EKS-CAP-00465

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAP-00465

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/ULK	391.8	1.6E-117	16	278	263

Status

Unreviewed

Ensembl Protein

ENSCPOP00000000921

UniProt Accession

H0UV96;

Protein Name

Protein Synonyms/Alias

Gene Name

ULK1

Gene Synonyms/Alias

ULK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCPOG00000001024	ENSCPOP00000000921	ENSCPOT00000001032

Organism

Cavia porcellus

Functional Description

Protein Length

1051

Protein Sequence
(FASTA)

MEPGRGGVET VGRFEFSRKD LIGHGAFAVV FKGRHREKHD LEVAVKCINK KNLAKSQTLL 60

GKEIKILKEL KHENIVALYD FQEMANSVYL VMEYCNGGDL ADYLHTMRTL SEDTIRLFLQ 120

QIAGAMRLLH SKGIIHRDLK PQNILLSNPG GRRANPNNIR VKIADFGFAR YLQSNMMAAT 180

LCGSPMYMAP EVIMSQHYDG KADLWSIGTI VYQCLTGKAP FQASSPQDLR LFYEKNKTLV 240

PAIPRETSAP LRQLLLALLQ RNHKDRMDFD EFFHHPFLDA SASVRKSPPV PVPSYPSSGS 300

GSSSSSSSTS HLASPPSLGE MAPLQKTLTS PADATGFLHG SRDSGGSSKD SCDTDDFVMV 360

PAQFPGDLVT EAASAKPPPD SLLCSGSSLV ASAGLESHGR TPSPSPSYSS SPSPSGRAGT 420

FSSSRYGASV PIPVPTQVHN YQRIEQNLQS PSQHHTPQCS ASRRSGGTSP LGFARASPSP 480

PSHADGAILA RKLSLGGGRP FTPSPQVGTI PERPGWSRAP SPQGAEVWAG RSPRPGSSVP 540

EHSPRTPGLG CRLHSAPNLS DLRVIQPKLP KPPTDPLGAA FSPPQPSPPP AASVLQSCRL 600

TPRGSPKLPD FLQRKPLPPI LGSPTKAIPS FDFPKVPSSQ NLLALLARQG VVVTPPRNRT 660

LPDLSEVGPF QGQQLGSGLR PAEDTKGPFG RSFSTSRLTD LLLKAAFGTQ ASDSGSTDSL 720

QEKPMEIAPS AGFGGNLHPG ARAGGASSPA PVVFTVGSPP SGTTPPPAPR TRMFSAISPT 780

VGSAGSSARH LMPGACGEVA PELTVPSHCC SISDPLSAHL EGAVTFEAPD LPEETLMEQE 840

HTETLHSLRF TLVFVQHVLE IAALKGNASE AAVGPEYQLQ ESVVADQISL LSREWGFAEQ 900

LVLYLKVAEL LSSGLQMAID QIRAGKLCLS STVKQVVRKL NELYKASVTS CQGLSLRLQR 960

FFLDKQRLLD GIHGVTAERL ILSHAVQMVQ SAALDEMFQH HEGCVPRYHK ALLLLEGLQH 1020

MLTDQADIEN IAKCKLCIER RLSALLSGVC A 1051

Nucleotide Sequence
(FASTA)

