EPS-CAP-00008

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-CAP-00008

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
DSP/aDSP	150.1	3.6E-44	133	278	146

Status

Unreviewed

Ensembl Protein

ENSCPOP00000002109

UniProt Accession

H0UYA5;

Protein Name

Protein Synonyms/Alias

Gene Name

DUSP27

Gene Synonyms/Alias

DUSP27;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCPOG00000002322	ENSCPOP00000002109	ENSCPOT00000002354

Organism

Cavia porcellus

Functional Description

Protein Length

1104

Protein Sequence
(FASTA)

MATSGDPEEE QVVPGEDDEV DVRAVQARYL RSPSPSQYSM VSDAETESIF MEPIHLSSSV 60

AAKQIINEEL KPRGLPTDTE CPGMLESAEQ LLVEDLYNRV KEKMDDTSLY NTPCVLDLQR 120

ALVQDRQEAP RNEVDEVWPN IFIAEKSVAV NKGRLKRLGI THILNAAHGT GVYTGPEFYT 180

GLEIQYLGVE VDDFPEVDIS QHFRKAAEFL DEALLTYRGK VLVSSEMGIS RSAVLVAAYL 240

MIFHNMAILE ALMTMRKKRA IYPNDGFLKQ LRELNEKLMG EDMGSTFGAR VHDLTVEEED 300

DTTSHLSHLS GSSLGKASQA SRPLTLIDEE EEEKLYAEWR KRQGLPESRA PQSGEGRGSV 360

ASGVRKIIQE WQSRNERYQA EGHRQWGLEE QEEEEESDTG SSIGRRRRRT LSESSISESV 420

SSQDIQVLKQ QLEMSSRSRG GRHRADSVST ESTWDVWNES LLEIEKEAAR RYHSQSRRLR 480

EDDEDSVTSE ASSFHNFCSR NKEKLTALER WKIKRIQFGF HKKDSEVGDG SSEPGAEEEE 540

GEKKSLSDVN LTAYQAWKLK HQKKVGSENR EEVVEMSKTE DTASAKKRQR RLELLERCRQ 600

TLEESQSMGS WEAGSSVASG SIPLSALWSA ASSVSADGDN ASVLSTQSHH SHMSQAASSI 660

GPRSACTPIP PLPNLPVGPS DAIAIASIQN WIASVVTETL AQKQNEMLLL SRPPSVASSR 720

AVPAASCPGD DQVSMLSGQS SSSLGSCPLL PSQARASCDA QSLLSSSSAL SSRAQGTGSS 780

IRGTSKPIYS LFADNVDLKE LGRKEREMQM ELREKMSEYK MEKLASDNKR SSLFKKKKIK 840

EDEDDGVGNG DEDTDSAIGS FQYSSRSNSQ KPETDTSSSL AVSGHYGNGS RAGKDRDSSI 900

SKWLSGLGTE ERSPPQSDWS GSSRGKYTRS SLLRETESKS SSYKFSKSRS QEQDTSSYYE 960

ADGSSVRSTS RFSSSSTREG REIHKFSRST FSETASSREG SPEPYFFRRT PEPSQGEESP 1020

EPQRPSWGRS SNWEDVEESS KSDFSEFGAK RKFTQSFFAS GRRSQYRRSN DREEEEEMDD 1080

EAIIAAWRRR QEETRTKLQR RRED 1104

Nucleotide Sequence
(FASTA)

