EKS-CAP-00431
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-CAP-00431
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/PDGFR600.51.0E-180588946359
StatusUnreviewed
Ensembl ProteinENSCPOP00000005411
UniProt AccessionH0V6S9;
Protein NameTyrosine-protein kinase receptor
Protein Synonyms/Alias
Gene NamePDGFRB
Gene Synonyms/Alias PDGFRB;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSCPOG00000005994ENSCPOP00000005411ENSCPOT00000006057
OrganismCavia porcellus
Functional Description
Protein Length1090
Protein Sequence
(FASTA)
KGQLLLLSLL LLLGPQISQG LVMVPAGPEL VLNLSSTFVL TCLGSAPVLW ERMSQVPQQE 60
VVMTQDGTFT SKLTLTNVTG GDTGEYFCTY NSSLELESSE RRRLYIFVPD PSMGFLPIDP 120
EDVFVFVTEI TETTIPCRVT DPRLVVTLHE KKEDVPLPIP YDHQRGFIGT FEDKTYICKT 180
TIGDREVESD AYYVYSLQVS SINVSVNAVQ TVVRQGENIT IMCIVTGNEV VNFEWMYPRK 240
ESGRQVEAVT DFLPDMPNHI RSILHIHDAE LGDSGTYICN VSESVNEHRD EKAINVTVVE 300
RGYVRLLQGL DTVEIAELHQ SRTLQVLIEA YPPPTVLWFK DNRTLGDTSV GEIALATRNV 360
SETRYVSELT LVRVKVAEAG SYTMRAFHED DEDQLSFRLQ VNVPVRVLEL SESHPANGDQ 420
TVRCRGRGMP QPHVSWFLCR DLKRCPHELL PTPLGNSSEE ESQLETNVTY WAEEQEYEVA 480
STLRLRHVDQ QLSVLCMVHN LLGQDVQEVT VVPHSLPFKV VVISAILALV VLTIVSLIIL 540
IILWQKKPRY EIRWKVIESV SSDGHEYIYV DPMQLPYDST WELPRDQLVL GRTLGSGAFG 600
QVVEATAHGL GHSQATMKVA VKMLKSTARS SEKQALMSEL KIMSHLGPHL NVVNLLGACT 660
KGGPIYIITE YCRYGDLVDY LHRNKHTFLQ HHSDKHRPPS IELYSNTLPV GLPLPSPVSL 720
SGESDGGYMD MSKDESVDYV PMLDMKGDIK YADIESSNYM APYDNYVPSA PERTYRATLI 780
NESPVLSYTD LVGFSYQVAN GMEFLASKNC VHRDLAARNV LICEGKLVKI CDFGLARDIM 840
RDSNYISKGS TFLPLKWMAP ESIFNSLYTT LSDVWSFGIL LWEIFTLGGT PYPELPMNEQ 900
FYNAIKRGYR MAQPAHASDE IYEIMQKCWE EKFEIRPPFS QLVLLLERLL GEGYKKKYQQ 960
VDEEFLRSDH PAILRSQARL PGFHGLRSPL DTSSVLYTAV QPNEGDNDYI IPLPDPKPEV 1020
AEEGPLEGSP SLASSTLNEA NTSSTISCDS PLDPQEEPDP EPPAEPEPEL EQPPDSGCPR 1080
PQVEVEDSFL 1090
Nucleotide Sequence
(FASTA)
AAAGGCCAGT TGCTGTTACT GTCACTGCTG TTGCTGCTGG GACCACAGAT CTCCCAAGGC 60
CTGGTCATGG TGCCTGCAGG CCCAGAGCTG GTTCTCAATC TCTCTAGCAC CTTTGTTCTG 120
ACCTGCTTGG GTTCAGCTCC AGTGCTGTGG GAACGAATGT CCCAGGTACC CCAACAGGAA 180
GTGGTCATGA CCCAGGATGG CACCTTCACC AGCAAACTGA CACTGACCAA CGTCACTGGG 240
GGAGACACAG GAGAATACTT CTGCACCTAC AACAGCTCCC TTGAGCTGGA GTCCAGTGAG 300
CGGAGGCGGC TGTACATCTT TGTGCCAGAT CCCAGTATGG GCTTCCTCCC CATAGACCCT 360
GAGGATGTAT TTGTCTTTGT CACGGAAATC ACTGAGACCA CCATCCCATG CCGAGTCACA 420
GACCCCCGGC TGGTGGTGAC GCTGCACGAG AAGAAAGAGG ATGTTCCTCT GCCTATCCCC 480
