EKS-CAP-00316

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAP-00316

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	431.2	1.7E-129	203	490	288

Status

Unreviewed

Ensembl Protein

ENSCPOP00000001497

UniProt Accession

H0UWQ3;

Protein Name

Protein Synonyms/Alias

Gene Name

ACVRL1

Gene Synonyms/Alias

ACVRL1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCPOG00000001660	ENSCPOP00000001497	ENSCPOT00000001681

Organism

Cavia porcellus

Functional Description

Protein Length

504

Protein Sequence
(FASTA)

MTLAYPKRGL LVLLMALGLT QGNPVEPFQT SLVTCTCQNP HCKGTTCQGL WCTAVLFVDE 60

EGHLQNFKGC GSQNEELCRG RATEFAHHFC CRQSFCNHNV SLSLETTQTP PEQPKVDSQL 120

PLILGPVLAL LVLVALGTLG LWHVRRRQEK QRGLYSDLGE SSLILKSSEQ RDSMLGEFLD 180

SNCTTGSGSG LPFLVQRTVA RQVTLVECVG KGRYGEVWRG LWHGESVAVK IFSSRDEQSW 240

FRETEIYNTV LLRHDNILGF IASDMTSRNS STQLWLITHY HEHGSLYDFL QRQTLEPQLA 300

LKLAVSAACG LAHLHVEIFG TQGKPAIAHR DLKSRNVLVK SNLQCCIADL GLAVMHSQGS 360

DYLDIGNNPR VGTKRYMAPE VLDEQIRTDC FESYKWTDIW AFGLVLWEIT RRTIVNGIVE 420

DYRPPFYDVV PNDPSFEDMK KVVCIDQQTP TIPNRLAVDP VLSGLAQMMQ ECWYPNPSAR 480

LTALRIKKTL QKLIQGSEKP KVIH 504

Nucleotide Sequence
(FASTA)

