EKS-CAP-00493

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAP-00493

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/MAPK	429.7	4.7E-129	40	328	289

Status

Unreviewed

Ensembl Protein

ENSCPOP00000002945

UniProt Accession

H0V0F7;

Protein Name

Protein Synonyms/Alias

Gene Name

MAPK3

Gene Synonyms/Alias

MAPK3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCPOG00000003253	ENSCPOP00000002945	ENSCPOT00000003296

Organism

Cavia porcellus

Functional Description

Protein Length

377

Protein Sequence
(FASTA)

AAAAQGGGGG EPRGAGGVGP GVSGEVEVVK GQPFDVGPRY TQLQYIGEGA YGMVSSAYDH 60

IRKTRVAIKK ISPFEHQTYC QRTLREIQIL LRFRHENVIG IRDILRAPTL EAMRDVYIVQ 120

DLMETDLYKL LRSQQLSNDH ICYFLYQILR GLKYIHSANV LHRDLKPSNL LINTTCDLKI 180

CDFGLARIAD PEHDHTGFLT EYVATRWYRA PEIMLNSKGY TKSIDIWSVG CILAEMLSNR 240

PIFPGKHYLD QLNHILGILG SPSQEDLNCI INMKARNYLQ SLPSKTKVAW AKLFPRSDSK 300

ALDLLDRMLT FNPNKRITVE EALAHPYLEQ YYDPTDEPVA EEPFTFDMEL DDLPKERLKE 360

LIFQETARFQ PGASDAP 377

Nucleotide Sequence
(FASTA)

GCGGCGGCTG CACAGGGGGG CGGGGGCGGG GAGCCCCGGG GAGCTGGTGG GGTGGGCCCG 60

GGGGTCTCGG GGGAAGTGGA GGTCGTGAAG GGGCAGCCGT TCGACGTGGG CCCGCGCTAC 120

ACGCAGCTGC AGTACATCGG CGAGGGTGCC TACGGCATGG TCAGCTCAGC TTATGACCAC 180

ATTCGAAAGA CTCGGGTGGC CATAAAGAAG ATCAGCCCCT TTGAGCATCA GACCTACTGT 240

CAGCGCACTC TACGGGAGAT CCAGATCTTG CTGCGGTTCC GCCATGAGAA TGTCATAGGC 300

ATCCGAGATA TTCTTCGGGC ACCTACCCTG GAAGCCATGA GAGATGTCTA CATTGTGCAG 360

GACCTGATGG AGACGGACCT GTACAAGTTG CTCAGAAGCC AGCAATTGAG CAATGACCAC 420

ATCTGCTACT TCCTCTACCA GATCCTTCGG GGCCTCAAGT ATATTCACTC GGCCAATGTG 480

CTCCACCGGG ATTTAAAGCC TTCCAACCTG CTCATCAACA CCACCTGCGA CCTTAAGATC 540

TGTGATTTCG GCCTGGCCCG GATTGCTGAT CCTGAGCATG ACCATACTGG CTTTCTAACT 600

GAGTATGTGG CCACACGCTG GTACCGGGCT CCAGAGATCA TGCTTAACTC TAAGGGCTAC 660

ACCAAGTCCA TCGACATCTG GTCTGTGGGC TGCATCCTGG CTGAGATGCT CTCCAACCGG 720

CCCATCTTCC CTGGAAAGCA CTACCTGGAC CAGCTCAACC ACATTCTGGG TATCCTGGGC 780

TCCCCATCCC AGGAGGACCT GAATTGTATC ATTAACATGA AGGCCCGAAA CTACCTACAG 840

TCTCTGCCCT CTAAGACTAA GGTGGCCTGG GCCAAGCTTT TTCCGAGGTC AGACTCCAAA 900

GCTCTTGACC TCCTGGACCG GATGTTAACT TTCAATCCCA ACAAGCGGAT CACAGTGGAG 960

GAGGCGCTGG CTCACCCCTA CCTGGAGCAG TACTATGACC CCACAGATGA GCCAGTGGCT 1020

GAAGAGCCCT TCACTTTTGA CATGGAGCTG GATGATCTAC CCAAGGAGCG GCTGAAGGAG 1080

CTTATCTTCC AAGAGACAGC CCGCTTTCAG CCAGGAGCAT CAGATGCCCC C 1131

Domain Profile

S: 1     yeslkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNi  60

         y++l+++geGayg+v sa+d+ +++rvaikk+s pf+++t ++rtlRE+++l +++heN+

Q: 40    YTQLQYIGEGAYGMVSSAYDHIRKTRVAIKKIS-PFEHQTYCQRTLREIQILLRFRHENV  98

         7899****************************9.**************************

S: 61    iklldvftpeeeleelkdvYlvtelmetdLkkviksqklsdehiklllyqilrglkylHs  120

         i + d++++ + le+++dvY+v++lmetdL+k+++sq+ls++hi ++lyqilrglky+Hs

Q: 99    IGIRDILRAPT-LEAMRDVYIVQDLMETDLYKLLRSQQLSNDHICYFLYQILRGLKYIHS  157

         *********99.************************************************

S: 121   anviHrDlKPsNllvnedcelkildFGlarsadkekekk..lteyvatrwYraPeillsl  178

         anv+HrDlKPsNll+n++c+lki+dFGlar+ad+e++++  lteyvatrwYraPei+l++

Q: 158   ANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTgfLTEYVATRWYRAPEIMLNS  217

         ***********************************99999********************

S: 179   keytkavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflkkieseearn  238

         k ytk++DiWsvGCIlaE+l+++p+fpgk+++dql++il +lg+ps+e+l++i + +arn

Q: 218   KGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARN  277

         ************************************************************

S: 239   yikslpkkkkkdfeelfpkaseealdLleklLvldpdkRisveeaLehpYl  289

         y++slp+k+k  +++lfp+++++aldLl+++L+++p+kRi+veeaL+hpYl

Q: 278   YLQSLPSKTKVAWAKLFPRSDSKALDLLDRMLTFNPNKRITVEEALAHPYL  328

         **************************************************7

Domain Sequence
(FASTA)

YTQLQYIGEG AYGMVSSAYD HIRKTRVAIK KISPFEHQTY CQRTLREIQI LLRFRHENVI 60

GIRDILRAPT LEAMRDVYIV QDLMETDLYK LLRSQQLSND HICYFLYQIL RGLKYIHSAN 120

VLHRDLKPSN LLINTTCDLK ICDFGLARIA DPEHDHTGFL TEYVATRWYR APEIMLNSKG 180

YTKSIDIWSV GCILAEMLSN RPIFPGKHYL DQLNHILGIL GSPSQEDLNC IINMKARNYL 240

QSLPSKTKVA WAKLFPRSDS KALDLLDRML TFNPNKRITV EEALAHPYL 289

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004707	; F:MAP kinase activity
GO:0000165	; P:MAPK cascade

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR003527	; MAP_kinase_CS.
IPR008349	; MAPK_ERK1/2.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS01351	; MAPK; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR01770

; ERK1ERK2MAPK.

Created Date

20-Feb-2013