EKS-CAP-00311

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAP-00311

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	456.4	3.5E-137	204	491	288

Status

Unreviewed

Ensembl Protein

ENSCPOP00000001026

UniProt Accession

H0UVI9;

Protein Name

Protein Synonyms/Alias

Gene Name

ACVR1B

Gene Synonyms/Alias

ACVR1B;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCPOG00000001136	ENSCPOP00000001026	ENSCPOT00000001148

Organism

Cavia porcellus

Functional Description

Protein Length

502

Protein Sequence
(FASTA)

MDMLRDYVLS LEKISPFLLI SPPKCPAALL CACTSCSQAN YTCETDGACM VSIFNLDGME 60

HHVRTCIPKV ELVPAGKPFY CLSSEDLRNT HCCYTDFCNK IDLRVPSGHP KEPEHPSMWG 120

PVELVGIIAG PVFLLFLIII IVFLVINYHQ RVYHNRQRLD MEDPSCEMCL SKDKTLQDLV 180

YDLSTSGSGS GLPLFVQRTV ARTIVLQEII GKGRFGEVWR GRWRGGDVAV KIFSSREERS 240

WFREAEIYQT VMLRHENILG FIAADNKDNG TWTQLWLVSD YHEHGSLFDY LNRYTVTIEG 300

MIKLALSAAS GLAHLHMEIV GTQGKPGIAH RDLKSKNILV KKNGMCAIAD LGLAVRHDAV 360

TDTIDIAPNQ RVGTKRYMAP EVLDETINMK HFDSFKCADI YALGLVYWEI ARRCNSGGVH 420

EEYQLPYYDL VPSDPSIEEM RKVVCDQKLR PNIPNWWQSY EALRVMGKMM RECWYANGAA 480

RLTALRIKKT LSQLSVQEDV KI 502

Nucleotide Sequence
(FASTA)

