EKS-CAJ-00267

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAJ-00267

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/PLK	426.9	5.9E-128	48	300	253

Status

Unreviewed

Ensembl Protein

ENSCJAP00000038355

UniProt Accession

F7I711;

Protein Name

Protein Synonyms/Alias

Gene Name

PLK1

Gene Synonyms/Alias

PLK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCJAG00000020626	ENSCJAP00000038354	ENSCJAT00000040521
ENSCJAG00000020626	ENSCJAP00000038353	ENSCJAT00000040520
ENSCJAG00000020626	ENSCJAP00000038355	ENSCJAT00000040522

Organism

Callithrix jacchus

Functional Description

Protein Length

597

Protein Sequence
(FASTA)

MSAAVTAGKL ARAPADPGKA GVPGAPAAAP PAKEIPEILV DPRSRRRYVR GRFLGKGGFA 60

KCFEISDADT KEVFAGKIVP KSLLLKPHQK EKMSMEISIH RSLAHQHVVG FHGFFEDNDF 120

VFVVLELCRR RSLLELHKRR KALTEPEARY YLRQIVLGCQ YLHQNRVIHR DLKLGNLFLN 180

EDLEVKIGDF GLATKVEYDG ERKKTLCGTP NYIAPEVLSK KGHSFEVDVW SIGCIMYTLL 240

VGKPPFETSC LKETYLRIKK NEYNIPKHIN PVATSLIQKM LQTDPTARPT INELLNDEFF 300

TSGYIPARLP ITCLTIPPRF SIAPSSLDSS NRKPLTVLNK GLENPLPERP REKEEPVVRE 360

TGEVVDCHLS DMLQQLHSVN ASKPSDRGLV RQEEAEDPAC IPIFWVSKWV DYSDKYGLGY 420

QLCDNSVGVL FNDSTRLILY NDGDSLQYIE RDGTESYLTV SSHPNSLMKK ITLLKYFRNY 480

MSEHLLKAGA NITPREGDEL ARLPYLRTWF RTRSAIILHL SNGSVQINFF QDHTKLILCP 540

LMAAVTYIDE KRDFRTYRLS LLEEYGCCKE LASRLRYART MVDKLLSSRS ANRLKAS 597

Nucleotide Sequence
(FASTA)

