EKS-CAP-00121

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAP-00121

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Met	453.5	2.1E-136	1063	1322	260

Status

Unreviewed

Ensembl Protein

ENSCPOP00000002118

UniProt Accession

H0UYB4;

Protein Name

Protein Synonyms/Alias

Gene Name

MST1R

Gene Synonyms/Alias

MST1R;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCPOG00000002332	ENSCPOP00000002118	ENSCPOT00000002364

Organism

Cavia porcellus

Functional Description

Protein Length

1381

Protein Sequence
(FASTA)

KGCDWPRWSS FRSLLLLLLL RLSAMTSIDQ DWRCPRTPYA ATRDFNVRYV VPFFSAGSPV 60

QAVVTYEDGQ DGSAVFVATR NRLHVLGPEL QIVQSLATGP AGDPSCQTCA ACGPGPHGPP 120

GDTDTLVLVL EPGLPALVSC GSSLQGRCFL HELEPHGTAL HLAAPACLFS ADRNLPEDCP 180

DCVASSLGTR VTVVEQGQAS YLYVASSLNA TVAASFSPRS VSIRRLRADA SGFEPGFAAL 240

SVLPKYLDSY HIEYVHSFHS GAFVYFLTVQ PASVTDTPGA LQTRLVRLNA LEPELDDYRE 300

LILDCDFAPK RRRRAPEGRH SYPVLQAAHS AHVGAQFASE LNIAEGHEVL FGAFVTGRAG 360

DSGMGPNSVV CAFPIDQLNT LIGEGVERCC GSSVISGPRR GLEFFQTLSF CPNLPFPEAP 420

SPNISCHYFP LLVSGSFSRV DLFNGLLGPA QITALYVTRF DNVTVAHMGT ADGRILQVEL 480

ARSLNYLLYV SNFSLGSSGQ PIRRDVSRLR DDLLFTSGDQ VRKVPIRGPG CRHFLTCRGC 540

LRTQRFMGCG WCGDVCGRQE ECPGSWQRDH CPPILTEFYP HSGPRRGSTR LTLCGSNFYL 600

RPDSPVPEGT HQVTVGQSPC QLLPQDTSSL RPVLQKDFVE ELECELEPSH TQAAGTTNVS 660

LSVTNTLPSR HFRIDGTSML GGFSFMEPVL TAVQPLFGPR AGGTRVTLEG QGLSIGTSRA 720

VLINGTQCQL EQVSEVQIVC ATPPAAATAS VPLGLQIGGA EVPGSWTFHY REDPIVLGIS 780

PNCGYAGSHV TIHGQHLTST WHLKLSFHDG QRAIENRCEG PFPEQHRCRL PEYMVRDPRG 840

WVIGNLSVQG DGAAHFTLPS FRFLPPPRPP SADLVPLKPE EHAVKFQYIG LDAVTDCVGV 900

NVTVGGKRCQ YEFRGDVVVC PLPPSVQLSK DGTPLKVCVD GDCHTVGRVV RAAPGGIPQN 960

ILLIVLLGLF LLVVLLAAAL VFNWWRRKQQ GPHHSTNSHA FSSTVLPALD GLHSPTGLHG 1020

GSYSEEASHV PLLRTESIRL RDLNSALLAE VKDVLIPHEQ VIIHSDQVIG KGHFGVVYHG 1080

EYTDEAQNQI HCAIKSLSRI TEAQEVEAFL REGLLMRGLH HPNVLALIGI LLPPEGLPRV 1140

LLPYMRHGDL LHFIRSPQRN PTVKDLISFG LQVARGMEYL AGQKFVHRDL AARNCMLDES 1200

FVVKVADFGL ARDVLDKEYY SVRQHRHACL PVKWMALESL QTYRFTTKSD VWSFGVLLWE 1260

LLTRGAPPYP HIDPFDLIYF LAQGRRLPQP EYCPNSLYQV MERCWEADPA ARPTFRALVV 1320

EVEQVVASLL GDHYVQLSAA YVNLGPGTMD KGNVLLEHPQ SSPLHRSMSW SRPLSEPPLP 1380

T 1381

Nucleotide Sequence
(FASTA)

