EKS-CAP-00457

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAP-00457

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/SGK	540.6	6.5E-163	98	355	258

Status

Unreviewed

Ensembl Protein

ENSCPOP00000001350

UniProt Accession

H0UWC0;

Protein Name

Protein Synonyms/Alias

Gene Name

SGK1

Gene Synonyms/Alias

SGK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCPOG00000001494	ENSCPOP00000001350	ENSCPOT00000001514

Organism

Cavia porcellus

Functional Description

Protein Length

431

Protein Sequence
(FASTA)

MTVKTEAARG TVTYSRMRGM VAILIAFMKQ RRMGLNDFIQ KIANNSYACK HPEVQSILKI 60

SQPQEPELMN ANPSPPPSPS QQINLGPSSN PHAKPSDFHF LKVIGKGSFG KVLLARHKAE 120

EAFYAVKVLQ KKAILKKKEE KHIMSERNVL LKNVKHPFLV GLHFSFQTAD KLYFVLDYIN 180

GGELFYHLQR ERCFLEPRAR FYAAEIASAL GYLHSLNIVY RDLKPENILL DSQGHIVLTD 240

FGLCKENIEH NGTTSTFCGT PEYLAPEVLH KQPYDRTVDW WCLGAVLYEM LYGLPPFYSR 300

NTAEMYDNIL NKPLQLKPNI TNSARHLLEG LLQKDRTKRL GAKDDFMEIK SHVFFSLINW 360

DDLINKKITP PFNPNVSGPS DLRHFDPEFT EEPVPSSIGR SPDSILITAS VKEAAEAFLG 420

FSYAPPMDSF L 431

Nucleotide Sequence
(FASTA)

ATGACGGTGA AAACCGAGGC TGCTAGAGGC ACTGTCACTT ACTCCAGAAT GAGGGGAATG 60

GTAGCGATTC TCATAGCTTT CATGAAGCAA AGAAGGATGG GCCTGAACGA CTTTATTCAG 120

AAGATAGCCA ATAACTCCTA TGCATGCAAA CACCCCGAAG TTCAGTCCAT TTTGAAAATC 180

TCCCAACCTC AGGAGCCTGA GCTAATGAAT GCCAACCCCT CTCCTCCACC AAGTCCTTCT 240

CAGCAAATCA ACCTTGGTCC ATCATCCAAT CCTCATGCCA AACCATCGGA CTTTCACTTC 300

TTGAAAGTGA TTGGGAAAGG CAGTTTTGGA AAGGTTCTTC TCGCAAGGCA CAAAGCAGAA 360

GAAGCATTCT ATGCAGTCAA AGTTTTACAG AAGAAAGCAA TCCTGAAAAA GAAAGAGGAG 420

AAGCACATCA TGTCAGAGCG GAACGTCCTA TTGAAGAATG TGAAGCACCC TTTCCTGGTG 480

GGCCTCCACT TCTCTTTCCA GACTGCCGAC AAACTGTACT TTGTCCTAGA CTACATTAAC 540

GGTGGAGAGT TATTCTACCA CCTCCAGAGG GAGCGCTGCT TCCTAGAACC CCGGGCTCGC 600

TTCTATGCTG CTGAAATAGC CAGTGCCTTG GGTTACCTGC ACTCTCTGAA CATCGTGTAT 660

AGAGACTTAA AACCAGAGAA TATTTTGCTA GATTCCCAGG GGCACATTGT CCTCACTGAC 720

TTTGGACTCT GCAAGGAAAA CATTGAACAT AATGGCACAA CATCCACCTT CTGCGGCACA 780

CCTGAGTATC TTGCACCCGA GGTACTTCAT AAGCAGCCTT ATGACAGGAC TGTGGACTGG 840

TGGTGCCTGG GAGCCGTCCT GTATGAGATG TTGTATGGCT TGCCTCCTTT TTATAGCCGA 900

AACACAGCTG AGATGTATGA CAACATCCTG AACAAACCCC TCCAGTTGAA ACCAAATATT 960

ACAAATTCTG CGAGGCATCT CCTGGAGGGG CTCCTGCAGA AGGACAGGAC CAAGAGGCTG 1020

GGAGCCAAGG ATGACTTTAT GGAGATTAAG AGTCACGTCT TCTTCTCCCT CATTAACTGG 1080

GATGATCTCA TAAACAAGAA GATTACTCCT CCTTTTAACC CAAATGTGAG TGGACCCAGT 1140

GACTTGCGGC ACTTCGATCC AGAGTTTACC GAGGAGCCTG TCCCCAGTTC AATCGGCAGG 1200

TCCCCTGACA GCATCCTCAT CACAGCCAGC GTAAAGGAAG CGGCCGAGGC GTTCCTTGGC 1260

TTCTCCTACG CGCCTCCCAT GGACTCTTTC CTCTGA 1296

Domain Profile

S: 1     fdflkvigkgsfgkvllakrkadekfyavkvlqkkailkkkeekhimaernvllknvkhp  60

         f+flkvigkgsfgkvlla++ka+e+fyavkvlqkkailkkkeekhim+ernvllknvkhp

Q: 98    FHFLKVIGKGSFGKVLLARHKAEEAFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHP  157

         9***********************************************************

S: 61    flvglhysfqtaeklyfvldyvnggelffhlqrersfleprarfyaaeiasalgylhsln  120

         flvglh+sfqta+klyfvldy+nggelf+hlqrer+fleprarfyaaeiasalgylhsln

Q: 158   FLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLN  217

         ************************************************************

S: 121   ivyrdlkpenilldskghvvltdfglckeeieaedttstfcgtpeylapevlrkkpydrt  180

         ivyrdlkpenillds+gh+vltdfglcke+ie++ ttstfcgtpeylapevl+k+pydrt

Q: 218   IVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNGTTSTFCGTPEYLAPEVLHKQPYDRT  277

         ************************************************************

S: 181   vdwwclgavlyemlyglppfysrdvaemydnilnkplqlkpgisvaalelleellekdrk  240

         vdwwclgavlyemlyglppfysr++aemydnilnkplqlkp+i+++a++lle+ll+kdr+

Q: 278   VDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRT  337

         ************************************************************

S: 241   krlgakedfleiknhvff  258

         krlgak+df+eik+hvff

Q: 338   KRLGAKDDFMEIKSHVFF  355

         *****************9

Domain Sequence
(FASTA)

FHFLKVIGKG SFGKVLLARH KAEEAFYAVK VLQKKAILKK KEEKHIMSER NVLLKNVKHP 60

FLVGLHFSFQ TADKLYFVLD YINGGELFYH LQRERCFLEP RARFYAAEIA SALGYLHSLN 120

IVYRDLKPEN ILLDSQGHIV LTDFGLCKEN IEHNGTTSTF CGTPEYLAPE VLHKQPYDRT 180

VDWWCLGAVL YEMLYGLPPF YSRNTAEMYD NILNKPLQLK PNITNSARHL LEGLLQKDRT 240

KRLGAKDDFM EIKSHVFF 258

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013