EKS-CAP-00405

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAP-00405

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	421.6	9.4E-127	235	484	250

Status

Unreviewed

Ensembl Protein

ENSCPOP00000004688

UniProt Accession

H0V4Y0;

Protein Name

Protein Synonyms/Alias

Gene Name

BLK

Gene Synonyms/Alias

BLK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCPOG00000005215	ENSCPOP00000004688	ENSCPOT00000005270

Organism

Cavia porcellus

Functional Description

Protein Length

499

Protein Sequence
(FASTA)

MGLLSSKRQV PEKGKAWSPV KAGSRSQAPP PLPPLVVFNH LPPPPPNEHP DQEDHYVVAL 60

YDYAAVNDRD LQMCKGEKLQ VLKETGDWWL AKSLITGREG YVPSNFVAPV ETLEVEKWFF 120

RSISRKEAER QLLAPLNKVG SFLIRESETT KGSFSLSVKD VTAQGDMVKH YKIRSLDEGG 180

YYISPRTTFP SLQALVQHYT KKGDGLCQRL TAPCATMAPQ NPWAQDEWEI PRQSLRLVRK 240

LGSGQFGEVW MGYYKNNVKV AIKTLKEGTM SPEAFLGEAN LMKTLQHERL VRLYAVVTKE 300

PIYIVTEYMA RGCLLDFLKT DEGSRLSLQR LIDMSAQVAE GMAYIERMNS IHRDLRAANI 360

LVSEALCCKI ADFGLARIVD SEYTAQEGAK FPIKWTAPEA IHFGVFSIKA DVWSFGVLLM 420

EIITYGRVPY PGMSNPEVIR NLERGYRMPC PDTCPPALYR DVISECWRGR PEERPTFEFL 480

QSVLEDFYTA TEAQYELQP 499

Nucleotide Sequence
(FASTA)

