EKS-CAP-00145

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAP-00145

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Csk	471.3	5.1E-142	195	440	246

Status

Unreviewed

Ensembl Protein

ENSCPOP00000003112

UniProt Accession

H0V0W0;

Protein Name

Protein Synonyms/Alias

Gene Name

CSK

Gene Synonyms/Alias

CSK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCPOG00000003446	ENSCPOP00000003112	ENSCPOT00000003490

Organism

Cavia porcellus

Functional Description

Protein Length

450

Protein Sequence
(FASTA)

LPTLQAAWPS GTECIAKYNF HGTAEQDLPF CKGDVLTIVA VTKDPNWYKA KNKVGREGII 60

PANYVQKREG VKAGTKLSLM PWFHGKITRE QAERLLYPPE TGLFLVREST NYPGDYTLCV 120

SCDGKVEHYR IMYHASKLSI DEEVYFENLM QLVEHYTTDA DGLCTRLIKP KVMEGTVAAQ 180

DEFYRSGWAL NLKELKLLQT IGKGEFGDVM LGDYRGNKVA VKCIKNDATA QAFLAEASVM 240

TQLRHSNLVQ LLGVIVEEKG GLYIVTEYMA KGSLVDYLRS RGRSVLGGDC LLKFSLDVCE 300

AMEYLEGNNF VHRDLAARNV LVSEDNVAKV SDFGLTKEAS STQDTGKLPV KWTAPEALRE 360

KKFSTKSDVW SFGILLWEIY SFGRVPYPRI PLKDVVPRVE KGYKMDAPDG CPPAVYEVMK 420

NCWHLDAAVR PSFLQLREQL EHIKAHELHL 450

Nucleotide Sequence
(FASTA)

TTGCCCACCC TGCAGGCCGC CTGGCCGTCC GGTACAGAAT GTATTGCCAA GTACAACTTC 60

CATGGCACTG CCGAGCAGGA CCTTCCCTTC TGCAAAGGGG ATGTGCTCAC CATTGTAGCC 120

GTCACCAAGG ATCCCAACTG GTACAAAGCC AAGAACAAGG TGGGCCGTGA GGGCATCATC 180

CCGGCCAACT ATGTCCAGAA GCGGGAGGGC GTGAAGGCAG GCACCAAACT CAGTCTCATG 240

CCCTGGTTCC ACGGCAAGAT CACCCGGGAG CAGGCCGAGC GGCTCCTGTA CCCACCGGAA 300

ACAGGTCTGT TCCTGGTTCG GGAAAGCACC AACTACCCCG GTGACTACAC ACTGTGTGTG 360

AGCTGCGATG GCAAGGTAGA GCACTACCGA ATCATGTACC ATGCCAGCAA GCTGAGCATT 420

GATGAGGAGG TCTACTTTGA GAACCTCATG CAGCTGGTGG AGCACTACAC CACAGACGCA 480

GACGGGCTCT GCACTCGCCT CATCAAACCA AAGGTCATGG AGGGCACCGT GGCGGCCCAG 540

GATGAGTTCT ACCGCAGTGG CTGGGCGCTG AACCTAAAGG AGCTGAAGCT GCTGCAGACC 600

ATCGGGAAGG GGGAGTTTGG AGATGTGATG CTGGGTGACT ACCGGGGCAA CAAGGTCGCT 660

GTCAAGTGCA TCAAGAATGA TGCCACCGCC CAGGCCTTCC TAGCTGAAGC CTCTGTCATG 720

ACGCAACTGC GGCACAGCAA CCTGGTACAG CTCCTGGGTG TCATCGTGGA GGAGAAGGGT 780

GGGCTGTACA TTGTCACTGA ATACATGGCT AAGGGGAGCC TGGTGGACTA CCTGCGGTCG 840

AGGGGCCGGT CCGTGTTGGG CGGAGACTGT CTCCTCAAGT TCTCACTAGA TGTCTGCGAA 900

GCCATGGAAT ACCTGGAGGG CAACAACTTT GTTCACCGGG ACCTGGCCGC CCGGAATGTG 960

CTGGTGTCAG AGGACAATGT GGCCAAGGTC AGCGACTTTG GCCTTACCAA GGAGGCCTCG 1020

AGCACGCAGG ACACGGGCAA GCTGCCTGTC AAGTGGACGG CGCCTGAGGC CCTGCGAGAG 1080

AAGAAATTCT CCACCAAGTC CGATGTGTGG AGTTTCGGGA TCCTTCTCTG GGAAATCTAC 1140

TCCTTCGGGC GAGTGCCTTA CCCAAGAATT CCCCTGAAGG ACGTCGTCCC TCGGGTGGAG 1200

AAGGGCTACA AGATGGATGC CCCGGACGGC TGCCCGCCCG CCGTCTATGA GGTCATGAAG 1260

AACTGCTGGC ACCTGGACGC GGCCGTGCGC CCCTCCTTCC TGCAGCTCCG TGAGCAGCTT 1320

GAGCACATCA AGGCCCACGA GCTGCACCTG TGA 1353

Domain Profile

S: 1     lklgetigkgefgdvllgeyrgekvavkvikndataqafldeasvmtklehenlvkllgv  60

         lkl +tigkgefgdv+lg+yrg+kvavk+ikndataqafl+easvmt+l+h+nlv+llgv

Q: 195   LKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVMTQLRHSNLVQLLGV  254

         6899********************************************************

S: 61    ileek.glylvteyvakgslvdylrsrgrallekkqllkfaldvaegmeyleskklvhrd  119

         i+eek gly+vtey+akgslvdylrsrgr++l+ ++llkf+ldv+e+meyle++++vhrd

Q: 255   IVEEKgGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRD  314

         *****99*****************************************************

S: 120   laarnvlvsedlvakvsdfglakeeskdldsgklpvkwtapealkekkfstksdvwsfgi  179

         laarnvlvsed+vakvsdfgl+ke+s+++d+gklpvkwtapeal+ekkfstksdvwsfgi

Q: 315   LAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKWTAPEALREKKFSTKSDVWSFGI  374

         ************************************************************

S: 180   llweifsfgrvpypriplkdvvkavekgykmeapegcppevyelmkeaweleaakrpsfa  239

         llwei+sfgrvpypriplkdvv++vekgykm+ap+gcpp+vye+mk++w+l+aa rpsf

Q: 375   LLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMKNCWHLDAAVRPSFL  434

         ************************************************************

S: 240   klkekl  245

         +l+e+l

Q: 435   QLREQL  440

         ***997

Domain Sequence
(FASTA)

LKLLQTIGKG EFGDVMLGDY RGNKVAVKCI KNDATAQAFL AEASVMTQLR HSNLVQLLGV 60

IVEEKGGLYI VTEYMAKGSL VDYLRSRGRS VLGGDCLLKF SLDVCEAMEY LEGNNFVHRD 120

LAARNVLVSE DNVAKVSDFG LTKEASSTQD TGKLPVKWTA PEALREKKFS TKSDVWSFGI 180

LLWEIYSFGR VPYPRIPLKD VVPRVEKGYK MDAPDGCPPA VYEVMKNCWH LDAAVRPSFL 240

QLREQL 246

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013