EKS-CAP-00418

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAP-00418

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE11	364.9	2.9E-109	636	892	257

Status

Unreviewed

Ensembl Protein

ENSCPOP00000003829

UniProt Accession

H0V2Q4;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP3K5

Gene Synonyms/Alias

MAP3K5;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCPOG00000004244	ENSCPOP00000003829	ENSCPOT00000004289

Organism

Cavia porcellus

Functional Description

Protein Length

1326

Protein Sequence
(FASTA)

PPPPPAGAFW NVDSAAPGPG CPAAAPGSNA ARCRGNSSSG GGRRTTVAYV INEASQGQLV 60

VAESEALQSL REACEAVGAT LETLHFGKLD FGETAVLDRF YNADIAVVEM SDAFRQPSLF 120

YHLGVRESFS MANNIILYCD TNSDSLQSLK EIICQKNTMC TGNYTFIPYM VSPHNKVYCC 180

DSSFMKGLTE LMQPNFELLL GPICLPLMDR FIQLLKVAQA SSSQYFRESI LNDIRKARNL 240

YTGKELAAEL TRIRQRVDNI EVLTADIVIN LLLSYRDIQD YDSIVKLVET LEKLPTFDLA 300

SHHHVKFHYA FALNRRNLPG DRAKALDIMI PMVESKGQVA SDMYCLVGRI YKDMFLDSNF 360

TDTESRDHGA SWYKKAFESE PTLQSGINYA VLLLAAGHQF ESSFELRKVG VKLSSLLGKK 420

GNLEKLQSYW EVGFFLGASV LANDHLRVIQ ASEKLFKLKT PAWYLKSIVE TILIYKHFVK 480

LTAEQPVAKQ ELVDFWMDFL VEATKTDVTV VRFPVLILEP TKIYQPSYLS INNEVEEKTI 540

SIWHVLPDDK KGIHEWNFSA SSVRGVSISK FEERCCFLYV LHNSDDFQIY FCTELHCKKF 600

FEMVNTITEE KGRSVEEGDC DSDSLEYDYE YDENGDRVVL GKGTYGIVYA GRDLSNQVRI 660

AIKEIPERDS RYSQPLHEEI ALHKHLKHKN IVQYLGSFSE NGFIKIFMEQ VPGGSLSALL 720

RSKWGPLKDN EQTIGFYTKQ ILEGLKYLHD NQIVHRDIKG DNVLINTYSG VLKISDFGTS 780

KRLAGINPCT ETFTGTLQYM APEIIDKGPR GYGKAADIWS LGCTMIEMAT GKPPFYELGE 840

PQAAMFKVGM FKVHPEIPES MSAEAKAFIL KCFEPDPDKR ACANDLLTDE FLKVSSKKKK 900

TQPKLSVLLP ISAEYLRSIS LPVPVLVEDT SSSSEYGSVS PDTELKVDPF SFKTRAKSCG 960

EKDVKGIRTL FLGIPDENFE DHSAPPSPEE KDSGFFMLRK DSERRATLHR ILTEDQDKIV 1020

RNLMECLAQG AEEPKLKWEH ITTLIVSLRE FVRSTDRKII ASTLSKLKLE LDFDSHGISQ 1080

VQVVLFGFQD AVNKVLRNHN IKPHWMFALD SIIRKAVQTA ITILVPELRP HFSLASESDT 1140

ADPEDLDVEE EHEEPPSNQT VRRPQAVIED AVATSGVSTL SSTVSHDSQS AHRSLSVQLG 1200

RMKIETNRLL EELVQKEKEL QAFLHQAIEE KEQEIKHLKL KYQPIDIPEL LVCHPNPPHR 1260

NTDNSELTDW LRQNGADEDT ISRFLDEKYT LVDVLYYVTR DDLKYLRLRG GMLCTLWKAI 1320

IDFRNK 1326

Nucleotide Sequence
(FASTA)

