EKS-CAP-00007
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-CAP-00007
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Eph489.02.2E-147613871259
StatusUnreviewed
Ensembl ProteinENSCPOP00000002774
UniProt AccessionH0UZZ7;
Protein Name
Protein Synonyms/Alias
Gene NameEPHA2
Gene Synonyms/Alias EPHA2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSCPOG00000003065ENSCPOP00000002774ENSCPOT00000003106
OrganismCavia porcellus
Functional Description
Protein Length976
Protein Sequence
(FASTA)
IEYRAVRACL ALLWGCAMVA AAVAQGKEVV LLDLAEAKGE LGWLTYPYGK GWDLAQNIMD 60
DMPIYMYTVC NVVTGDQDNW LRTNWVYRGE AERIFIELKF TVRDCNSFPG GASSCKETFN 120
LYYFESDMDY GTNFQKRHFT KIDTIAPDEI TLTSDFEARH VKLNVEERTV GPLTRKGFYL 180
AFQDIGACVA LLSVRVYYKK CPEMVQGLAR FPETIAGSDA PSLATVAGTC VEHAVVLPGG 240
EEPRMHCAVD GEWLVPIGQC LCEEGYEKVE DTCQACSPGF FKSQASESPC LQCPAHTLPS 300
LQGATSCECE EGYFRAPEDA LSTPCTRPPS APHYLTAVGM GAKVELRWTP PQDTGGREDI 360
VYRVTCEQCW PESGECGPCE ASVRYSEPPH ALTRTSVTVS DLEPHMNYTF AVEARNGVSG 420
LVTSRSFRTA SVSINQTEPP KVRLEGRTTT SLTVTWSIPV PQRSRVWKYE VTYHKKGDAN 480
SYNVHRTEGF SVTLENLAPD TTYLVQVQAL TQEGQGAGSK EHEFQTLSLE GSSNMAMIGG 540
VAVGVILLLV LAGIGFFIHH RRRRLRARQS SEDVYFSKSE QLKPLKTYVD PHTYEDPNQA 600
VLKFTTEIHP SCITRQKVIG AGEFGEVYKG TLKSSSGKKE VPVAIKTLKA GYTEKQRVDF 660
LSEASIMGQF SHHNIIRLEG VISKYKPMMI ITEYMENGAL DKFLREKDGE FSVLQLVGML 720
RGIASGMKYL ANMNYVHRDL AARNILVNSN LVCKVSDFGL SRVLEDDPEA TYTTSGGKIP 780
IRWTAPEAIS YRKFTSASDV WSYGIVMWEV MTYGERPYWE LSNHEVMKAI NDGFRLPTPM 840
DCPSAIYQLM MQCWQQERAR RPKFADIVSI LDKLIRAPNS LKTLADFDPR VSIRLPSTSG 900
SEGVPFRTVS EWLESIKMQQ YTEHFMAAGY TAIEKVVQMT SEDIKRIGVR LPGHQKRIAY 960
SLLGLKDQVN TVGIPI 976
Nucleotide Sequence
(FASTA)
ATTGAGTACC GGGCGGTCCG CGCCTGCCTG GCCCTGCTGT GGGGCTGCGC GATGGTGGCG 60
GCCGCGGTGG CGCAGGGCAA GGAAGTCGTC CTGTTGGACC TCGCAGAAGC CAAAGGGGAG 120
CTCGGCTGGC TCACATATCC TTACGGCAAA GGGTGGGACC TGGCACAGAA CATCATGGAC 180
GACATGCCCA TCTATATGTA CACGGTGTGC AACGTGGTGA CCGGTGACCA GGACAACTGG 240
CTGCGCACTA ACTGGGTATA CCGTGGCGAG GCCGAGCGGA TTTTCATCGA GCTCAAGTTC 300
ACCGTGCGGG ATTGCAACAG CTTCCCCGGC GGCGCCAGCT CCTGCAAAGA GACCTTCAAC 360
CTCTACTACT TTGAGTCGGA CATGGACTAC GGCACCAACT TCCAGAAGCG CCATTTCACA 420
AAGATCGACA CCATCGCGCC CGATGAGATC ACCCTCACCA GTGACTTCGA GGCCCGCCAT 480
GTGAAGCTGA ACGTGGAGGA GCGCACTGTG GGGCCGCTCA CGCGCAAGGG CTTCTACCTG 540
GCCTTCCAGG ACATCGGGGC CTGCGTGGCG CTGCTCTCTG TCCGTGTCTA CTACAAGAAG 600
TGCCCAGAGA TGGTGCAGGG GCTGGCACGC TTCCCCGAGA CCATTGCGGG CTCGGACGCA 660
CCGTCCCTGG CCACGGTGGC CGGCACCTGT GTGGAGCACG CCGTGGTGCT CCCCGGGGGA 720
GAAGAACCCC GCATGCACTG CGCAGTGGAC GGCGAGTGGC TGGTGCCCAT CGGGCAGTGC 780
CTGTGTGAAG AAGGCTATGA GAAGGTGGAG GACACCTGCC AAGCCTGTTC ACCGGGATTC 840
TTCAAGTCCC AGGCATCCGA GAGCCCCTGC CTGCAGTGCC CGGCACACAC GCTGCCATCC 900
