EKS-CAJ-00406

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAJ-00406

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/PDGFR	603.9	2.2E-181	516	874	359

Status

Unreviewed

Ensembl Protein

ENSCJAP00000039221

UniProt Accession

F7G5U7;

Protein Name

Tyrosine-protein kinase receptor

Protein Synonyms/Alias

Gene Name

PDGFRB

Gene Synonyms/Alias

PDGFRB;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCJAG00000021070	ENSCJAP00000039223	ENSCJAT00000041437
ENSCJAG00000021070	ENSCJAP00000039221	ENSCJAT00000041435

Organism

Callithrix jacchus

Functional Description

Protein Length

1024

Protein Sequence
(FASTA)

LTLSNLTGLD TGEYFCTYND SHGLELDERK RLYIFVPDPT VVFLPNDAEE LFIFLTEITE 60

TTIPCRVTDP QLVVTLHEKK GDVALPVLYD HQRGFSGIFE DRSYICKTTI GDREVDSDAY 120

YVYRLQVSSI NVSVNAVQTV VRQGENITLM CIVIGNEVVN FEWTYPRQES GRLVEPVTDF 180

LLDMPYHIRS ILHIPSAELD DSGTYICNVT ESVNDHQDEK AINVTVVESG YVRLLGELGA 240

LQFAELHRSR TLQVVFEAYP PPTVLWFKDN RTLGDSSAGE IALSTRNVSE TRYVSELTLV 300

RVKVAEAGHY TMRAFHEDAE VQLSFQLQIN VPVRVLELSE SHPDSGEQTV RCRGRGMPQP 360

DIIWSACRDL KRCPRELPPT LLGNSSEEES QLETNVTYWE EEQEFEVVST LRLQHVDRPM 420

SVRCTLRNAV GQDMQEVIVV PHSLPFKVVV ISAILALVVL TIISLIILIM LWQKKPRYEI 480

RWKVIESVSS DGHEYIYVDP MQLPYDSTWE LPRDQLVLGR TLGSGAFGQV VEATAHGLSH 540

SQATMKVAVK MLKSTARSSE KQALMSELKI MSHLGPHLNV VNLLGACTKG GPIYIITEYC 600

RYGDLVDYLH RNKHTFLQHH SDKRRPPSAE LYSNALPVGI PLPSHVSLTG ESDGGYMDMS 660

KDESVDYVPM LDMKGDVKYA DIESSNYTAP YDNYVPSAPE RTCQATLINE SPVLSYTDLV 720

GFSYQVANGM EFLASKNCVH RDLAARNVLI CEGKLVKICD FGLARDIMRD SNYISKGSTF 780

LPLKWMAPES IFNSLYTTLS DVWSFGILLW EIFTLGGTPY PELPMNEQFY NAIKRGYRMA 840

QPVHASDEIY EIMQKCWEEK FEIRPPFSQL VLLLERLLGE GYKKKYQQVD EEFLRSDHPA 900

ILRSQARLPG FHGLRSPLDT SSVLYTAVQP NESDNDYIIP LPDPKPEVAD EGPLEGSPSL 960

ASSTLNEVNT SSTISCDSPL EPQEEPEPEP QLELQVEPDP EPELEQPPDS GCPAPRPEAE 1020

DSFL 1024

Nucleotide Sequence
(FASTA)

