EPS-CAP-00018

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-CAP-00018

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	293.4	1.8E-87	23	289	267

Status

Unreviewed

Ensembl Protein

ENSCPOP00000002245

UniProt Accession

H0UYM7;

Protein Name

Protein Synonyms/Alias

Gene Name

PPM1A

Gene Synonyms/Alias

PPM1A;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCPOG00000002465	ENSCPOP00000002245	ENSCPOT00000002498

Organism

Cavia porcellus

Functional Description

Protein Length

382

Protein Sequence
(FASTA)

MGAFLDKPKM EKHNAQGQGN GLRYGLSSMQ GWRVEMEDAH TAVIGLPSGL ETWSFFAVYD 60

GHAGSQVAKY CCEHLLDHIT NNQDFKGSSG APSVENVKNG IRTGFLEIDE HMRVMSEKKH 120

GADRSGSTAV GVLISPQHTY FINCGDSRGL LCRNRKVHFF TQDHKPSNPL EKERIQNAGG 180

SVMIQRVNGS LAVSRALGDF DYKCVHGKGP TEQLVSPEPE VHDIERSEED DQFIILACDG 240

IWDVMGNEEL CDFVRSRLEV TDDLEKVCNE VVDTCLYKGS RDNMSVILIC FPNAPKVSPE 300

AVKKEAELDK YLECRVEEII KKQGEGVPDL VHVMRTLASE NIPSLPPGGE LASKRNVIEA 360

VYNRLNPYKN DDTDSTSTDD MW 382

Nucleotide Sequence
(FASTA)

