EKS-CAP-00439
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-CAP-00439
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Trk533.01.2E-160512781270
StatusUnreviewed
Ensembl ProteinENSCPOP00000002894
UniProt AccessionH0V0A7;
Protein NameTyrosine-protein kinase receptor
Protein Synonyms/Alias
Gene NameNTRK1
Gene Synonyms/Alias NTRK1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSCPOG00000003195ENSCPOP00000002894ENSCPOT00000003238
OrganismCavia porcellus
Functional Description
Protein Length798
Protein Sequence
(FASTA)
MLRGRRRGQA RWHCRATVLG NLLPWLMLAS VGATSCPDVC CPFSPSGLRC TRASTLNSLR 60
QLPGAENLTE LYVENQHHLQ HLELRDLQGL GELRNLTIVK SGLRFVAPEA FHFTPRLSRL 120
NLSFNDLESL SWRAVQGLSL QELVLSGNPL RCSCALHWLQ RWEEKGLGRV HTQGLRCLGP 180
RNESLPLSHN TSCGVPTVKV QMSSDSVDVG DNVLLQCHVE GQDLQQAGWI LTELEESATV 240
TKSGDLPSLE LTLANVTRSL NRKNVTCWAE NDVGRAENSV QVNVSFAASV HLEDAVEQHH 300
WCIPFTVDGQ PAPSLRWLFN GSVLNETGFI FTQFLESAPN ETARHGCLRL NQPTHVNNGI 360
YTLLADNPLG QANASISVAF MDNPFQFNPE DPIPVSFSPV DTNSTSGHPV EKKDETPFGV 420
SVAVGLAVFA CLFLSAVLLV LNKCGQRNKF GINRPAVLAP EDGLAMSLHF MTLGGSSLSP 480
AEGKGSGLQG HIIENPQYFS DACVHHIKRR DIVLKWELGE GAFGKVFLAE CHNLLPDQDK 540
MLVAVKALKE VSESARQDFQ REAELLTMLQ HQHIVRFFGV CTEGRPLLMI FEYMRHGDLN 600
RFLRSHGPDA KLLAGGEDVA PGPLGLGQLL AVASQVAAGM VYLASLHFVH RDLATRNCLV 660
GQGLVVKIGD FGMSRDIYST DYYRVGGRTM LPIRWMPPES ILYRKFTAES DVWSFGVVLW 720
EIFTYGQQPW YQLSNAEAIE CITQGRELER PRACPPEVYA IMRGCWQREP QQRHSIKDVH 780
ARLQVLAQAP PVYLDVLG 798
Nucleotide Sequence
(FASTA)
ATGCTGCGAG GCAGACGTCG CGGGCAGGCC CGCTGGCACT GCCGAGCCAC CGTGCTGGGC 60
AACCTGCTGC CCTGGCTGAT GCTAGCATCT GTGGGCGCCA CGTCCTGCCC TGATGTCTGC 120
TGCCCCTTCA GTCCCTCGGG GCTGCGTTGC ACCAGGGCTT CGACACTAAA TAGCCTCCGC 180
CAACTGCCGG GCGCCGAGAA CCTGACAGAG CTTTATGTGG AGAACCAGCA TCATCTGCAG 240
CATCTGGAGC TCCGTGACCT GCAGGGCCTG GGGGAACTAA GAAACCTCAC CATCGTGAAG 300
AGTGGTCTCC GTTTCGTGGC GCCAGAAGCC TTCCATTTCA CTCCTCGGCT CAGTCGCCTG 360
AACCTCTCCT TCAATGATCT GGAGTCTCTG TCCTGGAGAG CAGTGCAGGG CCTGTCCTTA 420
CAGGAGCTGG TCCTGTCTGG GAATCCCCTG CGATGTTCCT GTGCCCTGCA CTGGCTGCAG 480
CGCTGGGAGG AGAAGGGGCT GGGCAGAGTG CACACACAGG GGCTACGCTG TCTGGGGCCT 540
AGGAATGAGA GCTTGCCACT CAGCCACAAC ACCAGCTGCG GTGTGCCCAC AGTGAAGGTC 600
CAGATGTCCA GTGATTCTGT GGATGTGGGG GACAACGTGT TGCTACAGTG CCATGTGGAG 660
GGGCAGGACC TGCAGCAGGC TGGCTGGATC CTCACAGAGC TGGAGGAGTC GGCCACAGTG 720
ACGAAATCGG GGGATTTGCC GTCCTTGGAG CTGACCTTAG CCAATGTCAC CAGGAGCCTC 780
AACAGGAAGA ACGTGACATG CTGGGCAGAG AATGATGTGG GCCGGGCTGA GAACTCTGTC 840
