EKS-CAP-00333

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAP-00333

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/EGFR	498.4	3.8E-150	709	966	258

Status

Unreviewed

Ensembl Protein

ENSCPOP00000000034

UniProt Accession

H0UT18;

Protein Name

Protein Synonyms/Alias

Gene Name

EGFR

Gene Synonyms/Alias

EGFR;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCPOG00000000040	ENSCPOP00000000034	ENSCPOT00000000040

Organism

Cavia porcellus

Functional Description

Protein Length

1207

Protein Sequence
(FASTA)

SRPEATAGSS ILPYILTICP LCTSMESIPV CQGTSNKLTQ LGTFEDHFLS LQRMFNNCEV 60

VLGNLEITYV QRNYDLSFLK TIQEVAGYVL VALNTVERIP LENLQIVRGN VLYENTYALA 120

VLSNYGTGLR ELPLRSLQEI LHGAVRFSNN PVLCSVDTIQ WRDIVNNLFL SNMSLDWQSP 180

QSGCQKCDPS CPNGSCWGPG AENCQKLTKI ICAQQCSGRC RGKSPSDCCH NQCAAGCTGP 240

RESDCLVCRR FRDEATCKDT CPPLMLYNPT TYQMDVNPEG KYSFGATCVK KCPRNYVVTD 300

HGSCVRACSS DSYEIEEDGV RKCKKCPTSL SSVCNGIGIG EFKDTLSINA TNIKHFRNCT 360

TISGDLHILP VAFRGDSFTR TQPLDPKELD ILKTVKEITG FLLIQAWPEN RTNLHAFENL 420

EIIRGRTKQH GQFSLAVVGL NLTSLGLRSL KEISDGDVIV SGNRHLCYAN TIHWRKLFGT 480

AGQKTKIVNN RNERDCKADG HVCHPLCSSE GCWGPEAQDC VSCQNVSRGR ECVARCNIFE 540

GEPREFVENS ECIQCHPECL PQAMNVTCTG RGPDNCVQCA HHIDGPHCVK TCPAGVMGEN 600

NTLVWKYADA GRVCRLCHPN CTYGCTGPGL QGCAIEGTKV PSIATGIVGG LFLLVLLGLG 660

IGLLMRRRHI VRKRTLRRLL QERELVEPLT PSGEAPNQAL LRILKETEFK KIKVLGSGAF 720

GTVYKGLWIP EGEKVKIPVA IKELREATSP KANKEILDEA YVMASVDNPH VCRLLGICLT 780

STVQLVTQLM PFGCLLDYVR EHKDNIGSQH LLNWCVQIAK GMNYLEDRRL VHRDLAARNV 840

LVKTPQHVKI TDFGLAKLLG AEEKEYHAEG GKVPIKWMAL ESILHRIYTH QSDVWSYGVT 900

VWELMTFGSK PYDGIPASEI SSILEKGERL PQPPICTIDV YMIMVKCWMI DADSRPKFRE 960

LIVEFSKMAR DPQRYLVIQG DERMHLPSPT DSNFYRALMD EEDMEDIVDA DEYLIPQQSF 1020

FSSPSTSRTP LLSSLSANSN NSTGACVPRN GPQNCPVRSD GFLQRYSSDP TGTLTEDNLD 1080

DAFLPVPEYI NQSFPKRPAG SVQNPIYHNQ PLHPAPGRDP HYQNPHSHAV GNPEYLNTTQ 1140

STGVSGSFDS PGPWTQQGNH QLSLDNPDYQ QDFFPKEAKP NGIFKGPTAE NTEYLRVAPP 1200

SSEFIGA 1207

Nucleotide Sequence
(FASTA)

