EKS-CAP-00059

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAP-00059

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	383.6	5.1E-115	142	423	282

Status

Unreviewed

Ensembl Protein

ENSCPOP00000004697

UniProt Accession

H0V4Y9;

Protein Name

Protein Synonyms/Alias

Gene Name

CDK18

Gene Synonyms/Alias

CDK18;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCPOG00000005224	ENSCPOP00000004697	ENSCPOT00000005279

Organism

Cavia porcellus

Functional Description

Protein Length

472

Protein Sequence
(FASTA)

IIMNKMKNFK RRFSMPRTET IEESLAEFTE QFNQLHNQRN EDLQLGPLGR DPPLEPSPFS 60

PTDGGEEPGT LSPGMQYRRR QNQRRFSMED ISKRLSLPMD IRLPREFLQK LQLESPDLPR 120

PLSRMSRRAS LSDIGFGKLE TYVKLDKLGE GTYATVFKGR SKLTENLVAL KEIRLEHEEG 180

APCTAIREVS LLKNLKHANI VTLHDLIHTD RSLTLVFEYL DSDLKQYLDH CGNLMSMHNV 240

KIFMFQLLRG LAYCHRRKIL HRDLKPQNLL INERGELKLA DFGLARAKSV PTKTYSNEVV 300

TLWYRPPDVL LGSTEYSTPI DMWGVGCIHY EMATGRPLFP GSTVKEELHL IFRLLGTPTE 360

ETWPGVTALP EFRAYNFPAY LPQPLLSHAP RLDTDGINLL TGLLLYESKS RMSAEAALAH 420

PYFRSLGERV HQLEDTASIF SLKEIQLQKD PGYRGLAFQH AGRGKNRRQS IF 472

Nucleotide Sequence
(FASTA)

