EKS-CAP-00266

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAP-00266

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	382.5	7.9E-115	59	310	252

Status

Unreviewed

Ensembl Protein

ENSCPOP00000003716

UniProt Accession

H0V2F5;

Protein Name

Protein Synonyms/Alias

Gene Name

MARK4

Gene Synonyms/Alias

MARK4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCPOG00000004117	ENSCPOP00000003716	ENSCPOT00000004162

Organism

Cavia porcellus

Functional Description

Protein Length

744

Protein Sequence
(FASTA)

MSSRTALAPG NDRNSDTHGT LGSGRSSDKG PSWSSRSLGA RCRNSIASCP EEQPHVGNYR 60

LLRTIGKGNF AKVKLARHIL TGREVAIKII DKTQLNPSSL QKLFREVRIM KGLNHPNIVK 120

LFEVIETEKT LYLVMEYASA GEVFDYLVSH GRMKEKEARA KFRQIVSAVH YCHQKNIVHR 180

DLKAENLLLD AEANIKIADF GFSNEFTLGS KLDTFCGSPP YAAPELFQGK KYDGPEVDIW 240

SLGVILYTLV SGSLPFDGHN LKELRERVLR GKYRVPFYMS TDCESILRRF LVLNPAKRCT 300

LEQIMKDKWI NIGYEGEELK PYTEPEEDFG DTKRIEVMVG MGYTREEIKE ALTSQKYNEV 360

TATYLLLGRK TEEGGDRGTP GLALARVRAP SDTTNGTSSS KGTSHSKGQR SSSSTYQRQR 420

RHSDFCGPSP APLHPKRSPT STGDAELKEE RLPGRKASCS AAGSGSRGLP PSSPMVSSAH 480

NPNKAEIPER RKDSTSTPNN LPPSMMTRRN TYVCTERPGA ERPSLLANGK ENSSGTPRVP 540

PASPSSHSLA PPSGERSRLA RGSTVRSTFH GGQVRGGGCV QNGPPASPTL AHEAAPLPTG 600

PRTTTNLFTK LTSKLTRRVT DEPERIGGPE VTSGHLPWDQ AETAPRLLRF PWSVKLTSSR 660

PPEALMAALR QATAAARCRC RQPQPFLLAC LHGGAGGPEP LSHFEVEVCQ LPRPGLRGVL 720

FRRVAGTALA FRTLVTRISN DLEL 744

Nucleotide Sequence
(FASTA)