AGCAGACCAG AGGCCACAGC CGGGTCTTCT ATTCTCCCTT ATATTCTTAC CATTTGCCCG 60

TTGTGTACTT CAATGGAATC AATCCCAGTT TGCCAAGGAA CAAGCAACAA GCTCACCCAG 120

TTGGGCACTT TTGAAGACCA CTTCCTGAGC CTCCAGCGGA TGTTCAACAA CTGCGAGGTG 180

GTGCTGGGGA ATCTAGAGAT CACCTATGTG CAGAGGAACT ATGACCTTTC CTTCCTGAAG 240

ACCATCCAGG AGGTGGCCGG CTACGTGCTT GTTGCCCTCA ACACGGTGGA GAGGATCCCA 300

CTGGAGAACC TGCAGATCGT GCGTGGAAAC GTGCTCTATG AGAACACCTA TGCTCTGGCC 360

GTGCTGTCCA ACTACGGGAC CGGGCTGCGG GAGCTGCCCC TGAGGAGCCT GCAGGAGATC 420

CTGCATGGTG CCGTGCGCTT CAGCAACAAC CCCGTGCTCT GCAGTGTGGA CACCATCCAG 480

TGGCGGGACA TCGTGAACAA CCTCTTCCTG AGCAACATGT CGCTGGACTG GCAGAGCCCT 540

CAGAGCGGCT GCCAAAAGTG TGATCCGAGC TGTCCCAATG GGAGCTGCTG GGGCCCGGGC 600

GCGGAGAACT GCCAGAAACT GACCAAGATC ATCTGTGCCC AGCAGTGCTC AGGGCGCTGT 660

CGTGGCAAGT CTCCCAGCGA CTGCTGCCAC AACCAGTGTG CGGCTGGCTG CACTGGGCCG 720

CGGGAGAGCG ACTGTCTGGT CTGCCGCAGG TTCCGTGATG AGGCCACATG CAAGGACACC 780

TGCCCGCCGC TCATGCTGTA CAACCCCACC ACCTACCAGA TGGATGTCAA CCCCGAAGGG 840

AAGTACAGCT TCGGCGCCAC CTGCGTGAAG AAGTGTCCCC GGAACTACGT GGTGACTGAC 900

CATGGCTCCT GTGTCCGGGC CTGCAGCTCC GACAGCTACG AGATAGAGGA AGACGGTGTG 960

CGCAAGTGCA AAAAATGTCC AACCTCTCTC TCCTCAGTTT GCAATGGAAT AGGAATTGGG 1020

GAGTTTAAAG ACACACTTTC CATAAACGCC ACGAACATCA AGCACTTCAG GAACTGCACA 1080

ACCATCAGTG GGGACCTGCA TATCCTCCCA GTGGCATTTC GGGGGGATTC CTTCACGCGC 1140

ACGCAGCCCC TGGATCCCAA GGAGCTGGAC ATCCTGAAGA CCGTGAAGGA AATCACAGGG 1200

TTCCTGCTGA TTCAGGCCTG GCCTGAGAAC AGGACCAACC TCCACGCATT TGAGAACCTG 1260

GAAATCATCC GTGGCCGGAC AAAGCAACAT GGCCAGTTTT CTCTGGCTGT GGTTGGCCTG 1320

AACCTGACGT CCCTGGGTCT GCGCTCCCTG AAGGAGATCA GCGACGGAGA CGTGATCGTC 1380

TCCGGGAACC GGCATCTGTG CTACGCCAAC ACCATCCACT GGAGAAAACT GTTTGGAACT 1440

GCCGGACAGA AAACCAAAAT TGTAAACAAC AGGAATGAAA GGGACTGCAA GGCTGATGGT 1500

CACGTCTGCC ACCCGCTGTG CTCCTCCGAG GGCTGCTGGG GCCCCGAGGC CCAGGACTGC 1560

GTCTCCTGCC AGAATGTGAG CCGGGGCAGG GAGTGTGTGG CCAGGTGCAA CATCTTTGAG 1620

GGGGAGCCCA GAGAGTTCGT GGAGAATTCT GAGTGCATCC AGTGCCACCC GGAGTGCCTG 1680

CCCCAGGCCA TGAACGTGAC CTGCACCGGC AGGGGCCCTG ACAACTGTGT CCAGTGCGCC 1740

CACCACATCG ATGGCCCCCA CTGTGTCAAG ACCTGCCCGG CCGGGGTCAT GGGAGAGAAC 1800

AACACGCTGG TGTGGAAGTA CGCGGATGCT GGCCGGGTGT GCCGCCTGTG CCACCCCAAC 1860

