 240

TTTACTCATC TTTCTCAAAG AGAACGTTTC ACAGAGCATG AGGTGCAGAT TTATGTTGGA 300

GAGATTGTGC TTGCCCTCGA ACATCTCCAC AAGTTGGGGA TTATATATCG TGACATTAAG 360

CTTGAGAATA TTCTACTTGA TTCTAATGGC CATGTGGTGC TGACAGATTT TGGTCTGAGT 420

AAGGAGTTTG TGGCTGATGA AACTGAAAGA GCATATTCCT TTTGTGGAAC TATTGAATAC 480

ATGGCACCAG ATATTGTCAG AGGGGGAGAT TCAGGACATG ACAAGGCAGT TGATTGGTGG 540

AGTTTAGGTG TTCTGATGTA TGAATTACTA ACTGGAGCAT CTCCTTTCAC TGTTGATGGA 600

GAAAAAAATT CCCAAGCTGA GATATCTAGG AGAATATTAA AAAGTGAGCC TCCATATCCC 660

CAAGAAATGA GTGCTTTAGC TAAAGACCTA ATTCAGCGTC TTTTGATGAA AGATCCCAAG 720

AAGAGACTGG GATGTGGTCC ACGTGATGCA GATGAAATCA AAGAACATCT CTTCTTTCAG 780

AAAATAAATT GGGATGATTT AGCTGCCAAA AAAGTGCCTG CACCATTTAA GCCAGTCATT 840

CGAGATGAAT TAGATGTGAG TAACTTTGCA GAAGAGTTCA CAGAAATGGA TCCCACTTAT 900

TCTCCTGCAG CCCTGCCCCA GAGCTCCGAG AAGCTGTTTC AGGGCTATTC CTTCGTTGCG 960

CCTTCCATCC TGTTCAAGCG TAATGCAGCT GTCGTAGACC CTCTTCAGTT TCACGTGGGA 1020

GTCGAACGTC CTGGAGTGAC AAATGTCGCC AGGAGTGCAA TGATGAAGGA CTCTCCATTC 1080

TATCAACACT ATGACCTAGA TTTGAAGGAC AAACCACTGG GAGAAGGTAG TTTTTCAATT 1140

TGTCGAAAGT GCGTGCATAA GAAAAGTAAC CAAGCTTTTG CAGTCAAAAT AATCAGCAAA 1200

AGGATGGAAG CCAATACTCA GAAAGAAATA ACAGCTCTGA AACTCTGTGA AGGACACCCC 1260

AATATTGTGA AGTTGCATGA AGTTTTTCAT GATCAGCTTC ACACATTTCT AGTGATGGAA 1320

CTTCTGAATG GGGGAGAATT GTTTGAACGC ATTAAGAAAA AGAAGCACTT CAGTGAGACG 1380

GAAGCTAGCT ACATCATGAG GAAGCTTGTT TCCGCTGTAA GCCACATGCA TGACGTTGGA 1440

GTGGTGCACA GAGATTTGAA ACCTGAGAAT TTATTATTCA CTGATGAAAA TGACAATTTG 1500

GAAATTAAGG TAATTGACTT TGGGTTTGCA CGGCTAAAGC CGCCAGATAA TCAGCCCCTG 1560

AAAACTCCAT GCTTCACCCT TCATTATGCG GCCCCAGAGC TCTTGAATCA GAATGGCTAC 1620

GATGAGTCCT GTGACCTGTG GAGCTTGGGC GTCATTTTGT ACACAATGTT GTCAGGACAG 1680

GTTCCCTTCC AATCTCATGA CCGAAGTTTG ACATGTACCA GCGCAGTGGA AATCATGAAG 1740

AAAATTAAAA AGGGAGACTT CTCCTTTGAA GGAGAAGCCT GGAAGAATGT ATCCCAAGAA 1800

GCTAAAGATT TGATCCAAGG ACTTCTCACA GTTGATCCAA ACAAAAGGCT TAAAATGTCT 1860

GGCTTGAGGT ACAATGAATG GCTTCAAGAC GGCAGTCAGC TGTCCTCAAA TCCTCTGATG 1920

ACTCCGGATA TTCTGGGATC TTCAGGAGCT GCCGTGCATA CCTGCGTGAA AGCAACCTTC 1980

CACGCCTTTA ACAAATACAA GAGAGAGGGG TTTTGCCTTC AGAATGTCGA TAAGGCCCCT 2040

TTGGCTAAGA GAAGAAAAAT GAAAAAGACT AGCACCAGTA CAGAGACGCG CAGCAGTTCC 2100

