EKS-CAP-00253

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAP-00253

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE7	386.3	6.9E-116	69	361	293

Status

Unreviewed

Ensembl Protein

ENSCPOP00000002764

UniProt Accession

H0UZY7;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP2K1

Gene Synonyms/Alias

MAP2K1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCPOG00000003053	ENSCPOP00000002764	ENSCPOT00000003094

Organism

Cavia porcellus

Functional Description

Protein Length

393

Protein Sequence
(FASTA)

MPKKKPTPIQ LNPAPDGSAV NGTSSAETNL EALQKKLEEL ELDEQQRKRL EAFLTQKQKV 60

GELKDDDFEK ISELGAGNGG VVFKVSHKPS GLVMARKLIH LEIKPAIRNQ IIRELQVLHE 120

CNSPYIVGFY GAFYSDGEIS ICMEHMDGGS LDQVLKKAGR IPEQILGKVS IAVIKGLTYL 180

REKHKIMHRD VKPSNILVNS RGEIKLCDFG VSGQLIDSMA NSFVGTRSYM SPERLQGTHY 240

SVQSDIWSMG LSLVEMAVGR YPIPPPDAKE LELVFGCQVE GDAAEMPPRP RTPGRPLSSY 300

GMDSRPPMAI FELLDYIVNE PPPKLPSGVF SLEFQDFVNK CLIKNPAERA DLKQLMVHAF 360

IKRSDAEEVD FAGWLCATIG LNQPSTPTHV ASI 393

Nucleotide Sequence
(FASTA)

ATGCCCAAGA AGAAGCCGAC GCCCATCCAG CTGAACCCGG CCCCCGACGG CTCGGCGGTG 60

AACGGGACCA GCTCGGCCGA GACCAACCTA GAGGCTTTGC AGAAGAAGCT GGAGGAGCTG 120

GAGCTGGATG AGCAGCAGCG GAAGCGCCTC GAAGCTTTCC TGACACAGAA GCAGAAGGTG 180

GGCGAGCTGA AGGACGATGA CTTTGAGAAG ATCAGTGAGC TGGGTGCCGG CAATGGCGGT 240

GTGGTGTTCA AGGTCTCCCA CAAGCCATCT GGCCTGGTCA TGGCCCGAAA GCTTATCCAC 300

CTGGAGATCA AGCCAGCCAT CCGCAATCAG ATCATCCGTG AGCTGCAGGT TCTGCACGAG 360

TGCAACTCGC CCTACATTGT GGGCTTCTAT GGGGCCTTCT ACAGTGATGG CGAGATCAGC 420

ATCTGCATGG AGCACATGGA TGGAGGTTCC TTGGATCAAG TCCTGAAGAA AGCTGGAAGA 480

ATTCCTGAGC AAATTTTAGG AAAAGTTAGC ATTGCTGTGA TCAAAGGCCT GACATACCTG 540

AGGGAGAAGC ACAAGATTAT GCACAGAGAT GTCAAGCCCT CCAACATCCT GGTCAACTCC 600

CGCGGGGAGA TCAAGCTCTG TGACTTTGGG GTCAGCGGGC AGCTCATCGA TTCCATGGCC 660

AACTCCTTCG TGGGCACCCG GTCCTACATG TCGCCAGAGA GACTGCAGGG CACACACTAC 720

TCAGTGCAGT CGGACATCTG GAGCATGGGA CTGTCACTGG TGGAGATGGC GGTTGGGAGG 780

TACCCCATCC CCCCTCCAGA TGCCAAGGAG CTGGAGCTGG TGTTCGGGTG CCAGGTGGAA 840

GGAGATGCAG CTGAGATGCC GCCCAGGCCC AGGACCCCCG GAAGACCCCT GAGCTCATAT 900

GGAATGGACA GCCGGCCTCC CATGGCGATT TTCGAGCTGT TGGATTACAT AGTCAACGAG 960

CCACCTCCCA AACTGCCCAG TGGAGTCTTC AGTCTGGAAT TCCAGGACTT TGTAAATAAA 1020

TGCTTAATAA AGAACCCTGC GGAGAGAGCA GACTTGAAGC AGCTCATGGT TCATGCCTTC 1080

ATCAAGCGCT CTGATGCTGA GGAGGTGGAC TTCGCAGGTT GGCTCTGTGC CACCATCGGC 1140

CTTAACCAGC CCAGTACCCC GACCCACGTG GCCAGCATC 1179

Domain Profile

S: 2     ekleelGaGnggvVekvlhkksgkilavKtirleikkeeqkqilrelevlkkssnspyiv  61

         ek++elGaGnggvV kv+hk+sg ++a+K i+leik+++++qi+rel+vl+++ nspyiv

Q: 69    EKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHEC-NSPYIV  127

         799**************************************************.******

S: 62    kfyGafvsegdvsicmelmdgtsldkvlkkvlekkkripekvlgkiavavvkaleylkek  121

         +fyGaf+s+g++sicme+mdg+sld+vlkk    ++ripe++lgk+++av+k+l+yl+ek

Q: 128   GFYGAFYSDGEISICMEHMDGGSLDQVLKK----AGRIPEQILGKVSIAVIKGLTYLREK  183

         *****************************9....8*************************

S: 122   lkiiHRDvKPsNiLvnskGevKlCDFGvsgqlvdsiAksavGtksYmaPEriegkkkYsv  181

         +ki+HRDvKPsNiLvns+Ge+KlCDFGvsgql+ds+A+s+vGt+sYm+PEr++g ++Ysv

Q: 184   HKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQG-THYSV  242

         ******************************************************.*****

S: 182   ksdvWslGltlvelatgrypyeklke..................................  207

         +sd+Ws+Gl+lve+a+gryp++++++

Q: 243   QSDIWSMGLSLVEMAVGRYPIPPPDAkelelvfgcqvegdaaempprprtpgrplssygm  302

         ************************999*********************************

S: 208   .......ilellkaivneeppklpeeefseefqefvskClkkdekeRpklkellkhafi  259

                i+ell++ivne+ppklp+  fs efq+fv+kCl+k+++eR++lk+l+ hafi

Q: 303   dsrppmaIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFI  361

         *********************************************************97

Domain Sequence
(FASTA)

EKISELGAGN GGVVFKVSHK PSGLVMARKL IHLEIKPAIR NQIIRELQVL HECNSPYIVG 60

FYGAFYSDGE ISICMEHMDG GSLDQVLKKA GRIPEQILGK VSIAVIKGLT YLREKHKIMH 120

RDVKPSNILV NSRGEIKLCD FGVSGQLIDS MANSFVGTRS YMSPERLQGT HYSVQSDIWS 180

MGLSLVEMAV GRYPIPPPDA KELELVFGCQ VEGDAAEMPP RPRTPGRPLS SYGMDSRPPM 240

AIFELLDYIV NEPPPKLPSG VFSLEFQDFV NKCLIKNPAE RADLKQLMVH AFI 293

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Taeniopygia guttata"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013