EKS-CAP-00353
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-CAP-00353
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
STE/STE20331.43.8E-9918271254
StatusUnreviewed
Ensembl ProteinENSCPOP00000001320
UniProt AccessionH0UW94;
Protein NameMitogen-activated protein kinase kinase kinase kinase
Protein Synonyms/Alias
Gene NameMAP4K2
Gene Synonyms/Alias MAP4K2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSCPOG00000001461ENSCPOP00000001320ENSCPOT00000001480
OrganismCavia porcellus
Functional Description
Protein Length819
Protein Sequence
(FASTA)
MELLQRSSLQ DPRDRFELQR VGAGTYGDVY KARDTVTSEL AAVKIVKLDP GDDISSLQQE 60
ITILRECRHP NVVAYIGSYL RNDRLWICME FCGGGSLQEI YHATGPLEER QIAYVCREAL 120
KGLHHLHSQG KIHRDIKGAN LLLTLQGDVK LADFGVSGEL TASVAKRRSF IGTPYWMAPE 180
VAAVERKGGY NELCDVWALG ITAIELAELQ PPLFHLHPMR ALMLMSKSNF QPPKLREKTC 240
WTQNFHHFLK LALTKNPKKR PTAEKLLQHP FTTQHLPRAL LTQLLDKASD PHLGSLSPED 300
CELEAYDMFP DTIHSRGQHG SAERTPSEIQ FHQVKFGAPR RKETDPLNEP WEEEWTLLGK 360
EELSRSLLQS VQEALEERSL TIRPASDLQE LESPDDTMGT IKRAPFLGPP PVEPTTEDPH 420
SSTPGTLPPS PPEPNSPSLL PTAWATMKQQ DDPQRSACHG LPPTPKVHMG ACFSKVFNGC 480
PLRIHAAVTW VHPVTRDQFL VVGAEEGIYT LNLHELHEDT LEKLISHRCS WLYCVNNVLL 540
SLSGKSTHIW AHDLPGLFEQ RRLQQQAPLT IPTNRLTQHI IPRRFALSTK IPDTKGCLQC 600
RVVRNPYTGG TFLLAALPAS LLLLQWYEPL QKFLLLKNFS SPLPSPAGML EPLVLDGKEL 660
PQVCVGAEGP EGPGCRVLFH VLPLEAGLTP DILIPPEGIP GSAQQVIQVD RDTVLVSFER 720
CVRIVNLQGE PTATLAPELT FDFPIETVVC LQDSVLAFWS HGMQGRSLDT NEVTQEITDE 780
TRIFRVLGAH RDIILESIPT DNPGAHSNLY ILTGHQSSY 819
Nucleotide Sequence
(FASTA)
ATGGAGCTAC TGCAGAGAAG TTCACTGCAG GATCCGCGGG ACCGCTTTGA GCTGCAGCGC 60
GTGGGAGCCG GGACATATGG CGACGTCTAC AAGGCCCGCG ACACGGTCAC GTCCGAGCTG 120
GCCGCTGTGA AGATCGTCAA GCTCGACCCA GGGGACGACA TCAGCTCCCT CCAGCAAGAA 180
ATCACCATCC TCCGTGAGTG TCGCCACCCC AATGTGGTGG CTTACATTGG CAGCTACCTC 240
AGGAATGATC GCTTGTGGAT CTGCATGGAG TTCTGTGGAG GGGGGTCCCT GCAGGAAATT 300
TACCACGCCA CAGGGCCCCT GGAGGAACGG CAGATTGCCT ATGTCTGCAG AGAGGCCCTG 360
AAGGGTCTCC ACCACTTGCA TTCTCAGGGG AAGATCCACA GAGACATCAA GGGAGCCAAC 420
CTTCTCCTCA CTCTCCAGGG TGATGTCAAG CTGGCTGACT TTGGGGTATC AGGCGAGCTG 480
ACAGCATCCG TGGCCAAGAG AAGATCTTTC ATTGGAACTC CATACTGGAT GGCTCCAGAG 540
GTGGCTGCAG TGGAGCGCAA GGGTGGCTAC AATGAGCTAT GTGACGTCTG GGCCTTGGGT 600
ATCACCGCCA TTGAGCTGGC TGAGCTGCAG CCCCCTCTCT TTCACCTGCA CCCTATGAGG 660
