EKS-CAP-00322

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAP-00322

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/IRE	474.6	8.0E-143	550	811	262

Status

Unreviewed

Ensembl Protein

ENSCPOP00000000501

UniProt Accession

H0UU76;

Protein Name

Protein Synonyms/Alias

Gene Name

ERN1

Gene Synonyms/Alias

ERN1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCPOG00000000570	ENSCPOP00000000501	ENSCPOT00000000575

Organism

Cavia porcellus

Functional Description

Protein Length

955

Protein Sequence
(FASTA)

FASTSTVTLP ETLLFVSTLD GSLHAVSKRT GSIKWTLKED PVLQVPTHVE EPAFLPDPND 60

GSLYTLGGKN NEGLTKLPFT IPELVQASPC RSSDGILYMG KKQDIWYVVD LLTGEKQQTL 120

SSAFADSLCP STSLLYLGRT EYTITMYDTK TRELRWNATY FDYAASLPED DGDYKMSHFV 180

SNGDGLVVTV DSESGDVLWI QNYASPVVAF YVWQREGLRK VMHINVAVET LRYLTFMPGE 240

VGRITKWKYP FPKETEAKSK LTPTLYVGKY STSLYASPSM VHEGVTVVPR GSTLPLLEGP 300

QTDGVTIGDK GECVITPSTD LKFDPGLKGK SKLNYLRNYW LLIGHHETPL SASTKMLERF 360

PNNLPRHREN VIPADSEKKS FEEVINLVDQ TSETAPTAVS QDVEEKLARA PAKPEAPVDS 420

MLKDMATIIL STFLLVGWVA FIISYPLSMH QQRQLQHQQF QKELEKIQLL QQQPPPFHPP 480

GELTQDTELL DTSSPYSESS GTSSPSPSPR ASNHSLHSNS SASRAGTSGS LEQDDEGEEA 540

SMVIVGKISF CPKDVLGHGA EGTIVYRGMF DSRDVAVKRI LPECFSFADR EVQLLRESDE 600

HPNVIRYFCT ERDRQFQYIA IELCAATLQE YVEQKDFAHL GLEPITLLQQ TTSGLAYLHS 660

LNIVHRDLKP HNILLSMPNA HGRIKAMISD FGLCKKLAVG RHSFSRRSGV PGTEGWIAPE 720

MLSEDCKENP TYTVDIFSAG CVFYYVISEG SHPFGKSLQR QANILLGAYS LDCFNPEKHE 780

DVIARELIEN MIAMDPQQRP SAKRVLKHPF FWSVEKQLQF FQDVSDRIEK ESLDGPIVRQ 840

LERGGRAVVK MDWRENITVP LQTDLRKFRT YKGGSVRDLL RAMRNKKHHY RELPAEVQET 900

LGSLPDDFVR YFTSRFPHLL SHTYRAMELC SHERLFQPYY HEPPEPQPPV TPDAL 955

Nucleotide Sequence
(FASTA)

