EKS-CAP-00346

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAP-00346

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	353.3	7.7E-106	270	521	252

Status

Unreviewed

Ensembl Protein

ENSCPOP00000000574

UniProt Accession

H0UUE0;

Protein Name

Protein Synonyms/Alias

Gene Name

PAK3

Gene Synonyms/Alias

PAK3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCPOG00000000651	ENSCPOP00000000574	ENSCPOT00000000656

Organism

Cavia porcellus

Functional Description

Protein Length

546

Protein Sequence
(FASTA)

MSDGLDNEEK PPAPPLRMNS NNRDSSALNH SSKPLPMAPE EKNKKARLRS IFPGGGDKTN 60

KKKEKERPEI SLPSDFEHTI HVGFDAVTGE FTPDLYGSQM CPGKLPEGIP EQWARLLQTS 120

NITKLEQKKN PQAVLDVLKF YDSKETVNNQ KYMSFTSGDK SAHGYIAAHP SSTKTASEPP 180

LAPPVYNEPP PVIAPRPEHT KSIYTRSVVE SIASPAAPNK EVTPPSTENA NSSTLYRNTD 240

RQRKKSKMTD EEILEKLRSI VSVGDPKKKY TRFEKIGQGA SGTVYTALDI ATGQEVAIKQ 300

MNLQQQPKKE LIINEILVMR ENKNPNIVNY LDSYLVGDEL WVVMEYLAGG SLTDVVTETC 360

MDEGQIAAVC RECLQALDFL HSNQVIHRDI KSDNILLGMD GSVKLTDFGF CAQITPEQSK 420

RSTMVGTPYW MAPEVVTRKA YGPKVDIWSL GIMAIEMVEG EPPYLNENPL RALYLIATNG 480

TPELQNPERL SAVFRDFLNR CLEMDVDRRG SAKELLQHPF LKLAKPLSSL TPLIIAAKEA 540

IKNSSR 546

Nucleotide Sequence
(FASTA)

