EKS-CAP-00164

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAP-00164

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/PKG	510.3	8.5E-154	180	438	259

Status

Unreviewed

Ensembl Protein

ENSCPOP00000005259

UniProt Accession

H0V6E2;

Protein Name

Protein Synonyms/Alias

Gene Name

PRKG1

Gene Synonyms/Alias

PRKG1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCPOG00000005830	ENSCPOP00000005259	ENSCPOT00000005893

Organism

Cavia porcellus

Functional Description

Protein Length

490

Protein Sequence
(FASTA)

SALVNVKLWA IDRQCFQTIM MRTGLIKHTE YMEFLKSVPT FQSLPEEILS KLADVLEETH 60

YENGEYIIRQ GARGDTFFII SKGTVNVTRE ESPNEDPIFL RTLGKGDWFG EKALQGEDVR 120

TANVIAAEAV TCLVIDRDSF KHLIGGLDDV SNKAYEDAEA KAKYEAEAAF FANLKLSDFN 180

IIDTLGVGGF GRVELVQLKS EESKTFAMKI LKKRHIVDTR QQEHIRSEKQ IMQGAHSDFI 240

VRLYRTFKDS KYLYMLMEAC LGGELWTILR DRGSFEDSTT RFYTACVVEA FAYLHSKGII 300

YRDLKPENLI LDHRGYAKLV DFGFAKKIGF GKKTWTFCGT PEYVAPEIIL NKGHDISADY 360

WSLGILMYEL LTGSPPFSGP DPMKTYNIIL RGIDMIEFPK KIAKNAANLI KKLCRDNPSE 420

RLGNLKNGVK DIQKHKWFEG FNWEGLRKGT LTPPIIPSVA SPTDTSNFDS FPEDSDEPPP 480

DDNSGWDIDF 490

Nucleotide Sequence
(FASTA)