TTTGCAAGTA CCAGCACAGT GACTTTGCCT GAAACCTTGC TGTTTGTGTC AACCTTGGAT 60

GGAAGTTTGC ACGCTGTCAG CAAGAGGACA GGCTCAATCA AATGGACTTT AAAAGAAGAT 120

CCAGTCCTTC AGGTCCCAAC ACACGTGGAG GAGCCTGCCT TCCTTCCAGA TCCCAATGAT 180

GGAAGCCTGT ATACACTTGG GGGCAAGAAT AATGAAGGCT TGACGAAACT TCCCTTTACC 240

ATCCCAGAGT TGGTACAGGC ATCCCCATGC CGAAGCTCAG ATGGAATCCT GTACATGGGT 300

AAAAAGCAGG ACATTTGGTA CGTCGTTGAC CTCCTGACTG GTGAGAAGCA GCAGACTTTG 360

TCGTCAGCCT TTGCAGATAG TCTCTGCCCG TCAACCTCGC TTCTGTATCT TGGACGAACA 420

GAATACACTA TCACCATGTA TGACACCAAA ACCCGAGAGC TTCGCTGGAA TGCCACCTAC 480

TTTGACTACG CAGCCTCCCT GCCTGAGGAT GATGGGGACT ATAAGATGTC CCATTTTGTG 540

TCCAATGGCG ATGGCCTGGT GGTGACTGTG GACAGTGAAT CTGGGGATGT CCTGTGGATC 600

CAAAACTATG CCTCCCCTGT AGTGGCCTTC TACGTCTGGC AGCGGGAGGG TCTGAGGAAG 660

GTGATGCACA TCAACGTTGC TGTGGAGACC CTACGCTACC TGACCTTCAT GCCCGGGGAG 720

GTGGGCCGCA TCACCAAGTG GAAGTACCCA TTTCCCAAGG AGACCGAGGC CAAGAGCAAG 780

CTGACGCCTA CCCTGTATGT TGGAAAGTAC TCCACCAGCC TCTACGCCTC CCCCTCTATG 840

GTGCATGAGG GGGTCACCGT TGTGCCCCGA GGTAGCACTC TTCCTTTGTT GGAAGGCCCC 900

CAGACGGATG GTGTCACCAT TGGGGACAAG GGAGAGTGTG TGATCACACC CAGCACAGAC 960

CTCAAGTTTG ACCCTGGGCT CAAAGGGAAG AGCAAGCTCA ATTACTTGAG GAATTACTGG 1020

CTCCTGATAG GACACCATGA AACCCCACTG TCTGCATCCA CCAAGATGCT GGAGAGATTT 1080

CCCAACAATC TGCCCAGACA CCGGGAAAAT GTGATTCCTG CTGACTCGGA GAAAAAGAGC 1140

TTTGAGGAAG TTATCAACCT GGTTGACCAG ACTTCAGAAA CTGCACCCAC TGCTGTGTCT 1200

CAGGATGTGG AGGAGAAGTT GGCTCGTGCT CCTGCCAAGC CTGAGGCCCC TGTGGACTCC 1260

ATGCTCAAGG ACATGGCCAC CATCATCCTG AGTACCTTCC TCCTGGTCGG CTGGGTGGCC 1320

TTCATCATCT CCTACCCCCT GAGCATGCAC CAGCAGCGGC AGCTCCAGCA TCAGCAGTTC 1380

CAGAAGGAGC TGGAGAAGAT CCAGCTCCTG CAGCAGCAGC CGCCGCCCTT CCACCCACCT 1440

GGAGAGTTGA CACAGGACAC TGAGCTCCTG GACACGTCCA GCCCTTACTC AGAGAGCTCA 1500

GGGACCAGCA GCCCCAGCCC ATCCCCGAGA GCCTCCAACC ACTCACTGCA TTCCAACAGC 1560

TCTGCCTCTA GGGCTGGCAC CAGCGGCTCC CTGGAGCAGG ATGATGAGGG TGAGGAAGCC 1620

AGTATGGTGA TAGTTGGAAA AATTTCATTC TGCCCCAAAG ATGTGCTAGG CCATGGAGCT 1680

GAGGGCACCA TTGTGTACAG GGGCATGTTT GACAGCCGCG ATGTGGCTGT GAAGAGGATC 1740

CTTCCCGAGT GTTTCAGCTT TGCCGACCGT GAAGTCCAGC TGCTGCGAGA ATCAGACGAG 1800

CATCCCAATG TGATCCGCTA CTTCTGCACA GAGCGGGACC GGCAGTTCCA GTACATTGCC 1860

ATTGAGCTGT GTGCAGCCAC CCTGCAGGAG TACGTGGAGC AGAAGGACTT CGCCCACCTT 1920

GGCCTGGAGC CCATCACCTT GCTACAGCAG ACCACCTCAG GCCTGGCATA TCTCCACTCC 1980

CTCAACATTG TTCACAGAGA TCTGAAGCCC CACAACATTC TCCTCTCCAT GCCCAATGCA 2040

CATGGGAGGA TCAAGGCCAT GATCTCTGAC TTTGGCCTCT GCAAGAAGTT AGCAGTGGGC 2100

AGGCACAGTT TTAGCCGCCG TTCTGGGGTC CCTGGCACCG AAGGCTGGAT CGCTCCAGAG 2160

ATGCTGAGTG AAGACTGCAA GGAGAACCCT ACCTACACGG TGGACATCTT CTCCGCGGGC 2220

TGTGTCTTTT ACTATGTCAT CTCTGAGGGC AGCCACCCTT TTGGCAAGTC CCTGCAGCGG 2280

CAGGCCAACA TTCTCCTGGG CGCCTACAGT CTTGACTGCT TCAACCCGGA GAAGCATGAA 2340

GATGTCATCG CACGTGAGTT GATAGAAAAC ATGATCGCGA TGGATCCCCA GCAGCGGCCT 2400