CTGACACTGA GCAACCTCAC TGGGCTAGAC ACGGGAGAAT ACTTCTGCAC CTACAATGAC 60

TCCCATGGCC TGGAGCTCGA TGAGCGGAAA CGGCTCTACA TCTTTGTGCC AGATCCCACT 120

GTGGTCTTCC TCCCTAATGA TGCCGAGGAA CTATTCATCT TTCTCACGGA AATAACTGAG 180

ACCACAATTC CGTGCCGAGT GACAGACCCG CAGCTGGTGG TGACACTGCA TGAGAAAAAA 240

GGGGACGTTG CACTGCCTGT CCTCTACGAT CACCAACGAG GCTTTTCTGG TATCTTCGAG 300

GACAGAAGCT ACATCTGCAA AACCACCATT GGGGACAGGG AGGTGGATTC CGACGCCTAC 360

TATGTCTACA GACTCCAGGT GTCATCCATC AACGTCTCTG TGAACGCTGT GCAGACTGTG 420

GTCCGCCAGG GCGAGAACAT CACCCTCATG TGCATCGTGA TTGGGAATGA GGTGGTCAAC 480

TTTGAGTGGA CGTACCCCCG CCAAGAGAGC GGGCGGCTGG TGGAGCCGGT GACCGACTTC 540

CTCTTGGATA TGCCTTACCA CATCCGCTCC ATCCTGCACA TCCCCAGTGC CGAGTTGGAC 600

GACTCGGGGA CCTACATCTG CAATGTGACA GAGAGTGTGA ATGACCATCA GGATGAAAAG 660

GCCATCAACG TCACTGTGGT TGAGAGTGGC TACGTGCGTC TCCTGGGAGA GCTGGGTGCT 720

CTACAGTTTG CCGAGCTGCA CCGAAGCCGG ACGCTGCAGG TAGTGTTTGA GGCCTACCCG 780

CCACCCACTG TCCTGTGGTT CAAAGACAAC CGCACCCTGG GTGACTCCAG CGCTGGCGAG 840

ATCGCCCTGT CCACCCGCAA CGTGTCGGAG ACCCGGTACG TGTCAGAGCT GACCCTCGTT 900

CGCGTGAAGG TGGCAGAGGC TGGTCACTAC ACCATGCGGG CCTTCCATGA GGATGCTGAG 960

GTCCAGCTCT CCTTCCAGCT GCAGATCAAT GTTCCTGTCC GCGTGCTGGA GCTAAGCGAG 1020

AGCCACCCTG ACAGTGGGGA ACAGACTGTC CGCTGTCGTG GCAGGGGCAT GCCCCAGCCG 1080

GATATCATCT GGTCTGCCTG CAGAGACCTC AAAAGGTGTC CACGGGAGCT GCCGCCCACA 1140

TTGCTGGGGA ACAGTTCCGA AGAGGAGAGC CAGCTGGAGA CGAACGTGAC ATACTGGGAG 1200

GAGGAGCAGG AGTTTGAGGT GGTGAGCACT CTGCGTCTGC AGCACGTGGA TCGGCCAATG 1260

TCGGTGCGCT GCACGCTGCG CAACGCTGTG GGCCAGGACA TGCAGGAGGT CATCGTGGTG 1320

CCACACTCCC TGCCCTTCAA GGTGGTGGTG ATCTCAGCCA TCCTGGCCCT GGTAGTCCTC 1380

ACCATCATCT CCCTTATCAT CCTCATCATG CTTTGGCAGA AGAAACCACG TTACGAGATC 1440

CGATGGAAGG TGATTGAGTC TGTGAGCTCT GACGGCCATG AGTACATCTA CGTGGATCCC 1500

ATGCAGCTGC CCTATGACTC TACGTGGGAG CTGCCTCGGG ACCAGCTTGT GCTGGGACGT 1560

ACCCTCGGCT CTGGGGCCTT TGGGCAGGTG GTGGAGGCCA CGGCTCATGG CCTGAGCCAT 1620

TCTCAGGCCA CAATGAAAGT GGCCGTCAAG ATGCTGAAAT CCACAGCCCG AAGCAGTGAG 1680

AAGCAAGCCC TTATGTCGGA GCTGAAAATC ATGAGCCACC TTGGGCCTCA CCTGAACGTG 1740

GTCAACCTGC TGGGGGCCTG CACCAAAGGA GGACCCATCT ATATCATCAC TGAGTACTGC 1800

CGCTACGGAG ACCTGGTGGA CTACCTGCAC CGCAACAAGC ACACCTTTCT GCAGCACCAC 1860

TCCGACAAGC GCCGCCCGCC CAGTGCAGAG CTCTACAGCA ATGCACTGCC CGTTGGGATC 1920

CCACTGCCCA GCCATGTGTC CCTGACCGGG GAGAGCGACG GTGGCTACAT GGACATGAGC 1980

AAGGATGAGT CTGTGGACTA CGTGCCCATG CTGGACATGA AAGGAGATGT AAAATATGCA 2040

GACATCGAGT CCTCCAACTA CACGGCCCCT TATGATAACT ATGTTCCCTC TGCCCCTGAG 2100

AGGACCTGTC AGGCGACTTT GATCAACGAG TCTCCAGTAC TTAGCTACAC GGACCTCGTG 2160

GGCTTCAGCT ACCAGGTGGC CAATGGCATG GAGTTCCTGG CCTCCAAGAA TTGCGTCCAC 2220

CGAGACCTGG CGGCCAGGAA TGTGCTCATC TGCGAGGGCA AGCTGGTCAA GATCTGTGAC 2280

TTTGGCCTGG CTCGAGACAT CATGCGAGAC TCAAACTACA TCTCCAAAGG CAGCACCTTT 2340

TTACCTTTGA AGTGGATGGC CCCGGAGAGC ATCTTCAACA GCCTCTACAC CACCCTGAGT 2400

GACGTGTGGT CCTTCGGGAT CCTGCTGTGG GAGATCTTCA CTTTGGGTGG CACCCCTTAC 2460

CCGGAGCTGC CCATGAACGA GCAGTTCTAC AATGCCATCA AGCGGGGGTA CCGCATGGCC 2520

CAGCCTGTCC ACGCCTCCGA TGAGATCTAC GAGATCATGC AGAAGTGTTG GGAAGAGAAA 2580

TTTGAGATTC GGCCCCCCTT CTCCCAGCTG GTGCTGCTTC TCGAGAGACT GCTGGGCGAA 2640

GGTTACAAAA AGAAGTACCA GCAGGTGGAT GAGGAGTTTC TGAGGAGTGA CCACCCAGCC 2700

ATTCTTCGGT CCCAGGCCCG CTTGCCTGGG TTCCATGGCC TCCGGTCTCC CCTGGACACC 2760

AGCTCCGTCC TCTACACTGC TGTGCAGCCC AATGAGAGTG ACAACGACTA TATCATCCCC 2820

