EKS-CAJ-00405
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-CAJ-00405
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/PDGFR614.21.6E-184593950358
StatusUnreviewed
Ensembl ProteinENSCJAP00000034181
UniProt AccessionF6VUV9;
Protein NameTyrosine-protein kinase receptor
Protein Synonyms/Alias
Gene NamePDGFRA
Gene Synonyms/Alias PDGFRA;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSCJAG00000018415ENSCJAP00000034195ENSCJAT00000036123
ENSCJAG00000018415ENSCJAP00000034181ENSCJAT00000036109
OrganismCallithrix jacchus
Functional Description
Protein Length1089
Protein Sequence
(FASTA)
MGTSHPVFLV LGCLLTGLSL ILCQLSLPSV LPNENEKVVQ LNSSFSLRCF GESEVSWQYP 60
MSEEENPNVE IRNEENNSGL FVTVLEVSSA SAAHTGLYTC YYNHTQTEEN ELEGRHIYIY 120
VPDPDVAFVP LGMTDYLVIV EDDDSAIIPC RTTDPETPVT LHNSEGVVPA SYDSRQGFNG 180
TFTVGPYICE ATVEGKKFQT IPFNVYALKA TSKLDLEMEA LKTVYKSGET IVVTCAVFNN 240
EVVDLQWTYP GEVKGKGITM LEEIKVPSIK LVYTLTVPEA TVKDSGDYEC AARQATREVK 300
EMKKVTISVH EKGFIEIKPN FSQLEAVNLH EVKNFVVEVQ AYPTPRISWL KNNLTLIENL 360
TEITTDVEKI QETRYRSQLK LIRAKEEDSG HYTIVVQNED DVKSYTFELL TQVPSSILDL 420
VDDHHGSTGG QTVRCMAEGT PLPDIEWMIC KDIKKCNNET SWTILANNVS NIITEVHPRG 480
RSTVEGRVTF AKVEETIAVR CLAKNLLGAE NRELKLVAPT LRSELTVAAA VLVLLVIVII 540
SLIVLVVIWK QKPRYEIRWR VIESISPDGH EYIYVDPMQL PYDSRWEFPR DGLVLGRVLG 600
SGAFGKVVEG TAYGLSRSQP VMKVAVKMLK PTARSSEKQA LMSELKIMTH LGPHLNIVNL 660
LGACTKSGPI YIITEYCFYG DLVNYLHKNR DSFLSHHPEK AKKELDIFGL NPADESTRSY 720
VILSFENNGD YMDMKQADTT QYVPMLERKE VSKYSDIQRS LYDRPASYKK KSMLDSEVKN 780
LLSDDNSEGL TLLDLLSFTY QVARGMEFLA SKNCVHRDLA ARNVLLAQGK IVKICDFGLA 840
RDIMHDSNYV SKGSTFLPVK WMAPESIFDN LYTTLSDVWS YGILLWEIFS LGGTPYPGMM 900
VDSTFYNKIK SGYRMAKPDH ATSEVYEIMV KCWNSEPEKR PSFYHLSEIV ENLLPGQYKK 960
SYEKIHLDFL KSDHPAVARM RVDSDNAYIG VTYKNEEDKL KDWEGGLDEQ RLSADSGYII 1020
PLPDIDPVPE EEDLGKRNRH SSQTSEESAI ETGSSSSTFI KREDETIEDI DMMDDIGIDS 1080
SDLVEDSFL 1089
Nucleotide Sequence
(FASTA)
ATGGGGACTT CCCATCCGGT GTTCCTGGTC CTAGGCTGTC TTCTTACAGG GCTGAGCCTA 60
ATCCTCTGCC AGCTTTCATT ACCCTCTGTC CTTCCAAATG AAAATGAAAA GGTTGTGCAG 120
CTGAATTCAT CCTTTTCTCT GAGATGCTTT GGGGAGAGTG AAGTGAGCTG GCAGTACCCC 180
ATGTCTGAAG AAGAGAACCC CAATGTGGAA ATCAGAAATG AGGAAAACAA CAGTGGCCTT 240
TTTGTGACGG TCTTGGAAGT GAGCAGCGCC TCGGCAGCCC ACACAGGGCT GTACACTTGC 300
TATTACAACC ACACTCAGAC AGAAGAGAAT GAGCTTGAAG GCAGGCACAT TTACATCTAT 360
GTGCCAGACC CAGATGTTGC CTTTGTACCT CTAGGAATGA CGGATTATTT AGTCATTGTG 420
