EKS-CAJ-00446

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAJ-00446

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/DMPK	470.4	3.5E-141	76	338	263

Status

Unreviewed

Ensembl Protein

ENSCJAP00000038068

UniProt Accession

F7IR26;

Protein Name

Protein Synonyms/Alias

Gene Name

ROCK1

Gene Synonyms/Alias

ROCK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCJAG00000020477	ENSCJAP00000038068	ENSCJAT00000040217
ENSCJAG00000020477	ENSCJAP00000038071	ENSCJAT00000040220

Organism

Callithrix jacchus

Functional Description

Protein Length

1355

Protein Sequence
(FASTA)

MSTGDSFETR FEKIDNLLRD PKSEVNSDCL LDGLDALVYD LDFPALRKNK NIDNFLSRYK 60

DTINKIRDLR MKAEDYEVVK VIGRGAFGEV QLVRHKSTRK VYAMKLLSKF EMIKRSDSAF 120

FWEERDIMAF ANSPWVVQLF YAFQDDRYLY MVMEYMPGGD LVNLMSNYDV PEKWARFYTA 180

EVVLALDAIH SMGFIHRDVK PDNMLLDKSG HLKLADFGTC MKMNKEGMVR CDTAVGTPDY 240

ISPEVLKSQG GDGYYGRECD WWSVGVFLYE MLVGDTPFYA DSLVGTYSKI MNHKNSLTFP 300

DDNDISKEAK NLICAFLTDR EVRLGRNGVE EIKRHLFFKN DQWAWETLRD TVAPVVPDLS 360

SDIDTSNFDD LEEDKGEEET FPIPKAFVGN QLPFVGFTYY SSRRYLSSAN PNDNRTSSNA 420

DKSLQESLQK TIYKLEEQLH NEMQLKDEME QKCRTSNIKL DKIMKELDEE GNQRRNLEST 480

VSQIEKEKML LQHRINEYQR KAEQENEKRR NVENEVSTLK DQLEDLKKVS QNSQLANEKL 540

SQLQKQLEEA NDLLRTESDT AVRLRKSHTE MSKSISQLES LNRELQERNR ILENSKSQTD 600

KDYYQLQAIL EAERRDRSHD SEMIGDLQAR ITSLHEEVKH LKHNLEKVEG ERKEAQDMLN 660

HSEKEKNNLE IDLNYKLKSL QQRLEQEVNE HKVTKARLTD KHQSIEEAKS VAMCEMEKKL 720

KEEREAREKA ENRVVQVEKQ CSMLDVDLKQ SQQKLEHLTG NKERIEDEVK NLTLQLEQES 780

NKRLLLQNEL KTQAFEADNL KGLEKQMKQE INTLLEAKRL LEFELAQLTK QYRGNEGQMR 840

ELQDQLEAEQ YFSTLYKTQV KELKEEIEEK NRENLKKIQE LQNEKETLAT QLDLAETKAE 900

SEQLARGLLE EQYFELTQES KKAASRNRQE ITDKDHTVSR LEEANSMLTK DIEILRRENE 960

ELTEKMKRTE EEYKLEKEEE ISNLKAAFEK NINTERTLKT QAVNKLAEIM NRKDFKIDRK 1020

KANTQDLRKK EKENRKLQLE LNQEREKFNQ MVVKHQKELN DMQAQLVEEC AHRNELQMQL 1080

ASKESDIEQL RAKLLDLSDS TSVASFPSAD ETDGNLPESR IEGWLSVPNR GNIKRYGWKK 1140

QYVVVSSKKI LFYNDEQDKE QSNPSMVLDI DKLFHVRPVT QGDVYRAETE EIPKIFQILY 1200

ANEGECRKDV EMEPVQQAEK TNFQNHKGHE FIPTLYHFPA NCDACAKPLW HVFKPPPALE 1260

CRRCHVKCHR DHLDKKEDLI CPCKVSYDVT SARDMLLLAC SQDEQKKWVT HLVKKIPKNP 1320

PSGFVRASPR TLSTRSTANQ SFRKAVKNTS AQRPS 1355

Nucleotide Sequence
(FASTA)