CTCCAAGGCG CCACCTCCTG CGAGTGTGAG GAAGGCTACT TCCGGGCCCC CGAGGACGCA 960
CTGTCTACGC CCTGCACACG CCCGCCGTCC GCCCCACACT ACCTCACCGC CGTGGGCATG 1020
GGTGCCAAGG TGGAGCTGCG CTGGACGCCG CCCCAGGACA CGGGGGGCCG CGAGGACATT 1080
GTCTACAGGG TCACCTGTGA GCAGTGCTGG CCGGAGTCCG GCGAGTGTGG GCCCTGCGAG 1140
GCCAGCGTGC GCTACTCAGA GCCGCCACAT GCGCTCACCC GCACCAGCGT GACGGTCAGC 1200
GACCTGGAGC CACACATGAA CTACACCTTT GCCGTGGAAG CCCGCAACGG GGTCTCGGGC 1260
CTGGTGACCA GCCGCAGCTT CCGCACCGCC AGTGTCAGCA TCAACCAGAC AGAACCCCCC 1320
AAAGTAAGGC TGGAGGGCCG CACCACCACG TCACTGACTG TCACCTGGAG CATCCCTGTG 1380
CCACAGCGCA GCCGTGTGTG GAAGTATGAA GTCACCTACC ACAAGAAGGG GGATGCCAAC 1440
AGCTACAATG TGCACCGCAC CGAGGGCTTC TCTGTGACCC TGGAGAACCT GGCACCGGAC 1500
ACCACCTACC TGGTCCAGGT GCAGGCGCTG ACGCAGGAGG GCCAGGGAGC CGGCAGCAAG 1560
GAGCATGAGT TCCAAACCCT GTCCTTGGAA GGATCTAGCA ACATGGCCAT GATCGGTGGT 1620
GTGGCCGTCG GTGTCATCCT ACTCCTAGTG CTGGCTGGAA TTGGTTTCTT CATCCATCAC 1680
AGGAGGAGGA GGCTGCGGGC CCGCCAGTCC TCAGAGGATG TCTATTTCTC CAAGTCAGAA 1740
CAACTGAAGC CCCTGAAGAC ATACGTGGAC CCCCACACAT ATGAAGACCC TAACCAGGCT 1800
GTGCTGAAGT TCACCACGGA GATCCACCCG TCCTGCATCA CGCGGCAGAA GGTGATCGGG 1860
GCAGGAGAGT TTGGGGAGGT GTACAAGGGG ACCCTGAAGT CATCCTCGGG GAAGAAGGAG 1920
GTGCCCGTGG CCATCAAGAC GCTGAAAGCC GGCTACACGG AGAAGCAGCG AGTGGACTTC 1980
CTGAGCGAGG CCAGCATCAT GGGCCAGTTC AGCCACCACA ACATCATCCG CCTGGAGGGC 2040
GTCATCTCCA AATACAAACC CATGATGATC ATCACAGAGT ACATGGAGAA TGGAGCCCTG 2100
GACAAGTTCC TTCGGGAGAA GGACGGCGAA TTCAGCGTGC TACAGCTGGT GGGCATGCTG 2160
CGGGGCATCG CGTCCGGCAT GAAGTACCTG GCCAACATGA ATTACGTGCA CCGCGATCTG 2220
GCCGCCCGCA ACATCCTCGT CAACAGCAAC CTGGTCTGCA AAGTGTCTGA CTTCGGTCTG 2280
TCCCGAGTGC TGGAGGACGA CCCCGAGGCC ACCTATACCA CCAGTGGTGG CAAGATCCCA 2340
ATCCGCTGGA CAGCCCCAGA GGCCATCTCC TATCGCAAGT TCACCTCAGC CAGCGATGTG 2400
TGGAGCTACG GCATTGTCAT GTGGGAGGTG ATGACCTACG GTGAGCGGCC CTACTGGGAG 2460
CTGTCGAACC ACGAGGTGAT GAAAGCCATC AACGACGGCT TCCGGCTCCC CACGCCCATG 2520
GACTGTCCCT CGGCCATCTA CCAACTCATG ATGCAATGCT GGCAGCAGGA GCGCGCCCGG 2580
CGCCCCAAGT TTGCAGACAT CGTCAGCATC CTTGACAAGC TCATCCGAGC CCCCAACTCC 2640
CTCAAGACCC TCGCTGACTT TGACCCCCGG GTGTCCATCC GGCTGCCGAG CACCAGCGGC 2700
TCGGAGGGCG TCCCCTTCCG CACGGTGTCC GAGTGGCTAG AGTCCATCAA GATGCAGCAG 2760
TACACGGAGC ACTTCATGGC AGCCGGCTAC ACCGCCATCG AGAAGGTGGT GCAGATGACC 2820
AGCGAAGACA TCAAGAGGAT CGGGGTGCGG CTGCCCGGCC ACCAGAAGCG CATTGCCTAC 2880
AGCCTGCTGG GACTCAAGGA CCAGGTGAAC ACGGTGGGGA TCCCCATCTG A 2931
Domain Profile
S: 1     vkiekviGaGefGevcsGrlkl.pgkreiavaiktlkagstekqrrdflseasilGqfdh  59
         ++ +kviGaGefGev++G+lk  +gk+e++vaiktlkag+tekqr+dflseasi+Gqf+h
Q: 613   ITRQKVIGAGEFGEVYKGTLKSsSGKKEVPVAIKTLKAGYTEKQRVDFLSEASIMGQFSH  672
         56789****************9678***********************************
S: 60    pniirleGvvtkskpvmivteymengaldsflrkkdgqftviqlvgmlrGiasgmkylsd  119