AAGGGCTGTG ACTGGCCTCG ATGGAGCTCC TTCCGGTCCC TGCTGCTTCT GCTACTTTTG 60

CGGCTGTCTG CGATGACCTC CATAGACCAG GACTGGCGGT GCCCGCGCAC GCCCTACGCT 120

GCCACTCGCG ACTTTAATGT GAGGTATGTG GTGCCCTTCT TCTCCGCGGG CAGCCCAGTG 180

CAGGCCGTGG TGACCTATGA GGATGGTCAG GATGGCAGTG CTGTGTTTGT GGCCACACGC 240

AATCGCTTGC ACGTGCTTGG GCCTGAACTG CAGATTGTCC AGAGCCTGGC CACTGGCCCT 300

GCTGGAGACC CGAGCTGTCA GACCTGTGCA GCCTGTGGAC CAGGCCCCCA CGGCCCACCA 360

GGTGACACAG ACACACTGGT GCTAGTGCTG GAGCCTGGGC TGCCTGCATT GGTCAGCTGT 420

GGCTCCAGCC TGCAGGGCCG CTGCTTCCTG CATGAGCTGG AGCCTCATGG AACAGCCTTG 480

CACCTGGCAG CACCAGCTTG CCTCTTCTCT GCTGACCGAA ACCTGCCTGA GGACTGTCCT 540

GACTGTGTGG CTAGCTCCTT GGGCACCCGA GTAACTGTGG TTGAACAGGG CCAGGCTTCT 600

TACTTGTATG TGGCATCCTC ACTGAACGCA ACGGTGGCTG CCAGCTTCAG TCCCCGCTCC 660

GTGTCCATTC GGCGCCTCAG GGCTGATGCC TCAGGATTTG AACCAGGCTT TGCGGCCCTG 720

TCAGTGCTGC CCAAGTACCT GGATTCCTAC CATATCGAAT ACGTGCACAG CTTCCACTCT 780

GGAGCCTTTG TCTACTTCCT GACCGTGCAG CCTGCCAGTG TGACAGACAC TCCTGGTGCC 840

CTGCAAACGC GCCTGGTACG GCTCAATGCT CTGGAGCCGG AGTTAGACGA CTACCGGGAG 900

CTGATCCTTG ACTGCGATTT TGCACCAAAA CGCCGCCGCA GGGCCCCAGA GGGGAGGCAC 960

TCCTACCCAG TGCTTCAGGC AGCCCACTCG GCTCACGTGG GTGCCCAGTT CGCCTCTGAA 1020

TTAAACATTG CTGAGGGCCA CGAAGTGCTA TTTGGAGCCT TTGTGACCGG TAGGGCTGGT 1080

GACTCTGGCA TGGGCCCCAA CTCTGTAGTC TGCGCGTTCC CCATTGACCA GCTAAACACT 1140

CTAATTGGTG AGGGTGTGGA ACGCTGTTGT GGGTCTTCTG TTATCTCTGG TCCTCGAAGA 1200

GGCCTCGAGT TCTTCCAGAC ACTCAGTTTT TGCCCTAACC TGCCATTCCC CGAGGCTCCT 1260

AGCCCCAACA TTAGCTGCCA CTACTTCCCT CTGCTGGTCA GCGGCAGCTT CTCACGGGTG 1320

GACTTATTCA ACGGGCTTTT AGGACCAGCG CAGATCACTG CCTTGTATGT AACACGCTTT 1380

GACAATGTCA CAGTTGCCCA CATGGGCACA GCTGATGGAC GGATCCTGCA GGTAGAGCTA 1440

GCCAGGTCAC TCAACTACTT GCTGTATGTG TCTAACTTCT CACTGGGCAG CAGTGGACAG 1500

CCCATTCGGC GAGATGTCAG TCGCCTCAGG GATGACTTAC TCTTCACCTC TGGGGACCAG 1560

GTAAGGAAGG TACCTATTCG GGGCCCTGGC TGCCGCCACT TTCTCACCTG TAGAGGCTGC 1620

CTGAGAACAC AGCGCTTCAT GGGCTGTGGC TGGTGTGGAG ATGTATGTGG AAGACAGGAA 1680

GAGTGTCCTG GCTCCTGGCA ACGGGATCAC TGTCCACCTA TACTTACTGA GTTCTATCCT 1740

CACAGTGGGC CCCGAAGGGG CAGCACAAGG CTGACCTTGT GTGGCTCCAA CTTCTACTTG 1800

CGCCCTGATT CTCCAGTACC AGAGGGAACC CATCAGGTCA CAGTGGGCCA GAGTCCCTGC 1860

CAGCTGCTGC CTCAGGATAC CTCAAGCCTC AGGCCAGTAC TCCAGAAGGA CTTCGTAGAG 1920

GAGCTTGAGT GTGAGCTGGA GCCCTCACAC ACCCAGGCAG CAGGGACTAC CAATGTCAGC 1980

CTTTCTGTGA CTAACACGCT CCCCAGCAGG CACTTCCGCA TAGATGGCAC CTCCATGCTG 2040

GGAGGTTTCT CTTTCATGGA GCCAGTGCTA ACAGCAGTGC AACCCCTCTT CGGCCCACGG 2100

