EKS-CAP-00069
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-CAP-00069
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CMGC/CDK337.65.3E-1016295290
StatusUnreviewed
Ensembl ProteinENSCPOP00000002425
UniProt AccessionH0UZ32;
Protein Name
Protein Synonyms/Alias
Gene NameCDK4
Gene Synonyms/Alias CDK4;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSCPOG00000002670ENSCPOP00000002425ENSCPOT00000002704
OrganismCavia porcellus
Functional Description
Protein Length303
Protein Sequence
(FASTA)
MATSRYEPVA EIGVGAYGTV YKARDPHSGH FVALKSVRVP NGGGAGGGLP ISTVREVALL 60
RRLEAFEHPN VVRLMDVCAT SRTDREIKVT LVFEHVDQDL RTYLDKAPPP GLPVETIKDL 120
MRQFLRGLDF LHANCIVHRD LKPENILVTS GGTVKLADFG LARIYSYQMA LTPVVVTLWY 180
RAPEVLLQST YATPVDMWSV GCIFAEMFRR KPLFCGNSEA DQLGKIFDLI GLPPEDDWPR 240
DVSLPRGAFS PRGPRPVQSV VPEMEESGAQ LLLEMLTFNP HKRISAFRAL QHSYLHKEEG 300
DPE 303
Nucleotide Sequence
(FASTA)
ATGGCTACCT CTCGATATGA GCCAGTGGCT GAAATTGGTG TTGGTGCCTA TGGGACCGTG 60
TACAAGGCTC GAGACCCCCA CAGTGGCCAC TTCGTGGCCC TCAAGAGTGT GCGAGTACCC 120
AATGGAGGGG GAGCTGGAGG AGGCCTGCCC ATCAGTACAG TACGTGAGGT GGCCTTGCTA 180
AGGCGGCTGG AGGCATTCGA GCATCCCAAT GTTGTCCGGC TGATGGATGT CTGTGCCACT 240
TCTCGAACTG ACCGGGAGAT CAAAGTGACC CTAGTGTTTG AGCATGTAGA CCAAGACCTA 300
AGGACGTATC TCGACAAAGC ACCGCCACCA GGCTTGCCAG TTGAAACCAT CAAGGATTTG 360
ATGCGCCAGT TTCTAAGAGG CCTAGATTTT CTTCATGCCA ACTGCATCGT TCACCGAGAC 420
CTGAAACCAG AGAATATTCT GGTGACAAGT GGTGGAACTG TGAAGCTGGC AGACTTTGGC 480
CTAGCCCGAA TCTACAGCTA CCAGATGGCC CTTACACCGG TGGTGGTTAC ACTCTGGTAC 540
CGGGCTCCTG AAGTTCTTCT GCAGTCTACC TATGCAACAC CAGTGGACAT GTGGAGTGTT 600
GGCTGTATTT TTGCAGAGAT GTTTCGTCGA AAACCTCTCT TCTGTGGAAA CTCTGAAGCT 660
GACCAGTTGG GCAAAATCTT TGACCTGATT GGGCTGCCTC CAGAGGATGA CTGGCCACGA 720
GATGTATCTT TACCCCGAGG AGCCTTTTCC CCCAGAGGAC CTCGTCCAGT ACAGTCAGTG 780
GTACCTGAGA TGGAAGAGTC TGGAGCACAG CTACTGCTGG AGATGCTGAC ATTTAACCCA 840
CACAAGCGAA TCTCTGCCTT CCGAGCCCTG CAGCACTCTT ACCTACATAA GGAAGAAGGT 900
GACCCAGAAT AA 912
Domain Profile
S: 1     yeklekigeGtygkvykakdketgevvAlKkirlekeke...gvpitalrEisllkel..  55
         ye +++ig G+yg+vyka+d ++g++vAlK++r+ +      g+pi+++rE++ll++l  
Q: 6     YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGaggGLPISTVREVALLRRLea  65
         88899*****************************99874444***************988
S: 56    .khknivkLlevva....kdkkklyLvfefleqdLkkllkkkkkkklsleevkslllqll  110
          +h+n+v+L++v+a     ++ k++Lvfe+++qdL ++l+k +  +l+ e++k l++q+l
Q: 66    fEHPNVVRLMDVCAtsrtDREIKVTLVFEHVDQDLRTYLDKAPPPGLPVETIKDLMRQFL  125
         89************887444589*************************************
S: 111   eglaylHsnkilHRDlKpqNlLiskegklklaDfGlarafssplktytkevvTlwYraPe  170
         +gl++lH+n i+HRDlKp+N+L+++ g++klaDfGlar +s ++  +t++vvTlwYraPe
Q: 126   RGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMA-LTPVVVTLWYRAPE  184
         ******************************************999.**************
S: 171   lLlgakeYstavDiWsvgcilaelltrkplfqgkseidqlerifkllgtpsekvwpevsk  230
         +Ll+++ Y t vD+Wsvgci+ae+++rkplf g+se dql +if+l+g p e++wp+  +
Q: 185   VLLQST-YATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVS  243
         ***985.*****************************************************
S: 231   lpeykksfpkkkkkklkekvkklkekaldllekllaldpkkRisakealqhkyf  284
         lp+    f+++ ++ ++++v++++e++ +ll ++l+++p+kRisa +alqh+y+
Q: 244   LPRGA--FSPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYL  295
         ***65..9999*****************************************96
Domain Sequence
(FASTA)
YEPVAEIGVG AYGTVYKARD PHSGHFVALK SVRVPNGGGA GGGLPISTVR EVALLRRLEA 60
FEHPNVVRLM DVCATSRTDR EIKVTLVFEH VDQDLRTYLD KAPPPGLPVE TIKDLMRQFL 120
RGLDFLHANC IVHRDLKPEN ILVTSGGTVK LADFGLARIY SYQMALTPVV VTLWYRAPEV 180
LLQSTYATPV DMWSVGCIFA EMFRRKPLFC GNSEADQLGK IFDLIGLPPE DDWPRDVSLP 240
RGAFSPRGPR PVQSVVPEME ESGAQLLLEM LTFNPHKRIS AFRALQHSYL 290
KeywordATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Danio rerio"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Microcebus murinus"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Tarsius syrichta"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00068
EKS-ANC-00057
EKS-BOT-00070
EKS-CAJ-00069
EKS-CAF-00070
EKS-DAR-00083
EKS-ECT-00043
EKS-EQC-00069
EKS-ERE-00036
EKS-FEC-00069
EKS-GAA-00086
EKS-GOG-00068
EKS-HOS-00074
EKS-ICT-00064
EKS-LAC-00072
EKS-LOA-00072
EKS-MAM-00069
EKS-MAE-00028
EKS-MIM-00032
EKS-MUM-00072
EKS-MUP-00074
EKS-MYL-00074
EKS-NOL-00068
EKS-OCP-00045
EKS-ORC-00068
EKS-ORL-00079
EKS-OTG-00073
EKS-PAT-00064
EKS-POA-00068
EKS-PRC-00039
EKS-PTV-00061
EKS-RAN-00066
EKS-SAH-00064
EKS-SOA-00032
EKS-SUS-00062
EKS-TAS-00027
EKS-TUT-00064
EKS-XIM-00088
Gene Ontology
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013