EKS-CAP-00168
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-CAP-00168
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
AGC/PKC479.52.6E-144340598259
StatusUnreviewed
Ensembl ProteinENSCPOP00000003120
UniProt AccessionH0V0W8;
Protein NameProtein kinase C
Protein Synonyms/Alias
Gene NamePRKCB
Gene Synonyms/Alias PRKCB;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSCPOG00000003455ENSCPOP00000003120ENSCPOT00000003499
OrganismCavia porcellus
Functional Description
Protein Length671
Protein Sequence
(FASTA)
PAAGPPPSEA RRVPCAFARK GAFRQKNVHE VKNLNFIARF FKQPTFLQHL HRTFIWGFGK 60
QGFQCQVCCF VVHKRCHEFV TFSCPGADKG PASDDPRSKH KFKIHTYSSP TFCDHCGSLL 120
YGLIHQGMKC DTCMMNVHKR CVMNVPSLCG TDHTERRGRI YIQAHIDRDV LIVVVRDAKN 180
LVPMDPNGLS DPYVKLKLIP DPKSESKQKT KTIKCSLNPE WNETFRFQLK ESDKDRRLSV 240
EIWDWDLTSR NDFMGSLSFG ISELQKAGVD GWFKLLSQEE GEYFNVPVPP EGSEGNEELR 300
QKFERAKIGQ GTKPPEEKTT NTVSKIDNNG NRDRMKLTDF NFLMVLGKGS FGKVMLSERK 360
GTDELYAVKI LKKDVVIQDD DVECTMVEKR VLALPGKPPF LTQLHSCFQT MDRLYFVMEY 420
VNGGDLMYHI QQVGRFKEPH AVFYAAEIAI GLFFLQSKGI IYRDLKLDNV MLDSEGHIKI 480
ADFGMCKENI WDGVTTKTFC GTPDYIAPEI IAYQPYGKSV DWWAFGVLLY EMLAGQAPFE 540
GEDEDELFQS IMEHNVAYPK SMSKEAVAIC KGLMTKHPGK RLGCGPEGER DIKEHAFFRY 600
IDWEKLERKE IQPPYKPKAC GRNAENFDRF FTRHPPVLTP PDQEVIRNID QSEFEGFSFV 660
NSEFLKPEVK S 671
Nucleotide Sequence
(FASTA)
CCGGCTGCGG GCCCGCCGCC GAGCGAGGCG AGGAGAGTAC CGTGCGCTTT CGCCCGCAAA 60
GGTGCCTTCC GGCAAAAGAA CGTGCACGAG GTGAAGAACC TCAATTTCAT CGCCCGCTTC 120
TTCAAGCAGC CCACTTTTCT GCAGCACTTG CATCGGACTT TCATCTGGGG CTTTGGCAAG 180
CAGGGTTTCC AGTGTCAAGT TTGCTGCTTT GTTGTGCACA AGCGGTGCCA TGAATTTGTC 240
ACATTCTCTT GCCCTGGAGC TGACAAGGGA CCAGCCTCTG ATGACCCCCG GAGCAAACAC 300
AAGTTTAAGA TCCACACCTA CTCCAGCCCC ACATTTTGTG ACCACTGTGG GTCATTGCTG 360
TATGGACTCA TCCATCAGGG GATGAAATGC GATACCTGCA TGATGAACGT CCACAAGCGC 420
TGCGTGATGA ACGTCCCCAG CCTCTGTGGC ACTGATCACA CAGAACGCCG CGGCCGCATC 480
TACATCCAGG CCCACATCGA CAGGGACGTC CTCATTGTTG TTGTAAGAGA TGCTAAAAAC 540
CTTGTACCCA TGGACCCCAA TGGCTTGTCA GATCCCTATG TAAAACTGAA ACTGATTCCT 600
GATCCTAAAA GCGAGAGCAA GCAGAAGACC AAAACCATCA AGTGCTCCCT TAACCCTGAG 660
TGGAACGAGA CATTTAGATT TCAGCTGAAA GAATCAGACA AAGACAGAAG ACTGTCCGTG 720
GAGATTTGGG ATTGGGATCT GACCAGTAGG AATGACTTCA TGGGGTCTTT GTCCTTTGGG 780
ATTTCTGAGC TGCAGAAAGC TGGTGTTGAC GGATGGTTTA AGTTACTGAG CCAGGAGGAA 840