TGCACCTATG GATGTACCGG GCCAGGTCTG CAAGGCTGTG CAATAGAAGG GACCAAGGTC 1920

CCATCCATTG CTACTGGGAT CGTGGGTGGC CTCTTCCTGC TGGTGCTGCT GGGCCTGGGC 1980

ATCGGCCTCC TCATGAGGCG ACGCCACATT GTCCGCAAGC GCACGCTGCG CCGGCTGCTG 2040

CAGGAACGCG AGCTGGTGGA GCCCCTTACA CCCAGCGGAG AAGCCCCTAA CCAGGCCCTC 2100

CTGAGGATCC TGAAGGAAAC AGAATTCAAG AAGATCAAGG TGCTGGGCTC TGGAGCATTC 2160

GGCACAGTCT ACAAGGGACT CTGGATCCCG GAAGGTGAGA AAGTGAAGAT TCCTGTGGCC 2220

ATCAAGGAGT TGCGAGAAGC CACATCTCCG AAAGCCAACA AGGAAATCCT GGATGAAGCC 2280

TATGTGATGG CCAGCGTGGA CAACCCCCAT GTGTGCCGCC TTCTGGGCAT CTGCCTGACG 2340

TCCACTGTGC AGCTGGTCAC ACAACTCATG CCCTTTGGCT GCCTGCTGGA CTATGTGCGT 2400

GAGCACAAGG ACAACATCGG GTCCCAGCAC CTGCTCAACT GGTGTGTGCA GATCGCCAAG 2460

GGCATGAACT ACCTGGAGGA CCGGCGCTTG GTGCACCGAG ACCTGGCGGC CAGGAATGTC 2520

CTGGTGAAGA CACCACAGCA CGTCAAGATC ACAGACTTTG GGCTGGCCAA GCTCCTGGGC 2580

GCGGAGGAGA AGGAGTACCA TGCTGAGGGT GGCAAGGTGC CCATCAAATG GATGGCTTTG 2640

GAGTCAATTT TACACCGGAT TTATACCCAC CAGAGTGATG TCTGGAGCTA CGGAGTCACC 2700

GTGTGGGAGC TGATGACCTT CGGGTCCAAG CCCTATGACG GGATCCCTGC CAGTGAGATC 2760

TCATCCATCC TAGAGAAAGG AGAGCGCTTG CCACAGCCGC CCATCTGCAC CATCGACGTC 2820

TACATGATCA TGGTCAAATG CTGGATGATA GATGCAGATA GCCGCCCAAA GTTCCGCGAG 2880

CTGATCGTCG AGTTCTCCAA AATGGCCCGA GACCCCCAGC GCTACCTTGT CATTCAGGGG 2940

GATGAGAGGA TGCATTTGCC GAGCCCTACA GACTCCAATT TCTACCGTGC CCTGATGGAC 3000

GAGGAGGACA TGGAGGATAT CGTGGATGCG GACGAGTATC TCATTCCACA GCAGAGCTTC 3060

TTCAGCAGCC CCTCCACCTC TCGGACGCCC CTCCTGAGCT CGCTGAGTGC AAACAGCAAC 3120

AATTCTACCG GAGCTTGTGT TCCTAGGAAT GGGCCACAGA ACTGCCCTGT CAGAAGTGAT 3180

GGTTTCCTGC AGCGCTACAG CTCAGACCCC ACTGGCACCC TGACTGAGGA CAACCTGGAT 3240

GATGCCTTCC TCCCTGTGCC CGAATACATA AACCAGTCCT TCCCTAAAAG GCCTGCAGGC 3300

TCCGTGCAGA ACCCCATCTA TCACAATCAG CCCCTGCACC CCGCTCCAGG CAGAGACCCA 3360

CACTACCAGA ACCCCCACAG CCATGCCGTG GGCAACCCCG AATATCTCAA CACCACGCAG 3420

TCCACTGGTG TCAGTGGCAG CTTTGACAGC CCTGGCCCCT GGACCCAGCA GGGCAACCAC 3480

CAACTTAGCC TGGACAACCC CGACTACCAG CAGGACTTCT TTCCCAAGGA AGCCAAGCCC 3540

AACGGCATCT TTAAGGGGCC CACAGCTGAA AACACAGAAT ACCTTCGGGT GGCCCCGCCA 3600

AGCAGTGAGT TTATTGGAGC ATAA 3624

Domain Profile

S: 1     lkklkvlGsGafGtvykGiwipegenvkipvaikvleektgkkankelldealvlasldh  60

         +kk+kvlGsGafGtvykG+wipege+vkipvaik+l+e+t++kanke+ldea+v+as+d+

