EKS-CAP-00033

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAP-00033

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Jak	324.3	6.5E-97	874	1143	270

Status

Unreviewed

Ensembl Protein

ENSCPOP00000003938

UniProt Accession

H0V2Z6;

Protein Name

Tyrosine-protein kinase

Protein Synonyms/Alias

Gene Name

TYK2

Gene Synonyms/Alias

TYK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCPOG00000004366	ENSCPOP00000003938	ENSCPOT00000004413

Organism

Cavia porcellus

Functional Description

Protein Length

1164

Protein Sequence
(FASTA)

SFSRMPLCQW GGSARRGQPD GDELQPLAAA GGLRVLLHWA GPGGGQPWVT FSEASITAEE 60

VCLRVAQQVG ITPACFSLFA LFDADAQVWL PPNHILEVSG DTSQTLYFRM RFYFRNWHGM 120

NPHEPPVYRC RLPGPEVSSE QAEQGIQVLD PASFEYLFEQ GKYEFVNDVI SLWELSSEEE 180

IHHFKNESLG MAFLHLCHLA FCRNVPLEEV AKEISFTRCI PSSFRQQIRQ HSVLTRLRLR 240

SVFRRFVRTF RTAQLSRRAV MVKYLATLEH LAPRFGAERI PVRHLELLCQ ADRHEVLVTG 300

TGGIQWRPVQ PEGAGGSGVG SWNPKAGVPG RKARAHREAG GQPADRPQQP PWTYFCDFRD 360

VTHVVLKESR VSVHRQDNKC LEMSLPSRAA ALSFAALVDG YFRLTADSSH YLCHEVAPPR 420

LVLSIQDGIH GPLLEPFLRA KLQLEDGLYL FHWSASHLDR LLLAVAQRDL SPGDGGVRSV 480

SLHRFPVERQ AGGFVLEGWD RSFPSVRALR GALRGCCLRA GDHCFSLRRC CLPRPGEISN 540

LIIKRGPQAR TRQLNLSQLS FHRVQQDDIT QLSHLGQGTR TNVYEGLLRV GTPEEDKEDG 600

VDSGEPSGGR GQELRVVLKV LDPGHHDIML AFYETASLMS QVSHVHLAFV HGVCVRGSEN 660

IMVTEFVEHG PLDVWLRRER GRVPLAWKLV VAQQLASALS YLEDKNLVHG NVCGRNILLA 720

RLGLAEGTSP FIKLSDPGVG LGALSREERV ERIPWTAPES LPTGAGSLST AVDKWGFGAT 780

LLEICFDGEV PLQGRAPSEK ERFYQKQHQL PEPACPELAA VTSQCLSYER AQRPSFRTIL 840

RDLTRLQPHS LADISTVNPE SPASDPTVFH KRYLKKIRDL GEGHFGKVSL YCYDPNNDGT 900

GEMVAVKSLK ADCGPQLHSG WRREIDILRT LYHEHIVKYK GCCEDQGEKS VQLVMEYVPL 960

GSLRDYLPRH SVGLAQLLLF AQQICEGMAY LHAQHYIHRD LAARNVLLDN DRLVKIGDFG 1020

LAKAVPEGHE YYHVREDGDS PVFWYAPECL KECKFYYASD VWSFGVTLYE LLTYCDSRQS 1080

PPSKFMELIG VTQGQMTVLR LTELLEQGER LPRPDRCPPE IYLLMKNCWE AQASFRPTFQ 1140

NLVPILKSEQ EKHQGQAASV FTVC 1164

Nucleotide Sequence
(FASTA)