ATGGGACTGC TAAGCAGCAA GAGGCAGGTC CCCGAGAAGG GCAAGGCCTG GAGCCCTGTG 60

AAGGCTGGTT CCCGGAGCCA GGCTCCCCCA CCGCTGCCGC CCCTGGTCGT CTTTAACCAC 120

CTTCCCCCTC CACCTCCTAA TGAACACCCA GACCAAGAGG ACCATTACGT GGTGGCCCTG 180

TACGACTACG CTGCTGTGAA CGACCGGGAC CTGCAAATGT GCAAGGGGGA GAAGCTGCAG 240

GTCTTGAAGG AGACTGGGGA CTGGTGGTTG GCCAAATCAC TCATCACCGG AAGAGAGGGC 300

TACGTGCCCA GCAACTTCGT GGCCCCTGTG GAGACCCTGG AAGTGGAAAA GTGGTTCTTC 360

AGGTCCATCA GCCGGAAGGA GGCCGAACGG CAGCTGCTGG CCCCGCTGAA CAAGGTCGGC 420

TCCTTCCTCA TCAGAGAAAG TGAGACCACC AAAGGGTCCT TCTCCCTGTC TGTGAAGGAT 480

GTCACCGCCC AAGGGGACAT GGTCAAGCAC TATAAGATCC GATCCCTGGA TGAAGGGGGT 540

TACTACATCT CCCCCCGGAC CACCTTCCCC TCCCTCCAGG CCCTGGTGCA GCACTATACC 600

AAAAAAGGAG ACGGCTTGTG CCAGAGGCTG ACCGCACCCT GTGCGACCAT GGCTCCGCAG 660

AACCCCTGGG CCCAGGACGA GTGGGAAATC CCCCGGCAGT CCCTCCGGCT GGTGCGGAAG 720

CTGGGGTCTG GGCAGTTCGG CGAGGTCTGG ATGGGTTATT ACAAAAATAA CGTAAAGGTG 780

GCCATCAAAA CCTTAAAAGA GGGAACCATG TCCCCCGAAG CCTTCCTGGG TGAGGCCAAT 840

CTGATGAAGA CCCTGCAGCA CGAGCGGCTG GTCCGTCTGT ATGCTGTGGT CACCAAGGAG 900

CCCATCTACA TTGTCACCGA GTACATGGCC CGAGGGTGCC TGCTGGACTT CCTGAAGACA 960

GACGAAGGCA GCAGGCTGTC ACTCCAGAGA CTGATAGACA TGTCGGCCCA GGTCGCTGAA 1020

GGCATGGCGT ACATCGAGCG CATGAATTCC ATCCACCGAG ACCTACGGGC AGCCAACATC 1080

TTGGTGTCCG AGGCCCTGTG CTGCAAGATC GCGGACTTTG GCCTGGCCCG CATCGTGGAC 1140

AGCGAATATA CGGCCCAGGA GGGGGCCAAG TTCCCCATCA AGTGGACCGC CCCTGAGGCC 1200

ATCCACTTTG GGGTGTTCAG CATCAAAGCA GATGTATGGT CTTTCGGCGT CCTTCTGATG 1260

GAAATCATCA CCTATGGGCG TGTGCCCTAC CCAGGCATGA GCAACCCCGA GGTCATCCGC 1320

AACCTGGAGC GTGGCTACCG CATGCCATGC CCCGACACGT GCCCGCCCGC GCTCTACCGC 1380

GACGTGATCT CCGAGTGCTG GCGTGGGCGC CCCGAGGAAC GGCCCACCTT CGAGTTCCTG 1440

CAGTCGGTGC TGGAGGACTT CTATACAGCC ACCGAGGCCC AGTACGAGCT GCAGCCC 1497

Domain Profile

S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60

         l+lv+klG+GqfGevw+g++k++vkva+ktlkegt+speafl ea+++k+l+he+lv+ly

Q: 235   LRLVRKLGSGQFGEVWMGYYKNNVKVAIKTLKEGTMSPEAFLGEANLMKTLQHERLVRLY  294

         689*********************************************************

S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120

         avv++ ePiyivte+ma+G+lldflk++eg++l+l++l+d++aqvaeGmay+e++n ihr

Q: 295   AVVTK-EPIYIVTEYMARGCLLDFLKTDEGSRLSLQRLIDMSAQVAEGMAYIERMNSIHR  353

         ****9.******************************************************

S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180

         dl+a+n+lv+e l++k+adfGlar++ d+eyta+egak+PikWtaPeai++g+f+ik+dv

Q: 354   DLRAANILVSEALCCKIADFGLARIV-DSEYTAQEGAKFPIKWTAPEAIHFGVFSIKADV  412

         ************************99.899******************************

S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelye.lllecwkkdpe  239

         WsfG+ll+ei+t+G+vPypGm+n ev++++ergyr+p+p++cp  ly+ ++ ecw+ +pe

Q: 413   WSFGVLLMEIITYGRVPYPGMSNPEVIRNLERGYRMPCPDTCPPALYRdVISECWRGRPE  472

         ***********************************************99***********

S: 240   erPtfetlqevl  251

         erPtfe+lq+vl

Q: 473   ERPTFEFLQSVL  484

         ********9986

Domain Sequence
(FASTA)

LRLVRKLGSG QFGEVWMGYY KNNVKVAIKT LKEGTMSPEA FLGEANLMKT LQHERLVRLY 60

AVVTKEPIYI VTEYMARGCL LDFLKTDEGS RLSLQRLIDM SAQVAEGMAY IERMNSIHRD 120

LRAANILVSE ALCCKIADFG LARIVDSEYT AQEGAKFPIK WTAPEAIHFG VFSIKADVWS 180

FGVLLMEIIT YGRVPYPGMS NPEVIRNLER GYRMPCPDTC PPALYRDVIS ECWRGRPEER 240

PTFEFLQSVL 250

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013