TCAGCTTTAG TAAATGTGAA ACTCTGGGCC ATTGATCGGC AATGTTTTCA AACAATAATG 60

ATGAGGACAG GGCTCATCAA GCATACCGAG TACATGGAAT TTTTAAAAAG TGTTCCAACA 120

TTCCAGAGCC TTCCTGAAGA GATCCTTAGC AAGCTCGCTG ATGTCCTTGA GGAGACCCAT 180

TATGAAAATG GGGAATACAT TATCAGGCAA GGTGCAAGAG GGGACACCTT CTTTATCATC 240

AGCAAAGGAA CGGTAAATGT TACCCGTGAA GAGTCACCAA ATGAAGACCC AATCTTTCTT 300

AGAACTTTAG GAAAAGGAGA CTGGTTTGGA GAGAAGGCTT TGCAAGGGGA AGACGTGAGA 360

ACAGCAAATG TAATTGCTGC AGAAGCTGTG ACCTGCCTTG TGATTGACAG AGATTCTTTC 420

AAACATTTGA TTGGAGGATT GGATGATGTT TCGAATAAAG CATACGAAGA TGCAGAAGCT 480

AAAGCAAAAT ATGAAGCTGA AGCTGCATTC TTCGCCAACC TGAAGCTGTC TGATTTCAAC 540

ATCATTGACA CCCTTGGAGT TGGAGGTTTT GGACGAGTAG AACTGGTCCA GTTGAAAAGC 600

GAAGAATCCA AAACCTTTGC GATGAAGATT CTCAAGAAAC GTCATATTGT GGATACAAGA 660

CAGCAGGAGC ACATTCGCTC TGAGAAGCAG ATCATGCAGG GGGCTCATTC CGACTTCATA 720

GTGAGGCTTT ACAGAACGTT TAAGGACAGC AAATATTTGT ACATGTTGAT GGAGGCTTGC 780

CTAGGCGGAG AACTCTGGAC CATTCTCAGG GATAGAGGTT CATTTGAAGA TTCAACAACA 840

CGATTTTACA CAGCATGTGT CGTAGAAGCT TTTGCTTATC TCCATTCCAA AGGAATCATT 900

TATAGGGACC TCAAGCCAGA AAATCTCATC CTAGATCATC GAGGTTACGC CAAGCTGGTT 960

GATTTTGGCT TTGCAAAGAA AATAGGATTT GGAAAGAAAA CATGGACTTT TTGTGGAACT 1020

CCAGAGTATG TAGCTCCAGA GATCATCCTA AACAAAGGCC ACGACATTTC AGCAGACTAC 1080

TGGTCACTGG GAATTCTAAT GTATGAACTT CTGACTGGCA GTCCACCTTT CTCAGGCCCA 1140

GATCCCATGA AAACCTACAA CATCATACTG AGGGGGATCG ACATGATAGA ATTTCCAAAG 1200

AAGATTGCTA AAAATGCTGC AAATTTAATT AAGAAACTAT GCAGGGATAA TCCATCAGAA 1260

AGGCTAGGAA ACTTGAAAAA TGGAGTGAAA GACATTCAAA AGCACAAATG GTTTGAGGGC 1320

TTTAACTGGG AAGGCTTACG AAAAGGCACC TTGACGCCTC CCATAATTCC AAGTGTTGCA 1380

TCACCAACAG ACACAAGCAA TTTTGATAGT TTCCCTGAGG ACAGTGATGA GCCACCCCCT 1440

GACGACAACT CGGGCTGGGA CATAGACTTC 1470

Domain Profile

S: 2     kviatlgvggfgrvelvkvksdeskafalkilkkkhivdtkqqehvlsekrileeaksdf  61

         ++i+tlgvggfgrvelv++ks+esk+fa+kilkk+hivdt+qqeh++sek+i++ a+sdf

Q: 180   NIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAHSDF  239

         79**********************************************************

S: 62    ivklyrtfkdekyvyllleaclggelwtilrdrgsfddktakfivacvvealeylhskni  121

         iv+lyrtfkd+ky+y+l+eaclggelwtilrdrgsf+d+t++f++acvvea++ylhsk+i

Q: 240   IVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGI  299

         ************************************************************

S: 122   iyrdlkpenllldeegylklvdfgfakklksgkktwtfcgtpeyvapeiilnkghdlsvd  181

         iyrdlkpenl+ld++gy+klvdfgfakk++ gkktwtfcgtpeyvapeiilnkghd+s+d

Q: 300   IYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISAD  359

         ************************************************************

S: 182   ywalgilvyelltgkppfsgvdplktynlilkgidklelprkitkeaedlikklcrdnpa  241

         yw+lgil+yelltg+ppfsg+dp+ktyn+il+gid++e+p+ki+k+a++likklcrdnp+

Q: 360   YWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKIAKNAANLIKKLCRDNPS  419

         ************************************************************

S: 242   erlgylkggikdikkhkwf  260

         erlg+lk+g+kdi+khkwf

Q: 420   ERLGNLKNGVKDIQKHKWF  438

         ******************9

Domain Sequence
(FASTA)

NIIDTLGVGG FGRVELVQLK SEESKTFAMK ILKKRHIVDT RQQEHIRSEK QIMQGAHSDF 60

IVRLYRTFKD SKYLYMLMEA CLGGELWTIL RDRGSFEDST TRFYTACVVE AFAYLHSKGI 120

IYRDLKPENL ILDHRGYAKL VDFGFAKKIG FGKKTWTFCG TPEYVAPEII LNKGHDISAD 180

YWSLGILMYE LLTGSPPFSG PDPMKTYNII LRGIDMIEFP KKIAKNAANL IKKLCRDNPS 240

ERLGNLKNGV KDIQKHKWF 259

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004692	; F:cGMP-dependent protein kinase activity

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR002374	; cGMP_dep_kinase.
IPR018490	; cNMP-bd-like.
IPR018488	; cNMP-bd_CS.
IPR000595	; cNMP-bd_dom.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR014710	; RmlC-like_jellyroll.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00027	; cNMP_binding; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00100	; cNMP; 1.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00888	; CNMP_BINDING_1; 1.
PS00889	; CNMP_BINDING_2; 1.
PS50042	; CNMP_BINDING_3; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00104

; CGMPKINASE.

Created Date

20-Feb-2013