EKS-CAP-00413

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAP-00413

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/MLK	316.1	1.7E-94	161	396	236

Status

Unreviewed

Ensembl Protein

ENSCPOP00000000871

UniProt Accession

H0UV51;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP3K12

Gene Synonyms/Alias

MAP3K12;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCPOG00000000971	ENSCPOP00000000871	ENSCPOT00000000977

Organism

Cavia porcellus

Functional Description

Protein Length

892

Protein Sequence
(FASTA)

MACLHETRTP SPSFGGFVST LSEASMRKLD PDTSDCTPEK DLTPTQCVLR DVVPLGGQGA 60

GGPSPSPGGE PPPEPFANSI LQLHEQDAGG PGGATGSPES RASRVRADEV RLQCQSGSGF 120

LEGLFGCLRP VWTMIGKAYS TEHKQQQEDL WEVPFEEILD LQWVGSGAQG AVFLGRFHGE 180

EVAVKKVRDL KETDIKHLRK LKHPNIITFK GVCTQAPCYC ILMEFCAQGQ LYEVLRAGRP 240

VTPSLLVDWS MGIAGGMNYL HLHKIIHRDL KSPNMLITYD DVVKISDFGT SKELSDKSTK 300

MSFAGTVAWM APEVIRNEPV SEKVDIWSFG VVLWELLTGE IPYKDVDSSA IIWGVGSNSL 360

HLPVPSSCPD GFKILLRQCW NSKPRNRPSF RQILLHLDIA SADVLSTPQE TYFKSQAEWR 420

EEVKLHFEKI KSEGTCLHRL EEELVMRRRE ELRHALDIRE HYERKLERAN NLYMELNALM 480

LQLELKEREL LRREQALERR CPGLLKSHPS RGLLHGNTME KLIKKRNVPQ KLSPHSKRPD 540

ILKTESLLPK LDAALSGVGL PGCPKGPPSP GRSRRGKMRH RKASAKGSCG DLPGLRAAVP 600

PHELGGPGSP GALGVGPSAW EACPPALRGL HHDLLLRKMS SSSPDLLSAA LGARGRGATG 660

AGDPGSPPPA RGDTPPSEGS APGSTSPDSP GGAKGEPPPP VGPGEGSGLL GTGREGTAGR 720

GGSRAGSQHL TPAALLYRAA VTRSQKRGIS SEEEEGEVDS EVELTSSQRW PQGLNMRQSL 780

STFSSENPSD GEEGTASEPS PSGTPEVGST NTDERPDERS DDMCSQGSEI PLDPPASEVV 840

PEPEPSSLAV PHQDLLRGEQ GPPNSEDSDC DSTELDNSHS VDALRPPASL PP 892

Nucleotide Sequence
(FASTA)