ATGGATATGC TAAGGGATTA TGTCCTAAGT CTAGAAAAGA TTTCACCATT TTTGTTAATA 60

TCTCCTCCCA AATGTCCTGC AGCTCTGCTG TGTGCATGCA CCAGCTGCTC ACAGGCCAAC 120

TACACATGTG AAACAGATGG GGCCTGCATG GTTTCCATCT TCAACCTTGA TGGGATGGAG 180

CACCATGTAC GCACCTGCAT CCCCAAAGTG GAGCTGGTCC CTGCTGGGAA GCCTTTCTAC 240

TGCTTGAGCT CAGAGGATCT GCGTAACACC CACTGCTGCT ATACTGACTT CTGCAACAAG 300

ATTGACCTGA GGGTGCCCAG TGGTCACCCC AAGGAGCCTG AGCATCCTTC CATGTGGGGT 360

CCTGTGGAGC TGGTTGGCAT TATTGCCGGC CCAGTCTTCC TCCTATTTCT CATCATCATC 420

ATTGTTTTCC TTGTTATTAA CTATCATCAG CGTGTCTATC ACAACCGCCA GAGACTGGAC 480

ATGGAAGATC CCTCATGTGA GATGTGTCTC TCTAAAGACA AGACGCTGCA GGATCTTGTC 540

TATGATCTCT CCACATCAGG GTCTGGCTCA GGGTTACCCC TTTTTGTCCA GCGTACAGTG 600

GCCCGAACCA TTGTATTACA GGAGATTATT GGCAAAGGCC GTTTTGGAGA AGTGTGGCGC 660

GGCCGCTGGA GGGGTGGCGA TGTAGCTGTG AAAATTTTCT CTTCTCGTGA AGAACGATCT 720

TGGTTCCGGG AAGCAGAGAT ATATCAGACA GTTATGCTCC GCCATGAAAA CATCCTTGGG 780

TTTATTGCTG CTGACAATAA AGATAATGGC ACCTGGACAC AGCTGTGGCT TGTCTCTGAC 840

TATCATGAGC ATGGCTCCCT GTTTGATTAT CTTAACCGTT ACACAGTAAC CATCGAGGGC 900

ATGATTAAGC TGGCCCTGTC TGCTGCCAGT GGGTTGGCAC ATCTGCATAT GGAGATCGTA 960

GGCACCCAAG GGAAGCCTGG AATTGCTCAT CGAGATTTAA AATCAAAGAA TATTCTGGTG 1020

AAGAAAAACG GCATGTGTGC CATCGCAGAC CTGGGCCTGG CGGTTCGCCA TGATGCAGTC 1080

ACTGACACCA TTGACATTGC TCCAAATCAG AGGGTGGGAA CCAAACGATA CATGGCTCCT 1140

GAAGTACTTG ACGAAACTAT TAATATGAAA CACTTCGACT CCTTTAAATG TGCTGATATT 1200

TATGCCCTCG GGCTGGTATA TTGGGAGATT GCTCGAAGGT GCAATTCTGG AGGAGTCCAT 1260

GAAGAATATC AGCTGCCATA TTACGATTTA GTGCCCTCTG ACCCTTCCAT TGAGGAAATG 1320

CGAAAGGTTG TCTGTGACCA GAAGCTACGT CCCAACATCC CCAACTGGTG GCAGAGTTAT 1380

GAGGCATTAC GGGTGATGGG GAAGATGATG CGGGAGTGCT GGTATGCCAA CGGCGCAGCC 1440

CGCCTGACTG CACTGCGCAT CAAGAAGACC CTCTCGCAGC TCAGTGTGCA GGAAGATGTG 1500

AAGATCTAA 1509

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         + l+e+igkGr+geVw++++rg +vAvKifs+++e+sw+rE+eiyqtv+lrhenil+fia

Q: 204   IVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIA  263

         5789********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         ad+k+++++t+l+lv++yhe+gsL+dyL+r+t+++e +++lals+asGlahLH+eivgt+

Q: 264   ADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTIEGMIKLALSAASGLAHLHMEIVGTQ  323

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         g  Kp iaHRDlkskNilvkk+++c+iaDlGLa+++++ ++++d+a n++vGtkRYmaPE

Q: 324   G--KPGIAHRDLKSKNILVKKNGMCAIADLGLAVRHDAVTDTIDIAPNQRVGTKRYMAPE  381

         *..*********************************************************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         vl+e++n+k+f++fk+aD+Y+lgLv+WE+a+Rc++ ++++eey+lp+++ v+sdPs+eem

Q: 382   VLDETINMKHFDSFKCADIYALGLVYWEIARRCNS-GGVHEEYQLPYYDLVPSDPSIEEM  440

         ***********************************.************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         ++vv+++klrP+ip+ w++ eal+++ k+++ecW+a+++aRltalr+kk+l

Q: 441   RKVVCDQKLRPNIPNWWQSYEALRVMGKMMRECWYANGAARLTALRIKKTL  491

         *************************************************97

Domain Sequence
(FASTA)

IVLQEIIGKG RFGEVWRGRW RGGDVAVKIF SSREERSWFR EAEIYQTVML RHENILGFIA 60

ADNKDNGTWT QLWLVSDYHE HGSLFDYLNR YTVTIEGMIK LALSAASGLA HLHMEIVGTQ 120

GKPGIAHRDL KSKNILVKKN GMCAIADLGL AVRHDAVTDT IDIAPNQRVG TKRYMAPEVL 180

DETINMKHFD SFKCADIYAL GLVYWEIARR CNSGGVHEEY QLPYYDLVPS DPSIEEMRKV 240

VCDQKLRPNI PNWWQSYEAL RVMGKMMREC WYANGAARLT ALRIKKTL 288

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Microcebus murinus"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0007178	; P:transmembrane receptor protein serine/threonine kinase signaling pathway

KEGG

InterPros

IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013