EKS-CAJ-00172

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAJ-00172

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/PKC	480.3	3.3E-144	195	453	259

Status

Unreviewed

Ensembl Protein

ENSCJAP00000038394

UniProt Accession

F7I4L6;

Protein Name

Protein kinase C

Protein Synonyms/Alias

Gene Name

PRKCB

Gene Synonyms/Alias

PRKCB;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCJAG00000020643	ENSCJAP00000045789	ENSCJAT00000053956
ENSCJAG00000020643	ENSCJAP00000038396	ENSCJAT00000040565
ENSCJAG00000020643	ENSCJAP00000038385	ENSCJAT00000040554
ENSCJAG00000020643	ENSCJAP00000038394	ENSCJAT00000040563

Organism

Callithrix jacchus

Functional Description

Protein Length

526

Protein Sequence
(FASTA)

MNVPSLCGTD HTERRGRIYI QAHIDRDVLI VLVRDAKNLV PMDPNGLSDP YVKLKLIPDP 60

KSESKQKTKT IKCSLNPEWN ETFRFQLKES DKDRRLSVEI WDWDLTSRND FMGSLSFGIS 120

ELQKASVDGW FKLLSQEEGE YFNVPVPPEG SEGNEELRQK FEVSLKGQGG FSLFSPQLDR 180

NSTNGNRDRM KLTDFNFLMV LGKGSFGKVM LSERKGTDEL YAVKILKKDV VIQDDDVECT 240

MVEKRVLALP GKPPFLTQLH SCFQTMDRLY FVMEYVNGGD LMYHIQQVGR FKEPHAVFYA 300

AEIAIGLFFL QSKGIIYRDL KLDNVMLDSE GHIKIADFGM CKENIWDGVT TKTFCGTPDY 360

IAPEIIAYQP YGKSVDWWAF GVLLYEMLAG QAPFEGEDED ELFQSIMEHN VAYPKSMSKE 420

AVAICKGLMT KHPGKRLGCG PEGERDIKEH AFFRYIDWEK LERKEIQPPY KPKACGRNAE 480

NFDRFFTRHP PVLTPPDQEV IRNIDQSEFE GFSFVNSEFL KPEVKS 526

Nucleotide Sequence
(FASTA)