ATGGCCTGCC TCCATGAGAC CCGCACACCC TCCCCTTCCT TTGGGGGTTT TGTGTCTACC 60

CTAAGTGAGG CATCCATGCG CAAATTGGAC CCAGACACTT CAGACTGCAC ACCTGAGAAA 120

GACCTGACCC CCACCCAGTG TGTACTTCGA GATGTAGTGC CTCTTGGTGG GCAGGGCGCG 180

GGCGGACCCA GCCCCTCTCC GGGTGGAGAG CCACCCCCTG AGCCTTTTGC CAACAGCATC 240

CTACAGCTAC ATGAGCAGGA TGCAGGGGGT CCAGGGGGAG CTACTGGGTC ACCTGAAAGT 300

CGGGCATCTA GAGTTCGTGC TGATGAGGTA CGGTTGCAGT GCCAGAGTGG CAGTGGCTTC 360

CTTGAAGGCC TTTTTGGCTG CCTGCGCCCA GTATGGACCA TGATTGGCAA AGCCTACTCC 420

ACAGAACACA AGCAGCAGCA GGAAGACCTT TGGGAGGTCC CCTTTGAGGA AATCTTGGAC 480

CTGCAGTGGG TAGGCTCAGG GGCCCAGGGT GCTGTCTTCC TGGGGCGATT CCACGGGGAG 540

GAAGTGGCTG TGAAGAAGGT TCGAGACCTC AAGGAGACTG ACATCAAGCA CCTGCGAAAA 600

CTGAAGCACC CCAACATCAT CACATTCAAG GGCGTGTGTA CCCAAGCACC ATGCTACTGC 660

ATCCTCATGG AGTTCTGCGC ACAGGGCCAA CTGTATGAAG TGCTGCGGGC TGGCCGCCCT 720

GTCACCCCTT CCTTGCTGGT TGATTGGTCC ATGGGCATCG CCGGCGGCAT GAACTACCTA 780

CACCTGCACA AGATTATCCA CCGAGACCTC AAGTCTCCTA ACATGCTAAT CACGTATGAT 840

GACGTGGTGA AGATCTCAGA TTTTGGCACT TCCAAGGAGC TGAGTGACAA GAGCACCAAG 900

ATGTCCTTTG CAGGGACAGT AGCCTGGATG GCCCCTGAGG TGATCCGCAA TGAACCTGTG 960

TCTGAGAAAG TCGATATCTG GTCTTTTGGT GTGGTGCTAT GGGAACTACT GACTGGCGAG 1020

ATCCCCTACA AGGATGTAGA TTCCTCAGCC ATCATCTGGG GTGTGGGAAG CAACAGTCTG 1080

CATCTACCTG TGCCCTCCAG CTGCCCAGAC GGCTTCAAAA TCCTGCTTCG CCAGTGTTGG 1140

AATAGCAAGC CACGAAATCG GCCATCATTT CGACAAATCT TGCTACATCT GGACATTGCC 1200

TCAGCTGATG TACTCTCCAC ACCCCAGGAG ACTTACTTTA AGTCCCAGGC AGAATGGCGG 1260

GAAGAGGTAA AACTACACTT CGAAAAGATT AAGTCAGAAG GGACCTGTCT ACACCGACTA 1320

GAAGAGGAAC TGGTGATGCG AAGGAGGGAG GAGCTCAGAC ATGCCTTGGA CATCAGGGAA 1380

CACTATGAAC GGAAGCTGGA GAGAGCCAAC AACCTGTACA TGGAACTGAA TGCCCTTATG 1440

TTGCAGCTAG AACTCAAGGA GCGGGAGCTA CTCAGGAGGG AGCAAGCTTT AGAGCGGAGG 1500

TGCCCAGGCC TGCTGAAGTC ACACCCTTCC CGGGGCCTCC TGCATGGAAA CACCATGGAA 1560

AAGCTCATCA AGAAGAGAAA TGTGCCACAG AAACTATCAC CCCATAGCAA AAGGCCAGAC 1620

ATTCTCAAGA CAGAGTCTTT GCTACCTAAA CTAGATGCAG CCCTAAGTGG GGTGGGGCTT 1680

CCTGGGTGTC CTAAGGGCCC CCCCTCACCA GGACGGAGTC GCCGTGGCAA GATGCGTCAC 1740

CGCAAGGCCA GTGCCAAGGG CAGTTGTGGG GACCTGCCTG GGCTTCGTGC AGCTGTGCCA 1800

CCCCATGAAC TTGGAGGACC TGGAAGTCCT GGAGCCCTAG GAGTGGGACC CTCAGCTTGG 1860

GAGGCCTGCC CTCCAGCTCT CCGTGGGCTT CATCATGACC TTCTGCTCCG CAAGATGTCT 1920

TCTTCATCCC CAGACCTGCT GTCAGCTGCA CTGGGAGCCA GAGGGCGTGG GGCAACAGGA 1980

GCTGGGGATC CTGGTTCACC GCCCCCAGCC CGGGGTGACA CCCCACCAAG TGAGGGCTCA 2040

GCTCCAGGCT CCACCAGCCC AGATTCACCT GGGGGAGCCA AAGGAGAACC ACCTCCACCA 2100

GTAGGGCCTG GTGAAGGATC AGGGCTGCTG GGAACTGGAA GGGAAGGGAC AGCAGGCCGG 2160

GGAGGAAGCC GGGCTGGGTC TCAGCACTTG ACCCCAGCTG CACTGCTGTA CAGGGCTGCT 2220

