EKS-CAP-00334

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAP-00334

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/EGFR	488.7	3.4E-147	706	965	260

Status

Unreviewed

Ensembl Protein

ENSCPOP00000005210

UniProt Accession

H0V6A0;

Protein Name

Protein Synonyms/Alias

Gene Name

ERBB2

Gene Synonyms/Alias

ERBB2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCPOG00000005777	ENSCPOP00000005210	ENSCPOT00000005839

Organism

Cavia porcellus

Functional Description

Protein Length

1236

Protein Sequence
(FASTA)

GQRPTHLSLL PVCTGTDMKL QLPASPETHL EMLHTLYHGC QVVQGNLELT HLPADANLTF 60

VQDVQEVQGY LLIAHNRVGQ IPLQRLRIVR GTQLFEDKYA LAVLDNGDPL DSGTPALGTA 120

PEGLRELQLR NLTEILKGGI LIERNPQLCH QDTILWRDIL NKMNQKVPVQ VDTNRSRTCL 180

PCSPACRAPY CWGGSPQDCQ NLTRTVCAGG CARCKGPLPT DCCHEQCAAG CTGPKHSDCL 240

ACLHFNHSGT CEMHCPALVT YNTDTFESVS NPEGRYTFGA SCVTTCPYNY LSTDVGSCTL 300

VCPPNNQEVM KDGTQRCEKC SKPCARVCYG LGMEHLRTAR AVTSANIQEF AGCKKIFGSL 360

AFLPESFEGD PTSNTAPLQP KQLSVFETLE EITGYLYISA WPETMQNLGV FQNLRVIRGR 420

ILHNGAYSLT LQGLGLRWLG LRSLRELGSG LALVHHNPHL CFVHTVPWDQ LFRNPHQALL 480

HSGNRPEAEC AAEGQACDPL CAHGHCWGPG PTQCVNCSQF LRGQECVREC HVLQGLPREY 540

VNDRHCLLCH PECQPQNGSV TCFGSEADQC VACAHYKDPP LCVARCPSGV KLDLSYMPIW 600

KFPDEEGTCQ PCPINCTHSC VDLDDRGCPA EQRASPVTSI IAAVVGILLF VVMGVVVGFV 660

IRRRRQKIRK YTMRRLLQET ELVEPLTPSG AMPNQAQMRI LKETELRKVK VLGSGAFGTV 720

YKGIWIPDGE NVKIPVAIKV LRENTSPKAN KEILDEAYVM AGVGSPYVSR LLGICLTSTV 780

QLVTQLMPYG CLLDHVREHR GRLGSQDLLN WCVQIAKGMS YLEDVRLVHR DLAARNVLVK 840

SPNHVKITDF GLARLLDIDE TEYHADGGKV PIKWMALESI LRRRFTHQSD VWSYALGVTV 900

WELMTFGAKP YDGIPAREIP DLLEKGERLP QPPICTIDVY MIMVKCWMID SECRPRFREL 960

VAEFSRMARD PQRFVVIQNE DLGPTSPLDS TFYRSLLEDD DMGDLVDAEE YLVPQQGFFC 1020

PDPSPSTAGS THRRHRSSST RSGGGELTLG LEPPEEEPPR SPRAPSEGAG SDVFEGDAGM 1080

GAAKGLQSLP THDPSPLQRY SEDPTVPLAP ETDGYVAPLT CSPQPEYVNQ PEVQPQPPSP 1140

LEGPLSPVRP ASASLERPKT LSPGKNGIVK DVFAFGGAVE NPEYLAPRGG VQPHPLPTFS 1200

PAFDNLYYWN QDPPERGSPP STFEGTPTAE NPEYLG 1236

Nucleotide Sequence
(FASTA)