ATGTCTGACG GTCTGGATAA TGAAGAGAAA CCCCCAGCTC CTCCACTGAG GATGAATAGT 60

AACAACCGGG ATTCTTCAGC ACTCAACCAT AGCTCCAAGC CACTTCCCAT GGCCCCTGAA 120

GAGAAGAATA AGAAAGCCAG GCTCCGCTCT ATCTTCCCAG GAGGAGGGGA TAAAACAAAT 180

AAGAAGAAAG AGAAAGAACG CCCAGAGATC TCTCTTCCTT CAGACTTTGA GCATACGATT 240

CATGTGGGGT TTGATGCAGT CACCGGGGAA TTCACTCCAG ATCTCTATGG CTCACAGATG 300

TGCCCAGGGA AGCTCCCAGA GGGAATTCCC GAACAATGGG CACGATTACT CCAAACCTCC 360

AACATAACAA AACTGGAACA GAAGAAGAAT CCACAAGCTG TTTTAGATGT TCTCAAATTC 420

TATGATTCCA AAGAAACCGT CAACAACCAG AAATACATGA GCTTTACATC AGGAGATAAA 480

AGTGCACATG GATATATAGC AGCACATCCT TCAAGTACAA AAACAGCGTC TGAGCCTCCT 540

TTGGCGCCTC CTGTATATAA TGAGCCCCCA CCTGTTATTG CACCAAGACC AGAGCATACA 600

AAATCAATCT ATACTCGTTC TGTGGTTGAA TCCATTGCTT CACCAGCAGC ACCAAATAAA 660

GAAGTCACAC CACCTTCCAC TGAGAATGCC AATTCCAGTA CTTTGTATAG AAATACAGAT 720

CGGCAAAGGA AGAAATCGAA GATGACAGAT GAGGAGATCC TAGAGAAGCT AAGAAGCATT 780

GTAAGTGTTG GTGACCCAAA GAAAAAGTAC ACACGATTTG AAAAAATTGG TCAAGGGGCA 840

TCAGGTACTG TTTACACAGC ACTAGATATT GCAACAGGAC AAGAGGTGGC CATAAAGCAG 900

ATGAACCTTC AACAGCAACC CAAAAAGGAA TTAATAATTA ATGAAATTCT GGTCATGAGG 960

GAAAATAAGA ACCCCAATAT TGTTAATTAT TTAGATAGCT ACTTAGTGGG TGATGAATTG 1020

TGGGTAGTCA TGGAATACTT GGCTGGTGGC TCTTTGACGG ATGTGGTCAC AGAGACCTGT 1080

ATGGATGAAG GACAGATAGC AGCTGTCTGC AGAGAGTGCC TCCAAGCTCT GGATTTCTTG 1140

CACTCAAACC AAGTGATCCA TAGAGACATA AAGAGTGACA ATATTCTTCT CGGGATGGAT 1200

GGCTCTGTTA AACTGACTGA TTTTGGGTTC TGTGCCCAGA TCACTCCAGA GCAAAGTAAA 1260

CGAAGCACTA TGGTGGGCAC CCCCTACTGG ATGGCACCTG AGGTGGTGAC TCGAAAAGCT 1320

TATGGTCCGA AAGTTGATAT CTGGTCTCTG GGAATTATGG CAATCGAAAT GGTGGAAGGT 1380

GAACCCCCTT ATCTTAATGA AAATCCACTC AGGGCATTAT ATCTGATAGC CACTAATGGA 1440

ACCCCAGAGC TCCAGAATCC TGAGAGACTT TCAGCTGTAT TCCGTGACTT TTTAAATCGC 1500

TGTCTTGAGA TGGATGTGGA TAGGCGAGGA TCTGCCAAGG AGCTTTTGCA GCATCCATTT 1560

TTAAAATTAG CCAAGCCTCT CTCAAGCCTG ACTCCTCTGA TTATCGCTGC AAAGGAAGCG 1620

ATTAAGAACA GCAGCCGCTA G 1641

Domain Profile

S: 1     yelleeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkklkhpnive  60

         y+ +e+ig+Ga+g+vy+a ++ tg+ vaik++nl++q+k+e++++ei v+++ k+pniv+

Q: 270   YTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVN  329

         7889********************************************************

S: 61    ylesflkeeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLeylHskkvi  120

         yl+s+l+ +elw+vmeylagGsl+d+v+   ++ ++E qia+++re+l+aL++lHs++vi

Q: 330   YLDSYLVGDELWVVMEYLAGGSLTDVVT---ETCMDEGQIAAVCRECLQALDFLHSNQVI  386

         ****************************...9****************************

S: 121   HrdikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqeekgYdek  180

         Hrdik++niLl ++g+VkL+dfg++aq++ +++kr+t+vgtpywmAPEv++  +k Y  k

Q: 387   HRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVT--RKAYGPK  444

         ***************************************************..9******

S: 181   aDiwslGItaielaegepPfkdleplkallkilkneppklkskkkfskefkefvekclqk  240

         +DiwslGI+aie++egepP+ +++pl+al++i++n +p+l++++++s  f++f+++cl+

Q: 445   VDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEM  504

         ************************************************************

S: 241   npekRpsasellkhkFl  257

         ++++R sa+ell+h+Fl

Q: 505   DVDRRGSAKELLQHPFL  521

         ****************7

Domain Sequence
(FASTA)

YTRFEKIGQG ASGTVYTALD IATGQEVAIK QMNLQQQPKK ELIINEILVM RENKNPNIVN 60

YLDSYLVGDE LWVVMEYLAG GSLTDVVTET CMDEGQIAAV CRECLQALDF LHSNQVIHRD 120

IKSDNILLGM DGSVKLTDFG FCAQITPEQS KRSTMVGTPY WMAPEVVTRK AYGPKVDIWS 180

LGIMAIEMVE GEPPYLNENP LRALYLIATN GTPELQNPER LSAVFRDFLN RCLEMDVDRR 240

GSAKELLQHP FL 252

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000095	; PAK_box_Rho-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00786	; PBD; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00285	; PBD; 1.
SM00220	; S_TKc; 1.

Prosites

PS50108	; CRIB; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013