CCACCGCCGC CGCCAGCGGG GGCTTTCTGG AACGTGGACA GCGCTGCACC CGGCCCTGGG 60

TGTCCTGCCG CCGCCCCTGG GAGCAACGCC GCCCGGTGCC GGGGCAACTC CTCGAGCGGT 120

GGCGGGCGCC GGACCACCGT GGCATACGTG ATCAACGAGG CGAGCCAGGG GCAGTTGGTG 180

GTGGCCGAGA GCGAGGCTTT GCAGAGCCTG CGAGAGGCTT GTGAGGCTGT GGGCGCTACT 240

CTGGAGACCT TGCATTTTGG CAAACTAGAC TTCGGGGAAA CCGCGGTGCT GGACCGTTTT 300

TACAACGCAG ATATTGCTGT GGTGGAGATG AGTGATGCCT TCCGCCAACC CTCCCTGTTT 360

TACCATCTTG GCGTGAGGGA AAGCTTCAGC ATGGCCAACA ACATCATCCT CTACTGTGAT 420

ACCAACTCCG ACTCTCTGCA GTCCCTGAAG GAAATCATCT GCCAGAAGAA TACTATGTGC 480

ACTGGGAACT ATACCTTTAT CCCTTACATG GTGAGCCCGC ATAATAAGGT CTACTGCTGT 540

GACAGCAGCT TCATGAAGGG CTTGACGGAG CTCATGCAGC CCAACTTCGA GCTGCTTCTG 600

GGGCCCATCT GCTTACCACT CATGGACCGG TTCATCCAGC TTTTGAAGGT GGCGCAAGCA 660

AGTTCCAGCC AGTACTTCCG GGAATCTATA CTGAATGATA TCAGGAAAGC TCGAAATTTA 720

TACACTGGTA AAGAATTGGC AGCTGAATTG ACAAGAATTC GGCAGCGAGT AGATAACATT 780

GAAGTCTTGA CAGCAGACAT TGTCATCAAT CTATTGCTTT CCTACAGAGA TATACAGGAC 840

TATGATTCCA TTGTGAAGCT GGTAGAGACT TTAGAAAAAC TGCCAACCTT TGATTTGGCC 900

TCCCATCACC ATGTGAAGTT TCATTATGCA TTTGCGCTGA ATAGGAGAAA TCTCCCTGGA 960

GACAGAGCAA AAGCACTTGA TATTATGATT CCTATGGTGG AAAGCAAAGG ACAAGTTGCT 1020

TCAGATATGT ATTGCCTCGT TGGTCGAATC TACAAAGACA TGTTTTTAGA CTCTAATTTC 1080

ACTGACACTG AAAGTAGAGA CCATGGAGCT TCTTGGTACA AAAAGGCATT TGAATCTGAA 1140

CCAACACTAC AGTCAGGAAT TAATTATGCA GTCCTTCTCC TGGCAGCTGG ACACCAGTTT 1200

GAATCTTCCT TTGAGCTTCG GAAAGTTGGG GTGAAGCTAA GTAGCCTTCT TGGTAAAAAG 1260

GGAAACTTGG AAAAACTCCA GAGCTACTGG GAAGTTGGAT TTTTTCTTGG GGCCAGTGTG 1320

CTGGCCAATG ACCATCTGAG AGTCATTCAA GCATCTGAAA AGCTTTTCAA ACTAAAGACA 1380

CCAGCATGGT ACCTCAAGTC AATTGTAGAG ACAATTTTGA TATACAAGCA TTTTGTGAAG 1440

CTGACTGCAG AGCAGCCTGT GGCCAAGCAA GAACTTGTGG ACTTTTGGAT GGATTTCCTT 1500

GTTGAAGCCA CAAAAACAGA TGTTACTGTA GTTAGATTTC CAGTGTTAAT CCTGGAACCA 1560

ACCAAAATAT ATCAGCCTTC TTACTTGTCT ATCAACAATG AAGTCGAGGA AAAGACAATC 1620

TCTATTTGGC ATGTGCTTCC TGATGACAAG AAAGGTATAC ATGAGTGGAA TTTTAGTGCT 1680

TCCTCTGTCA GAGGAGTGAG TATTTCTAAA TTTGAAGAGC GATGCTGCTT TCTTTATGTG 1740

CTTCACAATT CTGATGACTT CCAAATCTAT TTCTGTACAG AACTTCACTG TAAAAAGTTT 1800

TTCGAAATGG TGAACACAAT TACCGAGGAG AAGGGGAGAA GTGTAGAGGA AGGAGACTGT 1860