ATGAGTGCGG CGGTGACTGC GGGAAAGCTG GCACGAGCAC CGGCCGACCC TGGGAAAGCC 60

GGGGTTCCCG GAGCTCCAGC GGCGGCCCCA CCAGCGAAAG AGATCCCAGA GATCCTAGTG 120

GACCCACGCA GTCGGCGGCG CTATGTACGG GGCCGCTTTT TGGGCAAGGG CGGCTTTGCC 180

AAGTGCTTCG AGATATCGGA CGCGGACACC AAGGAGGTGT TCGCGGGCAA GATTGTGCCT 240

AAGTCTCTGC TGCTCAAGCC GCACCAGAAA GAGAAGATGT CCATGGAAAT ATCCATTCAC 300

CGCAGCTTGG CCCACCAGCA CGTCGTAGGA TTCCACGGCT TTTTCGAGGA CAACGACTTC 360

GTGTTCGTGG TGTTGGAGCT ATGCCGCCGG AGGTCTCTCC TGGAGCTGCA CAAGAGGAGG 420

AAAGCCCTGA CTGAGCCTGA GGCCAGATAC TATCTGCGGC AGATTGTGCT TGGCTGCCAG 480

TACCTGCACC AAAACCGAGT TATTCACCGA GACCTCAAGC TGGGTAACCT TTTCCTGAAT 540

GAAGATCTGG AGGTGAAAAT AGGGGATTTT GGACTGGCAA CCAAAGTCGA GTATGACGGG 600

GAGAGGAAGA AGACCCTGTG CGGGACTCCT AATTACATAG CTCCCGAGGT GCTGAGCAAG 660

AAAGGGCACA GTTTCGAGGT GGATGTGTGG TCCATTGGGT GTATCATGTA TACCTTGTTA 720

GTGGGCAAAC CACCTTTTGA GACTTCTTGC CTAAAAGAGA CTTACCTCCG TATCAAGAAG 780

AATGAATACA ATATTCCCAA GCACATCAAC CCTGTGGCCA CCTCCCTCAT CCAGAAGATG 840

CTTCAGACAG ATCCCACTGC CCGCCCAACC ATTAACGAGC TGCTTAACGA CGAGTTCTTT 900

ACTTCTGGCT ACATCCCTGC CCGTCTCCCC ATTACCTGTC TGACCATTCC ACCAAGGTTT 960

TCAATCGCTC CCAGCAGCCT GGACTCCAGC AACCGGAAGC CCCTCACAGT CCTCAATAAA 1020

GGCTTGGAGA ACCCCCTGCC TGAGCGTCCC CGGGAAAAAG AGGAACCAGT GGTTCGAGAG 1080

ACGGGTGAGG TGGTCGACTG CCACCTCAGT GATATGCTGC AGCAGCTGCA TAGTGTCAAT 1140

GCCTCAAAGC CCTCAGACCG TGGGCTGGTC AGGCAAGAGG AGGCTGAGGA TCCTGCCTGT 1200

ATCCCCATCT TCTGGGTCAG CAAGTGGGTG GACTATTCGG ACAAGTACGG CCTTGGGTAT 1260

CAGCTGTGTG ATAACAGTGT GGGGGTGCTT TTCAATGACT CAACACGCCT TATTCTCTAC 1320

AACGATGGTG ACAGCCTGCA GTATATAGAG CGTGATGGCA CTGAGTCCTA CCTCACCGTG 1380

AGTTCCCATC CCAACTCTTT GATGAAGAAG ATCACCCTCC TTAAATATTT CCGCAATTAC 1440

ATGAGTGAGC ACTTGCTGAA GGCAGGTGCC AACATCACGC CACGTGAAGG TGATGAGCTT 1500

GCCCGGCTGC CCTACCTGCG GACCTGGTTC CGCACCCGCA GTGCCATCAT CCTGCACCTC 1560

AGCAACGGCA GCGTGCAGAT CAACTTCTTT CAGGATCACA CCAAGCTCAT CTTGTGCCCA 1620

CTGATGGCAG CCGTGACCTA CATTGACGAG AAGCGGGACT TCCGTACATA CCGCCTGAGT 1680

CTCCTGGAGG AGTACGGCTG CTGCAAGGAG CTGGCCAGCC GGCTCCGCTA TGCCCGCACC 1740

ATGGTGGACA AGCTGTTGAG CTCGCGCTCA GCCAACCGCC TCAAGGCCTC CTAA 1794

Domain Profile

S: 1     yergkllGkGgfakcyelkdletkevfavkvvpksllakekqrekvekeieihrslkhkn  60

         y rg++lGkGgfakc+e++d++tkevfa k+vpksll k++q+ek+++ei+ihrsl+h++

Q: 48    YVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQKEKMSMEISIHRSLAHQH  107

         89**********************************************************

S: 61    ivklyeffedkenvylvlelcsrrslaellkrrkaltepevryylrqivsglkylhekri  120

         +v ++ ffed+++v++vlelc+rrsl el+krrkaltepe+ryylrqiv g++ylh++r+

Q: 108   VVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHQNRV  167

         ************************************************************

S: 121   lhrdlklgnlflneelevkigdfGlatrlekeeerkktlcGtPnyiaPevlskkghslev  180

         +hrdlklgnlflne+levkigdfGlat++e+++erkktlcGtPnyiaPevlskkghs+ev

Q: 168   IHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEV  227

         ************************************************************

S: 181   diWslGcilytllvGkPPfetkelketyekikkaeyslPsslskeaksliakllkkePee  240

         d+Ws+Gci+ytllvGkPPfet++lkety +ikk+ey++P+++++ a+sli+k+l+++P++

Q: 228   DVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYNIPKHINPVATSLIQKMLQTDPTA  287

         ************************************************************

S: 241   rpsleevlkdefl  253

         rp+++e+l+def+

Q: 288   RPTINELLNDEFF  300

         ************8

Domain Sequence
(FASTA)

YVRGRFLGKG GFAKCFEISD ADTKEVFAGK IVPKSLLLKP HQKEKMSMEI SIHRSLAHQH 60

VVGFHGFFED NDFVFVVLEL CRRRSLLELH KRRKALTEPE ARYYLRQIVL GCQYLHQNRV 120

IHRDLKLGNL FLNEDLEVKI GDFGLATKVE YDGERKKTLC GTPNYIAPEV LSKKGHSFEV 180

DVWSIGCIMY TLLVGKPPFE TSCLKETYLR IKKNEYNIPK HINPVATSLI QKMLQTDPTA 240

RPTINELLND EFF 253

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000959	; POLO_box_duplicated_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF00659	; POLO_box; 2.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS50078	; POLO_BOX; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013