EKS-CAP-00426
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-CAP-00426
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Axl547.54.8E-165582846265
StatusUnreviewed
Ensembl ProteinENSCPOP00000000926
UniProt AccessionH0UVA1;
Protein Name
Protein Synonyms/Alias
Gene NameMERTK
Gene Synonyms/Alias MERTK;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSCPOG00000001029ENSCPOP00000000926ENSCPOT00000001037
OrganismCavia porcellus
Functional Description
Protein Length869
Protein Sequence
(FASTA)
PIFLEILVGQ LNLKAPKGGV IAETREETRP SQSLPRSLQV DHRPFSYPDT SGYQPASMLS 60
PTQPGRPHPG DTAGPQATSA AAKLRPPVAF NHTVGHIILS EHKDVKFNCS INIPNMYQET 120
ESVSWWKDGK ELRGAHNTVT QYYPDNEVTS IIASFSITSV QRSDNGSYIC KMKVNNIEIV 180
SDPINIEVQG LPYFTKQPES LNVTRNTAFN LTCHAVGPPE PVNIFWVRNS SRINERAETS 240
PSVLTVRGLT ETAIFSCEAH NDKGLTVSKG VQVNIKAIPS PPTEVHIHNS SAHSILVSWV 300
PGFDGYSPFR NCSIQVKEAD PLSNGSVMIF NTSASPHLYQ IQQLQALANY SISVSCMNEI 360
GWSALSPWIL ASTTEGAPST APLNVTVFLN ESTNKVDVRW MQPPIRQQDG ELVGYRIAHS 420
WQSDSTSKEL SEEVGRNSSR AQLSVQVYNA TFSVRIAAVT KGGVGPFSDP VKIFIPVQGG 480
VDSAPSSTPA PGSPEPVLII LGCFCAFVLI GLILYISLAI KRRVQETKFG TAFTEEDSEL 540
VVNYIAKKSY CRRAIELTLH SLGVSEELQN KLEDVVIDRN LLMLGKILGE GEFGSVMEGN 600
LKQQDGTSQK VAVKTMKLNN FSQREIEEFL SEAACMKDFS HPNVIRLLGV CIEMSSQGIP 660
KPMVILPFMK YGDLHTYLLY SRLETGPKHI PLQTLLRFMV DIALGMEYLS NRSFLHRDLA 720
ARNCMLRDDM TVCVADFGLS KKIYSGDYYR QGRIAKMPVK WIAIESLADR VYTSKSDVWA 780
FGVTMWEIAT RGMTPYPGVQ NHEMYDYLLH GHRLKQPEDC LDELYEIMFS CWSADPLDRP 840
TFSVLRLQLE KLLRLPDSQD KAAVIYMNT 869
Nucleotide Sequence
(FASTA)
CCTATATTTT TAGAAATACT TGTGGGCCAG CTAAACCTAA AGGCCCCTAA AGGAGGAGTG 60
ATTGCTGAAA CCAGGGAAGA AACCAGACCC TCCCAATCAC TCCCAAGGAG CCTGCAAGTG 120
GACCACAGGC CATTTTCCTA CCCTGACACC AGTGGGTACC AGCCTGCTTC GATGCTGTCA 180
CCGACCCAGC CTGGAAGGCC ACATCCAGGA GACACGGCTG GCCCCCAGGC CACCTCTGCT 240
GCAGCAAAGC TCCGACCACC TGTTGCATTT AATCACACAG TTGGACACAT AATACTTTCT 300
GAGCACAAAG ATGTCAAATT TAATTGCTCC ATCAATATAC CTAATATGTA CCAGGAAACT 360
GAAAGTGTTT CCTGGTGGAA AGATGGGAAG GAGTTGCGTG GAGCACATAA TACAGTTACA 420
CAGTATTATC CCGATAATGA AGTCACGTCA ATCATTGCAT CCTTCAGCAT AACCAGCGTG 480
CAGCGCTCAG ACAATGGATC GTACATCTGT AAGATGAAAG TGAACAATAT CGAGATTGTG 540
TCTGACCCCA TCAACATCGA GGTACAAGGA CTTCCCTACT TCACTAAGCA GCCCGAGAGC 600
CTCAATGTCA CCAGAAACAC AGCCTTCAAC CTCACCTGCC ATGCTGTGGG GCCCCCTGAG 660
CCGGTCAACA TTTTCTGGGT TCGAAACAGC AGCCGCATTA ACGAGCGGGC TGAAACATCT 720
CCCTCTGTTC TAACTGTCCG GGGTCTCACA GAGACGGCGA TCTTCAGTTG CGAGGCCCAC 780