ATGTCGACTG GGGACAGTTT TGAAACTCGA TTTGAAAAAA TCGACAACCT GCTGCGGGAT 60

CCCAAATCGG AAGTGAATTC GGATTGTTTG CTGGATGGAT TGGATGCTTT GGTATATGAT 120

TTGGATTTTC CTGCCTTAAG AAAAAACAAA AATATTGACA ACTTTTTAAG CAGATATAAA 180

GACACAATAA ATAAAATTAG AGATTTACGA ATGAAAGCTG AAGATTATGA AGTAGTGAAG 240

GTGATTGGTA GAGGTGCATT TGGAGAAGTT CAATTGGTAA GGCATAAATC CACCAGGAAG 300

GTATATGCTA TGAAGCTTCT CAGCAAATTT GAAATGATTA AGAGATCTGA TTCTGCTTTT 360

TTCTGGGAAG AAAGGGACAT CATGGCTTTT GCTAACAGTC CTTGGGTTGT TCAGCTTTTT 420

TATGCATTCC AAGATGATCG TTATCTCTAC ATGGTGATGG AATACATGCC TGGTGGAGAT 480

CTTGTAAACT TAATGAGCAA CTATGATGTG CCTGAAAAAT GGGCACGATT CTATACTGCA 540

GAAGTAGTTC TTGCATTGGA TGCAATCCAT TCCATGGGTT TTATTCATAG AGATGTGAAG 600

CCTGATAACA TGCTGCTCGA TAAATCTGGA CATTTGAAGT TAGCAGATTT TGGTACTTGT 660

ATGAAGATGA ATAAGGAAGG CATGGTACGA TGTGATACAG CAGTTGGAAC ACCTGATTAT 720

ATTTCCCCTG AGGTATTAAA ATCCCAGGGT GGTGATGGTT ATTATGGAAG AGAATGTGAC 780

TGGTGGTCGG TTGGAGTATT TTTATACGAA ATGCTTGTAG GTGATACACC TTTTTATGCA 840

GATTCTTTGG TTGGAACTTA CAGTAAAATT ATGAACCATA AAAATTCACT TACCTTTCCT 900

GATGATAATG ACATATCAAA AGAAGCAAAA AATCTTATTT GTGCCTTCCT TACTGACAGA 960

GAAGTGAGGT TAGGGCGAAA TGGTGTAGAA GAAATCAAAC GACATCTCTT CTTCAAAAAT 1020

GACCAGTGGG CTTGGGAAAC ACTTCGAGAC ACTGTAGCAC CAGTTGTACC TGATTTAAGT 1080

AGTGACATTG ATACTAGTAA TTTTGATGAC TTGGAAGAAG ATAAAGGAGA AGAAGAAACA 1140

TTCCCTATTC CTAAAGCTTT TGTTGGCAAT CAACTACCTT TTGTAGGATT TACATATTAT 1200

AGCAGTCGTA GATACTTATC TTCAGCAAAT CCTAATGATA ACAGAACTAG CTCCAATGCA 1260

GATAAAAGCT TGCAGGAAAG TTTGCAAAAA ACAATCTATA AGCTGGAAGA ACAGCTGCAT 1320

AACGAAATGC AGTTAAAAGA TGAAATGGAG CAGAAGTGCA GAACCTCAAA CATAAAACTA 1380

GACAAGATAA TGAAAGAATT GGATGAAGAG GGAAATCAAA GAAGAAATCT AGAATCTACA 1440

GTGTCTCAGA TTGAGAAGGA GAAAATGCTG CTACAGCATA GAATTAATGA GTACCAAAGA 1500

AAAGCTGAAC AGGAAAATGA GAAGAGAAGA AATGTAGAAA ACGAAGTTTC TACATTAAAG 1560

GATCAGTTGG AAGACCTAAA GAAAGTAAGT CAGAATTCAC AGCTTGCTAA TGAAAAACTG 1620

TCACAGTTAC AAAAGCAACT AGAAGAAGCC AATGACTTAC TTAGGACAGA ATCGGACACA 1680

GCTGTAAGAT TGAGGAAGAG TCACACAGAG ATGAGCAAGT CAATTAGTCA GCTAGAGTCC 1740

CTGAACAGAG AGTTGCAAGA GAGAAACCGA ATTTTAGAGA ATTCTAAGTC ACAAACAGAC 1800

AAAGATTATT ACCAGCTGCA AGCTATATTA GAAGCTGAAC GAAGAGACAG GAGTCATGAT 1860

TCTGAGATGA TTGGAGACCT TCAAGCTCGA ATTACATCTT TACACGAGGA GGTCAAGCAT 1920

CTCAAACATA ATCTTGAAAA AGTGGAAGGA GAAAGAAAAG AAGCTCAAGA CATGCTTAAT 1980

CACTCAGAAA AGGAAAAGAA TAATTTAGAG ATAGATTTAA ACTACAAACT TAAATCATTA 2040

CAACAACGGT TAGAACAAGA AGTAAATGAA CACAAAGTAA CCAAAGCTCG TTTAACTGAC 2100