TCAGCGAAGC GCGTGCTGAA ACACCCCTTC TTCTGGAGCG TGGAGAAGCA GCTCCAGTTC 2460

TTCCAGGATG TGAGTGACCG GATAGAAAAG GAATCCCTGG ATGGCCCGAT TGTGAGGCAG 2520

TTGGAGAGAG GCGGGCGAGC CGTGGTGAAG ATGGACTGGC GGGAGAATAT CACCGTGCCC 2580

CTCCAGACAG ATTTGCGTAA ATTTAGAACC TACAAGGGTG GCTCCGTCAG AGATCTCCTG 2640

CGAGCCATGA GAAACAAGAA GCACCACTAC CGGGAGCTCC CTGCGGAAGT GCAGGAGACG 2700

CTGGGCTCCC TCCCCGATGA CTTCGTGCGC TACTTCACGT CACGCTTCCC CCACCTCCTG 2760

TCACACACCT ACCGTGCCAT GGAATTGTGC AGCCACGAGA GACTCTTCCA GCCCTACTAC 2820

CACGAGCCCC CGGAACCCCA GCCCCCAGTG ACTCCAGATG CCCTC 2865

Domain Profile

S: 1     fspkdvlGkGaeGtvvfrGsfegrevavkrllsefvdlakrevkllresdehpnviryfc  60

         f+pkdvlG+GaeGt+v+rG+f+ r+vavkr+l+e++++a+rev+llresdehpnviryfc

Q: 550   FCPKDVLGHGAEGTIVYRGMFDSRDVAVKRILPECFSFADREVQLLRESDEHPNVIRYFC  609

         79**********************************************************

S: 61    tekdrqfryialelcaaslqdyvedkdlelqkelepisllkqiasGlahlhslkivhrdl  120

         te+drqf+yia+elcaa+lq+yve+kd++ + +lepi+ll+q++sGla+lhsl+ivhrdl

Q: 610   TERDRQFQYIAIELCAATLQEYVEQKDFA-HLGLEPITLLQQTTSGLAYLHSLNIVHRDL  668

         *****************************.******************************

S: 121   kpqnilislpdakgklrvlisdfGlckkldvGkssfsrrsgvsGteGwiapelleeltke  180

         kp+nil+s+p+a+g+++++isdfGlckkl+vG++sfsrrsgv+GteGwiape+l+e++ke

Q: 669   KPHNILLSMPNAHGRIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEMLSEDCKE  728

         ************************************************************

S: 181   rltsavdifslGcvfyyvlskGkhpfGdslkrqanilsgelsldklkeekdeeviaedli  240

         ++t++vdifs+Gcvfyyv+s+G+hpfG+sl+rqanil g++sld++++ek+e+via++li

Q: 729   NPTYTVDIFSAGCVFYYVISEGSHPFGKSLQRQANILLGAYSLDCFNPEKHEDVIARELI  788

         ************************************************************

S: 241   skmidkdplkrpsakkvlkhplf  263

         ++mi++dp++rpsak+vlkhp+f

Q: 789   ENMIAMDPQQRPSAKRVLKHPFF  811

         **********************9

Domain Sequence
(FASTA)

FCPKDVLGHG AEGTIVYRGM FDSRDVAVKR ILPECFSFAD REVQLLRESD EHPNVIRYFC 60

TERDRQFQYI AIELCAATLQ EYVEQKDFAH LGLEPITLLQ QTTSGLAYLH SLNIVHRDLK 120

PHNILLSMPN AHGRIKAMIS DFGLCKKLAV GRHSFSRRSG VPGTEGWIAP EMLSEDCKEN 180

PTYTVDIFSA GCVFYYVISE GSHPFGKSLQ RQANILLGAY SLDCFNPEKH EDVIARELIE 240

NMIAMDPQQR PSAKRVLKHP FF 262

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0016891	; F:endoribonuclease activity, producing 5'-phosphomonoesters
GO:0004674	; F:protein serine/threonine kinase activity
GO:0006397	; P:mRNA processing

KEGG

InterPros

IPR010513	; KEN_RNase_activator.
IPR011009	; Kinase-like_dom.
IPR018391	; PQQ_beta_propeller_repeat.
IPR000719	; Prot_kinase_cat_dom.
IPR006567	; PUG-dom.
IPR011047	; Quinonprotein_ADH-like.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF06479	; Ribonuc_2-5A; 1.

SMARTs

SM00564	; PQQ; 5.
SM00580	; PUG; 1.

Prosites

PS51392	; KEN; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013