EKS-CAP-00452

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAP-00452

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/WEE	336.7	8.1E-101	277	548	272

Status

Unreviewed

Ensembl Protein

ENSCPOP00000002822

UniProt Accession

H0V042;

Protein Name

Protein Synonyms/Alias

Gene Name

WEE1

Gene Synonyms/Alias

WEE1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCPOG00000003116	ENSCPOP00000002822	ENSCPOT00000003159

Organism

Cavia porcellus

Functional Description

Protein Length

625

Protein Sequence
(FASTA)

MSFLSRQQPP PSRRARAACS LRQKLIFSPC SDGSGHSTGE DSAFQEPDSP LPPAQSPTDP 60

GPESRRSPGQ APGSPGELEE EDMLLEGASP GADRDAAGGG AEGDSWEEEG FGSSSPVKSP 120

AAAYFLGSAF SPLRSGGAGG EGPGSPRPEQ PGTPPHKTFR KLRLFDTPHT PKSLLSKARG 180

IDSSSVKLRG SLFMDSEKSG KREYDIRQTP QVNINPFTPD SVLLHSSGQC RGRKRAYWND 240

SCEDMEVSDY EFEDETRPAK RITITESNMK SRYTTEFHEL EKIGSGEFGS VFKCVKRLDG 300

CIYAIKRSKK PLAGSVDEQN ALREVYAHAV LGQHSHVVRY FLCLGRKNDH MLSLNSYSNC 360

GSLADAISEN YRIMSYFKEV DLKDLLLQVG RGLRYIHSMS LVHMDIKPSN IFISRTSIPN 420

AASEEGDEDD WVSNRVMFKI GDLGHVTRIS SPQVEEGDSR FLANEVLQEN YTHLPKADIF 480

ALALTVVCAA GAEPLPRNGE QWHEIRQGRL PRIPQVLSQE FTELLKVMIH PDPERRPSAM 540

ALVKHSVLLS ASRKSAEQLR IELNAEKFKN SLLQKELKKA QMAKAAAEER ALFTDRMATR 600

STTQSNRTSR LIGKKMNRSV SLTIY 625

Nucleotide Sequence
(FASTA)

