EKS-CAJ-00371

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAJ-00371

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	448.4	1.3E-134	270	519	250

Status

Unreviewed

Ensembl Protein

ENSCJAP00000040055

UniProt Accession

F6W7M1;

Protein Name

Protein Synonyms/Alias

Gene Name

SRC

Gene Synonyms/Alias

SRC;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCJAG00000021512	ENSCJAP00000042929	ENSCJAT00000061915
ENSCJAG00000021512	ENSCJAP00000040054	ENSCJAT00000042312
ENSCJAG00000021512	ENSCJAP00000040055	ENSCJAT00000042313

Organism

Callithrix jacchus

Functional Description

Protein Length

536

Protein Sequence
(FASTA)

MGSNKSKPKD ASQRRRSLEP SENAHGAGGG AFPASQTPSK PASADGHRGP SAAFAPAAAE 60

PKLFGGFNSS DTVTSPQRAG PLAGGVTTFV ALYDYESRTE TDLSFKKGER LQIVNNTEGD 120

WWLAHSLSTG QTGYIPSNYV APSDSIQAEE WYFGKITRRE SERLLLNAEN PRGTFLVRES 180

ETTKGAYCLS VSDFDNAKGL NVKHYKIRKL DSGGFYITSR TQFNSLQQLV AYYSKHADGL 240

CHRLTTVCPT SKPQTQGLAK DAWEIPRESL RLEVKLGQGC FGEVWMGTWN GTTRVAIKTL 300

KPGTMSPEAF LQEAQVMKKL RHEKLVQLYA VVSEEPIYIV TEYMSKGSLL DFLKGETGKY 360

LRLPQLVDMA AQIASGMAYV ERMNYVHRDL RAANILVGEN LVCKVADFGL ARLIEDNEYT 420

ARQGAKFPIK WTAPEAALYG RFTIKSDVWS FGILLTELTT KGRVPYPGMV NREVLDQVER 480

GYRMPCPPEC PESLHDLMCQ CWRKEPEERP TFEYLQAFLE DYFTSTEPQY QPGENL 536

Nucleotide Sequence
(FASTA)