Q: 709   FKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDN  768

         59**********************************************************

S: 61    anlvrllglclsstlqlvtqllplGclldyvrehkdklGsqellnwcvqiakGmsyleek  120

         ++++rllg+cl+st+qlvtql+p+Gclldyvrehkd++Gsq+llnwcvqiakGm+yle++

Q: 769   PHVCRLLGICLTSTVQLVTQLMPFGCLLDYVREHKDNIGSQHLLNWCVQIAKGMNYLEDR  828

         ************************************************************

S: 121   rlvhrdlaarnvlvkspnhvkitdfGlaklleadekelkaeggkvpikwlalesilkrky  180

         rlvhrdlaarnvlvk+p+hvkitdfGlakll a+eke++aeggkvpikw+alesil+r+y

Q: 829   RLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIY  888

         ************************************************************

S: 181   thqsdvwsyGvtvwelltfGakpydgipakeipdllekGerlaqppictidvymvlvkcw  240

         thqsdvwsyGvtvwel+tfG+kpydgipa+ei+++lekGerl+qppictidvym++vkcw

Q: 889   THQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCW  948

         ************************************************************

S: 241   midaesrpkfkelaeefs  258

         mida+srpkf+el+ efs

Q: 949   MIDADSRPKFRELIVEFS  966

         ****************96

Domain Sequence
(FASTA)

FKKIKVLGSG AFGTVYKGLW IPEGEKVKIP VAIKELREAT SPKANKEILD EAYVMASVDN 60

PHVCRLLGIC LTSTVQLVTQ LMPFGCLLDY VREHKDNIGS QHLLNWCVQI AKGMNYLEDR 120

RLVHRDLAAR NVLVKTPQHV KITDFGLAKL LGAEEKEYHA EGGKVPIKWM ALESILHRIY 180

THQSDVWSYG VTVWELMTFG SKPYDGIPAS EISSILEKGE RLPQPPICTI DVYMIMVKCW 240

MIDADSRPKF RELIVEFS 258

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Ciona savignyi"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004716	; F:receptor signaling protein tyrosine kinase activity
GO:0004714	; F:transmembrane receptor protein tyrosine kinase activity
GO:0023014	; P:signal transduction by phosphorylation
GO:0007169	; P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

InterPros

IPR000494	; EGF_rcpt_L.
IPR006211	; Furin-like_Cys-rich_dom.
IPR006212	; Furin_repeat.
IPR009030	; Growth_fac_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016245	; Tyr_kinase_EGF/ERB/XmrK_rcpt.

Pfam

PF00757	; Furin-like; 1.
PF07714	; Pkinase_Tyr; 1.
PF01030	; Recep_L_domain; 2.

SMARTs

SM00261	; FU; 4.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013