ATTATCATGA ACAAGATGAA GAACTTCAAG CGTCGGTTCT CCATGCCCCG CACGGAGACC 60

ATAGAGGAGT CTTTGGCCGA ATTCACCGAG CAGTTCAACC AGCTCCACAA CCAGAGGAAT 120

GAGGACCTGC AGCTCGGTCC TCTTGGCAGA GACCCCCCAC TGGAGCCCAG CCCCTTCTCC 180

CCCACAGATG GCGGGGAAGA GCCTGGGACA CTGTCCCCTG GCATGCAGTA CCGGCGAAGG 240

CAGAACCAAC GCCGCTTCTC CATGGAGGAC ATCAGCAAGC GGCTCTCGCT GCCCATGGAT 300

ATCCGCCTGC CCCGGGAGTT CCTACAGAAG CTACAGCTAG AGAGCCCAGA CCTGCCCAGG 360

CCACTCAGCC GCATGTCACG CCGAGCCTCC CTGTCAGACA TCGGCTTTGG GAAACTGGAA 420

ACATATGTGA AGCTGGACAA GCTGGGCGAG GGCACCTACG CCACAGTCTT CAAGGGGCGC 480

AGCAAGCTGA CAGAGAACTT GGTGGCTCTG AAGGAGATCC GACTGGAGCA TGAGGAGGGA 540

GCACCCTGCA CTGCCATCCG AGAGGTGTCG CTGCTGAAGA ACCTGAAGCA CGCCAACATC 600

GTGACCCTGC ATGACCTCAT CCACACAGAT CGGTCCCTCA CGCTGGTGTT TGAGTACCTG 660

GACAGTGACC TGAAGCAGTA TTTGGACCAC TGTGGGAACC TCATGAGTAT GCACAATGTC 720

AAGATTTTCA TGTTCCAGCT ACTTCGGGGC CTGGCTTACT GCCACCGACG CAAGATCCTG 780

CACCGGGACC TGAAACCTCA GAACCTGCTC ATCAATGAGA GGGGCGAGCT GAAGCTGGCT 840

GACTTCGGGC TGGCCCGGGC CAAGTCAGTG CCCACAAAGA CCTACTCCAA TGAGGTGGTG 900

ACCCTGTGGT ACAGGCCCCC CGATGTGCTG CTGGGATCCA CAGAGTACTC CACACCCATT 960

GATATGTGGG GCGTGGGCTG CATCCACTAC GAGATGGCCA CAGGGAGGCC CCTCTTCCCC 1020

GGCTCCACGG TCAAGGAGGA GCTGCACCTC ATCTTTCGCC TCCTCGGGAC TCCTACAGAA 1080

GAGACGTGGC CCGGCGTGAC GGCCCTCCCA GAGTTCCGAG CTTACAACTT TCCCGCGTAT 1140

CTGCCGCAGC CGCTGCTCAG CCACGCCCCC AGGTTGGATA CTGACGGCAT CAACCTCCTG 1200

ACTGGCCTCC TCCTGTATGA ATCCAAGAGT CGCATGTCAG CAGAGGCAGC CCTGGCTCAC 1260

CCCTACTTCC GATCTCTGGG AGAACGTGTG CACCAGCTCG AGGACACTGC CTCCATCTTC 1320

TCCCTGAAGG AGATCCAGCT CCAGAAAGAC CCAGGGTACC GTGGCTTGGC CTTTCAGCAT 1380

GCAGGACGCG GGAAAAACCG GCGGCAGAGC ATCTTCTGA 1419

Domain Profile

S: 1     yeklekigeGtygkvykakdketgevvAlKkirlekekegvpitalrEisllkelkhkni  60

         y kl+k+geGty++v+k+++k t+++vAlK+irle+e eg p+ta+rE+sllk+lkh+ni

Q: 142   YVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEHE-EGAPCTAIREVSLLKNLKHANI  200

         7899********************************9.9*********************

S: 61    vkLlevvakdkkklyLvfefleqdLkkllkkkkkkklsleevkslllqlleglaylHsnk  120

         v+L+++++ ++++l+Lvfe+l++dLk++l+++ +  +s+++vk +++qll+glay+H++k

Q: 201   VTLHDLIH-TDRSLTLVFEYLDSDLKQYLDHCGN-LMSMHNVKIFMFQLLRGLAYCHRRK  258

         ********.99***********************.*************************

S: 121   ilHRDlKpqNlLiskegklklaDfGlarafssplktytkevvTlwYraPelLlgakeYst  180

         ilHRDlKpqNlLi+++g+lklaDfGlara s+p+kty++evvTlwYr+P++Llg++eYst

Q: 259   ILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTEYST  318

         ************************************************************

S: 181   avDiWsvgcilaelltrkplfqgkseidqlerifkllgtpsekvwpevsklpeyk.ksfp  239

          +D+W+vgci  e++t +plf+g++ +++l+ if+llgtp+e++wp+v+ lpe++ ++fp

Q: 319   PIDMWGVGCIHYEMATGRPLFPGSTVKEELHLIFRLLGTPTEETWPGVTALPEFRaYNFP  378

         *******************************************************99***

S: 240   kkkkkklkekvkklkekaldllekllaldpkkRisakealqhkyf  284

          + ++ l ++ ++l++++++ll+ ll ++ k+R+sa++al+h+yf

Q: 379   AYLPQPLLSHAPRLDTDGINLLTGLLLYESKSRMSAEAALAHPYF  423

         ********************************************9

Domain Sequence
(FASTA)

YVKLDKLGEG TYATVFKGRS KLTENLVALK EIRLEHEEGA PCTAIREVSL LKNLKHANIV 60

TLHDLIHTDR SLTLVFEYLD SDLKQYLDHC GNLMSMHNVK IFMFQLLRGL AYCHRRKILH 120

RDLKPQNLLI NERGELKLAD FGLARAKSVP TKTYSNEVVT LWYRPPDVLL GSTEYSTPID 180

MWGVGCIHYE MATGRPLFPG STVKEELHLI FRLLGTPTEE TWPGVTALPE FRAYNFPAYL 240

PQPLLSHAPR LDTDGINLLT GLLLYESKSR MSAEAALAHP YF 282

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013