TCTTTTTCCA GGATGCCTCT GTGCCAGTGG GGAGGCTCGG CGAGGCGCGG CCAGCCCGAC 60

GGGGATGAAT TGCAGCCCTT GGCCGCTGCG GGAGGCCTGC GGGTCCTTCT GCACTGGGCT 120

GGCCCTGGTG GTGGGCAGCC CTGGGTCACC TTCAGCGAGG CCTCAATAAC AGCTGAGGAG 180

GTCTGCCTCC GAGTGGCGCA GCAAGTCGGC ATCACACCAG CCTGCTTCAG TCTCTTCGCT 240

CTCTTTGATG CTGATGCCCA AGTGTGGCTG CCCCCAAACC ACATCCTGGA AGTTTCTGGA 300

GACACAAGCC AGACACTGTA TTTCCGCATG AGGTTTTACT TCCGGAACTG GCATGGCATG 360

AACCCGCACG AGCCACCTGT GTACCGCTGC AGACTCCCAG GGCCCGAGGT GTCCTCAGAG 420

CAGGCGGAGC AGGGGATACA AGTCTTGGAT CCAGCCTCCT TTGAGTACCT CTTTGAGCAG 480

GGCAAGTATG AGTTTGTGAA TGATGTGATA TCCCTGTGGG AGCTGTCCAG TGAGGAGGAA 540

ATCCACCACT TTAAGAATGA GAGCCTGGGC ATGGCATTTC TACACCTCTG CCACCTTGCT 600

TTCTGCCGCA ATGTCCCTCT GGAGGAGGTG GCCAAAGAGA TCAGCTTCAC GCGCTGCATC 660

CCGAGCTCCT TTCGGCAGCA GATCCGCCAG CACAGCGTGC TGACCCGCCT GCGCCTGCGC 720

AGCGTCTTCC GGCGCTTCGT GCGCACCTTC CGGACGGCGC AGCTGTCCCG GCGGGCCGTC 780

ATGGTCAAGT ACCTGGCCAC GCTGGAGCAC CTGGCGCCCC GCTTCGGCGC CGAGCGCATC 840

CCGGTGCGTC ACCTGGAGCT GCTGTGCCAG GCCGACAGGC ACGAGGTGCT GGTCACGGGC 900

ACCGGGGGCA TCCAGTGGCG CCCGGTACAG CCGGAGGGCG CCGGTGGCAG TGGTGTTGGT 960

AGCTGGAATC CGAAAGCCGG GGTGCCCGGG AGAAAGGCCA GGGCCCACAG GGAGGCAGGG 1020

GGGCAGCCGG CAGACCGGCC GCAGCAGCCA CCCTGGACCT ATTTCTGCGA CTTCCGGGAC 1080

GTCACCCACG TGGTCCTGAA GGAGAGTCGC GTCAGCGTCC ACCGGCAGGA CAACAAGTGC 1140

TTGGAAATGA GCCTGCCCTC CCGGGCTGCC GCCCTGTCCT TCGCAGCACT GGTGGACGGC 1200

TACTTCCGCC TGACGGCCGA CTCCAGCCAC TACCTGTGCC ATGAGGTGGC TCCCCCAAGG 1260

CTGGTCCTGA GCATTCAGGA TGGCATCCAC GGGCCTCTGC TGGAGCCGTT CCTGCGGGCC 1320

AAGCTGCAGC TGGAGGACGG ACTCTACCTC TTCCACTGGA GCGCCAGCCA CCTGGACCGC 1380

CTCCTCCTCG CCGTGGCCCA GCGGGACCTG AGCCCGGGCG ACGGTGGTGT GCGGAGCGTG 1440

TCCCTCCACA GGTTTCCAGT CGAGCGGCAG GCCGGGGGCT TCGTGCTGGA GGGCTGGGAC 1500

CGCTCCTTCC CCAGCGTGCG CGCCCTTCGG GGCGCCCTGC GGGGCTGCTG CCTCCGGGCT 1560

GGGGACCACT GCTTCTCCTT GCGCAGGTGT TGCCTGCCCC GGCCAGGAGA GATCTCCAAC 1620

CTCATCATCA AGCGGGGGCC TCAGGCCCGC ACCCGGCAGC TCAACCTCAG CCAGCTGAGC 1680

TTCCACAGAG TCCAGCAGGA TGACATCACC CAGCTGTCAC ACTTGGGCCA GGGCACGAGG 1740

ACCAACGTGT ATGAGGGTCT CCTGAGAGTG GGGACGCCCG AGGAGGACAA AGAGGATGGC 1800

GTGGACTCTG GGGAGCCCAG TGGGGGCCGT GGGCAGGAGC TGCGTGTGGT GCTGAAGGTG 1860

CTGGACCCAG GTCACCATGA CATCATGCTG GCCTTCTATG AGACAGCCAG CCTCATGAGC 1920