GTCACTCGAA GTCAGAAACG TGGCATTTCT TCAGAAGAGG AGGAAGGAGA GGTAGACAGT 2280

GAAGTGGAGC TAACATCAAG CCAGAGGTGG CCTCAAGGCC TGAATATGCG CCAGTCATTA 2340

TCTACCTTCA GCTCAGAGAA CCCATCAGAT GGCGAGGAAG GTACAGCTAG TGAGCCTTCC 2400

CCAAGTGGCA CACCTGAAGT GGGCAGTACC AACACTGATG AGCGGCCAGA CGAGCGATCT 2460

GATGACATGT GTTCCCAGGG CTCAGAAATC CCACTGGACC CACCTGCTTC AGAGGTGGTC 2520

CCTGAGCCTG AACCTAGCTC CCTGGCTGTC CCACACCAGG ACCTACTCAG AGGTGAGCAG 2580

GGCCCTCCCA ATTCTGAGGA CTCAGACTGT GACAGCACTG AATTGGACAA CTCCCACAGC 2640

GTTGATGCCT TGCGGCCCCC AGCCTCCCTC CCTCCATGA 2679

Domain Profile

S: 4     eeligsgafgkvykakwrkkevavKklreeaeekekleklereakllsklshpniiellG  63

          +++gsga+g+v+ ++++++evavKk+r+ +e+         ++k+l+kl+hpnii+++G

Q: 161   LQWVGSGAQGAVFLGRFHGEEVAVKKVRDLKET---------DIKHLRKLKHPNIITFKG  211

         689**************************9999.........******************

S: 64    vcleepnlllvmeyveggsLsnvlhekskreidlevlvswalqiArGmaYLhseapkkii  123

         vc++ p+++++me++++g+L++vl++   r ++++ lv+w++ iA Gm+YLh +   kii

Q: 212   VCTQAPCYCILMEFCAQGQLYEVLRA--GRPVTPSLLVDWSMGIAGGMNYLHLH---KII  266

         **************************..99************************...9**

S: 124   hrdLksknvLlseekktlkicdFGtarelsk.stkmsaagtlawmaPEvlkeekvseksD  182

         hrdLks+n+L+ + ++++ki+dFGt++els+ stkms+agt+awmaPEv+++e+vsek+D

Q: 267   HRDLKSPNMLI-TYDDVVKISDFGTSKELSDkSTKMSFAGTVAWMAPEVIRNEPVSEKVD  325

         ***********.99****************99****************************

S: 183   vwSygvvLWelltrevPykdlselaiaykvalkglrlpipsscpeklkkLmkecwnedpe  242

         +wS+gvvLWellt+e+Pykd+++ ai+++v++++l+lp+psscp+ +k L+++cwn++p+

Q: 326   IWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQCWNSKPR  385

         ************************************************************

S: 243   kRpsfseivks  253

         +Rpsf++i+ +

Q: 386   NRPSFRQILLH  396

         ********876

Domain Sequence
(FASTA)

LQWVGSGAQG AVFLGRFHGE EVAVKKVRDL KETDIKHLRK LKHPNIITFK GVCTQAPCYC 60

ILMEFCAQGQ LYEVLRAGRP VTPSLLVDWS MGIAGGMNYL HLHKIIHRDL KSPNMLITYD 120

DVVKISDFGT SKELSDKSTK MSFAGTVAWM APEVIRNEPV SEKVDIWSFG VVLWELLTGE 180

IPYKDVDSSA IIWGVGSNSL HLPVPSSCPD GFKILLRQCW NSKPRNRPSF RQILLH 236

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004709	; F:MAP kinase kinase kinase activity
GO:0000186	; P:activation of MAPKK activity
GO:0000165	; P:MAPK cascade
GO:0046777	; P:protein autophosphorylation

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR017419	; MAP3K12_MAP3K13.
IPR000719	; Prot_kinase_cat_dom.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF07714

; Pkinase_Tyr; 1.

SMARTs

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013