GCAGGGGGCA CCCGTGTCAC CCTTGAAGGC CAGGGCCTGT CTATAGGGAC CAGCCGGGCT 2160

GTGCTGATCA ATGGAACTCA ATGCCAGTTG GAACAGGTCA GCGAGGTGCA GATTGTATGT 2220

GCCACGCCCC CTGCTGCTGC TACGGCCAGT GTCCCCCTTG GCCTACAGAT AGGGGGTGCT 2280

GAGGTGCCTG GTTCCTGGAC CTTCCACTAC CGGGAAGACC CCATTGTGCT GGGTATCTCC 2340

CCCAACTGTG GCTATGCTGG CTCCCATGTC ACCATCCATG GCCAGCATCT GACATCAACG 2400

TGGCACCTAA AGCTGTCATT TCATGATGGG CAGAGGGCCA TAGAGAATAG GTGTGAGGGG 2460

CCATTTCCGG AGCAGCATCG ATGCCGTCTG CCTGAATATA TGGTCCGAGA CCCCCGGGGG 2520

TGGGTGATAG GGAATCTGAG TGTCCAGGGA GATGGAGCTG CTCACTTCAC ACTGCCCAGC 2580

TTTCGATTCC TACCCCCACC TCGTCCACCC AGCGCGGACC TAGTCCCACT GAAGCCTGAA 2640

GAACATGCAG TTAAGTTCCA GTATATTGGG CTGGACGCTG TGACTGACTG CGTTGGTGTA 2700

AATGTGACTG TGGGTGGTAA GAGATGCCAG TACGAGTTCC GGGGAGATGT GGTGGTCTGT 2760

CCCCTGCCTC CCTCAGTGCA ACTCAGCAAG GATGGTACCC CACTGAAGGT CTGTGTGGAT 2820

GGCGATTGTC ACACAGTGGG CAGAGTGGTC AGGGCAGCCC CAGGGGGCAT CCCACAGAAT 2880

ATCCTCCTTA TTGTCCTGCT GGGCTTATTC CTGCTTGTGG TTTTACTGGC TGCTGCACTA 2940

GTCTTCAACT GGTGGCGGAG GAAGCAACAA GGGCCACACC ACTCCACAAA CTCTCATGCC 3000

TTCTCTTCCA CAGTACTCCC TGCCCTTGAT GGTCTACATT CTCCCACTGG GCTTCATGGA 3060

GGATCCTACT CAGAGGAAGC TTCCCATGTC CCTCTGCTGC GGACAGAATC TATCCGGCTC 3120

AGGGACTTGA ACTCTGCACT CCTGGCCGAG GTCAAAGATG TACTGATTCC TCATGAACAA 3180

GTGATCATTC ACAGTGACCA AGTCATTGGC AAAGGCCACT TTGGAGTTGT CTACCATGGG 3240

GAATATACAG ACGAGGCCCA GAATCAAATC CACTGTGCCA TCAAATCGCT CAGTCGCATC 3300

ACAGAAGCGC AGGAGGTAGA AGCCTTCCTT CGAGAGGGGC TGCTCATGCG TGGCTTGCAC 3360

CACCCAAATG TTCTGGCTCT CATTGGGATC CTGCTACCAC CTGAAGGGCT GCCCCGTGTG 3420

CTGCTGCCCT ATATGCGCCA TGGAGACCTG CTCCATTTCA TCCGCTCCCC ACAGCGGAAC 3480

CCCACTGTGA AGGACCTCAT CAGCTTCGGC CTGCAGGTAG CCCGCGGTAT GGAGTACCTG 3540

GCAGGACAGA AGTTCGTGCA TAGGGACCTG GCTGCTAGGA ACTGCATGCT AGATGAGTCA 3600

TTTGTGGTCA AGGTGGCTGA CTTTGGTCTG GCCCGAGATG TCCTGGACAA GGAATACTAC 3660

AGCGTCCGTC AACACCGCCA TGCTTGCCTA CCTGTCAAGT GGATGGCACT GGAGAGCCTG 3720

CAGACCTACA GATTCACCAC CAAATCTGAC GTGTGGTCAT TTGGTGTGCT GCTATGGGAG 3780

CTGCTAACAC GGGGTGCCCC ACCATACCCC CACATTGACC CTTTTGACCT TATCTACTTC 3840

CTGGCCCAAG GTCGGCGCCT GCCTCAGCCT GAATATTGTC CCAATTCTCT GTACCAAGTC 3900

ATGGAGAGAT GCTGGGAGGC AGACCCAGCA GCACGACCCA CCTTCAGAGC ACTGGTGGTG 3960

GAAGTGGAGC AGGTTGTGGC CTCACTGCTT GGAGACCACT ATGTGCAGCT ATCTGCAGCC 4020

TATGTGAACT TGGGCCCTGG CACCATGGAC AAGGGGAATG TGCTCCTGGA ACATCCACAG 4080

TCCTCGCCTC TGCACAGGAG CATGTCTTGG TCCCGACCCC TCTCAGAGCC GCCTCTGCCC 4140

ACTTGA 4146

Domain Profile

S: 1     vdkeeviGkGhfGvvykgelsdsaskkikvavksleritdiekveeflreglvmkeldhp  60

