EKS-CAJ-00111
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-CAJ-00111
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Tec475.75.8E-143363613251
StatusUnreviewed
Ensembl ProteinENSCJAP00000034560
UniProt AccessionF7IG16;
Protein Name
Protein Synonyms/Alias
Gene NameITK
Gene Synonyms/Alias ITK;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSCJAG00000018825ENSCJAP00000034987ENSCJAT00000036944
ENSCJAG00000018825ENSCJAP00000034560ENSCJAT00000036497
ENSCJAG00000018825ENSCJAP00000035020ENSCJAT00000036977
OrganismCallithrix jacchus
Functional Description
Protein Length620
Protein Sequence
(FASTA)
MNNFILLEEQ LIKKSQQKRR TSPSNFKVRF FVLTKASLAY FEDRHGKKRT LKGSIELSRI 60
KCVEIVKSDI SIPCHYKYPF QVVHDNYLLY VFAPDRESRQ RWVLALKEET RNNNSLVPKY 120
HPNFWMDGKW RCCSQLEKLA AGCAHYDPTK NASKKPLPPT PEDNRRPLWE PEDTVVIALY 180
DYQTNDPQEL ALRRNEEYCL LDSSEIHWWR VQDRNGHEGY VPSSYLVEKS PNNLETYEWY 240
NKSISRDKAE KLLLDTGKEG AFMVRDSRTP GTYTVSVFTK AIVSENNPCI KHYHIKETND 300
NPKRYYVAEK YVFDSIPLLI NYHQHNGGGL VTRLRYPVCF GRQKAPVTAG LRYGKWVIDP 360
SELTFVQEIG SGQFGLVHLG YWLNKDKVAI KTIREGAMSE EDFIEEAEVM MKLSHPKLVQ 420
LYGVCLEQAP ICLVFEFMEH GCLSDYLRSQ RGLFAAETLL GMCLDVCEGM AYLEEACVIH 480
RDLAARNCLV GENQVIKVSD FGMTRFVLDD QYTSSTGTKF PVKWASPEVF SFSRYSSKSD 540
VWSFGVLMWE VFSEGKIPYE NRSNSEVVED ISTGFRLYKP RLASSHVYQI MNHCWKERPE 600
DRPAFSRLLR QLAEIAESGL 620
Nucleotide Sequence
(FASTA)
ATGAACAACT TTATCCTCCT GGAAGAACAG CTCATCAAGA AATCCCAACA AAAGAGAAGA 60
ACCTCTCCCT CGAACTTTAA AGTCCGCTTC TTTGTGTTAA CCAAAGCTAG CCTGGCATAC 120
TTTGAGGATC GTCATGGGAA GAAGCGCACA CTGAAGGGCT CCATTGAGCT CTCCCGAATC 180
AAATGTGTCG AGATTGTGAA AAGTGACATC AGCATCCCAT GCCACTATAA ATACCCATTT 240
CAGGTCGTGC ATGACAACTA CCTCCTATAC GTGTTTGCTC CAGATCGTGA GAGCCGGCAG 300
CGCTGGGTGC TGGCCCTTAA AGAAGAAACG AGGAATAATA ACAGTTTGGT GCCCAAGTAT 360
CATCCTAATT TCTGGATGGA TGGGAAGTGG AGGTGCTGTT CTCAGCTGGA GAAGCTTGCA 420
GCAGGCTGTG CCCACTATGA TCCAACCAAG AATGCTTCAA AGAAGCCTCT TCCTCCTACT 480
CCTGAAGACA ACAGGCGACC ACTTTGGGAA CCTGAAGACA CTGTGGTCAT TGCCTTGTAT 540
GACTACCAAA CCAACGATCC CCAGGAACTC GCCCTACGGC GCAATGAAGA ATACTGCCTG 600
CTGGACAGTT CCGAGATTCA CTGGTGGAGA GTCCAGGACA GGAATGGGCA TGAAGGATAT 660
GTACCAAGCA GTTATCTGGT GGAAAAATCT CCAAATAATC TGGAAACCTA TGAGTGGTAC 720
AATAAGAGTA TCAGCCGAGA CAAAGCTGAA AAACTTCTTT TAGACACAGG CAAAGAAGGA 780
GCCTTCATGG TCAGAGATTC CAGGACCCCA GGAACATACA CTGTGTCCGT GTTCACTAAG 840
GCCATTGTAA GTGAGAACAA TCCCTGTATA AAGCACTATC ACATCAAGGA AACAAATGAC 900
AATCCTAAGC GATACTATGT GGCTGAAAAG TACGTGTTTG ATTCCATCCC TCTTCTCATC 960
AACTATCACC AACATAATGG AGGAGGCCTG GTCACTCGAC TCCGGTATCC AGTTTGTTTT 1020
GGGAGGCAGA AAGCCCCGGT CACGGCGGGG CTGAGATACG GGAAATGGGT GATCGATCCC 1080
TCGGAGCTCA CTTTTGTGCA AGAGATTGGC AGTGGGCAAT TTGGGTTGGT GCATCTGGGC 1140
TACTGGCTCA ACAAGGACAA GGTGGCTATC AAAACCATTC GAGAAGGGGC TATGTCAGAA 1200
GAGGACTTCA TAGAGGAGGC TGAAGTCATG ATGAAACTCT CTCATCCCAA ACTGGTCCAG 1260
CTGTATGGGG TGTGCCTGGA GCAGGCCCCC ATCTGCCTGG TGTTTGAGTT CATGGAGCAC 1320
GGCTGCCTGT CGGATTATCT GCGCAGCCAG AGGGGACTTT TTGCTGCAGA GACCCTGCTG 1380
GGCATGTGTC TGGATGTGTG TGAGGGCATG GCCTACCTGG AAGAGGCGTG TGTCATCCAC 1440
AGAGACTTGG CTGCCCGAAA TTGTTTGGTG GGAGAAAACC AAGTCATCAA GGTGTCTGAC 1500
TTTGGGATGA CAAGGTTCGT TCTTGATGAT CAGTACACCA GTTCCACAGG CACCAAGTTC 1560
CCGGTGAAGT GGGCATCCCC GGAAGTTTTC TCTTTCAGTC GCTATAGCAG CAAGTCGGAT 1620
