EKS-CAJ-00168
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-CAJ-00168
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CAMK/RSKb430.16.1E-129389648260
StatusUnreviewed
Ensembl ProteinENSCJAP00000033181
UniProt AccessionF6RZV0;
Protein NameRibosomal protein S6 kinase
Protein Synonyms/Alias
Gene NameRPS6KA4
Gene Synonyms/Alias RPS6KA4;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSCJAG00000017957ENSCJAP00000033181ENSCJAT00000035067
OrganismCallithrix jacchus
Functional Description
Protein Length746
Protein Sequence
(FASTA)
MGDEDEDEGC AVELRITEAN LTGHEEKVSV ENFELLKVLG TGAYGKVFLV RKAGGHDAGK 60
LYAMKVLRKA ALVQRAKTQE HTRTERSVLE LVRQAPFLVT LHYAFQTDAK LHLILDYVSG 120
GEMFTHLYQR QYFKEAEVRV YGGEIVLLEH LHKVGLFFRQ LLWESVILAA SDKKVQLKMV 180
GICFLFLLFC VGTSSTPERV PSSPGPHPPR FQYNKFFFLF FDVKLGIGIV LSEGERSQGG 240
RRNSCPSQMQ MGHCLMEELS REGGLSAEMI PFPQGLDWVA LAARKVPAPF RPQIRSELDV 300
GNFAEEFTRL EPVYSPPGSP PPGDPRIFQG YSFVAPSILF DHNNAVMTDV LEAPGAGDRP 360
GRAAVARSAM MQPPGLAFFQ QYELDLREPA LGQGSFSVCR RCRQRQSGQE FAVKILSRRL 420
EANTQREVAA LRLCQSHPNV VNLHEVHQDQ LHTYLVLELL RGGELLEHIR KKRHFSESEA 480
SQILRSLVSA VSFMHEEAGV VHRDLKPENI LYADDTPGAP VKIIDFGFAR LRPQSPGGPM 540
QTPCFTLQYA APELLAQQGY DESCDLWSLG VILYMMLSGQ VPFQGASGQG GQSQAAEIMC 600
KIREGRFSLD GEAWQGVSEE AKELVRGLLT VDPAKRLKLE GLRGSSWLQD GSARSSPPLR 660
TPDVLESSGP AVRSGLNATF MAFNRGKREG FFLKSVENAP LAKRRKQKLR SATASRRGSS 720
APAAPGRAPA ASKGAPRRAN GPLPPS 746
Nucleotide Sequence
(FASTA)
ATGGGGGACG AGGACGAGGA TGAGGGCTGC GCCGTGGAGC TGCGGATCAC AGAAGCCAAC 60
CTGACCGGGC ACGAGGAGAA GGTGAGCGTG GAGAACTTCG AGCTGCTCAA GGTGTTGGGC 120
ACGGGAGCCT ACGGCAAGGT GTTCCTGGTG CGGAAGGCGG GCGGGCACGA TGCGGGGAAG 180
CTGTACGCCA TGAAGGTGCT GCGCAAGGCG GCGCTGGTGC AGCGCGCCAA GACGCAGGAG 240
CACACGCGCA CCGAGCGCTC CGTGCTGGAG CTGGTGCGCC AGGCGCCCTT CCTGGTCACG 300
CTGCACTACG CTTTCCAGAC GGATGCCAAG CTGCACCTCA TCCTGGACTA TGTGAGCGGC 360
GGGGAGATGT TCACCCACCT CTACCAGCGC CAGTACTTCA AGGAGGCTGA GGTGCGCGTG 420
TATGGGGGTG AGATAGTGCT GCTGGAACAC CTGCACAAGG TGGGCCTTTT TTTTCGACAG 480
CTTCTTTGGG AGTCAGTCAT CTTGGCTGCA AGTGACAAAA AAGTCCAACT CAAAATGGTG 540
GGTATCTGTT TTTTGTTTCT GCTTTTCTGC GTGGGGACTT CATCTACCCC TGAGAGGGTC 600
CCCAGCAGTC CCGGACCACA TCCTCCTAGA TTTCAGTACA ATAAATTCTT TTTTCTATTT 660