CAGGTGTCTC ACGTCCACCT GGCCTTCGTG CACGGTGTCT GCGTGCGTGG CTCTGAGAAC 1980

ATCATGGTGA CTGAGTTCGT GGAGCACGGG CCCCTGGACG TGTGGCTGCG GCGGGAGCGG 2040

GGCCGTGTGC CCCTGGCTTG GAAGCTGGTG GTTGCCCAGC AGCTGGCCAG CGCCCTCAGC 2100

TACCTGGAGG ACAAGAACCT GGTGCACGGG AATGTGTGTG GCCGGAACAT CCTCCTGGCC 2160

CGGCTGGGGC TGGCAGAAGG CACCAGCCCG TTCATCAAGC TCAGTGACCC TGGCGTGGGG 2220

CTGGGTGCCC TCTCCAGGGA GGAGCGGGTG GAGCGCATCC CCTGGACGGC GCCCGAGAGC 2280

CTGCCCACCG GGGCCGGCAG CCTGAGCACA GCCGTGGACA AGTGGGGCTT CGGAGCCACC 2340

CTGCTGGAGA TCTGCTTTGA CGGCGAGGTG CCCCTGCAGG GCCGCGCCCC CTCCGAGAAA 2400

GAGCGCTTCT ACCAGAAGCA GCACCAGCTG CCCGAGCCCG CGTGCCCTGA GCTGGCCGCA 2460

GTCACCAGCC AGTGCCTGAG CTATGAGCGG GCCCAGCGGC CGTCCTTCCG CACCATCTTG 2520

CGTGACCTCA CTCGGCTGCA GCCCCACAGT CTTGCGGACA TCTCGACTGT GAACCCCGAG 2580

TCACCAGCGT CAGACCCCAC GGTGTTCCAT AAGCGCTATT TGAAAAAGAT CCGCGATCTG 2640

GGGGAGGGTC ACTTTGGCAA GGTCAGCCTG TACTGCTATG ACCCAAACAA CGATGGCACT 2700

GGCGAGATGG TGGCCGTGAA ATCCCTCAAG GCGGACTGTG GGCCTCAGCT CCACTCGGGC 2760

TGGAGGCGGG AGATCGACAT CCTGCGCACG CTCTACCATG AGCACATCGT CAAGTACAAG 2820

GGCTGCTGTG AGGACCAAGG CGAGAAGTCG GTGCAGCTTG TCATGGAGTA CGTGCCGCTG 2880

GGCAGCCTCC GAGATTACCT GCCCCGGCAC AGCGTCGGCC TTGCCCAGCT GCTGCTGTTT 2940

GCCCAGCAGA TCTGCGAGGG CATGGCCTAT CTGCACGCCC AGCACTACAT CCACCGCGAC 3000

CTGGCCGCGC GCAATGTGCT GCTGGACAAC GACAGGCTCG TCAAGATCGG GGACTTCGGC 3060

CTGGCCAAGG CTGTGCCTGA AGGCCACGAG TACTACCACG TGCGCGAGGA CGGGGACAGC 3120

CCCGTGTTCT GGTACGCCCC TGAGTGCCTC AAAGAGTGTA AGTTCTACTA TGCGTCCGAC 3180

GTCTGGTCCT TCGGTGTCAC GCTGTATGAG CTGCTGACGT ACTGTGACTC CAGGCAGAGC 3240

CCGCCCTCGA AATTCATGGA GCTCATAGGC GTCACCCAGG GCCAGATGAC TGTGCTGAGG 3300

CTCACGGAGT TGCTGGAACA AGGAGAGAGG TTGCCCCGGC CAGACAGATG TCCCCCGGAG 3360

ATCTATCTCC TCATGAAGAA CTGCTGGGAA GCCCAGGCCT CCTTCCGGCC CACCTTCCAG 3420

AACCTGGTTC CCATCCTCAA GTCGGAGCAG GAGAAACACC AGGGCCAGGC CGCCTCCGTG 3480

TTCACTGTGT GCTGA 3495

Domain Profile

S: 1     lkqiesLgkgtftkvfevredaegdsteeevalkvLk.esgedisrdfkreaeilsqlsh  59

         lk+i++Lg+g+f+kv ++++d+++d t+e+va+k Lk ++g++  +++ re++il++l+h

Q: 874   LKKIRDLGEGHFGKVSLYCYDPNNDGTGEMVAVKSLKaDCGPQLHSGWRREIDILRTLYH  933

         6899********************************************************

S: 60    ehivklkgvcvaegen..rlVmeyvesGsLdiyLrkkkealslsslldvakqlakameYL  117