ATGGCGACCA GTGGGGACCC AGAGGAGGAG CAGGTGGTTC CAGGCGAGGA CGATGAAGTT 60

GACGTGAGAG CAGTGCAGGC CCGCTACCTC CGAAGCCCTT CACCCAGCCA GTACTCAATG 120

GTCTCTGACG CGGAAACTGA GAGCATCTTC ATGGAGCCCA TTCACCTCTC CTCCTCTGTT 180

GCTGCCAAAC AGATCATCAA TGAAGAGCTC AAGCCTCGAG GACTCCCCAC AGACACAGAG 240

TGTCCGGGCA TGCTGGAGTC TGCTGAGCAG CTGCTGGTGG AAGACCTGTA CAATCGTGTG 300

AAGGAAAAGA TGGATGACAC CAGTTTATAC AATACCCCTT GTGTACTGGA CCTGCAGCGA 360

GCTCTGGTCC AGGATCGCCA GGAGGCCCCC CGGAATGAGG TGGATGAGGT CTGGCCCAAC 420

ATCTTCATAG CTGAGAAGAG CGTGGCTGTG AACAAGGGGA GGTTGAAGAG GCTCGGGATC 480

ACCCACATCC TGAATGCTGC ACATGGCACT GGTGTGTACA CTGGCCCCGA ATTCTACACT 540

GGCCTGGAGA TCCAGTACCT GGGAGTGGAG GTGGATGACT TTCCGGAGGT GGACATCTCT 600

CAACATTTCC GGAAGGCTGC CGAGTTCCTT GATGAAGCAC TGCTGACCTA CAGAGGGAAA 660

GTCCTGGTCA GTAGTGAAAT GGGCATCAGT CGATCAGCAG TGCTGGTGGC TGCCTACCTG 720

ATGATCTTCC ACAACATGGC CATCCTGGAG GCCCTGATGA CCATGCGCAA GAAGCGGGCC 780

ATCTACCCCA ATGACGGCTT CCTGAAGCAG CTGCGGGAAC TCAATGAGAA GCTGATGGGC 840

GAAGATATGG GGAGCACATT TGGGGCCAGA GTGCACGACT TGACAGTAGA GGAGGAGGAT 900

GACACCACCA GCCACTTGAG CCATCTGAGC GGCTCCTCCT TGGGGAAGGC CAGCCAGGCC 960

TCCCGGCCTC TCACCCTCAT TGACGAAGAG GAGGAGGAAA AGCTGTATGC AGAGTGGAGG 1020

AAGCGGCAGG GCCTGCCCGA AAGCAGGGCT CCCCAGAGCG GAGAGGGCAG GGGCTCTGTA 1080

GCCTCTGGCG TGAGGAAGAT CATCCAGGAG TGGCAGAGCC GAAATGAGCG GTACCAAGCT 1140

GAAGGGCATC GGCAGTGGGG TCTGGAGGAG CAGGAGGAAG AGGAGGAGAG TGACACAGGC 1200

TCCTCCATAG GGCGGAGACG CAGACGCACC CTGAGTGAGA GCAGCATCTC TGAGAGCGTG 1260

AGCAGCCAGG ACATCCAGGT GCTGAAGCAG CAGCTGGAGA TGAGCAGCCG GAGCAGAGGT 1320

GGCAGGCACC GCGCAGACTC GGTGTCCACT GAGAGCACCT GGGACGTGTG GAATGAGAGC 1380

CTGCTGGAGA TCGAGAAGGA GGCTGCTCGC AGGTACCACT CCCAGAGCAG GAGGCTGCGG 1440

GAGGACGATG AGGACAGCGT GACCTCGGAG GCCAGCTCCT TCCATAACTT CTGCAGCAGG 1500

AACAAGGAGA AGCTCACTGC CCTGGAAAGG TGGAAGATCA AGAGGATTCA GTTTGGATTT 1560

CACAAGAAAG ACTCTGAGGT GGGGGATGGC AGCAGTGAGC CTGGGGCCGA GGAGGAAGAG 1620

GGGGAGAAGA AGAGCCTCTC AGATGTCAAC CTGACAGCCT ACCAGGCCTG GAAGCTGAAG 1680

CATCAGAAGA AGGTGGGCAG TGAGAACAGG GAGGAGGTGG TGGAGATGAG CAAGACAGAG 1740

GACACAGCCT CGGCCAAGAA GAGGCAGCGC AGGCTGGAGC TCCTGGAGCG GTGCAGGCAG 1800

ACGCTGGAGG AAAGCCAGTC CATGGGTAGC TGGGAGGCAG GCAGCTCAGT GGCCAGTGGG 1860

AGCATCCCCC TGTCGGCACT ATGGTCTGCA GCCTCTTCGG TCAGTGCCGA CGGGGACAAT 1920

GCATCAGTGC TCAGCACTCA GAGCCACCAC TCCCACATGT CCCAGGCTGC AAGCAGCATA 1980

GGACCACGCT CAGCCTGCAC ACCCATTCCC CCCCTGCCTA ACCTGCCTGT GGGGCCCAGC 2040

GACGCCATTG CCATCGCCAG CATCCAGAAC TGGATTGCCA GTGTAGTCAC TGAGACCCTC 2100

GCCCAGAAGC AGAATGAAAT GCTATTGCTG TCTCGCCCAC CATCTGTGGC AAGCTCGAGG 2160

GCTGTACCAG CAGCCAGCTG CCCGGGGGAT GACCAGGTGT CCATGCTCAG TGGACAGAGC 2220

AGCTCTTCCC TGGGGAGCTG CCCGCTGCTG CCCAGCCAGG CCAGAGCCAG TTGTGATGCA 2280

CAGTCCCTGC TGTCTTCCAG CTCCGCGCTG AGCTCAAGGG CCCAAGGCAC GGGGAGCAGC 2340

