EKS-CAP-00297

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAP-00297

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/PLK	412.5	6.7E-124	62	314	253

Status

Unreviewed

Ensembl Protein

ENSCPOP00000001964

UniProt Accession

H0UXX0;

Protein Name

Protein Synonyms/Alias

Gene Name

PLK3

Gene Synonyms/Alias

PLK3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCPOG00000002167	ENSCPOP00000001964	ENSCPOT00000002195

Organism

Cavia porcellus

Functional Description

Protein Length

646

Protein Sequence
(FASTA)

MEPAAGSPSP RAFPRAAAPP APPAGPGPPA SALRAPPEGT LAGPPAPDPG RLITDPHSGR 60

TYFKGRLLGK GGFARCYEAT DTESGSPYAV KIVPRSRVSK PHQREKILNE IELHRDLQHR 120

HIVRFSHHFE DADNIYIFLE LCSRKSLAHI WKARHTLLEP EVRYYLRQIL SGLKYLHQRG 180

ILHRDLKLGN FFITENMELK VGDFGLAARL EPLEQRKKTI CGTPNYVAPE VLLRQGHGPE 240

ADVWSLGCVM YTLLCGSPPF ETADLKETYR CIKQVHYTLP ASLSLPARQL LAAILRASPR 300

DRPSIDQILR HDFFTKGYTP DRLPVSSCVT VPDLTPPNPA KSLFAKVTKS LFGRKKSKNK 360

SQPEREEVSC LVSSLMRTSL GHRGAGPEVP ATSGPTPVGL VETAAEESSP RGTPASSGDG 420

FEEGLTVATV VESALCALRN CVAFMPPAEQ NPAPLAQPEP LVWVSKWVDY SNKFGFGYQL 480

SSCRVAVLFN DGTHMALSAN RKMVHYNPTS TKHFSFSVGA VPRALQPQLG ILRYFASYME 540

QHLMKGGDLP SIEEVEAPAP PLLLQWVKTD QALLMLFSDG TVQVNFYGDH TKLILSGWEP 600

LLVTFVARNR SAYTYLASHL QQLGCTPDLR QRLRYALRLL RDRSPA 646

Nucleotide Sequence
(FASTA)