ATGGAGCCCG GCCGCGGCGG CGTGGAGACC GTGGGCCGCT TCGAGTTTTC CCGCAAGGAC 60

CTGATCGGCC ACGGCGCCTT CGCGGTGGTC TTCAAGGGCC GCCACCGCGA GAAGCATGAC 120

CTGGAGGTCG CGGTCAAGTG CATTAACAAG AAGAACCTGG CCAAGTCCCA GACGCTGTTG 180

GGGAAGGAAA TCAAAATTCT CAAGGAGCTG AAGCACGAGA ACATTGTGGC ACTGTATGAC 240

TTCCAGGAAA TGGCCAATTC TGTCTACTTG GTCATGGAGT ACTGCAATGG TGGTGACCTG 300

GCCGACTACC TGCACACCAT GCGGACCCTG AGCGAGGACA CCATCCGGCT CTTCCTGCAG 360

CAGATTGCTG GTGCCATGCG GCTGCTGCAC AGCAAGGGCA TCATTCACCG CGACTTGAAG 420

CCGCAGAACA TCCTGCTGTC TAACCCTGGG GGACGACGCG CGAACCCCAA CAACATCCGG 480

GTCAAGATTG CCGACTTTGG CTTCGCCCGC TACCTGCAGA GCAACATGAT GGCGGCCACG 540

CTGTGCGGCT CCCCCATGTA CATGGCTCCT GAGGTCATCA TGTCCCAGCA CTATGACGGG 600

AAGGCAGACC TGTGGAGCAT CGGCACCATT GTCTACCAGT GCCTCACGGG CAAGGCCCCG 660

TTTCAGGCCA GCAGTCCTCA GGACCTGCGA CTGTTCTACG AAAAAAACAA GACACTGGTC 720

CCTGCCATCC CCCGCGAGAC CTCGGCTCCC CTGCGGCAGC TGCTCCTGGC GCTGCTGCAG 780

CGCAACCATA AAGACCGCAT GGACTTCGAT GAGTTTTTCC ACCACCCTTT TCTGGACGCC 840

AGCGCCTCTG TCAGGAAGTC CCCGCCCGTG CCTGTACCCT CCTACCCGAG CTCAGGGTCC 900

GGCAGCAGCT CCAGCAGCAG CTCCACCTCG CACCTGGCCT CTCCTCCGTC GCTGGGGGAG 960

ATGGCACCAC TGCAGAAGAC GCTGACCTCC CCTGCAGATG CCACTGGCTT CTTGCATGGC 1020

TCCCGGGACT CGGGCGGCAG CAGCAAGGAC TCCTGTGACA CTGATGACTT TGTCATGGTC 1080

CCTGCTCAGT TCCCAGGTGA CTTGGTGACC GAGGCAGCCA GTGCCAAGCC CCCGCCCGAC 1140

AGCCTGCTCT GCAGTGGGAG TTCGCTGGTA GCCTCTGCCG GGCTGGAGAG CCATGGCCGG 1200

ACACCATCCC CATCCCCGTC CTACAGCAGC TCACCCAGTC CCTCAGGCCG GGCTGGCACC 1260

TTCTCCAGCA GCAGGTACGG CGCCTCGGTC CCCATCCCCG TCCCCACTCA GGTACACAAC 1320

TACCAGCGCA TCGAGCAGAA CCTACAGTCG CCCAGCCAAC ACCACACCCC CCAGTGCTCT 1380

GCCAGCCGCA GGTCGGGTGG CACCAGCCCC CTGGGCTTTG CCCGGGCGAG CCCGTCACCC 1440

CCATCCCATG CTGACGGCGC TATCCTGGCC AGGAAGTTGT CTCTGGGTGG GGGCCGGCCC 1500

TTCACACCAT CCCCACAGGT GGGAACCATC CCTGAGCGGC CTGGCTGGAG CAGGGCACCC 1560

TCTCCGCAGG GAGCTGAGGT GTGGGCTGGC AGGTCCCCGA GACCAGGCTC TTCTGTGCCG 1620

GAGCACTCCC CCCGCACCCC TGGGCTGGGC TGCCGCCTGC ACAGTGCCCC CAACCTGTCA 1680

GACCTGCGTG TCATCCAACC CAAGCTGCCC AAGCCCCCCA CGGACCCACT GGGAGCTGCC 1740

TTCAGCCCCC CGCAACCCAG CCCACCACCG GCCGCTTCCG TGCTGCAGTC CTGCCGGCTC 1800

ACCCCACGCG GATCGCCCAA GCTTCCCGAT TTCCTGCAGC GGAAGCCCCT ACCCCCCATC 1860

CTTGGCTCCC CGACCAAGGC CATACCCTCC TTCGACTTCC CCAAGGTCCC CAGCTCTCAG 1920

AACCTCTTGG CTCTGCTGGC CCGACAGGGC GTGGTGGTGA CACCCCCCCG AAACCGGACG 1980

CTGCCTGACC TCTCAGAGGT GGGGCCCTTC CAGGGACAGC AGCTGGGCTC TGGCCTGCGG 2040

CCAGCTGAGG ACACCAAGGG CCCCTTTGGC CGGTCCTTCA GCACCAGCCG CCTCACGGAT 2100

CTGCTGCTCA AGGCTGCATT TGGGACGCAG GCCTCAGACT CGGGCAGCAC GGACAGCCTG 2160

CAGGAGAAAC CCATGGAGAT TGCACCCTCT GCTGGCTTTG GAGGGAACCT GCACCCAGGA 2220

GCCCGTGCTG GGGGTGCCAG CAGCCCTGCC CCTGTGGTAT TCACAGTGGG GTCACCTCCC 2280

AGTGGGACTA CGCCGCCCCC TGCGCCCCGC ACCCGCATGT TCTCAGCCAT ATCTCCCACA 2340