GAGGACGATG ATTCTGCCAT CATACCTTGT CGCACCACTG ATCCCGAGAC TCCTGTAACC 480
TTACACAACA GTGAGGGGGT GGTACCTGCC TCCTATGACA GCAGACAGGG CTTTAATGGG 540
ACCTTCACTG TCGGGCCCTA TATCTGTGAG GCCACTGTCG AAGGGAAAAA GTTCCAGACC 600
ATCCCTTTTA ACGTTTATGC TTTAAAAGCA ACATCAAAGC TGGATCTAGA AATGGAAGCT 660
CTTAAAACCG TGTATAAGTC AGGGGAAACG ATTGTAGTCA CCTGTGCTGT ATTTAATAAT 720
GAGGTGGTTG ACCTTCAGTG GACTTACCCT GGAGAAGTGA AAGGCAAAGG CATCACAATG 780
CTTGAAGAAA TCAAAGTCCC ATCCATCAAA TTGGTGTACA CTTTGACGGT CCCCGAGGCC 840
ACGGTGAAAG ACAGTGGAGA TTACGAATGT GCTGCCCGCC AGGCTACCAG GGAGGTCAAA 900
GAAATGAAGA AAGTCACTAT TTCTGTCCAT GAGAAAGGCT TCATTGAGAT CAAACCCAAC 960
TTCAGCCAGT TGGAAGCTGT CAACCTGCAT GAAGTCAAAA ATTTTGTCGT AGAGGTGCAG 1020
GCCTACCCAA CTCCCAGGAT ATCCTGGCTG AAAAACAACC TGACTCTGAT TGAAAATCTC 1080
ACCGAGATCA CCACTGATGT AGAAAAGATT CAGGAAACAA GGTATCGAAG CCAATTAAAG 1140
CTAATCCGTG CTAAGGAAGA AGACAGTGGC CATTACACTA TTGTAGTTCA AAATGAAGAT 1200
GATGTGAAGA GCTATACTTT TGAACTGTTA ACTCAAGTTC CTTCATCCAT TCTGGACTTG 1260
GTTGATGATC ACCATGGCTC AACTGGGGGA CAAACTGTGA GGTGCATGGC TGAAGGCACG 1320
CCGCTTCCTG ATATTGAGTG GATGATTTGC AAGGATATTA AGAAATGTAA TAACGAAACT 1380
TCCTGGACAA TTTTGGCCAA CAATGTCTCA AACATCATCA CGGAGGTCCA TCCCCGAGGC 1440
AGGAGTACTG TGGAGGGCCG TGTGACTTTC GCCAAGGTGG AGGAGACCAT TGCGGTGCGA 1500
TGCCTGGCTA AGAATCTCCT TGGTGCTGAG AACCGAGAGC TGAAGCTCGT AGCTCCCACC 1560
CTGCGTTCTG AACTCACGGT GGCTGCCGCG GTCCTGGTGC TGTTGGTGAT TGTGATCATC 1620
TCACTCATTG TTCTGGTCGT CATTTGGAAA CAGAAACCGA GGTATGAAAT TCGCTGGAGG 1680
GTCATTGAAT CAATCAGCCC TGATGGACAT GAATATATTT ACGTGGACCC GATGCAGCTG 1740
CCTTATGACT CAAGATGGGA GTTTCCAAGA GATGGACTAG TGCTTGGTCG GGTGTTGGGG 1800
TCTGGAGCGT TTGGGAAGGT GGTTGAAGGA ACAGCCTATG GATTAAGCCG ATCCCAGCCG 1860
GTCATGAAGG TTGCCGTGAA GATGTTAAAG CCCACGGCCA GATCCAGTGA AAAACAAGCT 1920
CTCATGTCTG AACTGAAGAT AATGACTCAC CTGGGGCCAC ACTTGAACAT TGTAAACTTG 1980
CTGGGAGCCT GTACCAAGTC AGGCCCCATC TACATCATCA CAGAGTACTG CTTCTATGGA 2040
GATTTGGTAA ACTATTTGCA TAAGAATAGG GATAGCTTCC TGAGCCACCA CCCGGAGAAG 2100
GCAAAGAAAG AACTGGATAT CTTTGGATTG AACCCTGCTG ATGAAAGCAC ACGGAGCTAT 2160
GTTATTTTGT CTTTTGAAAA CAATGGTGAC TACATGGACA TGAAGCAAGC TGATACTACA 2220
CAGTATGTCC CCATGCTGGA AAGGAAAGAA GTTTCTAAAT ATTCCGACAT CCAGAGATCA 2280
CTCTATGATC GTCCAGCCTC ATATAAGAAG AAATCTATGT TAGACTCAGA AGTCAAAAAC 2340
CTCCTTTCAG ATGATAACTC TGAAGGCCTC ACTTTGTTGG ATTTGTTGAG CTTCACCTAT 2400