GGACAGCGTC CTACCCATCT GTCCCTCCTG CCAGTGTGCA CGGGCACCGA CATGAAACTG 60

CAGCTCCCCG CCAGCCCTGA GACCCACCTG GAGATGCTCC ACACCCTCTA CCATGGCTGC 120

CAGGTGGTGC AGGGGAACCT GGAGCTCACC CATCTTCCCG CCGATGCCAA CCTCACCTTC 180

GTGCAGGATG TCCAGGAGGT ACAGGGCTAC TTGCTAATTG CCCACAATCG AGTGGGACAG 240

ATCCCTCTGC AGAGGCTGAG GATCGTGCGG GGCACCCAGC TCTTCGAGGA CAAATACGCC 300

CTGGCCGTGC TGGACAACGG GGACCCTCTG GACAGCGGCA CCCCAGCCCT GGGGACTGCC 360

CCAGAAGGGC TGCGGGAGCT GCAGCTCCGG AATCTCACAG AGATCCTGAA GGGAGGTATC 420

CTGATTGAGC GGAACCCCCA GCTCTGCCAC CAGGACACCA TTCTGTGGAG GGACATCTTG 480

AACAAGATGA ATCAGAAGGT GCCTGTGCAA GTGGACACCA ACCGCTCGAG GACCTGCCTG 540

CCCTGCTCCC CGGCCTGCAG AGCCCCCTAC TGCTGGGGAG GAAGCCCCCA AGACTGTCAG 600

AACTTGACCC GCACAGTGTG TGCTGGCGGC TGTGCCCGCT GCAAAGGCCC GCTGCCCACG 660

GACTGCTGCC ATGAGCAGTG CGCGGCAGGC TGCACAGGCC CCAAGCATTC CGACTGCCTG 720

GCCTGCCTGC ATTTCAACCA CAGCGGCACC TGTGAGATGC ACTGCCCGGC CCTGGTCACC 780

TACAACACCG ACACTTTTGA GTCCGTGTCC AACCCCGAGG GCCGCTACAC CTTCGGCGCC 840

AGTTGTGTGA CCACCTGTCC CTACAACTAC CTCTCCACGG ATGTGGGCTC CTGCACACTG 900

GTCTGTCCCC CAAACAATCA GGAGGTGATG AAGGACGGGA CCCAGCGCTG TGAGAAGTGC 960

AGCAAGCCGT GTGCCCGAGT GTGCTACGGG CTGGGCATGG AGCACCTCCG CACTGCCAGG 1020

GCCGTCACCA GCGCCAACAT CCAGGAGTTT GCAGGCTGCA AGAAGATCTT CGGGAGCCTG 1080

GCGTTTTTGC CGGAGAGCTT CGAGGGGGAC CCCACCTCCA ACACGGCGCC CCTGCAGCCC 1140

AAGCAGCTCA GTGTGTTTGA GACCCTGGAG GAGATCACAG GTTACCTGTA CATCTCTGCA 1200

TGGCCCGAGA CCATGCAGAA CCTTGGTGTC TTCCAGAACC TGCGGGTCAT CCGGGGGCGC 1260

ATTCTGCACA ACGGTGCCTA CTCACTCACC CTGCAAGGCC TGGGCCTCCG TTGGCTGGGG 1320

CTGCGCTCCC TTCGGGAGTT GGGCAGCGGC CTGGCCCTGG TCCACCACAA TCCCCACCTC 1380

TGCTTCGTGC ACACGGTGCC CTGGGACCAG CTCTTCCGGA ACCCACACCA GGCCCTGCTG 1440

CATAGTGGCA ACCGGCCCGA GGCCGAGTGC GCTGCTGAGG GCCAGGCCTG TGACCCACTG 1500

TGCGCTCATG GCCACTGCTG GGGACCGGGC CCCACCCAGT GTGTCAACTG CAGCCAGTTC 1560

CTCCGGGGCC AAGAGTGTGT GAGGGAGTGC CACGTCCTAC AAGGGCTGCC CCGGGAGTAT 1620

GTGAATGACA GGCACTGCCT GCTGTGCCAC CCTGAGTGCC AGCCCCAGAA TGGCTCTGTG 1680

ACCTGCTTTG GATCGGAGGC TGACCAGTGC GTGGCCTGTG CCCACTACAA GGACCCTCCC 1740

CTGTGTGTGG CCCGCTGCCC CAGCGGCGTG AAGCTTGACC TCTCCTACAT GCCCATCTGG 1800

AAGTTCCCGG ATGAGGAGGG CACCTGCCAG CCCTGCCCGA TCAATTGCAC CCATTCCTGC 1860

GTGGACCTGG ATGACAGGGG CTGCCCAGCT GAGCAGAGAG CCAGCCCTGT GACGTCCATC 1920