         +++++viGkGhfGvvy+ge++d+a+++i++a+ksl+rit+ ++ve+flregl+m++l+hp

Q: 1063  IHSDQVIGKGHFGVVYHGEYTDEAQNQIHCAIKSLSRITEAQEVEAFLREGLLMRGLHHP  1122

         5899********************************************************

S: 61    nvlsllGialddeglplvvlpymkkGdlksfirneernltvkdllefalqvakgmeylas  120

         nvl+l+Gi l++eglp v+lpym++Gdl +fir+++rn+tvkdl++f+lqva+gmeyla

Q: 1123  NVLALIGILLPPEGLPRVLLPYMRHGDLLHFIRSPQRNPTVKDLISFGLQVARGMEYLAG  1182

         ************************************************************

S: 121   kkfvhrdlaarnclldekltvkvadfGlardvldkelyvveeerdarlpvkwlaleslqt  180

         +kfvhrdlaarnc+lde+++vkvadfGlardvldke+y+v+++r+a lpvkw+aleslqt

Q: 1183  QKFVHRDLAARNCMLDESFVVKVADFGLARDVLDKEYYSVRQHRHACLPVKWMALESLQT  1242

         ************************************************************

S: 181   fkqfttksdvwsfGvllwelltrgatpysevasfdltlylkegrrlrkpeycpdklydvm  240

         ++ fttksdvwsfGvllwelltrga+py+++++fdl+++l++grrl++peycp++ly+vm

Q: 1243  YR-FTTKSDVWSFGVLLWELLTRGAPPYPHIDPFDLIYFLAQGRRLPQPEYCPNSLYQVM  1301

         **.*********************************************************

S: 241   lkcwkakpaerpqfsdlvsii  261

          +cw+a+pa+rp+f  lv  +

Q: 1302  ERCWEADPAARPTFRALVVEV  1322

         ***************999765

Domain Sequence
(FASTA)

IHSDQVIGKG HFGVVYHGEY TDEAQNQIHC AIKSLSRITE AQEVEAFLRE GLLMRGLHHP 60

NVLALIGILL PPEGLPRVLL PYMRHGDLLH FIRSPQRNPT VKDLISFGLQ VARGMEYLAG 120

QKFVHRDLAA RNCMLDESFV VKVADFGLAR DVLDKEYYSV RQHRHACLPV KWMALESLQT 180

YRFTTKSDVW SFGVLLWELL TRGAPPYPHI DPFDLIYFLA QGRRLPQPEY CPNSLYQVME 240

RCWEADPAAR PTFRALVVEV 260

Keyword

ATP-binding; Complete proteome; Disulfide bond; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Danio rerio"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Pan troglodytes"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity
GO:0004872	; F:receptor activity
GO:0007275	; P:multicellular organismal development

KEGG

InterPros

IPR013783	; Ig-like_fold.
IPR014756	; Ig_E-set.
IPR002909	; IPT_TIG_rcpt.
IPR011009	; Kinase-like_dom.
IPR003659	; Plexin-like.
IPR016201	; Plexin-like_fold.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001627	; Semaphorin/CD100_Ag.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR015943	; WD40/YVTN_repeat-like_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF01403	; Sema; 1.
PF01833	; TIG; 3.

SMARTs

SM00429	; IPT; 3.
SM00423	; PSI; 1.
SM00630	; Sema; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS51004	; SEMA; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013