GACAGTGACT CCCTGGAGTA TGACTATGAA TATGATGAAA ATGGTGACAG AGTCGTTTTA 1920

GGAAAAGGCA CTTACGGAAT TGTCTACGCG GGTCGGGACT TAAGCAACCA AGTCAGAATT 1980

GCTATTAAAG AAATCCCAGA GAGAGATAGC AGATACTCTC AGCCCCTGCA TGAAGAAATA 2040

GCCTTGCATA AGCATCTGAA GCACAAAAAT ATTGTCCAGT ATCTGGGCTC TTTCAGTGAG 2100

AATGGCTTCA TTAAAATCTT CATGGAGCAG GTCCCAGGAG GAAGTCTTTC TGCTCTCCTT 2160

CGTTCCAAAT GGGGTCCATT AAAAGACAAT GAGCAAACAA TTGGCTTTTA CACAAAGCAA 2220

ATACTGGAAG GATTAAAATA CCTCCACGAC AATCAGATAG TTCACCGGGA TATAAAGGGC 2280

GACAATGTAT TGATTAATAC CTACAGTGGT GTTCTCAAGA TCTCTGATTT CGGGACATCA 2340

AAGAGGCTTG CTGGCATAAA CCCATGCACC GAAACCTTTA CTGGTACCCT TCAGTACATG 2400

GCACCAGAAA TAATCGATAA AGGACCACGA GGCTACGGCA AAGCAGCAGA TATTTGGTCT 2460

TTGGGCTGCA CAATGATTGA AATGGCCACA GGAAAACCAC CATTTTATGA ACTAGGAGAA 2520

CCACAAGCAG CCATGTTCAA GGTGGGGATG TTTAAAGTTC ACCCTGAGAT TCCAGAGTCC 2580

ATGTCTGCAG AAGCCAAGGC ATTCATATTG AAGTGTTTTG AACCAGACCC TGACAAGAGA 2640

GCCTGTGCTA ATGACTTACT TACAGATGAG TTCTTAAAAG TTTCCAGCAA AAAGAAAAAG 2700

ACACAACCTA AGCTTTCAGT CCTTCTACCC ATCTCAGCTG AGTACCTCCG CAGCATTTCC 2760

TTGCCAGTGC CCGTCCTAGT GGAAGACACC AGCAGCAGCA GCGAGTACGG CTCTGTTTCC 2820

CCTGACACGG AGTTAAAGGT GGATCCCTTC TCTTTCAAAA CCAGAGCCAA ATCCTGTGGA 2880

GAAAAAGATG TGAAAGGAAT ACGGACACTG TTTTTAGGCA TTCCAGATGA AAACTTTGAA 2940

GATCACAGCG CTCCACCTTC CCCTGAAGAA AAAGACTCTG GATTCTTTAT GCTGCGGAAG 3000

GACAGTGAGA GGAGAGCCAC GTTGCACAGA ATCCTGACAG AAGACCAAGA CAAGATTGTG 3060

CGGAATTTAA TGGAGTGTTT AGCTCAGGGT GCTGAAGAAC CTAAACTAAA ATGGGAGCAC 3120

ATTACAACCC TCATTGTGAG CCTCAGAGAG TTTGTGAGAT CTACAGACCG GAAGATCATA 3180

GCCTCTACAC TGTCAAAGCT GAAATTAGAG CTGGACTTCG ACAGCCATGG TATCAGCCAA 3240

GTGCAGGTGG TCCTCTTTGG TTTCCAAGAT GCGGTCAATA AAGTTCTTCG GAATCATAAC 3300

ATCAAGCCGC ACTGGATGTT CGCCTTAGAC AGCATCATAC GAAAGGCTGT ACAAACAGCC 3360

ATTACCATTC TGGTTCCAGA GCTGAGGCCG CATTTTAGCC TTGCATCAGA GAGTGACACC 3420

GCTGATCCGG AAGACTTGGA TGTAGAGGAA GAGCACGAGG AACCACCTTC CAATCAAACA 3480

GTCCGAAGAC CCCAGGCTGT CATTGAAGAT GCTGTTGCCA CCTCAGGGGT GAGCACACTG 3540

AGCTCCACTG TGTCTCATGA TTCTCAGAGT GCTCACCGAT CACTGAGTGT GCAGCTTGGA 3600

AGGATGAAAA TAGAAACTAA TAGACTACTG GAAGAATTGG TTCAGAAAGA AAAAGAATTA 3660

CAAGCCTTCC TTCATCAAGC CATTGAAGAA AAAGAGCAAG AAATTAAGCA CCTGAAGCTG 3720

