EKS-CAP-00257

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAP-00257

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE7	337.2	6.5E-101	168	419	252

Status

Unreviewed

Ensembl Protein

ENSCPOP00000000870

UniProt Accession

H0UV50;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP2K5

Gene Synonyms/Alias

MAP2K5;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCPOG00000000970	ENSCPOP00000000870	ENSCPOT00000000976

Organism

Cavia porcellus

Functional Description

Protein Length

448

Protein Sequence
(FASTA)

MPWLALGPYL AMDNQVLVIR IKIPNSGAVD WTVHSGPQLL FRDVLDVIGQ VLPEATTTAF 60

EYEDEDGDRI TVRSDEEMKA MLSYYYSTVM EQQVNGQLIE PLQIFPRACK PPGERNIHGL 120

KVNTRAGPSQ HSSPAVLDSL PSNSLKKSSA ELKKILANGQ MNEQDIRYQD TLGHGNGGTV 180

YKAYHVPSGK ILAVKVILLD ITLELQKQIM SELEILYKCD SSYIIGFYGA FFVENRISIC 240

TEFMDGGSLD VYKKIPEHVL GRIAVAVVNG LTYLWSLKIL HRDVKPSNML VNTRGQVKLC 300

DFGVSTQLVN SIAKTYVGTN AYMAPERISG EQYGIHSDVW SLGISFMELA LGRFPYPQIQ 360

KNQGSLMPLQ LLQCIVDEDS PVLPVGEFSE PFVHFITQCM RKQPKERPAP EELMGHPFIM 420

QFNDGNATVV SMWVCRALEE RRSQQGPP 448

Nucleotide Sequence
(FASTA)

ATGCCGTGGC TGGCCCTTGG CCCCTATCTT GCCATGGACA ACCAGGTGCT GGTGATTCGC 60

ATCAAGATTC CAAATAGTGG CGCGGTGGAC TGGACAGTGC ACTCCGGGCC TCAGTTACTC 120

TTCAGAGATG TGCTGGATGT GATAGGCCAG GTTTTGCCTG AAGCCACAAC TACAGCATTT 180

GAATATGAAG ATGAAGATGG TGATAGAATT ACTGTGAGAA GTGATGAAGA AATGAAGGCA 240

ATGCTGTCAT ATTATTATTC CACGGTAATG GAACAGCAAG TAAATGGACA GTTAATAGAG 300

CCTTTGCAGA TATTTCCAAG AGCCTGCAAG CCTCCTGGGG AACGGAACAT ACATGGCCTG 360

AAGGTGAATA CCCGGGCCGG ACCCTCACAA CACAGTAGCC CAGCAGTCTT GGATTCACTT 420

CCAAGCAATA GCTTAAAGAA GTCTTCTGCC GAACTAAAAA AAATATTAGC CAATGGCCAG 480

ATGAATGAAC AAGACATACG ATATCAAGAC ACCCTTGGTC ATGGCAACGG AGGCACTGTC 540

TACAAGGCAT ATCATGTCCC AAGTGGGAAA ATACTAGCAG TAAAGGTTAT ACTATTAGAT 600

ATTACACTGG AACTTCAGAA GCAAATTATG TCTGAATTGG AGATTCTTTA CAAGTGTGAT 660

TCATCATATA TCATAGGATT TTATGGGGCA TTTTTTGTAG AAAACAGAAT TTCCATTTGT 720

ACAGAATTCA TGGATGGGGG ATCTTTGGAT GTATATAAGA AAATTCCAGA ACACGTCCTT 780

GGAAGAATTG CAGTAGCAGT TGTTAATGGC CTTACCTATT TGTGGAGTCT AAAGATTTTA 840

CACAGAGATG TGAAGCCTTC CAATATGCTT GTAAACACAA GAGGACAAGT CAAGCTATGT 900

GATTTTGGCG TAAGCACTCA ACTGGTGAAT TCTATAGCCA AGACGTATGT TGGAACAAAT 960

GCTTATATGG CGCCTGAAAG AATTTCAGGA GAACAGTATG GAATTCATTC TGATGTCTGG 1020

AGCTTAGGAA TCTCTTTCAT GGAGCTTGCT CTTGGGAGGT TCCCATATCC TCAGATTCAG 1080

AAAAACCAGG GATCTTTAAT GCCTCTCCAG CTTCTGCAGT GCATTGTTGA TGAGGATTCG 1140

CCCGTCCTTC CGGTTGGAGA GTTCTCCGAG CCATTTGTAC ATTTCATCAC TCAGTGCATG 1200

CGGAAACAGC CAAAAGAAAG GCCAGCACCT GAGGAACTGA TGGGTCACCC GTTCATCATG 1260

CAGTTCAATG ACGGAAATGC CACTGTGGTA TCCATGTGGG TGTGCAGAGC CCTGGAGGAG 1320

AGGCGGAGCC AGCAGGGCCC CCCA 1344

Domain Profile

S: 3     kleelGaGnggvVekvlhkksgkilavKtirleikkeeqkqilrelevlkkssnspyivk  62

           ++lG+Gngg+V+k+ h +sgkilavK i l+i+ e qkqi++ele+l k+ +s+yi++

Q: 168   YQDTLGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKC-DSSYIIG  226

         5689************************************************.*******

S: 63    fyGafvsegdvsicmelmdgtsldkvlkkvlekkkripekvlgkiavavvkaleylkekl  122

         fyGaf+ e+++sic+e+mdg+sld v+kk       ipe+vlg+iavavv++l+yl+ +l

Q: 227   FYGAFFVENRISICTEFMDGGSLD-VYKK-------IPEHVLGRIAVAVVNGLTYLW-SL  277

         ************************.6886.......9********************.78

S: 123   kiiHRDvKPsNiLvnskGevKlCDFGvsgqlvdsiAksavGtksYmaPEriegkkkYsvk  182

         ki+HRDvKPsN+Lvn++G+vKlCDFGvs+qlv+siAk++vGt++YmaPEri+g ++Y ++

Q: 278   KILHRDVKPSNMLVNTRGQVKLCDFGVSTQLVNSIAKTYVGTNAYMAPERISG-EQYGIH  336

         *****************************************************.******

S: 183   sdvWslGltlvelatgrypyeklke......ilellkaivneeppklpeeefseefqefv  236

         sdvWslG++++ela gr+py++ ++      +l+ll++iv+e++p+lp  efse f++f+

Q: 337   SDVWSLGISFMELALGRFPYPQIQKnqgslmPLQLLQCIVDEDSPVLPVGEFSEPFVHFI  396

         ***********************9999*********************************

S: 237   skClkkdekeRpklkellkhafi  259

         ++C++k++keRp  +el+ h+fi

Q: 397   TQCMRKQPKERPAPEELMGHPFI  419

         **********************7

Domain Sequence
(FASTA)

YQDTLGHGNG GTVYKAYHVP SGKILAVKVI LLDITLELQK QIMSELEILY KCDSSYIIGF 60

YGAFFVENRI SICTEFMDGG SLDVYKKIPE HVLGRIAVAV VNGLTYLWSL KILHRDVKPS 120

NMLVNTRGQV KLCDFGVSTQ LVNSIAKTYV GTNAYMAPER ISGEQYGIHS DVWSLGISFM 180

ELALGRFPYP QIQKNQGSLM PLQLLQCIVD EDSPVLPVGE FSEPFVHFIT QCMRKQPKER 240

PAPEELMGHP FI 252

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000270	; OPR_PB1.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00564	; PB1; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00666	; PB1; 1.
SM00220	; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013