EPS-CAP-00023

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-CAP-00023

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	210.1	4.5E-62	709	954	246

Status

Unreviewed

Ensembl Protein

ENSCPOP00000001405

UniProt Accession

H0UWH1;

Protein Name

Protein Synonyms/Alias

Gene Name

PHLPP1

Gene Synonyms/Alias

PHLPP1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCPOG00000001553	ENSCPOP00000001405	ENSCPOT00000001573

Organism

Cavia porcellus

Functional Description

Protein Length

1243

Protein Sequence
(FASTA)

PLPPTLYVQL HGETTRREAD EKPLQIQNDY LFQLGFGELW RVQEEGMDSE IGCLIRFYAG 60

KPHSSGSSER IQLSGMYNVR KGKMQLPVNR WTRRHVILCG TCLIVSSVKD SLTGKMHVLP 120

LIGGKVEEVK KHQHCLAFSS SGPQSQTYYI CFDTFTEYLR WLRQVSKVAS QRISSVDLSC 180

CSLEHLPANL FYSQDLTHLN LKQNFIRQNP SLPAARGLNE LQRFTKLKSL NLSNNHLGDF 240

PLAVCSIPTL TELNVSCNAL RAVPASVGAM HNLHTFLLDG NFLQSLPAEL ENMHQLSYLG 300

LSFNEFTDIP EVLEKLTAMD KLCMSGNCME TLRLQALRRM PHIKHVDLRL NIIRKLVADE 360

VEFLQHVTQL DLRDNKLGDL DAMIFNNLEV LHCERNQLVT LSICGYFLKA LYASSNELVQ 420

LDVYPVPNYL SYMDVSRNRL ENVPEWVFES RKLEVLDIGH NQICDLPARL FCNSSLRKLL 480

AGHNQLARLP ERLERTSVEV LDVQHNQLVE LPPNLLLKAD SLRFLNASAN KLENLPPATL 540

SEETNSILQE LYLTNNNLTD KCVPLLTGHP HLKILHMAYN RLQSFPASKM AKLEELEEID 600

ISGNKLKAIP TTILNCRRMH TVIAHSNCIE VFPEVMQLPE IKCVDLSCNE LSEVTLPENL 660

PPKLQELDLT GNPRLALDHK TLELLNNIRC FKIDQPSAGD ASGAPAVWSH GYTEASGVKN 720

KLCVAALSVN NFCDNREALY GVFDGDRNVE VPYLLQCTMS DILAEELQKT KNEEEYMVNT 780

FIVMQRKLGT AGQKLGGAAV LCHIKHDPVD PGGSFTLTSA NVGKCQTVLC RNGKPLPLSR 840

SYVMSCEEEL KRIKQHKAII TEDGKVNGVT ESTRILGYTF LHPSVVPRPH VQSVLLTPQD 900

EFFILGSKGL WDSLSIEEAV EAVRNVPDAL AAAKKLCTLA QSYGCHDSVS AVVVQLSVTE 960

DSFCCCELAT TGSVPPPSPG IFPPSVNMVI KDRPSDGLGV PSSSSGMASE ISSELSTSEM 1020

SSEVGSTASD EPPSGALNDS SSAYPSEQRC MLHPVCLSNS FQRQLSSATF SSAFSDNGLD 1080

SDDEEPIEGV FTNGSRVEVE VDIHCSRAKE KEKQQHQLQM PAEASDEGIV ISANEDEPGL 1140

PRKADFSSVG TIGRRRANGS VAPQERSHNV IEVATDAPLR KPGGYFAAPA QPDPDDQFII 1200

PPELEEEVKE IMKHHQEQQQ QPPPLPQQPL QRQFPTDQLP DCY 1243

Nucleotide Sequence
(FASTA)