ATCGCAGCCG TGGTCGGCAT CCTGCTCTTT GTGGTCATGG GCGTGGTCGT CGGCTTTGTC 1980

ATCAGACGCA GGCGGCAGAA GATCCGAAAG TACACTATGC GGCGGCTCCT GCAGGAGACT 2040

GAGCTGGTGG AGCCGCTCAC GCCCAGTGGG GCGATGCCCA ACCAGGCTCA GATGCGGATC 2100

CTCAAGGAGA CGGAGCTCAG GAAGGTGAAG GTGCTCGGAT CCGGAGCTTT CGGCACCGTC 2160

TACAAGGGCA TCTGGATCCC TGACGGGGAA AACGTGAAGA TCCCAGTGGC CATCAAAGTG 2220

TTGCGGGAGA ACACATCCCC CAAAGCCAAC AAGGAAATCT TGGACGAAGC CTACGTGATG 2280

GCTGGTGTGG GTTCCCCCTA TGTTTCCCGT CTCCTGGGCA TCTGCCTGAC ATCCACGGTG 2340

CAGCTGGTGA CACAGCTCAT GCCCTACGGC TGCCTGCTGG ACCACGTCCG GGAGCACCGC 2400

GGCCGCCTGG GCTCCCAGGA CCTGCTCAAC TGGTGCGTGC AGATCGCCAA GGGCATGAGC 2460

TACCTGGAGG ATGTGCGCCT GGTGCACAGG GACCTGGCTG CCCGCAATGT GCTGGTCAAG 2520

AGCCCTAACC ATGTGAAGAT CACGGACTTC GGGCTGGCAC GGCTGTTGGA CATCGATGAG 2580

ACAGAGTACC ACGCGGATGG GGGCAAGGTG CCCATCAAGT GGATGGCCCT GGAGTCCATC 2640

CTGCGCCGGC GTTTTACCCA CCAGAGTGAT GTGTGGAGCT ACGCCCTAGG GGTGACGGTG 2700

TGGGAGCTGA TGACTTTTGG GGCCAAACCC TATGATGGGA TCCCGGCCCG CGAGATCCCC 2760

GACCTCCTGG AGAAGGGCGA GCGGCTGCCC CAGCCCCCCA TTTGCACCAT TGACGTCTAC 2820

ATGATCATGG TCAAATGTTG GATGATCGAT TCTGAATGTC GGCCTCGATT CCGGGAGCTG 2880

GTGGCTGAGT TCTCCCGCAT GGCCAGGGAC CCCCAGCGTT TCGTGGTCAT CCAGAATGAG 2940

GACCTGGGCC CTACCAGCCC CTTGGATAGC ACCTTCTACC GATCGCTGTT GGAGGACGAC 3000

GACATGGGAG ACCTGGTGGA TGCTGAGGAG TACCTGGTGC CCCAGCAGGG GTTCTTCTGC 3060

CCTGACCCCA GCCCAAGCAC TGCGGGCAGC ACCCACCGCA GGCACCGAAG CTCTTCTACC 3120

CGGAGCGGTG GCGGGGAGCT GACACTGGGG CTAGAGCCCC CCGAAGAGGA GCCACCCCGG 3180

TCCCCACGGG CCCCCTCAGA AGGGGCCGGC TCTGACGTGT TCGAGGGTGA TGCGGGAATG 3240

GGGGCAGCCA AGGGGCTGCA GAGCCTCCCT ACACATGACC CCAGCCCCCT GCAGCGGTAC 3300

AGTGAGGACC CTACAGTCCC CCTGGCCCCG GAGACGGATG GCTACGTTGC CCCACTGACC 3360

TGCAGCCCCC AGCCTGAATA TGTCAACCAG CCCGAGGTCC AGCCACAGCC GCCATCACCC 3420

CTAGAGGGTC CTCTGTCCCC CGTTCGGCCT GCCAGTGCCT CTCTGGAAAG GCCCAAGACT 3480

CTCTCCCCTG GGAAGAATGG GATTGTCAAG GATGTTTTTG CCTTTGGGGG TGCTGTGGAG 3540

AACCCTGAGT ACTTGGCACC CCGGGGAGGT GTCCAGCCCC ATCCTCTGCC CACCTTCAGC 3600

CCAGCCTTTG ACAACCTCTA TTACTGGAAT CAAGACCCAC CAGAGCGGGG GTCTCCACCC 3660

AGCACCTTCG AAGGGACCCC TACAGCAGAG AACCCGGAGT ACCTGGGC 3708

Domain Profile

S: 1     lkklkvlGsGafGtvykGiwipegenvkipvaikvleektgkkankelldealvlasldh  60