GGCGAGTACT TCAACGTGCC TGTGCCGCCG GAAGGAAGCG AGGGCAATGA AGAGCTGCGG 900
CAGAAATTTG AGAGGGCCAA GATTGGCCAG GGCACCAAGC CTCCAGAAGA AAAGACGACT 960
AATACCGTCT CCAAAATTGA CAACAATGGC AACCGAGACC GGATGAAACT GACTGATTTT 1020
AACTTTCTGA TGGTGCTGGG GAAAGGCAGT TTTGGCAAGG TCATGCTGTC AGAACGAAAG 1080
GGCACAGATG AGCTCTATGC TGTGAAGATC CTGAAGAAGG ACGTGGTGAT CCAGGACGAT 1140
GATGTAGAGT GCACCATGGT GGAGAAGCGG GTGCTGGCCC TACCGGGGAA GCCACCATTC 1200
CTGACCCAGC TGCACTCCTG CTTCCAGACC ATGGACCGCC TGTACTTCGT GATGGAGTAT 1260
GTGAATGGGG GTGATCTTAT GTACCACATT CAACAGGTTG GCCGATTCAA GGAGCCTCAC 1320
GCTGTATTTT ACGCTGCAGA AATTGCAATC GGTCTATTCT TCTTACAGAG CAAGGGCATC 1380
ATTTACCGGG ACCTAAAACT TGACAACGTG ATGTTGGACT CTGAGGGCCA CATCAAGATT 1440
GCTGACTTTG GCATGTGTAA GGAGAACATC TGGGATGGGG TGACAACCAA GACATTCTGT 1500
GGCACTCCAG ACTACATTGC CCCCGAGATA ATTGCTTACC AGCCTTATGG GAAGTCTGTG 1560
GACTGGTGGG CATTCGGAGT CCTGCTGTAT GAAATGTTGG CTGGGCAGGC CCCATTCGAG 1620
GGAGAAGATG AGGATGAACT TTTCCAGTCC ATCATGGAAC ACAACGTGGC GTATCCAAAG 1680
TCTATGTCCA AGGAAGCTGT GGCCATCTGC AAAGGGCTGA TGACCAAGCA CCCAGGCAAA 1740
CGTCTGGGCT GTGGACCTGA AGGCGAACGT GACATCAAAG AGCATGCATT TTTCCGGTAT 1800
ATCGATTGGG AGAAACTTGA ACGCAAAGAG ATCCAGCCTC CCTATAAACC AAAAGCTTGT 1860
GGGCGAAATG CTGAGAACTT CGACCGATTT TTCACCCGCC ATCCACCAGT CCTAACACCT 1920
CCTGACCAGG AAGTCATCAG GAATATTGAC CAATCAGAAT TCGAAGGATT TTCTTTTGTT 1980
AACTCTGAAT TTTTAAAACC CGAAGTCAAG AGC 2013
Domain Profile
S: 1     fellkvlGkGsfgkvllaelkktdelyaikvlkkdvvlqdddveltlvekrvlalaskkp  60
         f++l+vlGkGsfgkv+l+e+k+tdelya+k+lkkdvv+qdddve+t+vekrvlal  k+p
Q: 340   FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPP  399
         99**********************************************************
S: 61    flvqlfscfqtedrlffvleyvnGGdlmfhiqkarklkeerarfyaaeiilalkflhekg  120
         fl+ql+scfqt+drl+fv+eyvnGGdlm+hiq+++++ke++a+fyaaei+++l+fl++kg
Q: 400   FLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKG  459
         ************************************************************
S: 121   iiyrdlkldnvlldaeGhikladfGlckeeilegkttstfcGtPdyiaPeilkeeeygks  180
         iiyrdlkldnv+ld+eGhik+adfG+cke+i++g tt+tfcGtPdyiaPei+++++ygks
Q: 460   IIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKS  519
         ************************************************************
S: 181   vdwwalGvllyemlagqsPfegededelfesilekevlyPkslskeaveilkglltkdpe  240