TTTGACGTGA AGTTGGGAAT AGGGATTGTG TTATCAGAGG GAGAAAGAAG CCAGGGAGGC 720
AGGAGGAATA GCTGTCCATC CCAAATGCAG ATGGGCCATT GCCTCATGGA GGAACTGTCC 780
AGGGAGGGTG GCCTGAGTGC AGAGATGATT CCCTTTCCTC AGGGCCTGGA TTGGGTTGCT 840
CTGGCTGCCA GGAAGGTTCC AGCCCCATTC AGGCCCCAGA TCCGCTCAGA GCTGGATGTG 900
GGCAACTTTG CAGAGGAATT CACTCGGCTG GAGCCTGTCT ACTCACCCCC TGGAAGCCCC 960
CCACCTGGAG ACCCCCGAAT CTTTCAGGGA TACTCCTTTG TGGCACCCTC CATCCTCTTC 1020
GATCACAACA ACGCAGTGAT GACCGATGTG CTGGAAGCAC CTGGTGCTGG AGACCGGCCA 1080
GGTCGGGCAG CGGTGGCCAG GAGCGCCATG ATGCAGCCTC CAGGACTCGC CTTCTTCCAG 1140
CAGTACGAGC TGGACCTGCG GGAGCCTGCG CTGGGCCAGG GCAGCTTCTC TGTGTGTCGC 1200
CGCTGCCGCC AGCGTCAGAG CGGCCAGGAG TTCGCGGTCA AGATCCTCAG TCGCAGGCTG 1260
GAGGCGAACA CGCAGCGCGA AGTGGCCGCC TTGCGCCTGT GCCAGTCACA CCCCAACGTG 1320
GTGAATCTGC ACGAGGTGCA TCAAGACCAG CTGCATACGT ACCTGGTCCT GGAGCTGCTG 1380
CGGGGCGGGG AGCTGCTGGA GCACATCCGC AAGAAGCGGC ACTTCAGCGA GTCCGAGGCG 1440
AGTCAGATCC TCCGCAGCCT CGTGTCGGCC GTGAGCTTCA TGCACGAGGA GGCGGGCGTG 1500
GTGCACCGCG ACCTCAAGCC GGAGAACATC CTGTACGCGG ACGACACGCC CGGGGCCCCG 1560
GTGAAGATCA TCGACTTCGG GTTCGCGCGG CTGCGGCCGC AGAGTCCCGG GGGGCCCATG 1620
CAGACCCCCT GCTTCACGCT GCAGTACGCG GCCCCCGAGC TGCTGGCGCA GCAGGGCTAC 1680
GACGAGTCCT GTGACCTCTG GAGCCTGGGC GTCATTCTGT ACATGATGCT GTCGGGGCAG 1740
GTGCCCTTCC AGGGGGCTTC TGGCCAGGGC GGACAGAGTC AGGCGGCCGA GATCATGTGC 1800
AAAATTCGCG AGGGGCGATT CTCCCTTGAC GGGGAGGCCT GGCAGGGCGT ATCCGAGGAA 1860
GCCAAGGAGC TGGTCCGAGG GCTCCTGACC GTGGACCCCG CCAAGCGGCT CAAGCTCGAG 1920
GGACTGCGGG GCAGCTCCTG GCTGCAGGAC GGCAGCGCGC GCTCCTCGCC CCCGCTCCGG 1980
ACGCCAGATG TGCTTGAGTC CTCCGGGCCC GCGGTGCGCT CGGGGCTCAA CGCCACCTTC 2040
ATGGCGTTCA ACCGGGGCAA GCGGGAGGGC TTCTTCCTGA AGAGTGTGGA GAACGCACCC 2100
CTGGCCAAGC GGCGGAAGCA GAAGCTGCGG AGCGCCACCG CCTCCCGCCG GGGCTCCTCT 2160
GCACCAGCCG CCCCGGGTCG AGCCCCCGCA GCCTCCAAGG GGGCCCCCCG CCGAGCCAAC 2220
GGCCCCCTGC CCCCCTCCTA A 2241
Domain Profile
S: 5     edlGvGsysvckrcvhkatnqefavkiidks.krdtseeieillryeqhpnivtlkdvyd  63
           lG+Gs+svc+rc++++++qefavki++++ +++t++e+++l+++++hpn+v+l++v++
Q: 389   PALGQGSFSVCRRCRQRQSGQEFAVKILSRRlEANTQREVAALRLCQSHPNVVNLHEVHQ  448
         579*********************************************************
S: 64    dgkyvylvlellkGGelldrikkkkffsereasailrtlvkaveylheq.Gvvhrdlkpe  122
