EKS-CAP-00217

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAP-00217

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/LISK	471.9	4.9E-142	310	579	270

Status

Unreviewed

Ensembl Protein

ENSCPOP00000002447

UniProt Accession

H0UZ53;

Protein Name

Protein Synonyms/Alias

Gene Name

LIMK2

Gene Synonyms/Alias

LIMK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCPOG00000002696	ENSCPOP00000002447	ENSCPOT00000002730

Organism

Cavia porcellus

Functional Description

Protein Length

617

Protein Sequence
(FASTA)

MGSYLSIPAY FTSRDPFRCS ECQDSLTNWY YEKDGKLYCH KDYWGKFGEF CHGCSLLMTG 60

PVMVAGEFKY HPECFACMSC KVIIEDGDAY ALVQHASLYC GKCHNEVVLA PMFERLSTES 120

VQDQLPYSVT LISMPATTEG RRGFSVTVES ACSNYATTVQ VKEVNRTHIS PNNRNAIHPG 180

DRILEINGTP VRTLRVEEVE DAVNQTSQTL QLLIEHDPVS QRLDQLRLDA RLSPHMQNTR 240

HSHTLSTLDT KENLEGTLRR RSLRRSNSIS KSPGPSSPKE PLLLSRDISR SESLRCSSSY 300

SQQIFRPCDL IHGEVLGKGF FGQAIKVIHK ATGKVMVMKE LIRCDEETQK TFLTEVKVMR 360

SLDHPNVLKF IGVLYKDKKL NLLTEYIEGG TLKDFLRSVD PFPWQQKVRF AKGIASGMAY 420

LHSMCIIHRD LNSHNCLIKL DKTVVVADFG LSRLIVEERK RPPVEKATTK KRTLRKSDRK 480

KRYTVVGNPY WMAPEMLNGK SYDETVDVFS FGIVLCEIIG QVYADPDCLP RTLDFGLNVK 540

LFWEKFVPTD CPPAFFPLAA ICCRLEPESR PTFSKLEDSF EALSLYLGEL GIPLPTELEE 600

LDHTVSMQYG LTRDSPP 617

Nucleotide Sequence
(FASTA)

