EKS-CAP-00296

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAP-00296

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/PLK	424.2	1.8E-127	53	305	253

Status

Unreviewed

Ensembl Protein

ENSCPOP00000005331

UniProt Accession

H0V6L0;

Protein Name

Protein Synonyms/Alias

Gene Name

PLK1

Gene Synonyms/Alias

PLK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCPOG00000005910	ENSCPOP00000005331	ENSCPOT00000005973

Organism

Cavia porcellus

Functional Description

Protein Length

604

Protein Sequence
(FASTA)

MNTGATAGKL ARAPADLGKA GVPGVAAPGA QAAAPPAKEI PELLVDPRSR RCYARGRFLG 60

KGGFAKCFEI SDTDTKEVFA GKIVPKSLLL KPHQKEKMSM EISIHRSLAH QHIVGFHGFF 120

EDNDFVFVIL ELCNRRSLLE LHKRRKALTE PEARYYLRQI VLGCQYLHRN RVIHRDLKLG 180

NLFLNEDLEV KIGDFGLATR VEYDGERKKT LCGTPNYIAP EVLSKKGHSF EVDVWSIGCI 240

MYTLLVGKPP FETSCLKETY LRIKKNEYSI PKHINPVAAS LIQKMLQTDP TARPPIHELL 300

NDEFFTSGYI PARLPITCLT IPPRFSIAPS SLEPSNRKPL TVLNKGMENP LPERPREKEE 360

PVVQEASETI ECQLGDLLQQ LHSVNASKPA ERGLVRQEEA EDPACIPIFW VSKWVDYSDK 420

YGLGYQLCDN SVGVLFNDST RLILYNDGDS LQYIERDGVE SYLTVSSHPN SLMKKITLLK 480

YFRNYMSEHL LKAGANITPR EGDELARLPY LRTWFRTRSA IILHLSNGTV QINFFQDHTK 540

LILCPLMAAV TYIDEKRDFR TYRLSLLEEY GCCRELASRL RYARTMVDKL LSSRSACNRV 600

KVSS 604

Nucleotide Sequence
(FASTA)