AATGACAAAG GACTGACCGT GTCCAAGGGT GTGCAGGTCA ACATCAAAGC GATTCCCTCC 840
CCACCAACCG AAGTCCACAT CCACAACAGT TCGGCGCACA GCATTCTGGT CTCCTGGGTC 900
CCTGGTTTTG ATGGCTACTC CCCATTCAGG AACTGCAGCA TTCAGGTCAA GGAAGCTGAT 960
CCTCTGAGTA ACGGCTCAGT CATGATTTTT AACACCTCGG CTTCACCACA TCTGTATCAA 1020
ATCCAGCAGC TGCAAGCCCT GGCCAATTAC AGCATCAGTG TGTCCTGTAT GAACGAAATT 1080
GGCTGGTCCG CACTGAGCCC GTGGATTCTG GCCAGCACCA CGGAGGGAGC TCCATCCACA 1140
GCACCTTTAA ATGTCACTGT GTTTCTGAAC GAGTCTACTA ATAAGGTGGA TGTCAGATGG 1200
ATGCAGCCTC CAATCAGGCA GCAGGATGGG GAGCTGGTGG GCTACCGGAT AGCTCACTCG 1260
TGGCAGAGTG ACAGCACTTC TAAAGAACTC TCTGAAGAAG TCGGCCGAAA CAGCAGCCGG 1320
GCTCAGCTTT CTGTCCAAGT CTACAATGCC ACGTTCTCAG TGAGGATTGC AGCTGTCACT 1380
AAAGGAGGAG TTGGGCCTTT CAGCGACCCG GTGAAGATAT TCATCCCTGT GCAGGGTGGG 1440
GTAGACTCTG CCCCATCATC AACGCCAGCA CCAGGCAGCC CCGAGCCTGT GCTCATCATC 1500
CTCGGCTGTT TCTGTGCATT CGTTTTGATC GGGTTGATTT TATACATTTC CCTGGCAATC 1560
AAAAGAAGAG TGCAGGAGAC AAAGTTTGGG ACTGCATTCA CAGAGGAGGA TTCTGAATTA 1620
GTTGTAAATT ATATAGCCAA GAAGTCCTAC TGTCGGCGAG CTATTGAACT TACCTTACAC 1680
AGCTTGGGAG TTAGTGAGGA ACTGCAAAAT AAACTAGAAG ATGTCGTGAT TGACAGGAAT 1740
CTTCTAATGC TTGGAAAAAT TCTGGGGGAA GGAGAGTTCG GGTCTGTGAT GGAAGGAAAT 1800
CTGAAACAGC AAGACGGGAC CTCTCAGAAG GTGGCGGTGA AGACCATGAA GTTGAACAAC 1860
TTCTCACAGC GGGAGATCGA AGAGTTTCTC AGTGAGGCAG CGTGCATGAA AGACTTCAGC 1920
CACCCTAACG TCATCCGACT TCTAGGCGTG TGTATCGAAA TGAGCTCTCA GGGCATCCCG 1980
AAGCCCATGG TGATTTTACC CTTCATGAAA TACGGGGACC TGCACACCTA CTTACTGTAC 2040
TCCCGGCTGG AGACGGGACC AAAGCATATT CCCCTGCAGA CGCTGTTGAG GTTCATGGTG 2100
GACATTGCAC TGGGAATGGA GTATCTCAGC AACAGGAGTT TTCTGCATCG GGACTTAGCT 2160
GCTCGGAACT GCATGTTGCG TGATGACATG ACTGTCTGTG TGGCCGACTT CGGCCTCTCC 2220
AAGAAGATTT ACAGCGGCGA TTACTACCGC CAAGGCCGCA TCGCAAAGAT GCCTGTCAAG 2280
TGGATTGCCA TCGAGAGTCT CGCAGACCGA GTCTACACAA GTAAAAGCGA CGTGTGGGCA 2340
TTTGGCGTGA CCATGTGGGA AATAGCGACA CGGGGAATGA CCCCCTATCC GGGAGTCCAG 2400
AACCATGAGA TGTATGACTA CCTTCTCCAC GGCCACAGGC TGAAGCAGCC CGAGGACTGC 2460
CTGGATGAAC TGTACGAAAT CATGTTCTCC TGCTGGAGCG CGGACCCCTT GGACCGACCC 2520
ACCTTCTCGG TGCTGAGGCT GCAGCTGGAG AAGCTCTTGA GACTGCCTGA CTCCCAGGAC 2580
AAAGCGGCCG TCATCTACAT GAACACC 2607
Domain Profile
S: 1     lvlgkvlgegefgsvmegqlkqedgsilkvavktlkldiiarseieeflseaacmkefdh  60
         l+lgk+lgegefgsvmeg+lkq+dg+++kvavkt+kl++++++eieeflseaacmk+f+h
Q: 582   LMLGKILGEGEFGSVMEGNLKQQDGTSQKVAVKTMKLNNFSQREIEEFLSEAACMKDFSH  641
         589*********************************************************
