EKS-CAP-00163
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-CAP-00163
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CAMK/RSKb424.61.3E-127415674260
StatusUnreviewed
Ensembl ProteinENSCPOP00000000659
UniProt AccessionH0UUL4;
Protein NameRibosomal protein S6 kinase
Protein Synonyms/Alias
Gene NameRPS6KA4
Gene Synonyms/Alias RPS6KA4;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSCPOG00000000740ENSCPOP00000000659ENSCPOT00000000745
OrganismCavia porcellus
Functional Description
Protein Length765
Protein Sequence
(FASTA)
MGDEDEEEGC EVELRITEAN LTGHEEKVSV ENFELLKVLG TGAYGKVFLV RKAGGHDAGK 60
LYAMKVLRKA ALVQRAKTQE HTRTERSVLE LVRQAPFLVT LHYAFQTDAK LHLILDYVSG 120
GEMFTHLYQR QYFKEAEVRV YGGEIVLALE HLHKLGIVYR DLKLENVLLD SEGHIVLTDF 180
GLSKEFLTEE KERTFSFCGT IEYMAPEIIR SKAGHGKAVD WWSLGILLFE LLTGASPFTL 240
EGERNTQAEV SRRILKCSPP FPSRIGPVAQ DLLRRLMCKD PKKRLGAGPQ GAQDVKNHPF 300
FQGLDWAALA ARKIPAPFQP QIRSELDVGN FAEEFTRLEP VYSPPGSPPP GDPRIFQGYS 360
FVAPSILFDH NNAVMTDVLE VSGAGDRPGR AAVARSAMMQ DSPFFQQYEL DLREPALGQG 420
SFSVCRRCRQ RQSGQEFAVK ILSRRLEANT QREVAALRLC QTHPNVVTLH EVHHDQLHTY 480
LVLELLRGGE LLEHIRKKRH FSESEASQIL RRLVSAVSFM HEEAGVVHRD LKPENILYAD 540
DTPGAPVKII DFGFARLRPQ SPAGPMQTPC FTLQYAAPEL LAQGGYDESC DLWSLGVILY 600
MMLSGQVPFQ GASGQGGQSQ AAEIMCKIRE GRFSLAGEAW QGVSEEAKEL VRGLLTVDPT 660
KRLKLEGLRG SSWLQDGSAR SSPPLRTPDV LESSGPAVRS GLNATFLAFN RGKREGFFLK 720
SVENAPLAKR RKQKLRSAAA ARRGSPVPAA AKGAARRANG PLPPS 765
Nucleotide Sequence
(FASTA)
ATGGGGGACG AAGATGAGGA GGAGGGCTGC GAGGTGGAGC TTCGGATCAC AGAAGCCAAT 60
CTGACTGGGC ATGAGGAGAA GGTGAGCGTG GAGAACTTCG AGCTGCTCAA GGTGCTGGGC 120
ACGGGAGCCT ACGGGAAGGT GTTCCTGGTG CGGAAGGCAG GCGGGCACGA TGCGGGGAAG 180
CTATATGCCA TGAAGGTGCT GCGCAAGGCG GCGCTGGTGC AGCGCGCCAA GACCCAGGAG 240
CACACGCGCA CAGAGCGCTC GGTGCTAGAG CTGGTGCGCC AGGCGCCCTT CCTGGTCACA 300
CTGCACTACG CCTTCCAGAC GGATGCCAAG CTGCATCTCA TCCTGGACTA CGTGAGCGGT 360
GGCGAGATGT TCACCCACCT TTACCAGCGC CAGTACTTCA AAGAGGCCGA GGTGCGTGTG 420
TACGGCGGTG AGATCGTGCT GGCTCTGGAA CACCTGCACA AGCTGGGCAT CGTCTATCGA 480
GACCTGAAGC TGGAGAATGT GCTCCTGGAC TCTGAGGGCC ACATTGTCCT CACGGACTTT 540
GGGCTGAGCA AGGAGTTCCT GACGGAGGAG AAAGAGCGGA CCTTCTCCTT CTGTGGCACC 600
ATCGAGTACA TGGCCCCTGA GATCATCCGT AGCAAGGCAG GGCACGGCAA GGCTGTGGAC 660
TGGTGGAGCC TGGGCATCTT GCTTTTTGAG CTGCTGACGG GCGCCTCACC TTTCACACTG 720