         ehivk+kg+c ++ge+  +lVmeyv+ GsL++yL+++  ++ l++ll +a+q++++m+YL

Q: 934   EHIVKYKGCCEDQGEKsvQLVMEYVPLGSLRDYLPRH--SVGLAQLLLFAQQICEGMAYL  991

         ****************9********************..*********************

S: 118   edkklvhrdvaarnvLveresnegtppfvklsdpglakavnqd.eYylvreerdsripwl  176

         ++++++hrd+aarnvL+++++       vk++d+glakav+++ eYy vre++ds+++w+

Q: 992   HAQHYIHRDLAARNVLLDNDRL------VKIGDFGLAKAVPEGhEYYHVREDGDSPVFWY  1045

         **********************......********************************

S: 177   apeclseaknlstasdvWsFgvtlyellt.cskgesp.........lrsesle.......  219

         apecl+e+k +++asdvWsFgvtlyellt c++ +sp         +     +

Q: 1046  APECLKECK-FYYASDVWSFGVTLYELLTyCDSRQSPpskfmeligV-----Tqgqmtvl  1099

         *********.***************************9988555443.....35555588

S: 220   rklelleekerlpkpk.cpaelaelmtnclsyepsqrpsFrail  262

         r++elle++erlp+p+ cp e++ lm+nc+++++s+rp+F++++

Q: 1100  RLTELLEQGERLPRPDrCPPEIYLLMKNCWEAQASFRPTFQNLV  1143

         *****************************************986

Domain Sequence
(FASTA)

LKKIRDLGEG HFGKVSLYCY DPNNDGTGEM VAVKSLKADC GPQLHSGWRR EIDILRTLYH 60

EHIVKYKGCC EDQGEKSVQL VMEYVPLGSL RDYLPRHSVG LAQLLLFAQQ ICEGMAYLHA 120

QHYIHRDLAA RNVLLDNDRL VKIGDFGLAK AVPEGHEYYH VREDGDSPVF WYAPECLKEC 180

KFYYASDVWS FGVTLYELLT YCDSRQSPPS KFMELIGVTQ GQMTVLRLTE LLEQGERLPR 240

PDRCPPEIYL LMKNCWEAQA SFRPTFQNLV 270

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; SH2 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Takifugu rubripes"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005856	; C:cytoskeleton
GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0004715	; F:non-membrane spanning protein tyrosine kinase activity
GO:0007243	; P:intracellular protein kinase cascade

KEGG

InterPros

IPR019749	; Band_41_domain.
IPR019748	; FERM_central.
IPR000299	; FERM_domain.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016251	; Tyr_kinase_non-rcpt_Jak/Tyk2.
IPR016045	; Tyr_kinase_non-rcpt_TYK2_N.

Pfam

PF07714

; Pkinase_Tyr; 2.

SMARTs

SM00295	; B41; 1.
SM00252	; SH2; 1.
SM00219	; TyrKc; 2.

Prosites

PS50057	; FERM_3; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 2.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR01823	; JANUSKINASE.
PR00109	; TYRKINASE.
PR01827	; YKINASETYK2.

Created Date

20-Feb-2013