CAAGTTGCCC GAGGAATGGA GTTTTTGGCT TCAAAAAATT GTGTCCACCG GGATCTGGCT 2460
GCTCGCAACG TCCTCCTGGC ACAAGGAAAA ATTGTGAAGA TCTGTGACTT CGGCCTGGCC 2520
AGAGACATCA TGCATGACTC GAACTACGTG TCAAAAGGCA GTACCTTTCT GCCTGTGAAG 2580
TGGATGGCTC CTGAGAGCAT CTTTGACAAC CTCTACACCA CACTGAGTGA CGTCTGGTCT 2640
TATGGCATTC TGCTCTGGGA GATCTTTTCC CTTGGTGGCA CCCCTTACCC CGGCATGATG 2700
GTGGATTCTA CTTTCTATAA TAAGATCAAG AGTGGGTACC GGATGGCCAA GCCTGACCAC 2760
GCTACCAGTG AAGTCTACGA GATCATGGTG AAATGCTGGA ACAGCGAGCC GGAGAAGAGA 2820
CCCTCCTTTT ACCACCTGAG TGAGATTGTG GAGAATCTGC TGCCTGGACA ATATAAAAAG 2880
AGTTATGAAA AAATTCACCT GGACTTCCTG AAGAGTGACC ATCCTGCCGT GGCACGCATG 2940
CGTGTGGACT CAGACAATGC GTACATTGGT GTCACCTACA AAAACGAGGA AGATAAGCTG 3000
AAGGACTGGG AGGGTGGCCT GGATGAGCAG AGGCTGAGCG CTGACAGTGG CTACATCATT 3060
CCTCTGCCTG ACATCGACCC TGTCCCTGAG GAGGAGGACC TGGGCAAGAG GAACAGACAC 3120
AGCTCACAGA CCTCTGAAGA GAGTGCCATT GAGACAGGTT CCAGCAGTTC GACCTTCATC 3180
AAGAGAGAGG ATGAGACCAT CGAAGACATC GACATGATGG ACGACATCGG CATAGACTCT 3240
TCAGACCTGG TGGAAGACAG CTTCCTGTAA 3270
Domain Profile
S: 1     lelGkvlGsGafGkvveatayGlsksdavlkvavkmlkstarssekealmselkilshlG  60
         l+lG+vlGsGafGkvve+tayGls+s++v+kvavkmlk+tarssek+almselki++hlG
Q: 593   LVLGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLG  652
         78**********************************************************
S: 61    ehenivnllGactkgGpiyviteyccyGdllnylrrkresflkkslekkkekeeeldska  120
         +h+nivnllGactk+Gpiy+iteyc+yGdl+nyl+++r+sfl+++ ek    ++eld+++
Q: 653   PHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSHHPEK---AKKELDIFG  709
         **********************************************99...778999999
S: 121   l.ladkslrsksslssesseeyvdlkkd................vsdvssskadklasek  163
         l +ad+s+rs+++ls+e++++y+d+k++                +sd+++s +d++as+k
Q: 710   LnPADESTRSYVILSFENNGDYMDMKQAdttqyvpmlerkevskYSDIQRSLYDRPASYK  769
         99*************************9********************************
S: 164   kksalerevkaaleeedsevleledllsfsyqvakGmeflaskncvhrdlaarnvllteG  223
         kks+l++evk+ l++++se+l+l dllsf+yqva+Gmeflaskncvhrdlaarnvll++G
Q: 770   KKSMLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQG  829
         ************************************************************
S: 224   kvvkicdfGlardimkdsnyvvkGnarlpvkwmapesifdslytvksdvwsyGillweif  283
         k+vkicdfGlardim+dsnyv+kG+++lpvkwmapesifd+lyt+ sdvwsyGillweif
