EKS-CAP-00064

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAP-00064

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	370.8	4.0E-111	39	323	285

Status

Unreviewed

Ensembl Protein

ENSCPOP00000002113

UniProt Accession

H0UYA9;

Protein Name

Protein Synonyms/Alias

Gene Name

CDK10

Gene Synonyms/Alias

CDK10;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCPOG00000002326	ENSCPOP00000002113	ENSCPOT00000002358

Organism

Cavia porcellus

Functional Description

Protein Length

360

Protein Sequence
(FASTA)

MADPDPESEQ IRLKCIRKEG FFTVPPEHRL GRCRSVKEFE KLNRIGEGTY GIVYRARDTK 60

TDEIVALKKV RMDKEKDGIP ISSLREITLL LRLRHPNIVE LKEVVVGNHL ESIFLVMGYC 120

EQDLASLLEN MPTPFSEAQV KCIVLQVLRG LQYLHRNFII HRDLKVSNLL MTDKGCVKTA 180

DFGLARAYGV PVKPMTPKVV TLWYRAPELL LGTTTQTTSI DMWAVGCILA ELLAHKPLLP 240

GTSEIHQVDL IVQLLGTPSE NIWPGFSKLP LVSQYSLRKQ PYNNLKHKFP WLSEAGLRLL 300

NFLFMYDPKK RATAGDCLES SYFKEKPLPC EPELMPTFPH HRNKRAAPGT AEGQSKRCKP 360

Nucleotide Sequence
(FASTA)

ATGGCGGATC CGGACCCAGA GTCGGAGCAG ATCCGCCTGA AGTGTATCCG TAAGGAAGGT 60

TTCTTCACGG TGCCTCCAGA ACACAGGTTA GGACGATGCC GGAGTGTGAA GGAGTTTGAG 120

AAGCTGAACC GCATCGGCGA GGGCACCTAT GGCATTGTTT ATCGGGCCCG GGACACAAAG 180

ACAGACGAGA TTGTTGCCCT GAAGAAGGTG CGGATGGACA AGGAGAAGGA CGGCATCCCC 240

ATCAGCAGCC TGAGGGAGAT CACGCTGCTC CTGCGTCTGC GCCACCCCAA CATTGTGGAG 300

CTAAAGGAGG TGGTGGTAGG AAACCACCTG GAGAGCATCT TCCTAGTAAT GGGTTACTGT 360

GAGCAGGACC TGGCCAGCCT CCTGGAAAAC ATGCCCACGC CCTTCTCTGA GGCCCAGGTC 420

AAGTGCATTG TGCTGCAGGT GCTCCGGGGC CTCCAGTACC TGCACAGGAA CTTCATCATC 480

CACAGGGACC TGAAGGTCTC TAATCTCCTC ATGACTGACA AGGGCTGTGT GAAGACAGCG 540

GACTTTGGCC TGGCCCGGGC CTATGGTGTC CCAGTGAAAC CAATGACCCC CAAGGTGGTC 600

ACCCTCTGGT ACCGTGCCCC TGAGTTGCTG CTGGGGACCA CAACCCAGAC TACCAGCATC 660

GACATGTGGG CCGTGGGCTG CATCCTGGCT GAGCTGTTGG CCCACAAGCC CCTCCTCCCT 720

GGCACGTCTG AGATCCACCA AGTTGACCTG ATTGTGCAGC TGCTGGGGAC GCCTAGTGAG 780

AACATCTGGC CGGGCTTTTC CAAGCTGCCA CTTGTCAGCC AGTACAGCTT GAGGAAGCAG 840

CCATACAACA ACCTCAAGCA CAAGTTTCCG TGGCTCTCAG AGGCTGGGCT GCGCCTGCTG 900

AATTTCCTCT TCATGTATGA TCCCAAGAAA AGGGCGACAG CAGGGGACTG CCTGGAGAGT 960

TCCTACTTTA AGGAGAAGCC CCTACCCTGT GAGCCGGAGC TCATGCCCAC CTTCCCCCAC 1020

CACCGCAACA AGCGGGCTGC CCCAGGCACT GCAGAAGGCC AGAGCAAGCG GTGCAAACCC 1080

Domain Profile

S: 1     yeklekigeGtygkvykakdketgevvAlKkirlekekegvpitalrEisllkelkhkni  60

         +ekl++igeGtyg vy+a+d++t+e+vAlKk+r++kek+g+pi++lrEi+ll +l+h+ni

Q: 39    FEKLNRIGEGTYGIVYRARDTKTDEIVALKKVRMDKEKDGIPISSLREITLLLRLRHPNI  98

         89**********************************************************

S: 61    vkLlevvakdk.kklyLvfefleqdLkkllkkkkkkklsleevkslllqlleglaylHsn  119

         v+L+evv+ ++ ++++Lv+ ++eqdL++ll+++++  +s+++vk ++lq+l+gl+ylH+n

Q: 99    VELKEVVVGNHlESIFLVMGYCEQDLASLLENMPT-PFSEAQVKCIVLQVLRGLQYLHRN  157

         ********5555***********************.************************

S: 120   kilHRDlKpqNlLiskegklklaDfGlarafssplktytkevvTlwYraPelLlgakeYs  179

          i+HRDlK +NlL++++g++k aDfGlara+++p+k +t++vvTlwYraPelLlg+++ +

Q: 158   FIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVPVKPMTPKVVTLWYRAPELLLGTTTQT  217

         ************************************************************

S: 180   tavDiWsvgcilaelltrkplfqgkseidqlerifkllgtpsekvwpevsklpeyk.ksf  238

         t++D+W+vgcilaell++kpl++g+sei+q++ i++llgtpse++wp++sklp ++ +s+

Q: 218   TSIDMWAVGCILAELLAHKPLLPGTSEIHQVDLIVQLLGTPSENIWPGFSKLPLVSqYSL  277

         ********************************************************88**

S: 239   pkkkkkklkekvkklkekaldllekllaldpkkRisakealqhkyf  284

         +k+++++lk+k++ l+e++l+ll+ l+++dpkkR +a ++l+++yf

Q: 278   RKQPYNNLKHKFPWLSEAGLRLLNFLFMYDPKKRATAGDCLESSYF  323

         *********************************************8

Domain Sequence
(FASTA)

FEKLNRIGEG TYGIVYRARD TKTDEIVALK KVRMDKEKDG IPISSLREIT LLLRLRHPNI 60

VELKEVVVGN HLESIFLVMG YCEQDLASLL ENMPTPFSEA QVKCIVLQVL RGLQYLHRNF 120

IIHRDLKVSN LLMTDKGCVK TADFGLARAY GVPVKPMTPK VVTLWYRAPE LLLGTTTQTT 180

SIDMWAVGCI LAELLAHKPL LPGTSEIHQV DLIVQLLGTP SENIWPGFSK LPLVSQYSLR 240

KQPYNNLKHK FPWLSEAGLR LLNFLFMYDP KKRATAGDCL ESSYF 285

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013