ATGTCTTCGC GGACGGCGCT CGCCCCGGGC AATGATCGCA ACTCGGACAC GCATGGCACC 60

TTGGGCAGTG GCCGATCATC AGACAAAGGG CCGTCCTGGT CCAGCCGCTC CCTTGGTGCC 120

CGCTGCCGGA ACTCCATCGC CTCCTGCCCT GAGGAGCAGC CCCACGTGGG CAACTACCGC 180

TTGCTGAGGA CCATCGGGAA GGGCAACTTT GCCAAGGTCA AGCTGGCCCG GCACATCCTC 240

ACAGGCCGGG AGGTCGCCAT CAAGATCATT GATAAAACCC AGCTGAATCC CAGCAGCCTG 300

CAGAAGCTCT TCCGGGAAGT TCGCATCATG AAGGGCCTAA ACCACCCCAA CATTGTGAAG 360

CTCTTCGAGG TGATAGAGAC CGAGAAGACA CTGTATCTGG TGATGGAGTA CGCAAGTGCG 420

GGAGAAGTGT TTGACTACCT CGTGTCCCAC GGCCGCATGA AGGAGAAGGA AGCCAGAGCC 480

AAGTTCCGAC AGATCGTATC GGCCGTGCAC TATTGTCACC AGAAAAACAT CGTACACAGG 540

GACCTGAAGG CCGAGAACCT ATTGCTGGAT GCTGAGGCCA ACATCAAGAT CGCCGACTTC 600

GGCTTCAGCA ATGAGTTCAC GCTGGGCTCG AAGCTGGACA CGTTCTGCGG GAGCCCCCCA 660

TACGCCGCCC CAGAGCTGTT CCAGGGCAAG AAATACGACG GGCCGGAGGT GGACATCTGG 720

AGCCTCGGTG TCATCCTCTA CACCCTTGTC AGCGGCTCCC TGCCCTTCGA TGGCCACAAC 780

CTCAAGGAGC TTCGGGAGCG CGTCCTCCGG GGAAAATACC GGGTCCCCTT CTACATGTCC 840

ACGGACTGCG AGAGCATCCT CCGCAGGTTC CTGGTGCTGA ACCCAGCGAA ACGCTGCACT 900

CTAGAGCAAA TCATGAAAGA CAAATGGATC AACATCGGCT ATGAGGGTGA GGAGCTGAAG 960

CCATACACTG AGCCTGAGGA GGACTTTGGG GACACCAAGC GAATCGAGGT GATGGTGGGG 1020

ATGGGCTACA CACGGGAAGA AATCAAAGAG GCCCTGACCA GCCAGAAGTA CAACGAAGTG 1080

ACCGCCACCT ACCTCCTGCT GGGCAGGAAG ACTGAGGAGG GTGGGGACCG GGGCACCCCA 1140

GGGCTGGCCC TGGCACGGGT GCGGGCACCC AGCGACACCA CCAACGGCAC GAGCTCCAGC 1200

AAAGGTACCA GCCACAGCAA AGGGCAGCGG AGCTCCTCTT CCACCTACCA GCGCCAGCGC 1260

AGGCACAGCG ACTTCTGCGG CCCATCCCCA GCACCCCTGC ACCCCAAGCG CAGCCCCACC 1320

AGCACGGGTG ATGCAGAGCT GAAGGAAGAG CGGCTGCCCG GCCGGAAGGC GAGCTGCAGT 1380

GCGGCGGGCA GCGGAAGCCG GGGGCTGCCC CCCTCCAGCC CCATGGTCAG CAGTGCCCAC 1440

AACCCTAATA AGGCAGAGAT CCCCGAGCGG CGGAAGGACA GCACGAGCAC CCCTAACAAC 1500

CTGCCCCCCA GCATGATGAC CCGCAGGAAC ACCTACGTGT GCACGGAGCG CCCTGGGGCT 1560

GAGCGCCCAT CCCTGCTGGC AAACGGCAAA GAAAATAGCT CAGGCACCCC ACGGGTGCCC 1620

CCCGCCTCCC CCTCCAGTCA CAGCCTGGCT CCCCCATCAG GGGAGCGGAG CCGCCTGGCA 1680

CGTGGCTCCA CCGTCCGCAG CACCTTCCAT GGTGGCCAGG TCCGGGGTGG CGGGTGTGTG 1740

CAGAACGGGC CCCCCGCCTC TCCCACGCTG GCCCACGAGG CTGCACCCCT GCCCACCGGG 1800

CCACGTACCA CTACCAACCT CTTCACCAAG CTGACCTCCA AACTGACCCG ACGGGTCACA 1860

GACGAACCTG AGAGAATCGG GGGACCTGAG GTCACAAGTG GCCATCTACC TTGGGATCAA 1920

GCGGAAACCG CCCCCCGGCT GCTCCGATTC CCCTGGAGTG TGAAGCTGAC CAGCTCGCGC 1980

CCTCCCGAGG CCCTGATGGC AGCTCTGCGC CAGGCCACGG CGGCCGCCCG CTGCCGATGC 2040

CGCCAGCCAC AGCCCTTCTT GCTGGCCTGC CTGCACGGGG GTGCGGGCGG GCCCGAGCCC 2100

CTGTCCCACT TCGAAGTGGA AGTCTGCCAA CTGCCCCGGC CGGGCCTGCG GGGCGTGCTC 2160

TTCCGCCGCG TGGCGGGCAC CGCCCTGGCC TTCCGCACCC TCGTCACCCG CATCTCCAAC 2220

GACCTCGAGC TCTGA 2235

Domain Profile

S: 1     ykllktlGegsfgkVklakhketkekvavKiikkkklseeslekikrEieilkklkhpni  60

         y+ll+t+G+g+f+kVkla+h +t+++va+Kii+k++l+ +sl+k++rE++i+k l+hpni

Q: 59    YRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLNHPNI  118

         99**********************************************************

S: 61    ikllevietkkklylvleyasggeLfdyieekgrlkekearklfkqlvsavkYlhskgiv  120

         +kl+eviet+k+lylv+eyas ge+fdy++++gr+kekear+ f+q+vsav+Y+h+k+iv

Q: 119   VKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQKNIV  178

         ************************************************************

S: 121   HrDlKpeNllldkkenikiaDFGlanlfkegklletfcGsppYaaPellkgkkYegpkvD  180

         HrDlK+eNllld++ nikiaDFG++n+f+ g++l+tfcGsppYaaPel++gkkY+gp+vD

Q: 179   HRDLKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDGPEVD  238

         ************************************************************

S: 181   vWslGvvLyalvtgklPfdeenlkellekilkgkleipkklskelesLlrklLvvdpekR  240

         +WslGv+Ly+lv+g+lPfd++nlkel+e++l+gk+++p+++s+++es+lr++Lv +p+kR

Q: 239   IWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPFYMSTDCESILRRFLVLNPAKR  298

         ************************************************************

S: 241   atieeilkhewl  252

         +t+e+i+k++w+

Q: 299   CTLEQIMKDKWI  310

         ***********7

Domain Sequence
(FASTA)

YRLLRTIGKG NFAKVKLARH ILTGREVAIK IIDKTQLNPS SLQKLFREVR IMKGLNHPNI 60

VKLFEVIETE KTLYLVMEYA SAGEVFDYLV SHGRMKEKEA RAKFRQIVSA VHYCHQKNIV 120

HRDLKAENLL LDAEANIKIA DFGFSNEFTL GSKLDTFCGS PPYAAPELFQ GKKYDGPEVD 180

IWSLGVILYT LVSGSLPFDG HNLKELRERV LRGKYRVPFY MSTDCESILR RFLVLNPAKR 240

CTLEQIMKDK WI 252

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Takifugu rubripes"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR001772	; Kinase-assoc_KA1.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR000449	; UBA/transl_elong_EF1B_N.
IPR015940	; UBA/transl_elong_EF1B_N_euk.

Pfam

PF02149	; KA1; 1.
PF00069	; Pkinase; 1.
PF00627	; UBA; 1.

SMARTs

SM00220	; S_TKc; 1.
SM00165	; UBA; 1.

Prosites

PS50032	; KA1; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50030	; UBA; 1.

Prints

Created Date

20-Feb-2013