EPS-CAP-00012

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-CAP-00012

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
DSP/aDSP	124.4	3.1E-36	29	168	140

Status

Unreviewed

Ensembl Protein

ENSCPOP00000001169

UniProt Accession

H0UVW4;

Protein Name

Protein Synonyms/Alias

Gene Name

DUSP12

Gene Synonyms/Alias

DUSP12;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCPOG00000001290	ENSCPOP00000001169	ENSCPOT00000001306

Organism

Cavia porcellus

Functional Description

Protein Length

338

Protein Sequence
(FASTA)

MLEVQGPHHG CENPNPNADP ASSTERMLEV RPGLYLGGAA AVADPDQLRE AGITAVLTVD 60

SEPAFQAEAG FEGLRTLFVP ALDRPETDLL SHLDRCVAFI GQARAEGRAV LVHCHAGVSR 120

SVAIVTAFVM KTDQMTFEKA YEILQTLKPE AKMNEGFEWQ LQLYEAMGYE VDTSSAIYKQ 180

YRLQKVTEKY PELQNLPQEL FAIDPTTISQ GVKDEVLYKC RKCRRSLFRS SSILAHHEGS 240

GPLAFAHKRT APSFMLTQGS QAPCTSYFIE PVQWMAATLL GVMDGQLLCP KCSAKLGSFN 300

WYGEQCSCGR WITPAFQIHK NRVDEMKMLP ALGSQIRK 338

Nucleotide Sequence
(FASTA)

ATGTTGGAGG TGCAGGGCCC CCACCATGGC TGCGAGAACC CGAACCCCAA CGCGGACCCG 60

GCCAGCTCCA CCGAGCGAAT GCTGGAAGTG CGGCCGGGGC TGTACCTGGG TGGGGCGGCG 120

GCCGTCGCAG ATCCGGATCA GCTGAGGGAG GCTGGCATCA CCGCCGTGCT GACGGTGGAC 180

TCCGAACCTG CTTTCCAGGC AGAGGCTGGG TTCGAGGGCT TGCGGACCCT GTTCGTGCCG 240

GCTCTGGATA GACCCGAGAC CGACCTGCTC AGCCACCTGG ATCGGTGCGT GGCCTTCATC 300

GGCCAGGCCC GTGCCGAGGG CCGTGCGGTG CTGGTGCACT GTCATGCAGG GGTCAGTCGA 360

AGTGTTGCTA TTGTGACTGC TTTTGTGATG AAGACTGACC AAATGACTTT TGAAAAAGCG 420

TATGAGATCC TTCAGACTCT CAAGCCAGAG GCTAAGATGA ATGAGGGATT TGAGTGGCAA 480

CTGCAATTAT ACGAGGCAAT GGGGTATGAA GTGGACACAT CTAGTGCAAT TTATAAGCAA 540

TATCGTTTAC AGAAGGTTAC AGAGAAGTAT CCAGAATTGC AGAATTTACC TCAAGAACTC 600

TTTGCTATTG ACCCAACCAC CATTTCACAA GGAGTGAAAG ATGAAGTTCT CTACAAATGC 660

AGAAAGTGCA GACGATCCCT ATTTCGAAGT TCTAGCATAT TGGCTCATCA TGAAGGAAGT 720

GGGCCTCTAG CCTTTGCCCA CAAGAGAACG GCACCATCTT TTATGCTCAC CCAGGGGAGT 780

CAGGCTCCGT GCACCTCCTA CTTCATCGAG CCTGTGCAGT GGATGGCAGC CACGTTGTTG 840

GGAGTGATGG ATGGACAGCT TCTTTGCCCA AAATGCAGTG CCAAGTTGGG TTCCTTCAAT 900

TGGTATGGTG AACAGTGCTC CTGTGGTAGA TGGATAACAC CAGCTTTTCA AATACATAAG 960

AACAGAGTGG ATGAAATGAA AATGTTACCA GCTTTGGGAT CACAAATAAG AAAATGA 1017

Domain Profile

S: 4     eilpglylgdqataldrreLsklgitvvinaslsvikvqviPeylikkgityknipvdDs  63

         e+ pglylg++a + d  +L+++git v+++  +   +q+       +g + + +p+ D

Q: 29    EVRPGLYLGGAAAVADPDQLREAGITAVLTVDSE-PAFQAEA---GFEGLRTLFVPALDR  84

         799**************************98765.4556543...36799999*******

S: 64    dvtdllqyfdeaaefideakekggkvlvHCaaGvsRSatlvlaYLmkveglslsdAieav  123

         ++tdll+++d++++fi +a+ +g++vlvHC+aGvsRS+++v+a++mk+ ++++++A+e +

Q: 85    PETDLLSHLDRCVAFIGQARAEGRAVLVHCHAGVSRSVAIVTAFVMKTDQMTFEKAYEIL  144

         ************************************************************

S: 124   krkrpsiepnegfleQLlelekkl  147

         ++ +p++++negf +QL ++e ++

Q: 145   QTLKPEAKMNEGFEWQLQLYEAMG  168

         *********************987

Domain Sequence
(FASTA)

EVRPGLYLGG AAAVADPDQL REAGITAVLT VDSEPAFQAE AGFEGLRTLF VPALDRPETD 60

LLSHLDRCVA FIGQARAEGR AVLVHCHAGV SRSVAIVTAF VMKTDQMTFE KAYEILQTLK 120

PEAKMNEGFE WQLQLYEAMG 140

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Choloepus hoffmanni"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0008138	; F:protein tyrosine/serine/threonine phosphatase activity
GO:0008270	; F:zinc ion binding
GO:0006470	; P:protein dephosphorylation

KEGG

InterPros

IPR000340	; Dual-sp_phosphatase_cat-dom.
IPR020422	; Dual-sp_phosphatase_subgr_cat.
IPR024950	; DUSP.
IPR016278	; DUSP12.
IPR000387	; Tyr/Dual-specificity_Pase.
IPR007087	; Znf_C2H2.

Pfam

PF00782

; DSPc; 1.

SMARTs

SM00195

; DSPc; 1.

Prosites

PS50056	; TYR_PHOSPHATASE_2; 1.
PS50054	; TYR_PHOSPHATASE_DUAL; 1.
PS50157	; ZINC_FINGER_C2H2_2; 1.

Prints

Created Date

20-Feb-2013