AAGTACCAGC CAATAGATAT CCCTGAGTTG CTAGTATGTC ACCCGAATCC TCCACACCGA 3780

AACACTGATA ATTCTGAGCT CACAGACTGG CTGAGACAAA ATGGAGCTGA TGAAGACACT 3840

ATAAGTCGGT TTTTGGATGA GAAGTATACA CTAGTGGACG TTCTCTACTA CGTTACACGT 3900

GATGATCTAA AATACCTGAG ACTAAGGGGA GGGATGCTCT GCACACTGTG GAAGGCCATC 3960

ATTGACTTTC GAAACAAA 3978

Domain Profile

S: 3     krevigkGsfgsvyaaldvdtgellavKeveikpekksekkevkalkeEikllkelkHen  62

         +r v+gkG++g vya++d++++ ++a+Ke+   pe++s+  ++++l+eEi+l+k+lkH+n

Q: 636   DRVVLGKGTYGIVYAGRDLSNQVRIAIKEI---PERDSR--YSQPLHEEIALHKHLKHKN  690

         5789**************************...888775..9******************

S: 63    ivkyyGveveeeelkiflEyvegGslsslle.kygkle..esvikkytkqileglayLHe  119

         iv+y+G+ +e++ +kif+E+v+gGsls+ll+ k+g+l+  e++i +ytkqilegl+yLH+

Q: 691   IVQYLGSFSENGFIKIFMEQVPGGSLSALLRsKWGPLKdnEQTIGFYTKQILEGLKYLHD  750

         *******************************9*****9999*******************

S: 120   kkivHRDiKgaNillds.sgvvklsDFGaskrlaelntkaaelesltGtlaymaPEvikk  178

         ++ivHRDiKg+N+l+++ sgv+k+sDFG+skrla +n++   +e++tGtl+ymaPE+i+k

Q: 751   NQIVHRDIKGDNVLINTySGVLKISDFGTSKRLAGINPC---TETFTGTLQYMAPEIIDK  807

         ***************************************...8*****************

S: 179   kekgygrkaDiWslgcvviemltgkrPfaeldeelaimfkvgakktkPeipeklseegkd  238

         + +gyg++aDiWslgc++iem+tgk+Pf el+e++a+mfkvg+ k++Peipe++s+e+k+

Q: 808   GPRGYGKAADIWSLGCTMIEMATGKPPFYELGEPQAAMFKVGMFKVHPEIPESMSAEAKA  867

         ************************************************************

S: 239   flekcleldpkkrpsaeeLLkhefl  263

         f+ kc+e dp+kr++a++LL++efl

Q: 868   FILKCFEPDPDKRACANDLLTDEFL  892

         **********************996

Domain Sequence
(FASTA)

DRVVLGKGTY GIVYAGRDLS NQVRIAIKEI PERDSRYSQP LHEEIALHKH LKHKNIVQYL 60

GSFSENGFIK IFMEQVPGGS LSALLRSKWG PLKDNEQTIG FYTKQILEGL KYLHDNQIVH 120

RDIKGDNVLI NTYSGVLKIS DFGTSKRLAG INPCTETFTG TLQYMAPEII DKGPRGYGKA 180

ADIWSLGCTM IEMATGKPPF YELGEPQAAM FKVGMFKVHP EIPESMSAEA KAFILKCFEP 240

DPDKRACAND LLTDEFL 257

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR025136	; DUF4071.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR013761	; SAM/pointed.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF13281	; DUF4071; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013