EKS-CAP-00500

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAP-00500

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/MAPK	374.9	2.3E-112	129	415	287

Status

Unreviewed

Ensembl Protein

ENSCPOP00000000988

UniProt Accession

H0UVF3;

Protein Name

Protein Synonyms/Alias

Gene Name

NLK

Gene Synonyms/Alias

NLK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCPOG00000001093	ENSCPOP00000000988	ENSCPOT00000001104

Organism

Cavia porcellus

Functional Description

Protein Length

515

Protein Sequence
(FASTA)

MAAYNGGTSA AAAGHHHHHH HHLPHLPPPH LHHHHHPQHH LHPGSAAAVH PVQQHTSSAA 60

AAAAAAAAAA AMLNPGQQQP YFPSPAPGQA PGPAAAAPAQ VQAAAAATVK AHHHQHSHHP 120

QQQLDIEPDR PIGYGAFGVV WSVTDPRDGK RVALKKMPNV FQNLVSCKRV FRELKMLCFF 180

KHDNVLSALD ILQPPHIDYF EEIYVVTELM QSDLHKIIVS PQPLSSDHVK VFLYQILRGL 240

KYLHSAGILH RDIKPGNLLV NSNCVLKICD FGLARVEELD ESRHMTQEVV TQYYRAPEIL 300

MGSRHYSNAI DIWSVGCIFA ELLGRRILFQ AQSPIQQLDL ITDLLGTPSL EAMRTACEGA 360

KAHILRGPHK QPSLPVLYTL SSQATHEAVH LLCRMLVFDP SKRISAKDAL AHPYLDEGRL 420

RYHTCMCKCC FSTSTGRVYT SDFEPVTNPK FDDTFEKNLS SVRQVKEIIH QFILEQQKGN 480

RVPLCINPQS AAFKSFISST VAQPSEMPPS PLVWE 515

Nucleotide Sequence
(FASTA)

