EKS-CAP-00314

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAP-00314

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	452.4	6.1E-136	204	491	288

Status

Unreviewed

Ensembl Protein

ENSCPOP00000001467

UniProt Accession

H0UWM6;

Protein Name

Protein Synonyms/Alias

Gene Name

BMPR1B

Gene Synonyms/Alias

BMPR1B;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCPOG00000001626	ENSCPOP00000001467	ENSCPOT00000001647

Organism

Cavia porcellus

Functional Description

Protein Length

502

Protein Sequence
(FASTA)

MLLRSSGNLN VGTKKEDGES TAPTPRPKIL RCKCHHHCPE DSVNNICSTD GYCFTMIEED 60

DSGTPVVTSG CLGLEGSDFQ CRDTPIPHQR RSIECCTERN ECNKDLHPTL PPLKNRDFVD 120

GPIHHKALLI SVTVCSLLLV LIILFCYFRY KRQETRPRYS IGLEQDETYI PPGESLRDLI 180

EQSQSSGSGS GLPLLVQRTI AKQIQMVKQI GKGRYGEVWM GKWRGEKVAV KVFFTTEEAS 240

WFRETEIYQT VLMRHENILG FIAADIKGTG SWTQLYLITD YHENGSLYDY LKSTTLDTKS 300

MLKLAYSSVS GLCHLHTEIF STQGKPAIAH RDLKSKNILV KKNGTCCIAD LGLAVKFISD 360

TNEVDIPPNT RVGTKRYMPP EVLDESLNRN HFQSYIMADM YSFGLILWEV ARRCVSGGIV 420

EEYQLPYHDL VPSDPSYEDM REIVCIKKLR PSFPNRWSSD ECLRQMGKLM TECWAHNPAS 480

RLTALRVKKT LAKMSESQDI KL 502

Nucleotide Sequence
(FASTA)