GAGGGCGAGA GGAACACACA GGCCGAGGTG TCTCGACGGA TCCTGAAGTG CTCCCCTCCC 780
TTCCCTTCCC GGATCGGGCC TGTGGCACAG GACCTGTTGC GACGACTGAT GTGCAAGGAC 840
CCAAAGAAGC GGCTGGGTGC GGGTCCCCAG GGGGCGCAGG ATGTAAAGAA CCACCCTTTC 900
TTCCAGGGTC TGGATTGGGC AGCCCTGGCT GCCAGGAAGA TTCCAGCCCC ATTTCAGCCC 960
CAGATTCGCT CAGAGCTGGA CGTGGGCAAC TTCGCAGAGG AGTTTACTCG GCTGGAGCCT 1020
GTGTACTCAC CCCCTGGCAG CCCCCCACCT GGGGACCCCC GAATCTTTCA GGGATACTCC 1080
TTCGTGGCCC CCTCCATCCT GTTTGATCAC AACAATGCAG TGATGACCGA TGTGCTGGAA 1140
GTGTCTGGTG CTGGAGACCG GCCAGGCCGG GCAGCAGTGG CCAGGAGCGC CATGATGCAG 1200
GACTCGCCCT TCTTCCAGCA GTACGAGCTG GACCTGCGGG AGCCCGCGCT GGGCCAAGGT 1260
AGCTTCTCAG TGTGTCGCCG TTGCCGCCAG CGCCAAAGCG GCCAGGAGTT TGCAGTCAAG 1320
ATCCTCAGCC GCAGGCTGGA GGCGAACACA CAGCGTGAAG TGGCTGCCTT GCGGCTCTGC 1380
CAGACGCATC CTAATGTGGT GACGCTGCAT GAGGTGCACC ATGATCAGCT GCACACCTAC 1440
CTGGTCCTGG AGCTGCTGCG GGGCGGGGAG CTGCTGGAGC ACATCCGCAA GAAGCGGCAC 1500
TTCAGTGAGT CTGAGGCCAG CCAGATTCTG CGCAGGCTCG TGTCCGCCGT GAGCTTCATG 1560
CACGAGGAGG CCGGTGTCGT GCATCGCGAC CTCAAGCCCG AGAACATCCT ATACGCGGAT 1620
GACACGCCGG GGGCGCCGGT CAAGATCATC GACTTTGGGT TCGCACGGCT GCGGCCTCAG 1680
AGCCCCGCCG GGCCCATGCA GACGCCCTGC TTCACGCTGC AGTACGCAGC CCCTGAGCTG 1740
CTGGCACAGG GTGGCTACGA CGAGTCTTGC GATCTCTGGA GCCTGGGCGT CATTCTGTAC 1800
ATGATGCTGT CGGGACAGGT CCCCTTCCAA GGGGCTTCAG GCCAGGGCGG GCAGAGCCAG 1860
GCGGCAGAGA TCATGTGCAA GATCCGCGAG GGCCGATTCT CCCTCGCTGG GGAGGCCTGG 1920
CAGGGTGTGT CGGAGGAGGC CAAGGAGCTG GTGCGAGGGC TCCTGACTGT GGATCCCACC 1980
AAGCGGCTGA AGCTCGAGGG GCTGCGGGGC AGCTCGTGGC TGCAGGACGG CAGCGCGCGC 2040
TCCTCGCCCC CGCTGCGCAC CCCCGACGTG CTGGAGTCCT CCGGGCCCGC GGTGCGCTCG 2100
GGACTCAACG CCACCTTCCT GGCGTTCAAC CGCGGCAAGC GAGAGGGCTT CTTCCTGAAG 2160
AGCGTGGAGA ATGCGCCGCT GGCCAAGCGC CGCAAACAGA AGCTGCGCAG CGCCGCCGCT 2220
GCCCGCCGGG GCTCCCCTGT GCCCGCCGCT GCAAAGGGGG CTGCCCGCCG AGCCAACGGG 2280
CCCCTGCCCC CCTCCTAG 2298
Domain Profile
S: 5     edlGvGsysvckrcvhkatnqefavkiidks.krdtseeieillryeqhpnivtlkdvyd  63
           lG+Gs+svc+rc++++++qefavki++++ +++t++e+++l+++++hpn+vtl++v++
Q: 415   PALGQGSFSVCRRCRQRQSGQEFAVKILSRRlEANTQREVAALRLCQTHPNVVTLHEVHH  474
         579*********************************************************
S: 64    dgkyvylvlellkGGelldrikkkkffsereasailrtlvkaveylheq.Gvvhrdlkpe  122