ATGGCGGCTT ACAATGGCGG TACATCTGCA GCAGCAGCAG GTCACCACCA CCACCATCAT 60

CATCACCTTC CACACCTTCC TCCTCCTCAC CTTCACCACC ACCACCACCC TCAACACCAT 120

CTTCATCCGG GGTCGGCTGC TGCCGTACAC CCCGTGCAGC AGCATACCTC CTCGGCAGCT 180

GCGGCAGCCG CAGCAGCGGC TGCAGCTGCA GCCATGTTAA ACCCTGGGCA ACAGCAGCCA 240

TATTTCCCAT CACCGGCACC GGGTCAGGCT CCTGGACCAG CTGCAGCAGC CCCAGCTCAG 300

GTACAGGCTG CGGCAGCTGC TACAGTTAAG GCGCACCATC ATCAGCACTC CCACCATCCA 360

CAACAGCAGC TGGATATTGA GCCGGATAGA CCTATTGGAT ATGGAGCCTT TGGCGTTGTC 420

TGGTCAGTAA CAGATCCAAG AGATGGAAAG AGAGTAGCAC TCAAAAAGAT GCCCAACGTC 480

TTCCAGAATC TGGTCTCTTG CAAAAGAGTC TTCCGAGAAT TGAAGATGTT GTGTTTTTTT 540

AAACATGATA ATGTACTCTC TGCCCTTGAC ATACTCCAAC CTCCACACAT TGACTATTTT 600

GAAGAAATAT ATGTTGTCAC AGAATTGATG CAGAGTGACC TACATAAAAT TATCGTCTCT 660

CCTCAACCAC TCAGCTCAGA TCATGTCAAA GTTTTTCTTT ATCAGATTTT GCGAGGTTTG 720

AAATATCTCC ATTCAGCTGG CATTTTGCAT CGAGACATTA AGCCAGGGAA TCTCCTTGTG 780

AACAGCAACT GTGTTCTAAA GATTTGTGAT TTTGGATTGG CCAGAGTGGA AGAACTAGAT 840

GAATCCCGTC ATATGACTCA GGAAGTTGTT ACTCAGTATT ATCGGGCTCC AGAAATCCTG 900

ATGGGCAGTC GTCATTACAG CAATGCTATT GACATCTGGT CTGTCGGGTG TATCTTTGCA 960

GAACTACTAG GTCGAAGAAT ATTGTTTCAG GCACAAAGTC CCATCCAGCA GTTGGATTTG 1020

ATCACAGATC TGTTGGGCAC CCCATCACTG GAAGCGATGA GGACAGCTTG TGAAGGCGCT 1080

AAGGCACACA TACTCAGGGG TCCTCATAAG CAGCCATCTC TTCCTGTACT CTATACCCTG 1140

TCTAGCCAAG CTACACATGA AGCTGTTCAT CTCCTCTGCA GGATGTTGGT CTTTGATCCA 1200

TCAAAAAGAA TATCCGCTAA GGATGCCTTA GCCCACCCCT ACCTAGATGA AGGGCGCCTA 1260

AGATACCACA CCTGTATGTG TAAATGTTGC TTTTCCACCT CTACCGGAAG AGTTTATACC 1320

AGTGACTTTG AGCCCGTCAC CAATCCCAAA TTTGATGACA CTTTTGAGAA GAACCTCAGT 1380

TCTGTTCGAC AGGTAAAAGA AATTATTCAC CAGTTCATTT TGGAACAGCA GAAAGGAAAC 1440

AGAGTGCCTC TCTGCATCAA CCCTCAGTCT GCTGCTTTTA AGAGCTTTAT TAGTTCCACT 1500

GTTGCTCAGC CGTCTGAGAT GCCGCCGTCT CCTCTGGTGT GGGAG 1545

Domain Profile

S: 4     lkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNiikl  63

          +p+g Ga+gvv+s++d r+++rva+kk+ ++fq+ +s+kr++RElk+l  +kh+N+++

Q: 129   DRPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSA  188

         689*********************************************************

S: 64    ldvftpeeeleelkdvYlvtelmetdLkkviksq.klsdehiklllyqilrglkylHsan  122

         ld+++p + ++ ++++Y+vtelm++dL+k+i s   ls++h+k++lyqilrglkylHsa+

Q: 189   LDILQPPH-IDYFEEIYVVTELMQSDLHKIIVSPqPLSSDHVKVFLYQILRGLKYLHSAG  247

         *******9.**********************99879************************

S: 123   viHrDlKPsNllvnedcelkildFGlarsadkekekklteyvatrwYraPeillslkeyt  182

         ++HrD+KP+Nllvn++c lki+dFGlar+++ ++++++t++v+t++YraPeil+ +++y+

Q: 248   ILHRDIKPGNLLVNSNCVLKICDFGLARVEELDESRHMTQEVVTQYYRAPEILMGSRHYS  307

         *********************************999************************

S: 183   kavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflkkieseearnyiks  242

         +a+DiWsvGCI+aEll +++lf++++ i+ql++i+++lgtps e +++ ++  a+++i +

Q: 308   NAIDIWSVGCIFAELLGRRILFQAQSPIQQLDLITDLLGTPSLEAMRTACEG-AKAHILR  366

         ************************************************9996.7777777

S: 243   lpkkkkk..dfeelfpkaseealdLleklLvldpdkRisveeaLehpYl  289

          p+k+     + +l ++a++ea++Ll ++Lv+dp+kRis+++aL+hpYl

Q: 367   GPHKQPSlpVLYTLSSQATHEAVHLLCRMLVFDPSKRISAKDALAHPYL  415

         77666644457788888*******************************7

Domain Sequence
(FASTA)

DRPIGYGAFG VVWSVTDPRD GKRVALKKMP NVFQNLVSCK RVFRELKMLC FFKHDNVLSA 60

LDILQPPHID YFEEIYVVTE LMQSDLHKII VSPQPLSSDH VKVFLYQILR GLKYLHSAGI 120

LHRDIKPGNL LVNSNCVLKI CDFGLARVEE LDESRHMTQE VVTQYYRAPE ILMGSRHYSN 180

AIDIWSVGCI FAELLGRRIL FQAQSPIQQL DLITDLLGTP SLEAMRTACE GAKAHILRGP 240

HKQPSLPVLY TLSSQATHEA VHLLCRMLVF DPSKRISAKD ALAHPYL 287

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004707	; F:MAP kinase activity
GO:0000165	; P:MAPK cascade

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR003527	; MAP_kinase_CS.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS01351	; MAPK; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013