ATGCTTTTGA GAAGTTCAGG AAACTTAAAT GTGGGAACCA AGAAAGAGGA TGGTGAGAGC 60

ACAGCCCCCA CCCCTCGGCC GAAGATCTTG CGATGCAAAT GCCACCACCA CTGTCCAGAA 120

GACTCTGTCA ATAATATTTG CAGCACAGAC GGGTACTGCT TCACCATGAT AGAAGAAGAT 180

GACTCTGGGA CACCTGTGGT CACTTCCGGA TGTCTGGGAC TAGAAGGCTC AGATTTCCAG 240

TGTCGGGACA CTCCCATTCC TCATCAAAGA AGATCCATCG AATGCTGCAC AGAAAGGAAT 300

GAGTGTAATA AAGACCTGCA CCCTACACTG CCTCCACTGA AAAACAGAGA CTTTGTTGAT 360

GGACCTATAC ATCACAAGGC CTTACTTATT TCTGTGACTG TCTGTAGTTT GCTGTTGGTC 420

CTTATCATTT TATTCTGCTA CTTTAGGTAT AAAAGACAAG AAACCAGGCC ACGTTATAGC 480

ATTGGACTGG AACAGGATGA AACTTACATT CCTCCAGGAG AATCCCTGCG AGACCTGATT 540

GAGCAGTCTC AAAGCTCGGG AAGTGGATCA GGCCTCCCTC TGCTGGTCCA AAGGACAATA 600

GCAAAGCAGA TTCAGATGGT GAAACAGATT GGAAAAGGTC GTTATGGAGA AGTCTGGATG 660

GGAAAGTGGC GTGGTGAAAA GGTAGCTGTG AAAGTGTTCT TCACCACAGA GGAAGCCAGC 720

TGGTTCCGAG AGACAGAAAT ATATCAGACA GTGCTCATGC GGCATGAAAA CATTTTGGGG 780

TTCATTGCTG CAGATATCAA AGGGACAGGG TCCTGGACCC AGTTGTACCT CATCACAGAC 840

TATCATGAAA ATGGTTCTCT TTATGATTAT TTGAAGTCCA CCACCCTTGA CACTAAATCA 900

ATGCTAAAAC TAGCCTACTC CTCTGTCAGT GGCCTATGCC ACTTACACAC TGAAATCTTT 960

AGTACTCAAG GCAAACCAGC GATTGCCCAT CGAGACCTGA AAAGCAAGAA CATCCTGGTG 1020

AAGAAAAATG GAACTTGCTG TATAGCTGAC CTGGGCCTGG CTGTTAAATT TATTAGTGAT 1080

ACGAATGAAG TTGACATACC GCCCAACACG CGGGTCGGCA CGAAGCGCTA CATGCCTCCA 1140

GAGGTGCTGG ATGAGAGCTT GAACAGAAAT CACTTTCAGT CCTACATCAT GGCTGACATG 1200

TATAGCTTTG GACTCATCCT TTGGGAAGTT GCGAGGAGAT GTGTTTCTGG AGGAATCGTG 1260

GAAGAATACC AGCTTCCCTA CCATGACCTG GTGCCCAGCG ACCCTTCCTA TGAGGACATG 1320

AGGGAGATTG TGTGCATCAA GAAATTGCGC CCCTCATTTC CCAACCGGTG GAGCAGCGAT 1380

GAGTGTCTCA GGCAAATGGG AAAGCTCATG ACTGAGTGCT GGGCTCACAA TCCCGCATCC 1440

AGATTGACGG CCCTGCGTGT GAAGAAAACG CTTGCCAAAA TGTCAGAGTC CCAGGACATT 1500

AAGCTC 1506

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         ++++++igkGrygeVw++k+rge+vAvK+f+t++easw+rE+eiyqtvl+rhenil+fia

Q: 204   IQMVKQIGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIA  263

         799*********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         ad+k ++s+t+l+l+t+yhe+gsL+dyLk++tld++++l+la+s +sGl+hLH+ei+ t+

Q: 264   ADIKGTGSWTQLYLITDYHENGSLYDYLKSTTLDTKSMLKLAYSSVSGLCHLHTEIFSTQ  323

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         g  KpaiaHRDlkskNilvkk++tcciaDlGLa+k+ ++++e+d+  n++vGtkRYm PE

Q: 324   G--KPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIPPNTRVGTKRYMPPE  381

         *..*********************************************************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         vl+e+ln ++f+++ +aD+Ys+gL+lWEva+Rc + +++veey+lp+++ v+sdPs+e+m

Q: 382   VLDESLNRNHFQSYIMADMYSFGLILWEVARRCVS-GGIVEEYQLPYHDLVPSDPSYEDM  440

         ***********************************.************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         +e+v+ kklrP++p++w+++e+l+++ kl++ecW+++p++Rltalrvkk+l

Q: 441   REIVCIKKLRPSFPNRWSSDECLRQMGKLMTECWAHNPASRLTALRVKKTL  491

         *************************************************97

Domain Sequence
(FASTA)

IQMVKQIGKG RYGEVWMGKW RGEKVAVKVF FTTEEASWFR ETEIYQTVLM RHENILGFIA 60

ADIKGTGSWT QLYLITDYHE NGSLYDYLKS TTLDTKSMLK LAYSSVSGLC HLHTEIFSTQ 120

GKPAIAHRDL KSKNILVKKN GTCCIADLGL AVKFISDTNE VDIPPNTRVG TKRYMPPEVL 180

DESLNRNHFQ SYIMADMYSF GLILWEVARR CVSGGIVEEY QLPYHDLVPS DPSYEDMREI 240

VCIKKLRPSF PNRWSSDECL RQMGKLMTEC WAHNPASRLT ALRVKKTL 288

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0004702	; F:receptor signaling protein serine/threonine kinase activity
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0023014	; P:signal transduction by phosphorylation

KEGG

InterPros

IPR000333	; Activin_II/TGFBeta-II_recpt.
IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00653

; ACTIVIN2R.

Created Date

20-Feb-2013