GTGGGCTCCG CTGGGTCCTC TGCCCGCCAC CTGATGCCCG GGGCCTGTGG GGAGGTTGCC 2400

CCCGAACTCA CTGTTCCCAG CCACTGCTGC AGCATCAGTG ACCCCCTGTC GGCCCACCTG 2460

GAGGGGGCTG TGACCTTTGA GGCCCCTGAC CTGCCGGAGG AGACACTCAT GGAGCAAGAG 2520

CACACGGAGA CTCTGCACAG CCTGCGCTTC ACACTGGTGT TCGTGCAGCA CGTGCTGGAG 2580

ATCGCGGCGC TGAAGGGCAA TGCCAGTGAG GCGGCTGTGG GCCCCGAGTA CCAGCTGCAG 2640

GAGAGCGTGG TGGCTGACCA GATCAGCCTG CTGAGCCGCG AGTGGGGCTT TGCGGAGCAG 2700

CTGGTACTGT ACCTGAAAGT GGCCGAGCTG CTGTCCTCTG GCCTGCAGAT GGCCATTGAC 2760

CAGATCCGGG CCGGCAAGCT ATGCCTGTCT TCCACCGTGA AGCAGGTGGT GCGCAAGCTG 2820

AACGAGCTGT ACAAGGCCAG CGTGACGTCC TGCCAGGGCC TGAGCCTGCG GCTACAGCGC 2880

TTCTTCCTGG ACAAGCAGCG GCTGCTGGAT GGTATTCATG GCGTCACTGC TGAGAGGCTC 2940

ATCCTCAGCC ACGCCGTGCA GATGGTGCAG TCAGCGGCCC TGGACGAGAT GTTCCAGCAC 3000

CACGAAGGCT GCGTGCCTCG CTACCACAAG GCCCTGCTGC TGCTGGAGGG CCTGCAGCAC 3060

ATGCTCACGG ACCAGGCTGA CATCGAGAAC ATTGCCAAGT GCAAGCTGTG CATCGAGCGG 3120

AGACTGTCAG CCCTGCTGTC TGGTGTCTGC GCCTGA 3156

Domain Profile

S: 1     ysleeeiGkGsfavvykgrlrkktsqvvAikvvekkklkkslenlekeikilkelkheni  60

         +s ++ iG+G+favv+kgr+r+k++ +vA+k+++kk+l+ks++ l keikilkelkheni

Q: 16    FSRKDLIGHGAFAVVFKGRHREKHDLEVAVKCINKKNLAKSQTLLGKEIKILKELKHENI  75

         7889********************************************************

S: 61    valldveetskevylvmeycaggdLakllkqkkeLsedtvreflqqlasalkaLhskkiv  120

         val+d++e++++vylvmeyc+ggdLa++l+++++Lsedt+r flqq+a a+++Lhsk+i+

Q: 76    VALYDFQEMANSVYLVMEYCNGGDLADYLHTMRTLSEDTIRLFLQQIAGAMRLLHSKGII  135

         ************************************************************

S: 121   hrDlkPqniLlsyadakk.elkkvtlkladFglarvlkeesmaatlkGsplYmaPEvvke  179

         hrDlkPqniLls+  +++ + +++++k+adFg+ar+l++++maatl+Gsp+YmaPEv+++

Q: 136   HRDLKPQNILLSNPGGRRaNPNNIRVKIADFGFARYLQSNMMAATLCGSPMYMAPEVIMS  195

         *************999999*****************************************

S: 180   qqydakaDlWSiGtilyellvGkpPfaaesiseLvekiekndvleppipkeisselkdll  239

         q+yd kaDlWSiGti+y++l+Gk+Pf+a+s+++L+ ++ekn++l p ip+e+s+ l++ll

Q: 196   QHYDGKADLWSIGTIVYQCLTGKAPFQASSPQDLRLFYEKNKTLVPAIPRETSAPLRQLL  255

         ************************************************************

S: 240   qsLLqrdpkkRisfeelfahpfl  262

          +LLqr++k+R++f+e+f+hpfl

Q: 256   LALLQRNHKDRMDFDEFFHHPFL  278

         *********************96

Domain Sequence
(FASTA)

FSRKDLIGHG AFAVVFKGRH REKHDLEVAV KCINKKNLAK SQTLLGKEIK ILKELKHENI 60

VALYDFQEMA NSVYLVMEYC NGGDLADYLH TMRTLSEDTI RLFLQQIAGA MRLLHSKGII 120

HRDLKPQNIL LSNPGGRRAN PNNIRVKIAD FGFARYLQSN MMAATLCGSP MYMAPEVIMS 180

QHYDGKADLW SIGTIVYQCL TGKAPFQASS PQDLRLFYEK NKTLVPAIPR ETSAPLRQLL 240

LALLQRNHKD RMDFDEFFHH PFL 263

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR022708	; Ser/Thr_kinase_C.

Pfam

PF12063	; DUF3543; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013