ATGAATACGG GGGCAACAGC AGGAAAACTG GCGCGGGCAC CAGCTGACCT AGGGAAAGCA 60

GGAGTCCCTG GAGTTGCAGC TCCCGGAGCC CAAGCCGCTG CTCCGCCGGC AAAAGAGATT 120

CCGGAGCTCC TGGTGGACCC ACGCAGCCGG CGGTGCTATG CGCGGGGCCG CTTTTTGGGC 180

AAAGGCGGCT TCGCCAAGTG CTTCGAGATT TCGGACACCG ACACTAAGGA AGTATTCGCC 240

GGCAAGATTG TGCCCAAATC TTTGCTGCTT AAGCCGCACC AGAAAGAGAA GATGTCCATG 300

GAGATCTCCA TTCATCGCAG TCTTGCCCAC CAGCATATTG TAGGCTTCCA CGGTTTTTTT 360

GAAGACAACG ACTTCGTGTT CGTGATATTA GAGCTCTGCA ACCGGCGGTC CCTCTTGGAG 420

TTGCACAAGA GGAGGAAGGC CCTGACGGAG CCTGAGGCCC GTTACTACCT GCGGCAGATC 480

GTCCTGGGCT GTCAGTACCT ACACCGAAAT CGGGTTATCC ACAGAGACCT CAAGCTAGGC 540

AACCTGTTTC TGAACGAGGA TTTGGAGGTG AAAATAGGGG ATTTTGGATT GGCAACCAGA 600

GTGGAATATG ATGGGGAGCG GAAGAAGACT CTGTGTGGGA CTCCTAATTA TATAGCTCCT 660

GAGGTGCTGA GCAAGAAAGG GCACAGTTTC GAGGTGGACG TGTGGTCCAT TGGTTGCATC 720

ATGTATACCC TACTAGTTGG TAAACCACCT TTTGAGACCT CTTGCCTAAA AGAGACCTAC 780

CTTCGCATCA AGAAGAATGA ATACAGTATT CCCAAGCACA TCAACCCTGT GGCTGCGTCC 840

CTCATTCAGA AGATGCTACA GACTGACCCC ACTGCCCGCC CACCTATTCA TGAGCTGCTT 900

AATGACGAGT TCTTCACTTC TGGCTACATT CCTGCTCGCC TCCCTATCAC GTGCCTCACC 960

ATTCCACCAA GGTTTTCAAT AGCTCCCAGC AGCCTGGAGC CCAGCAACCG GAAGCCTCTC 1020

ACAGTCCTCA ATAAAGGCAT GGAGAACCCG CTGCCTGAGC GTCCCCGGGA GAAAGAAGAA 1080

CCAGTGGTTC AGGAGGCAAG TGAGACTATT GAATGCCAGC TTGGTGACTT GCTGCAGCAG 1140

CTGCACAGTG TCAATGCCTC TAAGCCTGCA GAGCGGGGCC TGGTGAGACA AGAGGAGGCT 1200

GAAGATCCTG CCTGCATCCC CATCTTCTGG GTCAGCAAAT GGGTGGACTA CTCAGACAAG 1260

TATGGCCTAG GGTATCAGCT TTGTGACAAC AGCGTGGGGG TGCTCTTCAA TGACTCTACT 1320

CGCCTCATCC TCTACAATGA TGGGGATAGC CTGCAGTACA TAGAGCGTGA CGGTGTTGAG 1380

TCCTACCTCA CCGTGAGTTC CCACCCCAAC TCCTTGATGA AGAAGATCAC TCTCCTCAAA 1440

TATTTCCGCA ACTACATGAG TGAACACTTG CTGAAGGCAG GTGCCAATAT CACGCCTCGG 1500

GAAGGTGACG AGCTGGCCCG ACTGCCCTAC CTGCGCACCT GGTTCCGCAC ACGCAGTGCC 1560

ATCATCCTGC ATCTCAGCAA TGGCACTGTG CAGATTAACT TCTTCCAGGA CCACACCAAG 1620

CTCATTCTGT GCCCACTGAT GGCAGCTGTG ACCTACATTG ATGAGAAGCG GGACTTCCGC 1680

ACATACCGCC TGAGTCTCCT AGAGGAGTAC GGCTGCTGCC GGGAGCTGGC CAGTCGCCTG 1740

CGCTATGCCC GCACCATGGT GGACAAGCTG TTGAGTTCGC GCTCAGCCTG CAATCGTGTC 1800

AAGGTCTCTT CCTAG 1815

Domain Profile

S: 1     yergkllGkGgfakcyelkdletkevfavkvvpksllakekqrekvekeieihrslkhkn  60

         y rg++lGkGgfakc+e++d++tkevfa k+vpksll k++q+ek+++ei+ihrsl+h++

Q: 53    YARGRFLGKGGFAKCFEISDTDTKEVFAGKIVPKSLLLKPHQKEKMSMEISIHRSLAHQH  112

         89**********************************************************

S: 61    ivklyeffedkenvylvlelcsrrslaellkrrkaltepevryylrqivsglkylhekri  120

         iv ++ ffed+++v+++lelc+rrsl el+krrkaltepe+ryylrqiv g++ylh++r+

Q: 113   IVGFHGFFEDNDFVFVILELCNRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRV  172

         ************************************************************

S: 121   lhrdlklgnlflneelevkigdfGlatrlekeeerkktlcGtPnyiaPevlskkghslev  180

         +hrdlklgnlflne+levkigdfGlatr+e+++erkktlcGtPnyiaPevlskkghs+ev

Q: 173   IHRDLKLGNLFLNEDLEVKIGDFGLATRVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEV  232

         ************************************************************

S: 181   diWslGcilytllvGkPPfetkelketyekikkaeyslPsslskeaksliakllkkePee  240

         d+Ws+Gci+ytllvGkPPfet++lkety +ikk+eys+P+++++ a+sli+k+l+++P++

Q: 233   DVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTA  292

         ************************************************************

S: 241   rpsleevlkdefl  253

         rp ++e+l+def+

Q: 293   RPPIHELLNDEFF  305

         ************8

Domain Sequence
(FASTA)

YARGRFLGKG GFAKCFEISD TDTKEVFAGK IVPKSLLLKP HQKEKMSMEI SIHRSLAHQH 60

IVGFHGFFED NDFVFVILEL CNRRSLLELH KRRKALTEPE ARYYLRQIVL GCQYLHRNRV 120

IHRDLKLGNL FLNEDLEVKI GDFGLATRVE YDGERKKTLC GTPNYIAPEV LSKKGHSFEV 180

DVWSIGCIMY TLLVGKPPFE TSCLKETYLR IKKNEYSIPK HINPVAASLI QKMLQTDPTA 240

RPPIHELLND EFF 253

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000959	; POLO_box_duplicated_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF00659	; POLO_box; 2.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS50078	; POLO_BOX; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013