CCTCTGCCTC CCACCCTATA CGTGCAGCTC CACGGAGAGA CCACCCGGCG CGAGGCAGAC 60

GAGAAGCCAC TACAGATCCA AAATGACTAC CTCTTCCAGC TAGGATTTGG GGAGTTGTGG 120

AGGGTGCAAG AAGAAGGCAT GGACTCAGAG ATTGGCTGCC TCATCCGCTT CTATGCAGGA 180

AAACCTCACA GCTCTGGTAG CTCTGAGCGG ATTCAGCTCT CAGGAATGTA TAATGTTCGC 240

AAAGGCAAAA TGCAGTTGCC AGTGAACCGG TGGACCAGAC GCCACGTTAT TCTGTGCGGG 300

ACCTGCTTGA TAGTATCATC TGTGAAGGAC AGCTTGACTG GAAAGATGCA TGTTTTGCCA 360

CTAATTGGTG GAAAAGTAGA AGAAGTGAAA AAGCACCAGC ACTGTTTAGC CTTCAGTTCC 420

TCGGGACCCC AAAGCCAGAC TTACTACATT TGCTTTGATA CTTTCACAGA GTATTTAAGG 480

TGGCTGCGGC AAGTTTCCAA GGTTGCTTCC CAACGCATTA GTTCAGTGGA CCTCTCATGT 540

TGTAGCCTGG AACATCTGCC TGCCAACCTG TTCTACAGCC AAGACCTCAC CCATCTCAAC 600

TTAAAACAAA ACTTCATAAG GCAAAATCCC AGCCTTCCAG CTGCCAGAGG GCTCAATGAA 660

CTGCAAAGGT TCACCAAGTT GAAGAGTCTT AACCTTTCCA ATAATCATCT AGGGGACTTC 720

CCATTAGCAG TCTGCAGTAT CCCAACCCTG ACAGAACTCA ACGTGTCCTG CAATGCCCTG 780

CGAGCAGTGC CGGCTTCCGT GGGGGCTATG CACAATTTGC ACACATTTTT GTTGGATGGA 840

AACTTTCTCC AGTCCCTTCC TGCTGAGTTG GAGAACATGC ACCAGCTCAG TTATCTTGGA 900

CTTTCATTCA ATGAATTCAC TGACATTCCA GAGGTGTTGG AAAAATTAAC TGCTATGGAT 960

AAACTTTGTA TGTCTGGAAA CTGTATGGAG ACCCTTAGGC TACAGGCTTT AAGAAGAATG 1020

CCTCACATTA AACATGTGGA CCTAAGACTG AATATAATTA GGAAACTTGT AGCAGATGAA 1080

GTGGAGTTTC TGCAGCATGT CACCCAGCTT GATCTTCGAG ACAATAAACT TGGTGATCTA 1140

GATGCTATGA TTTTCAACAA CCTTGAAGTT CTACACTGTG AAAGAAATCA ATTGGTGACA 1200

TTAAGCATTT GTGGCTATTT CTTAAAAGCA CTCTATGCCT CTTCTAATGA ACTTGTTCAA 1260

CTAGATGTTT ACCCAGTTCC GAATTATCTG TCCTACATGG ATGTTTCAAG GAACCGCTTA 1320

GAAAATGTGC CTGAGTGGGT ATTTGAAAGC CGAAAGCTAG AAGTTTTGGA TATTGGCCAC 1380

AATCAAATAT GCGACCTTCC AGCCCGCTTA TTTTGTAATA GTAGTCTCCG TAAACTGCTA 1440

GCAGGTCACA ACCAATTAGC ACGGCTGCCT GAAAGGCTGG AAAGAACTTC AGTGGAGGTC 1500

TTGGATGTGC AGCACAACCA GCTCGTTGAG CTACCACCTA ACCTTCTCCT GAAGGCTGAC 1560

AGCCTGCGAT TCCTGAATGC ATCTGCAAAC AAACTGGAAA ACCTTCCTCC AGCTACACTT 1620

TCTGAAGAGA CAAACAGTAT CTTACAGGAG TTGTATTTGA CAAATAACAA CCTCACAGAT 1680

AAATGTGTGC CCTTATTAAC AGGACACCCT CATCTGAAGA TCCTTCACAT GGCCTATAAT 1740