ATGGGGAGTT ACTTGTCCAT CCCGGCTTAC TTCACCTCCA GAGACCCCTT TCGGTGTTCA 60

GAATGCCAGG ATTCACTTAC TAACTGGTAC TACGAGAAGG ATGGGAAGCT CTACTGCCAC 120

AAGGACTACT GGGGGAAGTT TGGGGAATTC TGCCATGGAT GCTCCCTGCT GATGACAGGG 180

CCTGTCATGG TGGCTGGAGA GTTCAAGTAC CACCCAGAGT GCTTTGCCTG TATGAGCTGC 240

AAAGTGATCA TTGAGGATGG GGATGCATAT GCCCTGGTAC AGCATGCCTC ACTTTACTGT 300

GGGAAGTGCC ACAATGAGGT GGTGCTGGCT CCTATGTTTG AGCGGCTCTC CACAGAGTCT 360

GTTCAAGATC AGCTGCCCTA CTCCGTCACA CTCATCTCCA TGCCAGCCAC CACTGAGGGC 420

AGACGGGGCT TCTCTGTGAC TGTGGAGAGT GCCTGCTCCA ACTATGCCAC CACTGTGCAA 480

GTGAAAGAAG TCAACCGGAC GCATATCAGT CCCAACAATC GCAATGCCAT CCACCCTGGG 540

GACCGCATCC TGGAGATCAA TGGGACCCCT GTCCGCACAC TCCGAGTGGA GGAGGTGGAG 600

GATGCAGTTA ACCAAACGAG TCAGACACTT CAGCTGTTGA TAGAACACGA CCCAGTCTCC 660

CAGCGCCTGG ATCAGCTGCG GCTCGATGCT CGGCTCTCTC CCCACATGCA GAATACGAGA 720

CACTCTCATA CCCTCAGCAC CCTGGACACC AAGGAAAATC TGGAAGGGAC TCTGAGGAGA 780

CGCTCACTGA GGCGCAGTAA CAGTATCTCC AAGTCCCCTG GCCCCAGCTC ACCCAAGGAG 840

CCCCTGCTGC TCAGCCGTGA CATCAGCCGC TCAGAATCCC TCCGCTGTTC TAGCAGCTAC 900

TCACAGCAGA TCTTCCGACC ATGTGACCTG ATCCATGGGG AGGTCCTGGG GAAGGGCTTC 960

TTTGGACAGG CCATCAAGGT GATACATAAA GCCACAGGCA AAGTGATGGT CATGAAGGAG 1020

TTAATTCGAT GTGATGAAGA GACACAGAAG ACTTTTCTGA CTGAGGTGAA AGTGATGCGC 1080

AGTCTGGACC ATCCCAATGT GCTCAAGTTC ATTGGTGTGC TGTACAAGGA TAAGAAGCTG 1140

AACTTGCTGA CAGAGTACAT TGAGGGGGGC ACGCTGAAGG ACTTTCTACG CAGTGTGGAC 1200

CCATTCCCTT GGCAGCAGAA GGTCAGGTTT GCCAAAGGCA TCGCTTCTGG AATGGCCTAT 1260

TTGCACTCTA TGTGCATCAT CCACCGGGAT CTGAACTCAC ACAACTGCCT CATCAAGTTG 1320

GACAAGACTG TGGTGGTGGC AGACTTTGGG TTATCACGGC TCATAGTGGA AGAGAGGAAA 1380

AGGCCCCCAG TGGAGAAGGC CACCACTAAG AAACGCACGT TGCGCAAGAG TGACCGTAAG 1440

AAGAGGTATA CAGTAGTAGG AAACCCTTAC TGGATGGCTC CTGAGATGCT GAATGGAAAG 1500

AGCTACGACG AGACAGTGGA TGTCTTCTCT TTTGGGATCG TTCTCTGTGA GATCATTGGA 1560

CAAGTGTATG CAGATCCTGA TTGCCTGCCC CGCACACTGG ATTTTGGCCT CAACGTGAAG 1620

CTCTTCTGGG AGAAATTTGT CCCCACAGAC TGCCCCCCAG CCTTTTTCCC CCTAGCCGCT 1680

ATCTGCTGCA GACTGGAGCC TGAGAGCAGA CCAACATTCT CAAAACTGGA GGACTCCTTT 1740

GAGGCGCTCT CTTTATACCT GGGAGAGCTG GGCATCCCAC TGCCTACAGA GCTGGAGGAG 1800

CTGGACCACA CTGTGAGCAT GCAGTATGGC CTGACCCGGG ACTCACCCCC CTAA 1854

Domain Profile

S: 1     livgeklGkGffsevfkvthrasGevmvlkeliradeenrknllkevkllrklehpnvlk  60

         li+ge+lGkGff++++kv h+a+G+vmv+kelir+dee++k++l+evk++r+l+hpnvlk

Q: 310   LIHGEVLGKGFFGQAIKVIHKATGKVMVMKELIRCDEETQKTFLTEVKVMRSLDHPNVLK  369

         689*********************************************************

S: 61    fiGvlvkdkklhllteyiegGtlkellkskeslpwtqrvrlakdiasGlsylhskgiihr  120

         fiGvl+kdkkl+llteyiegGtlk++l+s +++pw+q+vr+ak+iasG++ylhs++iihr

Q: 370   FIGVLYKDKKLNLLTEYIEGGTLKDFLRSVDPFPWQQKVRFAKGIASGMAYLHSMCIIHR  429

         ************************************************************

S: 121   dlnsknclvredksvvvadfGlarlvveerkks......eklrslkkkdrkkrltvvGsP  174

         dlns+ncl++ dk+vvvadfGl+rl+veerk++      +k+r+l+k+drkkr+tvvG+P

Q: 430   DLNSHNCLIKLDKTVVVADFGLSRLIVEERKRPpvekatTKKRTLRKSDRKKRYTVVGNP  489

         *******************************999999999********************

S: 175   ywmaPevlkgksydekvdvfsfGivlceiiarveadPdylPrtedfgldvkafreklvae  234

         ywmaPe+l+gksyde+vdvfsfGivlceii++v+adPd+lPrt dfgl+vk f+ek+v++

Q: 490   YWMAPEMLNGKSYDETVDVFSFGIVLCEIIGQVYADPDCLPRTLDFGLNVKLFWEKFVPT  549

         ************************************************************

S: 235   dcPeaflklavvccdldpesrpsfeelekk  264

         dcP+af++la++cc+l+pesrp+f++le++

Q: 550   DCPPAFFPLAAICCRLEPESRPTFSKLEDS  579

         ***************************986

Domain Sequence
(FASTA)

LIHGEVLGKG FFGQAIKVIH KATGKVMVMK ELIRCDEETQ KTFLTEVKVM RSLDHPNVLK 60

FIGVLYKDKK LNLLTEYIEG GTLKDFLRSV DPFPWQQKVR FAKGIASGMA YLHSMCIIHR 120

DLNSHNCLIK LDKTVVVADF GLSRLIVEER KRPPVEKATT KKRTLRKSDR KKRYTVVGNP 180

YWMAPEMLNG KSYDETVDVF SFGIVLCEII GQVYADPDCL PRTLDFGLNV KLFWEKFVPT 240

DCPPAFFPLA AICCRLEPES RPTFSKLEDS 270

Keyword

Complete proteome; LIM domain; Metal-binding; Reference proteome; Zinc.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Choloepus hoffmanni"; ?>Danio rerio"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004672	; F:protein kinase activity
GO:0008270	; F:zinc ion binding

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR001478	; PDZ.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR001781	; Znf_LIM.

Pfam

PF00412	; LIM; 2.
PF00595	; PDZ; 1.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00132	; LIM; 1.
SM00228	; PDZ; 1.

Prosites

PS00478	; LIM_DOMAIN_1; 1.
PS50023	; LIM_DOMAIN_2; 1.
PS50106	; PDZ; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013