AGTGAGAGTT CCCATTCTTC TTCCTCTCAT TCTCATGGTA AAACTACACC CACCAAGACA 2160

CTGCAGCCCA GCAATCCTGC CGACAGCAAT AACCCAGAGA CCCTCTTCCA GTTCTCGGAC 2220

TGA 2223

Domain Profile

S: 2     evkedlGvGsysvckrcvhkatnqefavkiidks.krdtseeieillryeqhpnivtlkd  60

         +++++lG+Gs+s+c++cvhk++nq+favkii+k+ +++t++ei++l+++e+hpniv+l++

Q: 368   LKDKPLGEGSFSICRKCVHKKSNQAFAVKIISKRmEANTQKEITALKLCEGHPNIVKLHE  427

         5789******************************9*************************

S: 61    vyddgkyvylvlellkGGelldrikkkkffsereasailrtlvkaveylheqGvvhrdlk  120

         v++d+++++lv+ell+GGel++rikkkk+fse+eas+i+r+lv+av+++h++Gvvhrdlk

Q: 428   VFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGVVHRDLK  487

         ************************************************************

S: 121   penilyvdesdnaesikiidfGfaklkraengllktpcytlnfvapevlkrqGydeacdl  180

         pen+l++de+dn+e ik+idfGfa+lk+++n++lktpc+tl+++ape+l+++Gyde+cdl

Q: 488   PENLLFTDENDNLE-IKVIDFGFARLKPPDNQPLKTPCFTLHYAAPELLNQNGYDESCDL  546

         **************.*********************************************

S: 181   wslGvllytmlaGyvpf....angpedtaeeilakikeGkfslsGeawdsvseeakdlvs  236

         wslGv+lytml+G+vpf    +++++++a+ei++kik+G+fs++Geaw++vs+eakdl++

Q: 547   WSLGVILYTMLSGQVPFqshdRSLTCTSAVEIMKKIKKGDFSFEGEAWKNVSQEAKDLIQ  606

         *****************9998899************************************

S: 237   klltvdpakrlkleqllkhswl  258

         +lltvdp+krlk+++l++++wl

Q: 607   GLLTVDPNKRLKMSGLRYNEWL  628

         *********************7

Domain Sequence
(FASTA)

LKDKPLGEGS FSICRKCVHK KSNQAFAVKI ISKRMEANTQ KEITALKLCE GHPNIVKLHE 60

VFHDQLHTFL VMELLNGGEL FERIKKKKHF SETEASYIMR KLVSAVSHMH DVGVVHRDLK 120

PENLLFTDEN DNLEIKVIDF GFARLKPPDN QPLKTPCFTL HYAAPELLNQ NGYDESCDLW 180

SLGVILYTML SGQVPFQSHD RSLTCTSAVE IMKKIKKGDF SFEGEAWKNV SQEAKDLIQG 240

LLTVDPNKRL KMSGLRYNEW L 261

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007243	; P:intracellular protein kinase cascade

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR016239	; Ribosomal_S6_kinase_II.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 2.
PF00433	; Pkinase_C; 1.

SMARTs

SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 2.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 2.
PS00108	; PROTEIN_KINASE_ST; 2.

Prints

Created Date

20-Feb-2013