ATGGGCAGCA ACAAGAGCAA GCCCAAGGAT GCCAGCCAGC GGCGCCGCAG CCTGGAGCCC 60

TCCGAGAACG CGCACGGAGC CGGCGGGGGC GCTTTCCCCG CTTCGCAGAC CCCCAGCAAG 120

CCAGCCTCGG CCGACGGCCA CCGCGGTCCC AGCGCGGCCT TCGCCCCCGC GGCCGCCGAG 180

CCCAAGCTGT TCGGAGGCTT CAACTCCTCG GACACCGTCA CCTCCCCGCA GAGGGCGGGC 240

CCGCTGGCCG GTGGAGTGAC CACCTTTGTG GCCCTCTATG ACTATGAGTC TAGGACGGAG 300

ACAGACCTGT CCTTCAAGAA AGGCGAGCGG CTCCAGATCG TCAACAACAC AGAGGGAGAC 360

TGGTGGCTGG CCCACTCGCT CAGCACGGGA CAGACAGGCT ACATCCCCAG CAACTACGTG 420

GCACCCTCCG ACTCCATCCA GGCTGAAGAG TGGTATTTTG GCAAGATCAC CAGGCGGGAG 480

TCAGAGCGGC TACTGCTCAA CGCGGAGAAC CCGAGGGGGA CATTCCTAGT GCGGGAAAGT 540

GAGACCACGA AAGGTGCCTA CTGCCTCTCA GTGTCCGACT TCGACAACGC CAAGGGCCTC 600

AACGTGAAGC ACTACAAGAT CCGCAAGCTG GACAGCGGCG GCTTCTATAT TACCTCCCGC 660

ACCCAGTTCA ACAGTCTGCA GCAGCTGGTG GCCTACTACT CCAAACATGC CGACGGCCTG 720

TGCCACCGCC TCACCACTGT GTGCCCCACG TCTAAGCCAC AGACTCAAGG CCTGGCCAAG 780

GATGCCTGGG AGATCCCTCG GGAGTCACTG CGGCTGGAGG TCAAGCTGGG CCAGGGCTGC 840

TTTGGCGAGG TGTGGATGGG AACCTGGAAT GGCACCACCA GGGTGGCCAT CAAAACCCTG 900

AAGCCTGGCA CCATGTCTCC GGAGGCCTTC CTGCAGGAGG CCCAGGTCAT GAAGAAACTG 960

AGGCATGAGA AGCTGGTGCA GCTGTACGCC GTGGTTTCGG AGGAGCCCAT CTACATTGTC 1020

ACGGAGTACA TGAGCAAGGG GAGTTTGCTG GACTTTCTCA AGGGGGAAAC GGGCAAGTAC 1080

CTGCGGCTGC CTCAGCTGGT GGACATGGCT GCTCAGATCG CCTCTGGCAT GGCATATGTT 1140

GAGCGGATGA ACTACGTCCA TCGGGACCTT CGTGCAGCCA ACATCCTGGT GGGAGAGAAC 1200

TTGGTGTGCA AAGTGGCCGA CTTCGGGCTG GCTCGGCTCA TCGAAGACAA TGAGTACACA 1260

GCCCGGCAAG GTGCCAAATT CCCCATCAAG TGGACGGCTC CGGAAGCTGC CCTCTATGGC 1320

CGGTTCACCA TCAAGTCGGA TGTGTGGTCC TTCGGGATCC TGCTGACGGA GCTCACCACA 1380

AAGGGGCGGG TGCCCTACCC TGGGATGGTG AACCGAGAGG TGCTGGACCA GGTGGAGCGG 1440

GGCTACCGGA TGCCCTGCCC GCCCGAGTGT CCTGAGTCCC TGCACGACCT CATGTGCCAG 1500

TGCTGGCGGA AAGAGCCTGA GGAGCGGCCC ACTTTCGAGT ACCTGCAGGC CTTTCTGGAG 1560

GACTACTTCA CGTCCACTGA GCCCCAGTAC CAGCCTGGAG AGAACCTCTA G 1611

Domain Profile

S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60

         l+l+ klG+G+fGevw+g+w+g+++va+ktlk+gt+speafl+eaq++kklrheklv+ly

Q: 270   LRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLY  329

         68999*******************************************************

S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120

         avvse ePiyivte+m+kGslldflk e+gk+l+lp+lvd+aaq+a+Gmay+e++n++hr

Q: 330   AVVSE-EPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHR  388

         ****9.******************************************************

S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180

         dl+a+n+lvge+lv+kvadfGlarlied+eyta++gak+PikWtaPea+ +g+ftiksdv

Q: 389   DLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDV  448

         ************************************************************

S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee  240

         WsfGillte++tkG+vPypGm n+evl+qvergyr+p+p ecpe+l++l+++cw+k+pee

Q: 449   WSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEE  508

         ************************************************************

S: 241   rPtfetlqevl  251

         rPtfe+lq++l

Q: 509   RPTFEYLQAFL  519

         *******9876

Domain Sequence
(FASTA)

LRLEVKLGQG CFGEVWMGTW NGTTRVAIKT LKPGTMSPEA FLQEAQVMKK LRHEKLVQLY 60

AVVSEEPIYI VTEYMSKGSL LDFLKGETGK YLRLPQLVDM AAQIASGMAY VERMNYVHRD 120

LRAANILVGE NLVCKVADFG LARLIEDNEY TARQGAKFPI KWTAPEAALY GRFTIKSDVW 180

SFGILLTELT TKGRVPYPGM VNREVLDQVE RGYRMPCPPE CPESLHDLMC QCWRKEPEER 240

PTFEYLQAFL 250

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013