ATGAATGTCC CCAGCCTGTG TGGCACGGAC CACACGGAGC GCCGCGGCCG CATCTACATC 60

CAGGCCCACA TCGACAGGGA CGTCCTCATT GTCCTCGTAA GAGACGCTAA AAACCTGGTA 120

CCTATGGACC CCAATGGCTT GTCAGATCCC TACGTAAAAC TGAAACTGAT TCCTGATCCT 180

AAAAGTGAGA GCAAACAGAA GACCAAAACC ATCAAATGCT CCCTCAATCC CGAGTGGAAT 240

GAGACATTTA GATTTCAGCT GAAAGAATCG GACAAGGACA GAAGACTGTC AGTAGAGATT 300

TGGGACTGGG ATTTGACCAG CAGGAATGAC TTCATGGGAT CTTTGTCCTT TGGGATTTCT 360

GAACTGCAGA AAGCCAGTGT TGATGGCTGG TTTAAGTTAC TGAGCCAGGA GGAAGGCGAG 420

TACTTCAATG TGCCTGTCCC ACCAGAAGGA AGTGAGGGCA ATGAAGAACT GCGGCAGAAA 480

TTCGAGGTGA GTTTGAAAGG ACAGGGGGGT TTCAGTTTGT TTTCCCCTCA ACTTGATAGA 540

AATAGCACCA ATGGCAACAG AGACCGGATG AAACTGACCG ATTTTAACTT CCTAATGGTG 600

CTGGGGAAAG GCAGCTTTGG CAAGGTCATG CTCTCAGAGC GAAAAGGCAC AGATGAGCTC 660

TATGCTGTGA AGATCCTGAA GAAGGACGTC GTAATCCAAG ATGATGACGT GGAGTGCACC 720

ATGGTGGAGA AGCGGGTGCT GGCCCTGCCC GGGAAGCCGC CCTTCCTGAC CCAGCTCCAC 780

TCCTGCTTCC AGACTATGGA CCGCCTGTAC TTTGTGATGG AGTACGTGAA TGGGGGCGAC 840

CTCATGTATC ACATCCAGCA AGTCGGCCGG TTCAAGGAGC CCCATGCTGT ATTTTACGCT 900

GCAGAAATTG CAATCGGTCT GTTCTTCTTA CAGAGTAAGG GCATCATTTA CCGTGACCTA 960

AAACTTGACA ACGTGATGCT GGATTCTGAG GGGCACATCA AGATTGCTGA TTTTGGCATG 1020

TGTAAGGAAA ACATCTGGGA TGGGGTGACA ACCAAGACAT TCTGTGGCAC TCCAGACTAC 1080

ATCGCCCCCG AGATAATTGC TTATCAGCCC TATGGGAAGT CTGTGGATTG GTGGGCGTTT 1140

GGAGTCCTGC TGTATGAAAT GTTGGCTGGG CAGGCACCCT TTGAAGGGGA AGATGAAGAT 1200

GAGCTCTTCC AGTCCATCAT GGAACACAAT GTAGCCTATC CCAAGTCCAT GTCCAAGGAA 1260

GCTGTGGCCA TCTGCAAAGG GCTGATGACC AAACACCCGG GCAAACGTCT AGGTTGCGGA 1320

CCTGAAGGCG AACGTGACAT CAAAGAGCAT GCATTTTTCC GGTATATTGA TTGGGAGAAA 1380

CTTGAACGCA AAGAGATCCA GCCCCCATAT AAGCCAAAAG CTTGTGGGCG AAATGCTGAA 1440

AACTTCGACC GATTTTTCAC CCGCCATCCA CCAGTCCTAA CACCTCCCGA CCAGGAAGTC 1500

ATCAGGAATA TTGACCAATC AGAATTCGAA GGATTTTCCT TTGTTAACTC TGAATTTTTA 1560

AAACCCGAAG TCAAGAGCTA A 1581

Domain Profile

S: 1     fellkvlGkGsfgkvllaelkktdelyaikvlkkdvvlqdddveltlvekrvlalaskkp  60

         f++l+vlGkGsfgkv+l+e+k+tdelya+k+lkkdvv+qdddve+t+vekrvlal  k+p

Q: 195   FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPP  254

         99**********************************************************

S: 61    flvqlfscfqtedrlffvleyvnGGdlmfhiqkarklkeerarfyaaeiilalkflhekg  120

         fl+ql+scfqt+drl+fv+eyvnGGdlm+hiq+++++ke++a+fyaaei+++l+fl++kg

Q: 255   FLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKG  314

         ************************************************************

S: 121   iiyrdlkldnvlldaeGhikladfGlckeeilegkttstfcGtPdyiaPeilkeeeygks  180

         iiyrdlkldnv+ld+eGhik+adfG+cke+i++g tt+tfcGtPdyiaPei+++++ygks

Q: 315   IIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKS  374

         ************************************************************

S: 181   vdwwalGvllyemlagqsPfegededelfesilekevlyPkslskeaveilkglltkdpe  240

         vdwwa+Gvllyemlagq+Pfegededelf+si+e++v+yPks+skeav+i+kgl+tk+p

Q: 375   VDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPG  434

         ************************************************************

S: 241   krlGvkeegeedikehaff  259

         krlG+ +ege+dikehaff

Q: 435   KRLGCGPEGERDIKEHAFF  453

         ******************9

Domain Sequence
(FASTA)

FNFLMVLGKG SFGKVMLSER KGTDELYAVK ILKKDVVIQD DDVECTMVEK RVLALPGKPP 60

FLTQLHSCFQ TMDRLYFVME YVNGGDLMYH IQQVGRFKEP HAVFYAAEIA IGLFFLQSKG 120

IIYRDLKLDN VMLDSEGHIK IADFGMCKEN IWDGVTTKTF CGTPDYIAPE IIAYQPYGKS 180

VDWWAFGVLL YEMLAGQAPF EGEDEDELFQ SIMEHNVAYP KSMSKEAVAI CKGLMTKHPG 240

KRLGCGPEGE RDIKEHAFF 259

Keyword

ATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Repeat; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0004697	; F:protein kinase C activity
GO:0008270	; F:zinc ion binding
GO:0035556	; P:intracellular signal transduction

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR000008	; C2_Ca-dep.
IPR008973	; C2_Ca/lipid-bd_dom_CaLB.
IPR020477	; C2_dom.
IPR018029	; C2_membr_targeting.
IPR020454	; DAG/PE-bd.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR002219	; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR014375	; Protein_kinase_C_a/b/g.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00130	; C1_1; 2.
PF00168	; C2; 1.
PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00109	; C1; 2.
SM00239	; C2; 1.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS50004	; C2; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS00479	; ZF_DAG_PE_1; 2.
PS50081	; ZF_DAG_PE_2; 2.

Prints

PR00360	; C2DOMAIN.
PR00008	; DAGPEDOMAIN.

Created Date

20-Feb-2013