ATGGAGCCTG CCGCCGGCTC CCCGTCTCCG CGAGCCTTCC CGCGTGCAGC CGCCCCACCC 60

GCGCCCCCAG CCGGACCGGG ACCGCCAGCG AGCGCCCTGC GCGCGCCTCC GGAGGGGACG 120

CTGGCCGGAC CCCCGGCGCC AGATCCTGGG CGCCTCATCA CCGACCCGCA CAGCGGCCGC 180

ACCTACTTCA AAGGGCGCCT GTTGGGCAAG GGTGGATTTG CCCGCTGCTA CGAGGCCACC 240

GACACCGAGA GCGGCAGCCC CTACGCGGTT AAAATCGTCC CACGGAGCCG CGTCTCCAAG 300

CCGCATCAGC GCGAGAAGAT CCTCAACGAG ATTGAGCTGC ACCGAGACCT ACAGCACCGT 360

CATATTGTCC GTTTTTCACA CCACTTTGAG GATGCTGATA ACATATACAT TTTCTTGGAG 420

CTCTGCAGCC GAAAGTCCCT GGCCCACATC TGGAAGGCCC GACATACCCT GTTGGAACCA 480

GAGGTGCGCT ACTACCTACG CCAGATCCTT TCCGGCCTCA AGTACTTGCA CCAGCGGGGC 540

ATCTTGCACC GGGACCTCAA GCTGGGGAAT TTCTTCATCA CGGAGAACAT GGAACTGAAG 600

GTGGGGGATT TTGGGCTCGC AGCTCGGTTA GAGCCCCTGG AGCAGAGGAA GAAGACCATC 660

TGTGGCACCC CCAACTATGT GGCTCCAGAA GTGCTGCTGA GACAGGGCCA TGGCCCTGAG 720

GCAGACGTGT GGTCACTGGG CTGTGTCATG TACACGCTGC TGTGCGGGAG CCCCCCCTTT 780

GAGACAGCAG ACCTCAAGGA AACCTACCGC TGCATCAAGC AGGTTCACTA CACGTTGCCC 840

GCCAGCCTCT CACTGCCTGC CCGGCAGCTC CTGGCTGCCA TCCTTCGAGC CTCACCCCGA 900

GACCGCCCCT CTATTGACCA GATCCTGCGC CATGACTTCT TTACTAAGGG CTATACTCCT 960

GACCGGCTCC CTGTGAGCAG CTGTGTGACA GTCCCAGACC TGACACCCCC CAATCCAGCA 1020

AAGAGTCTGT TTGCCAAAGT TACTAAGAGT CTTTTTGGCA GGAAGAAGAG CAAGAATAAG 1080

AGCCAACCTG AGAGGGAGGA GGTCTCCTGT TTGGTGAGCA GCCTCATGCG CACATCCCTT 1140

GGCCATCGGG GTGCTGGGCC TGAGGTACCA GCAACTTCTG GTCCAACCCC TGTGGGCCTT 1200

GTAGAGACAG CAGCTGAAGA GAGCTCACCC CGTGGGACAC CGGCCAGCAG TGGAGATGGT 1260

TTTGAAGAAG GCCTGACTGT GGCCACAGTG GTAGAGTCAG CCCTCTGTGC TCTGAGAAAC 1320

TGTGTGGCCT TCATGCCCCC GGCGGAACAG AACCCTGCCC CACTGGCACA GCCAGAGCCT 1380

CTGGTGTGGG TCAGCAAATG GGTTGACTAC TCTAACAAGT TTGGCTTTGG GTACCAACTG 1440

TCCAGCTGCC GCGTAGCCGT GCTCTTCAAT GATGGCACAC ACATGGCCCT GTCAGCCAAC 1500

AGAAAGATGG TGCACTACAA CCCCACCAGC ACAAAGCACT TCTCCTTCTC CGTGGGTGCT 1560

GTGCCCCGGG CTCTGCAGCC TCAGCTGGGC ATCCTACGGT ATTTCGCCTC CTACATGGAG 1620

CAGCACCTCA TGAAGGGTGG GGATCTGCCC AGCATAGAAG AAGTAGAGGC ACCTGCCCCA 1680

CCCTTGCTGC TGCAGTGGGT TAAGACTGAT CAGGCCCTTC TGATGCTGTT CAGTGATGGC 1740

ACAGTCCAGG TGAACTTCTA TGGGGACCAC ACCAAGCTGA TCCTCAGTGG CTGGGAGCCC 1800

CTCCTTGTGA CTTTTGTGGC CCGAAATCGC AGTGCTTATA CTTACCTTGC CTCCCATCTC 1860

CAGCAGCTGG GCTGTACCCC AGACCTGCGA CAGCGATTGC GCTATGCCCT GCGCCTGCTC 1920

CGGGACCGCA GTCCAGCCTA G 1941

Domain Profile

S: 1     yergkllGkGgfakcyelkdletkevfavkvvpksllakekqrekvekeieihrslkhkn  60

         y +g+llGkGgfa+cye++d+e+++ +avk+vp+s++ k++qrek+ +eie+hr+l+h++

Q: 62    YFKGRLLGKGGFARCYEATDTESGSPYAVKIVPRSRVSKPHQREKILNEIELHRDLQHRH  121

         789*********************************************************

S: 61    ivklyeffedkenvylvlelcsrrslaellkrrkaltepevryylrqivsglkylhekri  120

         iv+++++fed++n+y++lelcsr+sla+++k+r++l epevryylrqi+sglkylh++ i

Q: 122   IVRFSHHFEDADNIYIFLELCSRKSLAHIWKARHTLLEPEVRYYLRQILSGLKYLHQRGI  181

         ************************************************************

S: 121   lhrdlklgnlflneelevkigdfGlatrlekeeerkktlcGtPnyiaPevlskkghslev  180

         lhrdlklgn+f++e++e+k+gdfGla+rle+ e+rkkt+cGtPny+aPevl ++gh+ e+

Q: 182   LHRDLKLGNFFITENMELKVGDFGLAARLEPLEQRKKTICGTPNYVAPEVLLRQGHGPEA  241

         ************************************************************

S: 181   diWslGcilytllvGkPPfetkelketyekikkaeyslPsslskeaksliakllkkePee  240

         d+WslGc++ytll+G+PPfet++lkety++ik+ +y+lP+sls +a++l+a++l+++P++

Q: 242   DVWSLGCVMYTLLCGSPPFETADLKETYRCIKQVHYTLPASLSLPARQLLAAILRASPRD  301

         ************************************************************

S: 241   rpsleevlkdefl  253

         rps++++l+++f+

Q: 302   RPSIDQILRHDFF  314

         ************8

Domain Sequence
(FASTA)

YFKGRLLGKG GFARCYEATD TESGSPYAVK IVPRSRVSKP HQREKILNEI ELHRDLQHRH 60

IVRFSHHFED ADNIYIFLEL CSRKSLAHIW KARHTLLEPE VRYYLRQILS GLKYLHQRGI 120

LHRDLKLGNF FITENMELKV GDFGLAARLE PLEQRKKTIC GTPNYVAPEV LLRQGHGPEA 180

DVWSLGCVMY TLLCGSPPFE TADLKETYRC IKQVHYTLPA SLSLPARQLL AAILRASPRD 240

RPSIDQILRH DFF 253

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000959	; POLO_box_duplicated_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR020658	; Ser/Thr_kinase_Plk3.

Pfam

PF00069	; Pkinase; 1.
PF00659	; POLO_box; 2.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS50078	; POLO_BOX; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013