Q: 830   KIVKICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIF  889
         ************************************************************
S: 284   slGstpypgllvdskfyklikeGyrmaqpayateeiyeimqkcweaepekrpsfkqlvel  343
         slG+tpypg++vds+fy++ik+Gyrma+p++at+e+yeim+kcw++epekrpsf++l+e+
Q: 890   SLGGTPYPGMMVDSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEI  949
         *********************************************************998
S: 344   l  344
         +
Q: 950   V  950
         6
Domain Sequence
(FASTA)
LVLGRVLGSG AFGKVVEGTA YGLSRSQPVM KVAVKMLKPT ARSSEKQALM SELKIMTHLG 60
PHLNIVNLLG ACTKSGPIYI ITEYCFYGDL VNYLHKNRDS FLSHHPEKAK KELDIFGLNP 120
ADESTRSYVI LSFENNGDYM DMKQADTTQY VPMLERKEVS KYSDIQRSLY DRPASYKKKS 180
MLDSEVKNLL SDDNSEGLTL LDLLSFTYQV ARGMEFLASK NCVHRDLAAR NVLLAQGKIV 240
KICDFGLARD IMHDSNYVSK GSTFLPVKWM APESIFDNLY TTLSDVWSYG ILLWEIFSLG 300
GTPYPGMMVD STFYNKIKSG YRMAKPDHAT SEVYEIMVKC WNSEPEKRPS FYHLSEIV 358
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>
EKS-AIM-00373
EKS-ANC-00388
EKS-BOT-00401
EKS-CAF-00401
EKS-CAP-00430
EKS-EQC-00393
EKS-FEC-00385
EKS-GAG-00339
EKS-GAA-00490
EKS-GOG-00393
EKS-HOS-00407
EKS-ICT-00380
EKS-LAC-00417
EKS-LOA-00410
EKS-MAM-00400
EKS-MEG-00333
EKS-MOD-00390
EKS-MUM-00433
EKS-MUP-00395
EKS-MYL-00396
EKS-NOL-00366
EKS-OCP-00085
EKS-ORN-00512
EKS-ORA-00350
EKS-ORC-00376
EKS-ORL-00470
EKS-OTG-00403
EKS-PAT-00380
EKS-PES-00356
EKS-POA-00392
EKS-RAN-00416
EKS-SAH-00370
EKS-TAG-00476
EKS-TAR-00508
EKS-TEN-00509
EKS-TUT-00117
EKS-XET-00512
Gene Ontology
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0005021; F:vascular endothelial growth factor-activated receptor activity
GO:0048010; P:vascular endothelial growth factor receptor signaling pathway
GO:0038084; P:vascular endothelial growth factor signaling pathway
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003599; Ig_sub.
IPR003598; Ig_sub2.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016243; Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824; Tyr_kinase_rcpt_3_CS.
IPR009134; Tyr_kinase_VEGFR_rcpt_N.
Pfam
PF07679; I-set; 2.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00409; IG; 2.
SM00408; IGc2; 1.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 3.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00240; RECEPTOR_TYR_KIN_III; 1.
Prints
PR01832; VEGFRECEPTOR.
Created Date20-Feb-2013