ATTAGGGGGA CCAGCAAGCC CATCTACAGC CTCTTTGCTG ACAATGTGGA CCTAAAGGAG 2400

CTCGGCCGGA AGGAGAGAGA GATGCAAATG GAGCTGAGGG AGAAGATGTC AGAGTACAAA 2460

ATGGAGAAAC TGGCTTCGGA CAATAAGCGC AGCTCCCTTT TCAAGAAGAA GAAGATCAAA 2520

GAAGATGAGG ATGATGGTGT GGGCAATGGG GATGAGGACA CAGACAGTGC CATCGGCAGC 2580

TTCCAGTATT CCTCCCGCAG TAATTCCCAA AAGCCTGAAA CAGACACCTC CTCCTCCCTG 2640

GCTGTCTCTG GTCACTATGG AAATGGCAGC AGAGCTGGCA AAGACAGGGA TAGCAGCATT 2700

AGTAAGTGGC TGAGTGGCCT AGGGACAGAG GAAAGATCTC CTCCTCAAAG TGACTGGTCA 2760

GGAAGCTCCA GAGGAAAGTA CACCAGATCA TCTTTGCTCC GGGAAACCGA GTCTAAATCT 2820

TCTAGTTACA AGTTCTCTAA ATCCCGGTCA CAGGAACAGG ATACCTCCTC CTACTATGAG 2880

GCAGATGGCA GCTCGGTAAG AAGCACCTCG CGGTTCTCTT CTTCCTCCAC CAGGGAGGGC 2940

AGAGAAATAC ATAAGTTCTC CAGGTCCACA TTCAGTGAGA CCGCAAGCTC TCGAGAGGGG 3000

AGCCCAGAAC CCTACTTCTT CCGCCGGACC CCCGAACCTT CCCAAGGGGA AGAGTCCCCG 3060

GAACCCCAGC GTCCCAGTTG GGGCAGGTCC AGCAACTGGG AAGACGTGGA AGAGTCATCC 3120

AAATCAGACT TCTCTGAATT TGGAGCCAAG AGGAAATTCA CCCAGAGCTT CTTTGCATCT 3180

GGGCGGCGGT CCCAGTATCG GAGGAGCAAC GACAGGGAGG AAGAGGAAGA GATGGATGAT 3240

GAGGCCATCA TCGCTGCCTG GAGACGACGG CAGGAAGAAA CTAGGACTAA GCTGCAGAGG 3300

AGGAGGGAGG ACTGA 3315

Domain Profile

S: 1     evteilpglylgdqataldrreLsklgitvvinaslsvikvqviPeylikkgityknipv  60

         ev+e++p+++++++ +a+++  L++lgit+++na++++    ++Pe+++  +i+y++++v

Q: 133   EVDEVWPNIFIAEKSVAVNKGRLKRLGITHILNAAHGTGV-YTGPEFYTGLEIQYLGVEV  191

         69**********************************8765.79*****************

S: 61    dDsdvtdllqyfdeaaefidea.kekggkvlvHCaaGvsRSatlvlaYLmkveglslsdA  119

         dD ++ d++q+f++aaef+dea  + +gkvlv +++G+sRSa+lv aYLm+++++++ +A

Q: 192   DDFPEVDISQHFRKAAEFLDEAlLTYRGKVLVSSEMGISRSAVLVAAYLMIFHNMAILEA  251

         **********************8999**********************************

S: 120   ieavkrkrpsiepnegfleQLlelekkl  147

         ++++++kr +i+pn+gfl+QL+el++kl

Q: 252   LMTMRKKR-AIYPNDGFLKQLRELNEKL  278

         ********.***************9987

Domain Sequence
(FASTA)

EVDEVWPNIF IAEKSVAVNK GRLKRLGITH ILNAAHGTGV YTGPEFYTGL EIQYLGVEVD 60

DFPEVDISQH FRKAAEFLDE ALLTYRGKVL VSSEMGISRS AVLVAAYLMI FHNMAILEAL 120

MTMRKKRAIY PNDGFLKQLR ELNEKL 146

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0008138	; F:protein tyrosine/serine/threonine phosphatase activity
GO:0006470	; P:protein dephosphorylation

KEGG

InterPros

IPR020417	; Atypical_DUSP.
IPR020405	; Atypical_DUSP_famA.
IPR000340	; Dual-sp_phosphatase_cat-dom.
IPR020422	; Dual-sp_phosphatase_subgr_cat.
IPR024950	; DUSP.
IPR000387	; Tyr/Dual-specificity_Pase.

Pfam

PF00782

; DSPc; 1.

SMARTs

SM00195

; DSPc; 1.

Prosites

PS50056	; TYR_PHOSPHATASE_2; 1.
PS50054	; TYR_PHOSPHATASE_DUAL; 1.

Prints

PR01908	; ADSPHPHTASE.
PR01909	; ADSPHPHTASEA.

Created Date

20-Feb-2013