GTGTGGTCAT TTGGTGTGCT GATGTGGGAA GTTTTCAGTG AAGGCAAAAT CCCATATGAA 1680
AACCGAAGCA ACTCAGAGGT GGTAGAAGAC ATCAGTACTG GATTTCGGTT GTACAAGCCC 1740
CGGCTAGCCT CCTCACATGT CTACCAGATT ATGAATCACT GCTGGAAAGA GAGACCAGAG 1800
GATCGGCCAG CCTTCTCCAG ACTGCTGCGT CAACTGGCTG AAATTGCAGA ATCAGGACTT 1860
TAG 1863
Domain Profile
S: 1     ltllkelgsgqfgvvklgkwrakidvaikaikegamseedfieeakvmmklshpklvqly  60
         lt+++e+gsgqfg+v+lg+w +k++vaik+i+egamseedfieea+vmmklshpklvqly
Q: 363   LTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIREGAMSEEDFIEEAEVMMKLSHPKLVQLY  422
         79**********************************************************
S: 61    gvclkqkpiyivteylengcllnylrekkkklekelllemckdvcegmeylerksfihrd  120
         gvcl+q+pi++v+e++e+gcl++ylr++++ +++e+ll mc dvcegm+yle++++ihrd
Q: 423   GVCLEQAPICLVFEFMEHGCLSDYLRSQRGLFAAETLLGMCLDVCEGMAYLEEACVIHRD  482
         ************************************************************
S: 121   laarnclvdeelvvkvsdfglaryvlddqyvssvgakfpvkwsppevlsyskyssksdvw  180
         laarnclv+e++v+kvsdfg++r+vlddqy+ss+g+kfpvkw++pev+s+s+yssksdvw
Q: 483   LAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFSFSRYSSKSDVW  542
         ************************************************************
S: 181   afgvlmwevfsegklpyekksnsevvekvsrglrlyrpklaskkvyevmkscwkekpeer  240
         +fgvlmwevfsegk+pye++snsevve++s+g+rly+p+las++vy++m++cwke+pe+r
Q: 543   SFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASSHVYQIMNHCWKERPEDR  602
         ************************************************************
S: 241   ptfkellsale  251
         p+f++ll++l+
Q: 603   PAFSRLLRQLA  613
         ********996
Domain Sequence
(FASTA)
LTFVQEIGSG QFGLVHLGYW LNKDKVAIKT IREGAMSEED FIEEAEVMMK LSHPKLVQLY 60
GVCLEQAPIC LVFEFMEHGC LSDYLRSQRG LFAAETLLGM CLDVCEGMAY LEEACVIHRD 120
LAARNCLVGE NQVIKVSDFG MTRFVLDDQY TSSTGTKFPV KWASPEVFSF SRYSSKSDVW 180
SFGVLMWEVF SEGKIPYENR SNSEVVEDIS TGFRLYKPRL ASSHVYQIMN HCWKERPEDR 240
PAFSRLLRQL A 251
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>
EKS-AIM-00101
EKS-ANC-00099
EKS-BOT-00110
EKS-CAF-00112
EKS-CAP-00105
EKS-DAR-00357
EKS-EQC-00108
EKS-FEC-00105
EKS-GAG-00090
EKS-GAA-00128
EKS-GOG-00111
EKS-HOS-00113
EKS-ICT-00105
EKS-LAC-00114
EKS-LOA-00106
EKS-MAM-00105
EKS-MEG-00085
EKS-MOD-00106
EKS-MUM-00112
EKS-MUP-00113
EKS-MYL-00124
EKS-NOL-00103
EKS-OCP-00072
EKS-ORA-00089
EKS-ORC-00102
EKS-ORL-00125
EKS-OTG-00112
EKS-PAT-00100
EKS-PES-00093
EKS-POA-00103
EKS-RAN-00108
EKS-SAH-00102
EKS-TAG-00138
EKS-TAR-00137
EKS-TEN-00127
EKS-XET-00091
Gene Ontology
GO:0005622; C:intracellular
GO:0005524; F:ATP binding
GO:0005543; F:phospholipid binding
GO:0004713; F:protein tyrosine kinase activity
GO:0035556; P:intracellular signal transduction
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR011993; PH_like_dom.
IPR001849; Pleckstrin_homology.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR001562; Znf_Btk_motif.
Pfam
PF00779; BTK; 1.
PF00169; PH; 1.
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00107; BTK; 1.
SM00233; PH; 1.
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS50003; PH_DOMAIN; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
PS51113; ZF_BTK; 1.
Prints
PR00401; SH2DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013