ATGAGCTTCC TCAGCCGGCA GCAGCCGCCG CCTTCCCGTC GCGCGAGGGC CGCCTGCAGC 60

TTGCGGCAGA AGCTGATCTT CTCGCCGTGC AGCGACGGCA GCGGCCACAG CACTGGCGAG 120

GACTCGGCCT TCCAGGAGCC CGACTCGCCG CTGCCGCCAG CGCAGAGTCC CACGGACCCC 180

GGGCCCGAGA GCCGCCGCTC GCCCGGCCAG GCGCCTGGCA GCCCTGGGGA ACTGGAGGAG 240

GAGGACATGC TGCTGGAGGG CGCCAGCCCC GGCGCCGACA GGGATGCGGC GGGCGGTGGC 300

GCCGAGGGCG ACTCGTGGGA GGAGGAGGGT TTCGGTTCGT CGTCGCCGGT CAAGTCGCCG 360

GCCGCCGCCT ACTTCCTGGG CAGCGCTTTC TCCCCGCTGC GCAGCGGCGG GGCTGGGGGC 420

GAGGGGCCCG GCTCTCCGCG GCCGGAGCAG CCGGGCACCC CGCCGCACAA GACCTTTCGC 480

AAGCTGAGGC TCTTCGACAC CCCGCACACG CCCAAGAGTT TGCTTTCCAA AGCTCGAGGA 540

ATTGATTCCA GCTCTGTTAA ACTTCGTGGT TCTCTTTTCA TGGACTCAGA AAAATCAGGA 600

AAAAGAGAGT ATGACATACG ACAGACTCCA CAAGTGAATA TCAATCCTTT TACCCCGGAT 660

TCTGTGTTGC TTCATTCCTC AGGACAATGT CGAGGGAGAA AGAGAGCATA CTGGAATGAT 720

TCCTGTGAAG ACATGGAAGT CAGTGATTAT GAGTTTGAAG ATGAAACAAG ACCTGCTAAG 780

AGAATTACAA TTACTGAAAG CAATATGAAG TCAAGATATA CGACAGAATT TCATGAACTG 840

GAGAAAATTG GCTCTGGGGA ATTTGGTTCT GTATTTAAGT GTGTGAAGAG GCTGGATGGA 900

TGCATTTATG CCATTAAGCG ATCAAAAAAG CCATTGGCTG GTTCTGTTGA TGAGCAGAAT 960

GCTTTGAGAG AGGTATATGC TCATGCAGTG CTTGGACAGC ATTCTCATGT GGTTCGCTAT 1020

TTTCTCTGCC TTGGGCGAAA GAATGATCAT ATGCTTTCTC TTAATTCTTA TTCAAATTGT 1080

GGAAGTTTAG CTGATGCTAT AAGTGAAAAC TACAGAATCA TGAGTTACTT TAAAGAAGTG 1140

GATTTGAAGG ATCTCCTTTT ACAAGTTGGT CGGGGTTTAA GATATATTCA TTCAATGTCT 1200

TTGGTTCACA TGGATATAAA ACCTAGTAAT ATTTTCATAT CTCGAACTTC CATCCCGAAT 1260

GCTGCCTCTG AAGAAGGAGA TGAGGATGAC TGGGTATCCA ACAGAGTTAT GTTTAAAATA 1320

GGTGATCTTG GGCATGTAAC AAGAATCTCT AGTCCACAAG TCGAAGAGGG TGATAGTCGT 1380

TTTCTTGCAA ATGAAGTTTT ACAGGAGAAT TATACCCATC TGCCAAAAGC GGATATTTTT 1440

GCCCTTGCCC TCACGGTAGT TTGTGCTGCT GGTGCTGAAC CTCTTCCCAG AAATGGAGAG 1500

CAGTGGCATG AAATCAGACA GGGAAGATTA CCTCGGATTC CACAAGTGCT TTCCCAGGAA 1560

TTTACAGAGT TGCTAAAAGT TATGATTCAT CCAGATCCAG AGAGAAGACC ATCAGCAATG 1620

GCACTGGTAA AGCATTCAGT ATTGTTGTCT GCATCTAGAA AGAGTGCTGA ACAATTACGA 1680

ATAGAATTGA ATGCTGAAAA GTTCAAAAAT TCACTTTTGC AAAAAGAACT CAAGAAAGCT 1740

CAAATGGCAA AAGCTGCGGC TGAGGAAAGA GCCCTGTTCA CTGACCGGAT GGCCACTAGA 1800

TCTACCACCC AGAGTAATAG AACCTCTCGA CTTATTGGAA AGAAAATGAA CCGCTCTGTC 1860

AGCCTTACTA TATACTGA 1878

Domain Profile

S: 1     FeevekiGkGefgevfkvvkredgklyAikkskkplkglskekkalrEvtahavlgqhen  60

         F+e+ekiG+Gefg+vfk+vkr+dg++yAik+skkpl+g+++e++alrEv+ahavlgqh++

Q: 277   FHELEKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQNALREVYAHAVLGQHSH  336

         99**********************************************************

S: 61    vvryisaW.eeddslyiqtElCeggsLeaalqeceakkkaleeaelkkilldlllglryl  119

         vvry+    +++d+++  + + + gsL++a++e+++++++++e  lk++ll++ +glry+

Q: 337   VVRYFLCLgRKNDHMLSLNSYSNCGSLADAISENYRIMSYFKEVDLKDLLLQVGRGLRYI  396

         ****99873677899999******************************************

S: 120   HssslvHlDikpenifi...................tkevtlklgDlGlvtelnsedksk  160

         Hs+slvH+Dikp+nifi                   +++v++k+gDlG+vt++   ++++

Q: 397   HSMSLVHMDIKPSNIFIsrtsipnaaseegdeddwvSNRVMFKIGDLGHVTRI---SSPQ  453

         *****************************************************...9***

S: 161   veEGDsrylakEilqeeyskl.kaDiFslgltilevaanvelPsnGeaWhklRkgklpde  219

         veEGDsr+la+E+lqe+y++l kaDiF+l+lt++++a++++lP+nGe+Wh++R+g+lp +

Q: 454   VEEGDSRFLANEVLQENYTHLpKADIFALALTVVCAAGAEPLPRNGEQWHEIRQGRLP-R  512

         **********************************************************.*

S: 220   ilkelsedlrellklmlepdperRptaeellkhevl  255

         i ++ls++++ellk+m++pdperRp+a++l+kh+vl

Q: 513   IPQVLSQEFTELLKVMIHPDPERRPSAMALVKHSVL  548

         *********************************986

Domain Sequence
(FASTA)

FHELEKIGSG EFGSVFKCVK RLDGCIYAIK RSKKPLAGSV DEQNALREVY AHAVLGQHSH 60

VVRYFLCLGR KNDHMLSLNS YSNCGSLADA ISENYRIMSY FKEVDLKDLL LQVGRGLRYI 120

HSMSLVHMDI KPSNIFISRT SIPNAASEEG DEDDWVSNRV MFKIGDLGHV TRISSPQVEE 180

GDSRFLANEV LQENYTHLPK ADIFALALTV VCAAGAEPLP RNGEQWHEIR QGRLPRIPQV 240

LSQEFTELLK VMIHPDPERR PSAMALVKHS VL 272

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004715	; F:non-membrane spanning protein tyrosine kinase activity
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007067	; P:mitosis

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR017164	; Wee1-like_protein_kinase.

Pfam

PF00069

; Pkinase; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013