CTGCCTGACC CCAAACCCGA GGTTGCTGAC GAGGGCCCAC TAGAGGGTTC CCCCAGCCTA 2880

GCCAGCTCCA CCCTGAATGA AGTCAACACC TCCTCCACCA TCTCCTGTGA CAGCCCCCTG 2940

GAGCCCCAGG AGGAACCAGA GCCAGAGCCC CAGCTTGAGC TCCAGGTGGA GCCGGACCCA 3000

GAGCCCGAGC TGGAGCAGCC GCCGGATTCA GGGTGCCCCG CACCTAGGCC AGAAGCTGAG 3060

GATAGCTTTC TGTAG 3075

Domain Profile

S: 1     lelGkvlGsGafGkvveatayGlsksdavlkvavkmlkstarssekealmselkilshlG  60

         l+lG++lGsGafG+vveata+Gls+s+a++kvavkmlkstarssek+almselki+shlG

Q: 516   LVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLG  575

         78**********************************************************

S: 61    ehenivnllGactkgGpiyviteyccyGdllnylrrkresflkkslekkkekeeeldska  120

         +h+n+vnllGactkgGpiy+iteyc+yGdl++yl+r++++fl+++++k++++++el+s+a

Q: 576   PHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHTFLQHHSDKRRPPSAELYSNA  635

         ************************************************************

S: 121   lladkslrsksslssesseeyvdlkkd................vsdvssskadklasekk  164

         l+++  l s++sl+ es++ y+d++kd                ++d++ss++++++++++

Q: 636   LPVGIPLPSHVSLTGESDGGYMDMSKDesvdyvpmldmkgdvkYADIESSNYTAPYDNYV  695

         ************************************************************

S: 165   ksalerevkaaleeedsevleledllsfsyqvakGmeflaskncvhrdlaarnvllteGk  224

          sa er+++a+l++e s vl+++dl+ fsyqva+Gmeflaskncvhrdlaarnvl++eGk

Q: 696   PSAPERTCQATLINE-SPVLSYTDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGK  754

         **************9.9*******************************************

S: 225   vvkicdfGlardimkdsnyvvkGnarlpvkwmapesifdslytvksdvwsyGillweifs  284

         +vkicdfGlardim+dsny++kG+++lp+kwmapesif+slyt+ sdvws+Gillweif+

Q: 755   LVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFT  814

         ************************************************************

S: 285   lGstpypgllvdskfyklikeGyrmaqpayateeiyeimqkcweaepekrpsfkqlvell  344

         lG+tpyp+l+++++fy++ik+Gyrmaqp +a++eiyeimqkcwe+++e rp+f+qlv ll

Q: 815   LGGTPYPELPMNEQFYNAIKRGYRMAQPVHASDEIYEIMQKCWEEKFEIRPPFSQLVLLL  874

         ********************************************************9986

Domain Sequence
(FASTA)

LVLGRTLGSG AFGQVVEATA HGLSHSQATM KVAVKMLKST ARSSEKQALM SELKIMSHLG 60

PHLNVVNLLG ACTKGGPIYI ITEYCRYGDL VDYLHRNKHT FLQHHSDKRR PPSAELYSNA 120

LPVGIPLPSH VSLTGESDGG YMDMSKDESV DYVPMLDMKG DVKYADIESS NYTAPYDNYV 180

PSAPERTCQA TLINESPVLS YTDLVGFSYQ VANGMEFLAS KNCVHRDLAA RNVLICEGKL 240

VKICDFGLAR DIMRDSNYIS KGSTFLPLKW MAPESIFNSL YTTLSDVWSF GILLWEIFTL 300

GGTPYPELPM NEQFYNAIKR GYRMAQPVHA SDEIYEIMQK CWEEKFEIRP PFSQLVLLL 359

Keyword

ATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004714	; F:transmembrane receptor protein tyrosine kinase activity
GO:0007169	; P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

InterPros

IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003599	; Ig_sub.
IPR003598	; Ig_sub2.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016243	; Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824	; Tyr_kinase_rcpt_3_CS.

Pfam

PF07679	; I-set; 1.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00409	; IG; 2.
SM00408	; IGc2; 1.
SM00219	; TyrKc; 1.

Prosites

PS50835	; IG_LIKE; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS00240	; RECEPTOR_TYR_KIN_III; 1.

Prints

Created Date

20-Feb-2013