         l+k+kvlGsGafGtvykGiwip+genvkipvaikvl+e+t++kanke+ldea+v+a + +

Q: 706   LRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGS  765

         69**********************************************************

S: 61    anlvrllglclsstlqlvtqllplGclldyvrehkdklGsqellnwcvqiakGmsyleek  120

         ++++rllg+cl+st+qlvtql+p+Gclld+vreh+++lGsq+llnwcvqiakGmsyle+

Q: 766   PYVSRLLGICLTSTVQLVTQLMPYGCLLDHVREHRGRLGSQDLLNWCVQIAKGMSYLEDV  825

         ************************************************************

S: 121   rlvhrdlaarnvlvkspnhvkitdfGlaklleadekelkaeggkvpikwlalesilkrky  180

         rlvhrdlaarnvlvkspnhvkitdfGla+ll+ de+e++a+ggkvpikw+alesil+r++

Q: 826   RLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRF  885

         ************************************************************

S: 181   thqsdvwsy..GvtvwelltfGakpydgipakeipdllekGerlaqppictidvymvlvk  238

         thqsdvwsy  Gvtvwel+tfGakpydgipa+eipdllekGerl+qppictidvym++vk

Q: 886   THQSDVWSYalGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVK  945

         ********9889************************************************

S: 239   cwmidaesrpkfkelaeefs  258

         cwmid+e+rp+f+el++efs

Q: 946   CWMIDSECRPRFRELVAEFS  965

         ******************96

Domain Sequence
(FASTA)

LRKVKVLGSG AFGTVYKGIW IPDGENVKIP VAIKVLRENT SPKANKEILD EAYVMAGVGS 60

PYVSRLLGIC LTSTVQLVTQ LMPYGCLLDH VREHRGRLGS QDLLNWCVQI AKGMSYLEDV 120

RLVHRDLAAR NVLVKSPNHV KITDFGLARL LDIDETEYHA DGGKVPIKWM ALESILRRRF 180

THQSDVWSYA LGVTVWELMT FGAKPYDGIP AREIPDLLEK GERLPQPPIC TIDVYMIMVK 240

CWMIDSECRP RFRELVAEFS 260

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004716	; F:receptor signaling protein tyrosine kinase activity
GO:0004714	; F:transmembrane receptor protein tyrosine kinase activity
GO:0023014	; P:signal transduction by phosphorylation
GO:0007169	; P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

InterPros

IPR021157	; Cyt_c1_TM_anchor_C.
IPR000494	; EGF_rcpt_L.
IPR006211	; Furin-like_Cys-rich_dom.
IPR006212	; Furin_repeat.
IPR009030	; Growth_fac_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016245	; Tyr_kinase_EGF/ERB/XmrK_rcpt.

Pfam

PF00757	; Furin-like; 1.
PF07714	; Pkinase_Tyr; 1.
PF01030	; Recep_L_domain; 2.

SMARTs

SM00261	; FU; 3.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013