GCCTTGATGC TGATGTCAAA AAGCAACTTC CAACCACCCA AGCTGCGAGA AAAAACATGT 720
TGGACCCAGA ACTTCCACCA CTTCCTCAAG CTGGCCCTGA CCAAGAACCC CAAGAAGAGG 780
CCCACAGCTG AGAAGCTTCT GCAGCACCCA TTCACGACAC AGCACCTCCC CCGGGCCCTC 840
CTCACTCAGC TCCTGGACAA GGCCAGCGAC CCCCATCTGG GAAGCCTGTC CCCTGAAGAC 900
TGTGAGCTGG AGGCTTATGA CATGTTTCCA GACACTATAC ACTCGAGGGG ACAGCACGGC 960
TCTGCTGAGA GGACGCCCTC TGAGATCCAG TTTCACCAGG TGAAGTTTGG TGCCCCTCGA 1020
AGGAAAGAAA CAGACCCACT CAATGAGCCG TGGGAGGAAG AGTGGACACT TCTGGGAAAG 1080
GAGGAACTGA GCAGGAGCCT GCTGCAGTCA GTCCAGGAGG CCCTGGAGGA AAGGAGTCTG 1140
ACCATCCGAC CAGCCTCAGA CCTGCAGGAG TTGGAGTCCC CAGATGACAC TATGGGAACC 1200
ATCAAGCGGG CCCCATTCTT GGGGCCACCG CCTGTTGAGC CAACAACTGA GGACCCTCAT 1260
TCTAGCACCC CAGGAACTCT GCCCCCATCC CCACCAGAAC CCAACAGCCC CTCACTGCTG 1320
CCCACAGCCT GGGCCACCAT GAAGCAGCAG GATGATCCTC AGAGGTCTGC CTGCCATGGG 1380
CTGCCCCCCA CCCCGAAAGT GCATATGGGC GCCTGCTTCT CCAAGGTCTT CAATGGCTGC 1440
CCCCTGCGAA TTCACGCTGC TGTCACTTGG GTCCACCCCG TCACTCGAGA TCAGTTCCTG 1500
GTGGTGGGAG CCGAGGAGGG CATCTACACG CTCAACCTGC ATGAGCTGCA CGAGGACACA 1560
CTGGAGAAGC TCATTTCCCA CCGCTGTTCC TGGCTTTACT GTGTGAACAA TGTGCTGCTG 1620
TCACTCTCAG GGAAGTCCAC ACATATCTGG GCCCATGACC TCCCTGGCCT GTTCGAGCAG 1680
CGGAGACTAC AGCAGCAGGC CCCCCTCACC ATCCCCACCA ACCGCCTCAC CCAGCACATC 1740
ATCCCCAGGC GCTTTGCACT GTCCACCAAG ATCCCAGACA CCAAAGGCTG CCTGCAGTGT 1800
CGCGTGGTGC GGAACCCCTA CACGGGCGGC ACCTTCCTAC TGGCTGCGCT GCCTGCCAGC 1860
CTGCTCCTGT TGCAGTGGTA TGAGCCGCTG CAGAAGTTCC TGCTGCTAAA GAACTTCTCT 1920
AGTCCTCTGC CAAGCCCAGC TGGGATGCTG GAGCCACTGG TGCTGGACGG GAAGGAGCTG 1980
CCACAGGTGT GTGTAGGTGC CGAAGGGCCT GAGGGGCCCG GCTGCCGTGT CCTCTTCCAC 2040
GTCCTGCCCC TGGAGGCCGG CCTGACACCT GACATCCTCA TCCCACCTGA GGGGATCCCA 2100
GGCTCAGCCC AGCAGGTGAT CCAGGTGGAC AGGGACACAG TTCTGGTCAG CTTTGAACGC 2160
TGCGTGAGGA TTGTGAATCT GCAGGGTGAG CCCACAGCCA CACTGGCCCC AGAACTGACC 2220
TTTGACTTCC CCATTGAGAC TGTGGTGTGT CTGCAGGACA GTGTGCTGGC CTTCTGGAGC 2280
CACGGCATGC AGGGCCGCAG CCTGGACACC AATGAGGTGA CACAGGAGAT CACAGATGAG 2340
ACAAGGATCT TCCGAGTGCT GGGGGCCCAC AGGGACATCA TCTTGGAGAG CATCCCCACC 2400
GACAACCCGG GGGCACACAG CAACTTGTAC ATCCTCACCG GCCACCAGAG CAGCTACTGA 2460
Domain Profile
S: 4     leeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkklkhpniveyle  63
         l+++g G++g+vy+ar++ t+el+a+k+++l+  +++++lq+ei++l++++hpn+v+y++