ATGACGTTGG CCTACCCTAA GAGGGGCCTT CTGGTGCTGC TGATGGCCTT GGGCCTGACC 60

CAGGGGAACC CTGTGGAGCC CTTTCAGACC TCATTGGTAA CCTGCACATG TCAGAACCCA 120

CACTGCAAGG GGACCACCTG CCAGGGACTC TGGTGTACAG CAGTGCTGTT TGTAGATGAA 180

GAAGGTCATC TCCAGAATTT TAAGGGATGT GGAAGCCAGA ACGAAGAGCT CTGTAGGGGG 240

CGTGCCACTG AATTCGCCCA TCATTTCTGC TGCCGCCAAT CCTTCTGCAA CCACAATGTA 300

TCCCTGTCGC TGGAGACCAC CCAGACTCCT CCGGAGCAGC CAAAAGTAGA TAGCCAGCTG 360

CCTCTGATCC TCGGCCCTGT GCTGGCCTTG CTAGTGCTGG TGGCCTTGGG TACCCTGGGC 420

CTGTGGCATG TCCGGCGGAG GCAGGAGAAG CAGCGAGGCC TGTACAGTGA CCTGGGCGAG 480

TCCAGCCTCA TCCTGAAATC ATCCGAGCAG AGGGACAGCA TGTTGGGGGA ATTCCTGGAT 540

AGCAACTGCA CCACAGGCAG TGGCTCAGGG CTCCCCTTTC TGGTGCAGAG GACAGTGGCA 600

CGGCAAGTCA CCCTGGTGGA GTGTGTGGGA AAGGGCCGCT ACGGTGAGGT GTGGCGGGGC 660

CTGTGGCATG GTGAGAGTGT AGCTGTCAAG ATCTTCTCCT CGAGGGATGA GCAGTCCTGG 720

TTCCGGGAGA CGGAGATCTA CAATACAGTG TTGCTCCGGC ATGACAACAT CCTAGGCTTC 780

ATCGCCTCAG ATATGACCTC CCGAAATTCC AGTACGCAGC TGTGGCTCAT CACGCACTAC 840

CATGAGCACG GCTCCCTCTA TGACTTCCTG CAGAGGCAGA CGCTTGAGCC TCAGCTGGCC 900

CTCAAGCTAG CTGTGTCCGC AGCGTGCGGC CTGGCACACC TGCACGTGGA GATCTTCGGC 960

ACACAGGGAA AACCGGCCAT TGCCCACCGT GATCTCAAGA GCCGCAATGT TCTGGTCAAG 1020

AGCAACCTTC AGTGTTGCAT TGCAGACCTG GGCCTGGCTG TGATGCACTC TCAGGGTAGC 1080

GATTACCTGG ACATTGGCAA CAACCCGAGA GTGGGCACCA AGCGGTACAT GGCACCGGAG 1140

GTGCTGGATG AGCAGATCCG CACCGACTGC TTCGAGTCTT ACAAGTGGAC CGACATCTGG 1200

GCCTTCGGCC TGGTGCTGTG GGAGATTACT CGGCGAACCA TTGTCAATGG TATTGTGGAG 1260

GACTATAGGC CACCTTTCTA TGATGTGGTG CCCAATGACC CCAGCTTCGA GGACATGAAG 1320

AAAGTGGTGT GTATTGACCA GCAAACTCCC ACCATCCCCA ACCGGCTGGC TGTAGACCCG 1380

GTCCTCTCAG GCCTGGCTCA GATGATGCAG GAATGCTGGT ACCCTAACCC CTCTGCCCGC 1440

CTCACTGCGC TTCGCATCAA GAAGACCCTA CAGAAACTCA TCCAAGGCTC AGAGAAGCCC 1500

AAAGTGATTC ACTAG 1515

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         ++l+e++gkGrygeVw++ ++ge+vAvKifs++de+sw+rE+eiy+tvllrh+nil+fia

Q: 203   VTLVECVGKGRYGEVWRGLWHGESVAVKIFSSRDEQSWFRETEIYNTVLLRHDNILGFIA  262

         5899********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         +d+++++s+t+l+l+t+yhe+gsL+d+L+r+tl+ + +l+la s+a+GlahLH ei+gt+

Q: 263   SDMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPQLALKLAVSAACGLAHLHVEIFGTQ  322

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         g  KpaiaHRDlks+N+lvk++l+cciaDlGLa+++++ ++ ld+ +n +vGtkRYmaPE

Q: 323   G--KPAIAHRDLKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIGNNPRVGTKRYMAPE  380

         *..*********************************************************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         vl+e++ +++fe++k++D++++gLvlWE+++R+   +++ve+y++pf++vv++dPs+e+m

Q: 381   VLDEQIRTDCFESYKWTDIWAFGLVLWEITRRTIV-NGIVEDYRPPFYDVVPNDPSFEDM  439

         *********************************99.************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         k+vv+ +++ P+ip+++  +++l+ l+++++ecW+ +p+aRltalr+kk+l

Q: 440   KKVVCIDQQTPTIPNRLAVDPVLSGLAQMMQECWYPNPSARLTALRIKKTL  490

         *************************************************97

Domain Sequence
(FASTA)

VTLVECVGKG RYGEVWRGLW HGESVAVKIF SSRDEQSWFR ETEIYNTVLL RHDNILGFIA 60

SDMTSRNSST QLWLITHYHE HGSLYDFLQR QTLEPQLALK LAVSAACGLA HLHVEIFGTQ 120

GKPAIAHRDL KSRNVLVKSN LQCCIADLGL AVMHSQGSDY LDIGNNPRVG TKRYMAPEVL 180

DEQIRTDCFE SYKWTDIWAF GLVLWEITRR TIVNGIVEDY RPPFYDVVPN DPSFEDMKKV 240

VCIDQQTPTI PNRLAVDPVL SGLAQMMQEC WYPNPSARLT ALRIKKTL 288

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0004702	; F:receptor signaling protein serine/threonine kinase activity
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0023014	; P:signal transduction by phosphorylation

KEGG

InterPros

IPR000333	; Activin_II/TGFBeta-II_recpt.
IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00653

; ACTIVIN2R.

Created Date

20-Feb-2013