CAGGTCAATG TCTCCTTTGC GGCCAGCGTA CACCTGGAGG ACGCTGTGGA GCAGCACCAC 900
TGGTGCATTC CCTTTACCGT GGATGGCCAG CCGGCACCCT CCCTGCGCTG GCTCTTCAAC 960
GGCTCCGTGC TCAACGAGAC TGGCTTCATC TTCACCCAGT TCCTGGAGTC AGCACCCAAC 1020
GAGACGGCGC GCCATGGCTG CCTGCGCCTC AACCAGCCCA CACACGTCAA CAACGGCATC 1080
TACACGCTGC TGGCTGACAA CCCATTGGGC CAGGCTAATG CCTCCATCTC AGTAGCCTTT 1140
ATGGACAACC CCTTCCAGTT CAACCCTGAG GACCCCATCC CCGTCTCATT CTCACCTGTG 1200
GACACTAACA GCACATCTGG ACACCCAGTG GAGAAGAAGG ATGAAACGCC TTTTGGGGTC 1260
TCCGTGGCTG TGGGCTTGGC TGTCTTTGCC TGCCTCTTCC TTTCCGCCGT GCTCCTCGTG 1320
CTCAACAAAT GTGGACAGAG AAACAAGTTT GGGATCAACC GCCCTGCTGT GCTGGCTCCA 1380
GAGGATGGGC TGGCCATGTC TCTGCATTTC ATGACATTGG GTGGCAGCTC TCTTTCGCCT 1440
GCTGAGGGCA AAGGTTCTGG ACTGCAAGGC CATATCATCG AGAACCCACA GTACTTCAGT 1500
GATGCCTGTG TCCATCACAT CAAGCGCCGG GACATTGTGC TCAAGTGGGA GCTGGGAGAG 1560
GGCGCCTTTG GAAAGGTCTT CCTTGCTGAG TGTCACAACC TGCTTCCTGA CCAGGATAAG 1620
ATGCTGGTGG CTGTTAAGGC TTTGAAGGAA GTGTCAGAGA GTGCTCGGCA AGACTTCCAG 1680
CGGGAGGCAG AGCTACTTAC CATGCTGCAG CACCAGCATA TTGTGCGCTT CTTTGGGGTC 1740
TGCACAGAGG GCCGCCCACT GCTGATGATC TTTGAGTACA TGCGGCATGG GGACCTCAAT 1800
CGCTTCCTCC GGTCCCACGG GCCTGATGCC AAGCTGCTGG CTGGCGGGGA GGATGTGGCT 1860
CCGGGTCCTC TGGGCCTTGG GCAGCTGCTG GCTGTGGCTA GCCAGGTGGC AGCAGGCATG 1920
GTTTACCTGG CCAGCCTTCA CTTTGTGCAC CGTGACCTGG CCACCCGCAA CTGTCTGGTG 1980
GGCCAGGGTC TGGTGGTCAA GATCGGGGAT TTCGGCATGA GCAGGGACAT CTACAGCACC 2040
GACTACTACC GCGTGGGGGG CCGCACCATG CTGCCCATCC GCTGGATGCC CCCTGAGAGC 2100
ATTCTCTACC GAAAGTTCAC TGCGGAGAGC GATGTGTGGA GCTTCGGTGT GGTGCTGTGG 2160
GAGATCTTCA CCTACGGCCA GCAGCCCTGG TACCAGCTCT CCAACGCCGA GGCAATCGAG 2220
TGCATCACAC AGGGCCGTGA ACTGGAGCGG CCCCGTGCCT GCCCTCCAGA GGTCTACGCT 2280
ATTATGCGGG GCTGCTGGCA GCGGGAGCCC CAACAACGCC ACAGCATCAA GGATGTGCAC 2340
GCCCGTCTGC AAGTGCTGGC CCAGGCGCCT CCTGTCTATC TGGACGTGCT AGGCTAG 2397
Domain Profile
S: 1     ivlkrelgegafgkvflaecynllpekdkllvavkalkdaseaarkdfkreaelltnlqh  60
         ivlk+elgegafgkvflaec+nllp++dk+lvavkalk+ se+ar+df+reaellt+lqh
Q: 512   IVLKWELGEGAFGKVFLAECHNLLPDQDKMLVAVKALKEVSESARQDFQREAELLTMLQH  571
         89**********************************************************
S: 61    ehivklyGvctegdplllvfeymkhGdlnkflrahgpdakllvegep..kgelglsqlla  118
         +hiv+++Gvcteg+pll++feym+hGdln+flr+hgpdakll++ge+  +g+lgl+qlla
Q: 572   QHIVRFFGVCTEGRPLLMIFEYMRHGDLNRFLRSHGPDAKLLAGGEDvaPGPLGLGQLLA  631
         ***********************************************999**********