         d++++ylvlell+GGell++i+kk++fse+eas+ilr+lv+av+++he+ Gvvhrdlkpe
Q: 449   DQLHTYLVLELLRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEaGVVHRDLKPE  508
         ***********************************************999**********
S: 123   nilyvdesdnaesikiidfGfaklkraeng.llktpcytlnfvapevlkrqGydeacdlw  181
         nily+d++++a+ +kiidfGfa+l+++++g +++tpc+tl+++ape+l++qGyde+cdlw
Q: 509   NILYADDTPGAP-VKIIDFGFARLRPQSPGgPMQTPCFTLQYAAPELLAQQGYDESCDLW  567
         ************.***************988*****************************
S: 182   slGvllytmlaGyvpf....angpedtaeeilakikeGkfslsGeawdsvseeakdlvsk  237
         slGv+ly+ml+G+vpf    ++g++++a+ei++ki+eG+fsl+Geaw++vseeak+lv++
Q: 568   SLGVILYMMLSGQVPFqgasGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEEAKELVRG  627
         ****************999889**************************************
S: 238   lltvdpakrlkleqllkhswl  258
         lltvdpakrlkle+l+ +swl
Q: 628   LLTVDPAKRLKLEGLRGSSWL  648
         ********************7
Domain Sequence
(FASTA)
PALGQGSFSV CRRCRQRQSG QEFAVKILSR RLEANTQREV AALRLCQSHP NVVNLHEVHQ 60
DQLHTYLVLE LLRGGELLEH IRKKRHFSES EASQILRSLV SAVSFMHEEA GVVHRDLKPE 120
NILYADDTPG APVKIIDFGF ARLRPQSPGG PMQTPCFTLQ YAAPELLAQQ GYDESCDLWS 180
LGVILYMMLS GQVPFQGASG QGGQSQAAEI MCKIREGRFS LDGEAWQGVS EEAKELVRGL 240
LTVDPAKRLK LEGLRGSSWL 260
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>
EKS-AIM-00156
EKS-BOT-00164
EKS-CAF-00171
EKS-CAP-00163
EKS-EQC-00155
EKS-FEC-00154
EKS-HOS-00170
EKS-ICT-00159
EKS-LOA-00163
EKS-MAM-00162
EKS-MUM-00169
EKS-MUP-00168
EKS-NOL-00157
EKS-OTG-00168
EKS-PAT-00154
EKS-RAN-00161
EKS-SAH-00158
EKS-SUS-00141
Gene Ontology
GO:0005524; F:ATP binding
GO:0000287; F:magnesium ion binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0007243; P:intracellular protein kinase cascade
KEGG
InterPros
IPR000961; AGC-kinase_C.
IPR011009; Kinase-like_dom.
IPR017892; Pkinase_C.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR016239; Ribosomal_S6_kinase_II.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 2.
PF00433; Pkinase_C; 1.
SMARTs
SM00133; S_TK_X; 1.
SM00220; S_TKc; 2.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS00107; PROTEIN_KINASE_ATP; 2.
PS50011; PROTEIN_KINASE_DOM; 2.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013