Q: 18    LQRVGAGTYGDVYKARDTVTSELAAVKIVKLDPGDDISSLQQEITILRECRHPNVVAYIG  77
         5789********************************************************
S: 64    sflkeeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLeylHskkviHrd  123
         s+l++++lw++me++ gGsl+++++   + +l+E+qiay++re+lk+L++lHs+++iHrd
Q: 78    SYLRNDRLWICMEFCGGGSLQEIYH--ATGPLEERQIAYVCREALKGLHHLHSQGKIHRD  135
         *************************..9********************************
S: 124   ikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqe.ekgYdekaD  182
         ik++n+Llt +g+VkL+dfgv+ +l+++++kr++++gtpywmAPEv a+e + gY+e +D
Q: 136   IKGANLLLTLQGDVKLADFGVSGELTASVAKRRSFIGTPYWMAPEVAAVErKGGYNELCD  195
         *************************************************98889******
S: 183   iwslGItaielaegepPfkdleplkallkilkne..ppklkskkkfskefkefvekclqk  240
         +w+lGItaielae +pP+++l+p++al++++k++  ppkl++k+ ++++f++f++ +l+k
Q: 196   VWALGITAIELAELQPPLFHLHPMRALMLMSKSNfqPPKLREKTCWTQNFHHFLKLALTK  255
         ***************************999999888************************
S: 241   npekRpsasellkhkF  256
         np+kRp+a++ll+h+F
Q: 256   NPKKRPTAEKLLQHPF  271
         ***************9
Domain Sequence
(FASTA)
LQRVGAGTYG DVYKARDTVT SELAAVKIVK LDPGDDISSL QQEITILREC RHPNVVAYIG 60
SYLRNDRLWI CMEFCGGGSL QEIYHATGPL EERQIAYVCR EALKGLHHLH SQGKIHRDIK 120
GANLLLTLQG DVKLADFGVS GELTASVAKR RSFIGTPYWM APEVAAVERK GGYNELCDVW 180
ALGITAIELA ELQPPLFHLH PMRALMLMSK SNFQPPKLRE KTCWTQNFHH FLKLALTKNP 240
KKRPTAEKLL QHPF 254
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00310
EKS-BOT-00321
EKS-CAJ-00329
EKS-CAF-00324
EKS-CIS-00081
EKS-DAR-00668
EKS-DIO-00040
EKS-EQC-00329
EKS-FEC-00324
EKS-GAA-00396
EKS-GOG-00316
EKS-HOS-00329
EKS-ICT-00315
EKS-LOA-00327
EKS-MUM-00354
EKS-MYL-00331
EKS-ORN-00418
EKS-ORL-00381
EKS-OTG-00342
EKS-PAT-00304
EKS-POA-00311
EKS-PTV-00073
EKS-RAN-00352
EKS-SUS-00279
EKS-TAG-00332
EKS-TAR-00419
EKS-XIM-00410
Gene Ontology
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0005083; F:small GTPase regulator activity
KEGG
InterPros
IPR001180; Citron.
IPR011009; Kinase-like_dom.
IPR021160; MAPKKKK.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
Pfam
PF00780; CNH; 1.
PF00069; Pkinase; 1.
SMARTs
SM00036; CNH; 1.
SM00220; S_TKc; 1.
Prosites
PS50219; CNH; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
Prints
Created Date20-Feb-2013