S: 119   iakqiaaGlvylasqhfvhrdlatrnclvgedllvkigdfgmsrdvystdyyrvggrtml  178
         +a+q+aaG+vylas+hfvhrdlatrnclvg++l+vkigdfgmsrd+ystdyyrvggrtml
Q: 632   VASQVAAGMVYLASLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTML  691
         ************************************************************
S: 179   pirwlppesilyrkfttesdvwslGvvlweiltyGkqpfyqlsnteviecitqGrvlerp  238
         pirw+ppesilyrkft esdvws+Gvvlwei+tyG+qp+yqlsn+e+iecitqGr+lerp
Q: 692   PIRWMPPESILYRKFTAESDVWSFGVVLWEIFTYGQQPWYQLSNAEAIECITQGRELERP  751
         ************************************************************
S: 239   racpkevydlmlgcwqrepqkrlnikeiya  268
         racp+evy++m+gcwqrepq+r++ik+++a
Q: 752   RACPPEVYAIMRGCWQREPQQRHSIKDVHA  781
         ****************************97
Domain Sequence
(FASTA)
IVLKWELGEG AFGKVFLAEC HNLLPDQDKM LVAVKALKEV SESARQDFQR EAELLTMLQH 60
QHIVRFFGVC TEGRPLLMIF EYMRHGDLNR FLRSHGPDAK LLAGGEDVAP GPLGLGQLLA 120
VASQVAAGMV YLASLHFVHR DLATRNCLVG QGLVVKIGDF GMSRDIYSTD YYRVGGRTML 180
PIRWMPPESI LYRKFTAESD VWSFGVVLWE IFTYGQQPWY QLSNAEAIEC ITQGRELERP 240
RACPPEVYAI MRGCWQREPQ QRHSIKDVHA 270
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Leucine-rich repeat; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00382
EKS-ANC-00399
EKS-BOT-00411
EKS-CAJ-00416
EKS-CAF-00411
EKS-DAR-00800
EKS-DIO-00067
EKS-EQC-00404
EKS-FEC-00394
EKS-GAM-00238
EKS-GAG-00348
EKS-GAA-00500
EKS-GOG-00403
EKS-HOS-00418
EKS-ICT-00391
EKS-LAC-00427
EKS-LOA-00421
EKS-MAM-00410
EKS-MEG-00341
EKS-MOD-00400
EKS-MUM-00444
EKS-MUP-00404
EKS-NOL-00373
EKS-OCP-00087
EKS-ORN-00525
EKS-ORC-00386
EKS-OTG-00414
EKS-PAT-00389
EKS-PES-00364
EKS-POA-00402
EKS-RAN-00426
EKS-SAH-00381
EKS-SUS-00364
EKS-TEN-00519
EKS-TUT-00123
EKS-XET-00523
EKS-XIM-00515
Gene Ontology
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0005030; F:neurotrophin receptor activity
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
InterPros
IPR000483; Cys-rich_flank_reg_C.
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003599; Ig_sub.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR020461; Tyr_kinase_neurotrophic_rcpt_1.
IPR020777; Tyr_kinase_NGF_rcpt.
IPR002011; Tyr_kinase_rcpt_2_CS.
Pfam
PF07679; I-set; 1.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00409; IG; 1.
SM00082; LRRCT; 1.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00239; RECEPTOR_TYR_KIN_II; 1.
Prints
PR01939; NTKRECEPTOR.
PR01940; NTKRECEPTOR1.
PR00109; TYRKINASE.
Created Date20-Feb-2013