         d++++ylvlell+GGell++i+kk++fse+eas+ilr lv+av+++he+ Gvvhrdlkpe
Q: 475   DQLHTYLVLELLRGGELLEHIRKKRHFSESEASQILRRLVSAVSFMHEEaGVVHRDLKPE  534
         ***********************************************999**********
S: 123   nilyvdesdnaesikiidfGfaklkraeng.llktpcytlnfvapevlkrqGydeacdlw  181
         nily+d++++a+ +kiidfGfa+l+++++  +++tpc+tl+++ape+l++ Gyde+cdlw
Q: 535   NILYADDTPGAP-VKIIDFGFARLRPQSPAgPMQTPCFTLQYAAPELLAQGGYDESCDLW  593
         ************.*************99755*****************************
S: 182   slGvllytmlaGyvpf....angpedtaeeilakikeGkfslsGeawdsvseeakdlvsk  237
         slGv+ly+ml+G+vpf    ++g++++a+ei++ki+eG+fsl Geaw++vseeak+lv++
Q: 594   SLGVILYMMLSGQVPFqgasGQGGQSQAAEIMCKIREGRFSLAGEAWQGVSEEAKELVRG  653
         ****************999889**************************************
S: 238   lltvdpakrlkleqllkhswl  258
         lltvdp+krlkle+l+ +swl
Q: 654   LLTVDPTKRLKLEGLRGSSWL  674
         ********************7
Domain Sequence
(FASTA)
PALGQGSFSV CRRCRQRQSG QEFAVKILSR RLEANTQREV AALRLCQTHP NVVTLHEVHH 60
DQLHTYLVLE LLRGGELLEH IRKKRHFSES EASQILRRLV SAVSFMHEEA GVVHRDLKPE 120
NILYADDTPG APVKIIDFGF ARLRPQSPAG PMQTPCFTLQ YAAPELLAQG GYDESCDLWS 180
LGVILYMMLS GQVPFQGASG QGGQSQAAEI MCKIREGRFS LAGEAWQGVS EEAKELVRGL 240
LTVDPTKRLK LEGLRGSSWL 260
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>
EKS-AIM-00156
EKS-ANC-00159
EKS-BOT-00164
EKS-CAJ-00168
EKS-CAF-00171
EKS-EQC-00155
EKS-FEC-00154
EKS-GAA-00194
EKS-HOS-00170
EKS-ICT-00159
EKS-LOA-00163
EKS-MAM-00162
EKS-MAE-00060
EKS-MUM-00169
EKS-MUP-00168
EKS-NOL-00157
EKS-ORN-00204
EKS-OTG-00168
EKS-PAT-00154
EKS-PES-00145
EKS-RAN-00161
EKS-SAH-00158
EKS-SUS-00141
EKS-TAR-00211
EKS-TEN-00204
Gene Ontology
GO:0005524; F:ATP binding
GO:0000287; F:magnesium ion binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0007243; P:intracellular protein kinase cascade
KEGG
InterPros
IPR000961; AGC-kinase_C.
IPR011009; Kinase-like_dom.
IPR017892; Pkinase_C.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR016239; Ribosomal_S6_kinase_II.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 2.
PF00433; Pkinase_C; 1.
SMARTs
SM00133; S_TK_X; 1.
SM00220; S_TKc; 2.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS00107; PROTEIN_KINASE_ATP; 2.
PS50011; PROTEIN_KINASE_DOM; 2.
PS00108; PROTEIN_KINASE_ST; 2.
Prints
Created Date20-Feb-2013