AAACATCAAT CTATTGAAGA GGCAAAGTCT GTGGCAATGT GTGAGATGGA AAAAAAGCTG 2160

AAAGAAGAAA GAGAAGCTCG AGAGAAGGCT GAAAATCGGG TTGTTCAGGT TGAGAAACAG 2220

TGTTCCATGC TAGATGTTGA TCTGAAGCAA TCTCAGCAGA AACTAGAACA TTTGACTGGA 2280

AATAAAGAAA GGATAGAGGA TGAAGTTAAG AATCTAACCC TGCAACTGGA GCAGGAATCA 2340

AATAAGCGGC TGTTGTTACA AAATGAATTG AAGACTCAGG CATTCGAGGC AGACAATTTA 2400

AAAGGTTTAG AAAAGCAGAT GAAACAGGAA ATAAATACTT TATTGGAAGC AAAGAGATTA 2460

TTAGAATTTG AGTTAGCTCA GCTTACAAAA CAGTATAGAG GAAATGAAGG ACAGATGCGG 2520

GAACTACAAG ATCAGCTTGA AGCTGAGCAA TATTTCTCGA CACTTTATAA AACCCAGGTA 2580

AAGGAACTTA AAGAAGAAAT TGAAGAAAAA AACAGAGAAA ATTTAAAGAA AATACAGGAA 2640

TTACAAAATG AAAAAGAAAC TCTTGCTACT CAGTTGGATC TAGCAGAAAC AAAAGCTGAG 2700

TCTGAGCAGT TGGCTCGAGG GCTTCTGGAA GAACAGTATT TTGAATTGAC ACAAGAAAGC 2760

AAGAAAGCTG CTTCAAGAAA TAGACAAGAG ATTACAGATA AAGATCACAC TGTTAGTCGG 2820

CTTGAAGAAG CAAACAGCAT GCTAACCAAA GATATTGAAA TATTAAGAAG AGAGAATGAA 2880

GAGCTAACAG AGAAAATGAA GAGGACAGAG GAAGAATATA AATTGGAGAA GGAGGAGGAA 2940

ATCAGTAATC TTAAGGCTGC TTTTGAAAAG AATATCAACA CTGAGCGAAC CCTTAAAACA 3000

CAGGCTGTTA ACAAGTTGGC TGAAATAATG AATCGAAAAG ATTTTAAAAT TGATAGAAAG 3060

AAAGCTAATA CACAAGATTT GAGAAAGAAA GAAAAGGAAA ATCGAAAGCT ACAACTGGAA 3120

CTCAACCAAG AAAGAGAGAA ATTCAACCAG ATGGTAGTGA AACATCAGAA GGAACTGAAT 3180

GACATGCAAG CGCAATTGGT AGAAGAATGT GCACATAGGA ATGAGCTTCA GATGCAGTTG 3240

GCCAGCAAAG AGAGTGATAT TGAGCAGTTG CGAGCTAAAC TTTTGGACCT CTCAGATTCT 3300

ACAAGTGTTG CTAGTTTTCC TAGTGCTGAT GAAACTGATG GGAACCTCCC AGAGTCAAGA 3360

ATTGAAGGTT GGCTTTCAGT ACCAAATAGA GGAAATATCA AACGATATGG CTGGAAGAAA 3420

CAGTATGTTG TGGTAAGCAG CAAAAAAATT TTGTTCTATA ATGATGAACA AGATAAGGAG 3480

CAATCCAATC CATCTATGGT ATTGGACATA GATAAACTGT TTCATGTTCG ACCTGTAACC 3540

CAAGGAGATG TGTATAGAGC TGAAACTGAA GAAATTCCTA AAATATTCCA GATACTATAT 3600

GCAAATGAAG GTGAATGTAG AAAAGATGTA GAGATGGAAC CAGTACAACA AGCTGAAAAA 3660

ACTAATTTCC AAAATCACAA AGGCCATGAG TTTATTCCTA CACTCTACCA CTTTCCTGCC 3720

AATTGTGATG CCTGTGCCAA ACCTCTCTGG CATGTTTTTA AGCCACCCCC TGCCCTAGAA 3780

TGTCGAAGAT GCCATGTTAA GTGCCACAGA GATCACTTAG ATAAGAAAGA AGACTTAATT 3840

TGTCCATGTA AAGTAAGTTA TGATGTAACA TCAGCAAGAG ATATGCTGCT GTTAGCATGT 3900

TCTCAGGATG AACAAAAAAA ATGGGTAACT CATTTAGTAA AGAAAATTCC TAAGAATCCA 3960

CCATCTGGTT TTGTTCGTGC CTCCCCTCGA ACACTTTCTA CAAGATCCAC TGCAAATCAG 4020

TCTTTCCGGA AAGCGGTCAA AAATACATCT GCACAGAGGC CATCA 4065

Domain Profile

S: 1     feilkviGrGafgevavvrekatekvyamkilkklellkraesaffreerdvlvkadsew  60

         +e++kviGrGafgev++vr+k+t+kvyamk+l+k+e++kr++saff+eerd++++a+s+w