S: 61    pnvirlvgvslessekgrlpkpvvilpfmkygdlhafllysrlgenpvylplqtlvkfmv  120
         pnvirl+gv++e+s++g +pkp+vilpfmkygdlh++llysrl+++p+++plqtl++fmv
Q: 642   PNVIRLLGVCIEMSSQG-IPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLLRFMV  700
         ****************9.******************************************
S: 121   diasgmeylssrnfihrdlaarncmlaedmtvcvadfglskkiysgdyyrqgriaklpvk  180
         dia gmeyls+r f+hrdlaarncml++dmtvcvadfglskkiysgdyyrqgriak+pvk
Q: 701   DIALGMEYLSNRSFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAKMPVK  760
         ************************************************************
S: 181   wiaiesladrvytsksdvwafgvtmweiatrgqtpyagvenaeiydyllqgnrlkqpedc  240
         wiaiesladrvytsksdvwafgvtmweiatrg+tpy+gv+n+e+ydyll+g+rlkqpedc
Q: 761   WIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRLKQPEDC  820
         ************************************************************
S: 241   ldelydlmyrcweadpkdrpsfsvlr  266
         ldely++m++cw+adp drp+fsvlr
Q: 821   LDELYEIMFSCWSADPLDRPTFSVLR  846
         *************************9
Domain Sequence
(FASTA)
LMLGKILGEG EFGSVMEGNL KQQDGTSQKV AVKTMKLNNF SQREIEEFLS EAACMKDFSH 60
PNVIRLLGVC IEMSSQGIPK PMVILPFMKY GDLHTYLLYS RLETGPKHIP LQTLLRFMVD 120
IALGMEYLSN RSFLHRDLAA RNCMLRDDMT VCVADFGLSK KIYSGDYYRQ GRIAKMPVKW 180
IAIESLADRV YTSKSDVWAF GVTMWEIATR GMTPYPGVQN HEMYDYLLHG HRLKQPEDCL 240
DELYEIMFSC WSADPLDRPT FSVLR 265
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00370
EKS-ANC-00383
EKS-BOT-00400
EKS-CAJ-00403
EKS-CAF-00399
EKS-CIS-00152
EKS-DAR-00776
EKS-EQC-00388
EKS-GAM-00236
EKS-GAG-00337
EKS-GAA-00487
EKS-GOG-00385
EKS-HOS-00401
EKS-ICT-00376
EKS-LAC-00414
EKS-LOA-00404
EKS-MAM-00397
EKS-MEG-00328
EKS-MOD-00384
EKS-MUM-00430
EKS-MUP-00389
EKS-MYL-00395
EKS-NOL-00363
EKS-ORN-00510
EKS-ORA-00346
EKS-ORC-00375
EKS-OTG-00400
EKS-PAT-00373
EKS-PES-00354
EKS-POA-00390
EKS-RAN-00412
EKS-TAG-00470
EKS-TAR-00501
EKS-TAS-00047
EKS-TEN-00499
EKS-XET-00510
EKS-XIM-00502
Gene Ontology
GO:0016021; C:integral to membrane
GO:0005524; F:ATP binding
GO:0004713; F:protein tyrosine kinase activity
KEGG
InterPros
IPR003961; Fibronectin_type3.
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003599; Ig_sub.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF00041; fn3; 2.
PF07679; I-set; 1.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00060; FN3; 2.
SM00409; IG; 2.
SM00219; TyrKc; 1.
Prosites
PS50853; FN3; 2.
PS50835; IG_LIKE; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013