         vdwwa+Gvllyemlagq+Pfegededelf+si+e++v+yPks+skeav+i+kgl+tk+p 
Q: 520   VDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPG  579
         ************************************************************
S: 241   krlGvkeegeedikehaff  259
         krlG+ +ege+dikehaff
Q: 580   KRLGCGPEGERDIKEHAFF  598
         ******************9
Domain Sequence
(FASTA)
FNFLMVLGKG SFGKVMLSER KGTDELYAVK ILKKDVVIQD DDVECTMVEK RVLALPGKPP 60
FLTQLHSCFQ TMDRLYFVME YVNGGDLMYH IQQVGRFKEP HAVFYAAEIA IGLFFLQSKG 120
IIYRDLKLDN VMLDSEGHIK IADFGMCKEN IWDGVTTKTF CGTPDYIAPE IIAYQPYGKS 180
VDWWAFGVLL YEMLAGQAPF EGEDEDELFQ SIMEHNVAYP KSMSKEAVAI CKGLMTKHPG 240
KRLGCGPEGE RDIKEHAFF 259
KeywordATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Repeat; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.
Sequence SourceEnsembl
Orthology
Ortholog group
Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-BOT-00168
EKS-CAE-00131
EKS-CAJ-00172
EKS-CAF-00175
EKS-CII-00114
EKS-CIS-00205
EKS-DAR-00459
EKS-EQC-00173
EKS-FEC-00158
EKS-GAM-00088
EKS-GAG-00144
EKS-GAA-00202
EKS-GOG-00171
EKS-HOS-00174
EKS-ICT-00163
EKS-LAC-00180
EKS-MAM-00166
EKS-MOD-00167
EKS-MUM-00173
EKS-MUP-00172
EKS-MYL-00177
EKS-NOL-00161
EKS-OCP-00107
EKS-ORN-00212
EKS-ORC-00156
EKS-OTG-00174
EKS-PAT-00159
EKS-PES-00148
EKS-POA-00165
EKS-RAN-00164
EKS-SAH-00162
EKS-TEN-00211
EKS-XET-00157
EKS-XIM-00206
Gene Ontology
GO:0005622; C:intracellular
GO:0005524; F:ATP binding
GO:0004697; F:protein kinase C activity
GO:0008270; F:zinc ion binding
GO:0035556; P:intracellular signal transduction
KEGG
InterPros
IPR000961; AGC-kinase_C.
IPR000008; C2_Ca-dep.
IPR008973; C2_Ca/lipid-bd_dom_CaLB.
IPR020477; C2_dom.
IPR018029; C2_membr_targeting.
IPR020454; DAG/PE-bd.
IPR011009; Kinase-like_dom.
IPR017892; Pkinase_C.
IPR002219; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR014375; Protein_kinase_C_a/b/g.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00130; C1_1; 2.
PF00168; C2; 1.
PF00069; Pkinase; 1.
PF00433; Pkinase_C; 1.
SMARTs
SM00109; C1; 2.
SM00239; C2; 1.
SM00133; S_TK_X; 1.
SM00220; S_TKc; 1.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS50004; C2; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PS00479; ZF_DAG_PE_1; 1.
PS50081; ZF_DAG_PE_2; 2.
Prints
PR00360; C2DOMAIN.
PR00008; DAGPEDOMAIN.
Created Date20-Feb-2013