Q: 76    YEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPW  135

         89**********************************************************

S: 61    ivqlqyafqdekylylvmeylvGGdlltllskyedklpeelarfylaelvlaldsvhelg  120

         +vql+yafqd++yly+vmey++GGdl++l+s+y+  +pe++arfy+ae+vlald++h++g

Q: 136   VVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYD--VPEKWARFYTAEVVLALDAIHSMG  193

         **********************************..9***********************

S: 121   yvhrdikpdnilldksGhikladfGsclklnedgtvkssvavGtpdyispevlkaleegk  180

         ++hrd+kpdn+lldksGh+kladfG+c+k+n++g+v++++avGtpdyispevlk+++ g+

Q: 194   FIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVLKSQG-GD  252

         ********************************************************9.**

S: 181   geygkecdwwslGvilyellvgetpfyaeslvetyskilnhkeslkfpedekvseeakdl  240

         g+yg+ecdwws+Gv+lye+lvg+tpfya+slv tyski+nhk+sl+fp+d+++s+eak+l

Q: 253   GYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFPDDNDISKEAKNL  312

         ************************************************************

S: 241   ikklltsreerlgregiedlkkhpff  266

         i+++lt+re rlgr+g+e++k+h ff

Q: 313   ICAFLTDREVRLGRNGVEEIKRHLFF  338

         *************************9

Domain Sequence
(FASTA)

YEVVKVIGRG AFGEVQLVRH KSTRKVYAMK LLSKFEMIKR SDSAFFWEER DIMAFANSPW 60

VVQLFYAFQD DRYLYMVMEY MPGGDLVNLM SNYDVPEKWA RFYTAEVVLA LDAIHSMGFI 120

HRDVKPDNML LDKSGHLKLA DFGTCMKMNK EGMVRCDTAV GTPDYISPEV LKSQGGDGYY 180

GRECDWWSVG VFLYEMLVGD TPFYADSLVG TYSKIMNHKN SLTFPDDNDI SKEAKNLICA 240

FLTDREVRLG RNGVEEIKRH LFF 263

Keyword

ATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0005543	; F:phospholipid binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0000910	; P:cytokinesis
GO:0035556	; P:intracellular signal transduction

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011072	; HR1_rho-bd.
IPR011009	; Kinase-like_dom.
IPR011993	; PH_like_dom.
IPR017892	; Pkinase_C.
IPR001849	; Pleckstrin_homology.
IPR002219	; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR020684	; Rho-assoc_coiled-coil_kin.
IPR015008	; Rho-bd.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF02185	; HR1; 1.
PF00169	; PH; 1.
PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.
PF08912	; Rho_Binding; 1.

SMARTs

SM00109	; C1; 1.
SM00233	; PH; 1.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS50003	; PH_DOMAIN; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50081	; ZF_DAG_PE_2; 1.

Prints

Created Date

20-Feb-2013