CGACTTCAGA GTTTTCCAGC AAGTAAAATG GCAAAACTGG AGGAACTTGA AGAAATTGAT 1800

ATCAGCGGTA ATAAATTGAA AGCCATCCCA ACCACGATCT TGAATTGCAG GCGCATGCAC 1860

ACTGTGATTG CTCACTCTAA TTGCATTGAA GTCTTTCCTG AAGTTATGCA GCTCCCAGAA 1920

ATCAAGTGTG TGGACCTGAG CTGTAATGAG CTAAGTGAAG TCACTTTGCC AGAAAACCTG 1980

CCACCCAAAC TACAAGAACT CGACCTGACT GGAAATCCCC GCCTTGCCCT GGACCACAAA 2040

ACTCTGGAAC TGCTGAATAA TATCCGCTGC TTTAAGATTG ATCAGCCTTC AGCAGGAGAT 2100

GCATCTGGAG CCCCAGCTGT ATGGAGTCAT GGTTACACTG AGGCTTCAGG GGTGAAAAAC 2160

AAGTTGTGTG TTGCAGCTCT GTCTGTCAAT AATTTCTGTG ACAACCGAGA GGCTCTGTAT 2220

GGTGTATTTG ATGGAGACCG CAATGTGGAG GTACCTTACC TTCTCCAGTG TACCATGAGT 2280

GACATTTTGG CTGAAGAGCT GCAGAAAACT AAAAACGAAG AAGAATACAT GGTCAATACA 2340

TTCATCGTTA TGCAAAGAAA ACTTGGAACT GCTGGACAGA AACTTGGTGG TGCTGCTGTC 2400

CTTTGTCATA TCAAGCATGA CCCTGTGGAC CCTGGAGGAT CCTTCACCTT GACCTCTGCT 2460

AATGTGGGCA AGTGCCAGAC AGTTCTCTGT CGAAATGGGA AGCCACTGCC TCTGTCCAGA 2520

TCATATGTCA TGAGCTGTGA AGAAGAGCTG AAGAGAATTA AGCAGCACAA AGCCATTATC 2580

ACTGAGGATG GCAAGGTGAA TGGAGTGACT GAGTCCACAC GCATCCTGGG CTACACCTTC 2640

CTCCACCCCA GTGTGGTGCC TCGCCCCCAC GTGCAGTCTG TGCTCCTCAC CCCCCAGGAC 2700

GAGTTCTTCA TTCTGGGCAG CAAGGGGCTG TGGGACAGCT TGTCCATTGA GGAGGCTGTG 2760

GAGGCCGTGC GCAACGTGCC CGATGCCTTA GCTGCTGCCA AGAAGCTGTG CACCCTGGCC 2820

CAGAGCTATG GCTGCCACGA CAGTGTCAGT GCCGTGGTAG TGCAGCTCAG TGTCACCGAG 2880

GACAGCTTCT GTTGCTGTGA GCTTGCTACC ACTGGGAGTG TCCCACCACC CAGCCCAGGC 2940

ATCTTCCCTC CCTCTGTCAA CATGGTAATC AAGGATCGGC CCTCAGACGG GCTGGGTGTG 3000

CCGTCCTCCA GCAGTGGCAT GGCCTCTGAG ATCAGCAGTG AGCTCTCCAC TTCAGAGATG 3060

AGCAGTGAGG TGGGGTCAAC AGCCTCTGAT GAGCCCCCAT CCGGAGCCCT AAATGACAGC 3120

AGCTCTGCCT ATCCTAGCGA GCAGCGCTGC ATGCTGCACC CCGTCTGTCT GTCCAACTCC 3180

TTCCAGCGCC AGCTGTCCAG TGCCACTTTC TCCAGCGCCT TCTCGGACAA TGGCCTTGAC 3240

AGTGATGATG AAGAACCAAT TGAGGGCGTC TTCACCAATG GCAGTCGGGT GGAGGTAGAG 3300

GTGGACATCC ACTGTAGTCG GGCTAAGGAG AAGGAGAAGC AGCAGCACCA GCTACAGATG 3360

CCAGCTGAGG CCAGCGATGA AGGCATTGTC ATCAGCGCCA ATGAGGATGA GCCGGGTCTT 3420