         +niirleGv++k kp+mi+teymengald+flr+kdg+f+v+qlvgmlrGiasgmkyl++
Q: 673   HNIIRLEGVISKYKPMMIITEYMENGALDKFLREKDGEFSVLQLVGMLRGIASGMKYLAN  732
         ************************************************************
S: 120   mgyvhrdlaarnilvnsnlvckvsdfGlsrvleddseaayttsggkipirwtapeaiayr  179
         m+yvhrdlaarnilvnsnlvckvsdfGlsrvledd+ea+yttsggkipirwtapeai+yr
Q: 733   MNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTSGGKIPIRWTAPEAISYR  792
         ************************************************************
S: 180   kftsasdvwsyGivlwevlsyGerpywdmsnqdvikaieegyrlpppmdcpaalyqlmld  239
         kftsasdvwsyGiv+wev++yGerpyw++sn++v+kai++g+rlp+pmdcp+a+yqlm++
Q: 793   KFTSASDVWSYGIVMWEVMTYGERPYWELSNHEVMKAINDGFRLPTPMDCPSAIYQLMMQ  852
         ************************************************************
S: 240   cwqkdraerpkfeqivsil  258
         cwq++ra+rpkf++ivsil
Q: 853   CWQQERARRPKFADIVSIL  871
         ****************985
Domain Sequence
(FASTA)
ITRQKVIGAG EFGEVYKGTL KSSSGKKEVP VAIKTLKAGY TEKQRVDFLS EASIMGQFSH 60
HNIIRLEGVI SKYKPMMIIT EYMENGALDK FLREKDGEFS VLQLVGMLRG IASGMKYLAN 120
MNYVHRDLAA RNILVNSNLV CKVSDFGLSR VLEDDPEATY TTSGGKIPIR WTAPEAISYR 180
KFTSASDVWS YGIVMWEVMT YGERPYWELS NHEVMKAIND GFRLPTPMDC PSAIYQLMMQ 240
CWQQERARRP KFADIVSIL 259
KeywordATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00009
EKS-ANC-00009
EKS-BOT-00008
EKS-CAJ-00009
EKS-CAF-00010
EKS-DAR-00015
EKS-EQC-00010
EKS-FEC-00007
EKS-GAM-00004
EKS-GAA-00016
EKS-GOG-00009
EKS-HOS-00011
EKS-ICT-00009
EKS-LAC-00010
EKS-LOA-00010
EKS-MAM-00009
EKS-MAE-00001
EKS-MEG-00012
EKS-MUM-00010
EKS-MUP-00010
EKS-MYL-00011
EKS-NOL-00009
EKS-OCP-00002
EKS-ORN-00018
EKS-ORA-00008
EKS-ORC-00009
EKS-ORL-00015
EKS-OTG-00010
EKS-PAT-00012
EKS-PES-00008
EKS-POA-00010
EKS-RAN-00009
EKS-SAH-00008
EKS-SUS-00007
EKS-TAR-00014
EKS-TEN-00014
EKS-XIM-00015
Gene Ontology
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0005003; F:ephrin receptor activity
KEGG
InterPros
IPR001090; Ephrin_rcpt_lig-bd_dom.
IPR003961; Fibronectin_type3.
IPR008979; Galactose-bd-like.
IPR009030; Growth_fac_rcpt.
IPR013783; Ig-like_fold.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001660; SAM.
IPR013761; SAM/pointed.
IPR021129; SAM_type1.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016257; Tyr_kinase_ephrin_rcpt.
IPR001426; Tyr_kinase_rcpt_V_CS.
Pfam
PF01404; Ephrin_lbd; 1.
PF00041; fn3; 2.
PF07714; Pkinase_Tyr; 1.
PF00536; SAM_1; 1.
SMARTs
SM00615; EPH_lbd; 1.
SM00060; FN3; 2.
SM00454; SAM; 1.
SM00219; TyrKc; 1.
Prosites
PS51550; EPH_LBD; 1.
PS50853; FN3; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00790; RECEPTOR_TYR_KIN_V_1; 1.
PS00791; RECEPTOR_TYR_KIN_V_2; 1.
PS50105; SAM_DOMAIN; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013