ATGGGAGCAT TTTTAGACAA ACCAAAGATG GAAAAGCATA ATGCCCAGGG GCAGGGTAAT 60

GGGTTGCGAT ATGGGCTAAG CAGCATGCAA GGCTGGCGAG TTGAAATGGA GGATGCACAT 120

ACGGCTGTGA TTGGTTTACC AAGTGGACTT GAAACGTGGT CTTTCTTTGC TGTGTACGAT 180

GGGCATGCTG GTTCTCAGGT TGCCAAATAC TGCTGTGAGC ATTTGTTAGA TCACATCACC 240

AATAACCAGG ATTTTAAAGG GTCTTCAGGA GCACCTTCTG TAGAAAATGT AAAGAATGGA 300

ATCAGAACAG GTTTTCTGGA GATTGATGAA CACATGAGAG TTATGTCAGA GAAGAAACAC 360

GGTGCAGACA GAAGTGGGTC AACAGCTGTG GGGGTCCTGA TTTCTCCTCA GCATACTTAC 420

TTCATTAACT GTGGAGACTC AAGAGGTCTG CTGTGTAGGA ACAGGAAAGT TCACTTCTTC 480

ACACAAGATC ACAAACCAAG TAATCCGCTG GAAAAAGAAA GAATTCAGAA TGCAGGTGGC 540

TCTGTAATGA TTCAGCGTGT GAATGGCTCT CTAGCTGTAT CCAGGGCCCT TGGGGATTTT 600

GATTACAAAT GTGTCCATGG AAAAGGTCCT ACAGAGCAGC TTGTCTCACC AGAGCCTGAA 660

GTCCATGATA TCGAGAGATC TGAAGAAGAC GATCAATTTA TTATTCTTGC ATGTGATGGT 720

ATCTGGGATG TTATGGGAAA CGAAGAGCTC TGTGATTTTG TAAGATCCAG GCTTGAAGTC 780

ACTGATGATC TTGAGAAAGT TTGCAATGAA GTAGTTGACA CCTGTTTGTA TAAGGGAAGT 840

CGAGACAACA TGAGTGTGAT TTTGATCTGT TTTCCTAATG CACCCAAAGT ATCTCCAGAA 900

GCAGTGAAGA AGGAGGCAGA GCTGGACAAG TACCTGGAAT GCAGAGTAGA AGAAATCATA 960

AAGAAGCAGG GGGAAGGCGT CCCAGACTTA GTCCATGTGA TGCGCACGTT AGCGAGTGAG 1020

AACATCCCCA GCCTCCCACC AGGGGGTGAA CTGGCAAGCA AGCGGAATGT AATTGAAGCT 1080

GTTTACAATA GACTGAATCC TTACAAAAAT GATGACACTG ACTCTACATC AACTGATGAT 1140

ATGTGGTAA 1149

Domain Profile

S: 2     lvgvvsvngrrnemedavtsspnflkspekkdrlaffgvyDGhggsevakfcseklheil  61

         ++g++s++g+r emeda+t++ ++ +     + ++ff+vyDGh+gs+vak+c e+l +++

Q: 23    RYGLSSMQGWRVEMEDAHTAVIGLPSGL---ETWSFFAVYDGHAGSQVAKYCCEHLLDHI  79

         69****************9855554444...45***************************

S: 62    aeele....sseseerkvkkalakaFlstdeelkvleeksldidksGstavvalikdskl  117

         +++ +    s++++ ++vk+ ++++Fl++de+++v++ek++  d+sGstav +li++++

Q: 80    TNNQDfkgsSGAPSVENVKNGIRTGFLEIDEHMRVMSEKKHGADRSGSTAVGVLISPQHT  139

         ***9999999999***********************************************

S: 118   yvanvGdSravLcrngkavelssdHkpsredEleRieeaggsvilkdgaRvlGvLavsRa  177

         y++n+GdSr +Lcrn+k++  ++dHkps++ E+eRi++aggsv+ +   Rv+G+LavsRa

Q: 140   YFINCGDSRGLLCRNRKVHFFTQDHKPSNPLEKERIQNAGGSVMIQ---RVNGSLAVSRA  196

         **********************************************...***********

S: 178   lGdlylk.........pyvtpePevtshrltsede.fliLasDGlwdvvsneeavslvrd  227

         lGd+++k         ++v+pePev+ +++++ed+ f+iLa+DG+wdv+ nee++++vr+

Q: 197   LGDFDYKcvhgkgpteQLVSPEPEVHDIERSEEDDqFIILACDGIWDVMGNEELCDFVRS  256

         ******************************999999************************

S: 228   vlekkeaeqeaakkLvklalargskdnvsaivv  260

         +le +++++++++++v+++l +gs+dn+s+i++

Q: 257   RLEVTDDLEKVCNEVVDTCLYKGSRDNMSVILI  289

         ****************************99976

Domain Sequence
(FASTA)

RYGLSSMQGW RVEMEDAHTA VIGLPSGLET WSFFAVYDGH AGSQVAKYCC EHLLDHITNN 60

QDFKGSSGAP SVENVKNGIR TGFLEIDEHM RVMSEKKHGA DRSGSTAVGV LISPQHTYFI 120

NCGDSRGLLC RNRKVHFFTQ DHKPSNPLEK ERIQNAGGSV MIQRVNGSLA VSRALGDFDY 180

KCVHGKGPTE QLVSPEPEVH DIERSEEDDQ FIILACDGIW DVMGNEELCD FVRSRLEVTD 240

DLEKVCNEVV DTCLYKGSRD NMSVILI 267

Keyword

Complete proteome; Hydrolase; Magnesium; Metal-binding; Protein phosphatase; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0000287	; F:magnesium ion binding
GO:0030145	; F:manganese ion binding
GO:0004722	; F:protein serine/threonine phosphatase activity
GO:0006470	; P:protein dephosphorylation

KEGG

InterPros

IPR001932	; PP2C-like.
IPR012911	; PP2C_C.
IPR000222	; PP2C_Mn2_Asp60_BS.
IPR015655	; Protein_Pase_2C.

Pfam

PF00481	; PP2C; 1.
PF07830	; PP2C_C; 1.

SMARTs

SM00331	; PP2C_SIG; 1.
SM00332	; PP2Cc; 1.

Prosites

PS01032

; PP2C; 1.

Prints

Created Date

20-Feb-2013