CCCAGGAAGG CGGACTTTTC TTCTGTAGGA ACCATTGGGC GCCGCAGGGC TAACGGCTCT 3480

GTAGCGCCCC AGGAAAGGAG CCACAATGTG ATTGAGGTTG CTACAGATGC CCCTCTTCGG 3540

AAGCCTGGAG GCTATTTTGC TGCCCCAGCT CAGCCAGATC CTGACGATCA GTTTATCATT 3600

CCCCCAGAGC TGGAAGAGGA AGTCAAAGAG ATCATGAAAC ACCACCAGGA GCAGCAGCAG 3660

CAGCCACCAC CACTACCGCA GCAGCCCCTG CAGCGGCAGT TTCCGACGGA CCAGCTGCCG 3720

GACTGTTAT 3729

Domain Profile

S: 2     lvgvvsvngrrnemedavtsspnflkspekkdrlaffgvyDGhggsevakfcseklheil  61

         ++g+++ +g +n+++ a+ s++nf++++e+     ++gv+DG+++ ev + +++++++il

Q: 709   SHGYTEASGVKNKLCVAALSVNNFCDNREA-----LYGVFDGDRNVEVPYLLQCTMSDIL  763

         689***********************9885.....9************************

S: 62    aeelesseseerkvkkalakaFlstdeelkvleeksldidksGstavvalikds......  115

         aeel+    ++++ ++++ ++F+ ++++l       ++ +k G +av+++ik++

Q: 764   AEELQ----KTKNEEEYMVNTFIVMQRKL------GTAGQKLGGAAVLCHIKHDpvdpgg  813

         ***99....999*****************......99***********************

S: 116   ..klyvanvGdSravLcrngkavelssdHkpsredEleRieeaggsvilkdgaRvlGvLa  173

           +l+ anvG++++vLcrngk+++ls+ + +s+e+El+Ri+++++ ++++   +v+Gv++

Q: 814   sfTLTSANVGKCQTVLCRNGKPLPLSRSYVMSCEEELKRIKQHKAIITEDG--KVNGVTE  871

         *99*****************************************9999998..*******

S: 174   vsRalGdlylkpyvtpePevtshrltsedefliLasDGlwdvvsneeavslvrdvlekke  233

          +R lG ++l+p v+p+P+v+s+ lt++def+iL+s+Glwd +s eeav++vr+v +

Q: 872   STRILGYTFLHPSVVPRPHVQSVLLTPQDEFFILGSKGLWDSLSIEEAVEAVRNVPD---  928

         *********************************************************...

S: 234   aeqeaakkLvklalargskdnvsaivv  260

          + +aakkL++la+++g++d+vsa+vv

Q: 929   -ALAAAKKLCTLAQSYGCHDSVSAVVV  954

         .************************97

Domain Sequence
(FASTA)

SHGYTEASGV KNKLCVAALS VNNFCDNREA LYGVFDGDRN VEVPYLLQCT MSDILAEELQ 60

KTKNEEEYMV NTFIVMQRKL GTAGQKLGGA AVLCHIKHDP VDPGGSFTLT SANVGKCQTV 120

LCRNGKPLPL SRSYVMSCEE ELKRIKQHKA IITEDGKVNG VTESTRILGY TFLHPSVVPR 180

PHVQSVLLTP QDEFFILGSK GLWDSLSIEE AVEAVRNVPD ALAAAKKLCT LAQSYGCHDS 240

VSAVVV 246

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>