TATGATCACC AACGAGGTTT CATTGGTACT TTTGAGGACA AGACCTACAT TTGCAAAACC 540
ACCATTGGGG ACAGGGAAGT GGAATCCGAT GCCTACTATG TCTACAGCCT ACAGGTGTCA 600
TCCATCAATG TCTCTGTGAA TGCAGTGCAG ACTGTGGTAC GCCAGGGTGA GAACATCACC 660
ATCATGTGCA TCGTGACGGG GAATGAGGTG GTCAACTTTG AGTGGATGTA CCCCCGAAAG 720
GAGAGTGGGC GGCAGGTAGA GGCAGTGACG GACTTCCTCC CTGACATGCC AAACCACATT 780
CGCTCCATCC TGCACATCCA CGACGCTGAG CTGGGTGACT CAGGGACCTA CATTTGCAAT 840
GTGTCAGAGA GTGTGAACGA GCACCGAGAC GAGAAGGCCA TCAACGTCAC TGTGGTCGAG 900
AGAGGCTATG TGAGGCTGCT GCAAGGGCTG GACACTGTGG AAATCGCTGA GCTGCACCAG 960
AGCCGGACAC TGCAGGTGCT GATCGAAGCT TACCCTCCGC CCACTGTCCT GTGGTTCAAA 1020
GACAACCGCA CCCTTGGTGA CACCAGTGTC GGCGAGATAG CCCTGGCCAC ACGCAATGTG 1080
TCCGAGACCC GGTATGTGTC GGAGCTGACA CTGGTGCGGG TGAAGGTGGC AGAGGCTGGC 1140
AGTTACACCA TGCGGGCCTT CCATGAGGAT GACGAGGACC AGCTGTCTTT CCGGCTGCAG 1200
GTCAATGTCC CTGTCCGTGT GCTGGAGCTG AGCGAGAGCC ACCCTGCCAA TGGGGACCAG 1260
ACAGTCCGCT GTCGCGGCCG AGGCATGCCC CAGCCACATG TCAGCTGGTT TCTCTGCAGA 1320
GACCTCAAAA GGTGTCCGCA CGAGCTGTTG CCCACGCCTC TGGGGAACAG TTCTGAAGAG 1380
GAGAGCCAGC TGGAGACCAA CGTGACATAC TGGGCTGAGG AGCAGGAGTA CGAGGTGGCG 1440
AGCACGTTGC GCCTGCGCCA TGTGGATCAG CAGCTGTCGG TGCTCTGCAT GGTGCACAAC 1500
CTGCTGGGCC AGGACGTGCA GGAGGTCACC GTGGTGCCAC ACTCCCTGCC CTTCAAGGTG 1560
GTAGTGATCT CAGCCATCCT GGCCTTGGTG GTTCTCACCA TTGTCTCTCT CATCATCCTC 1620
ATCATACTTT GGCAGAAGAA ACCACGCTAT GAGATCCGGT GGAAGGTGAT TGAGTCTGTG 1680
AGCTCCGACG GCCATGAGTA CATCTATGTG GACCCCATGC AGCTTCCCTA TGACTCCACG 1740
TGGGAGCTGC CAAGGGACCA GCTTGTGCTT GGACGCACCC TCGGCTCCGG GGCCTTCGGG 1800
CAGGTGGTGG AGGCCACAGC TCACGGGCTG GGTCACTCAC AGGCCACCAT GAAAGTGGCT 1860
GTCAAGATGC TGAAATCCAC GGCCCGTAGC AGTGAGAAGC AAGCCCTCAT GTCAGAGCTG 1920
AAGATCATGA GTCACCTAGG GCCCCACCTG AACGTGGTCA ACCTGCTGGG GGCCTGCACC 1980
AAAGGAGGAC CCATCTACAT CATCACTGAG TACTGCCGCT ACGGCGACCT GGTGGACTAC 2040
CTGCACCGCA ACAAGCACAC CTTCCTGCAG CACCACTCGG ACAAGCACCG CCCTCCCAGC 2100
ATCGAGCTCT ATAGCAACAC CTTACCTGTG GGGCTGCCCT TGCCCAGCCC CGTGTCCCTG 2160
AGTGGGGAGA GTGACGGTGG CTACATGGAC ATGAGCAAGG ATGAGTCAGT GGACTACGTG 2220
CCCATGCTGG ACATGAAGGG AGACATCAAA TACGCAGACA TCGAGTCCTC CAACTACATG 2280
GCCCCGTACG ATAACTACGT CCCCTCCGCC CCTGAGAGGA CCTACCGGGC AACTCTGATC 2340
AATGAGTCCC CCGTGCTCAG CTACACAGAC CTCGTGGGCT TCAGCTACCA GGTGGCAAAT 2400
GGCATGGAGT TCTTGGCCTC CAAGAATTGT GTCCACCGAG ACCTGGCAGC CAGGAACGTG 2460
CTCATCTGCG AAGGCAAGCT AGTCAAGATC TGTGACTTCG GCCTGGCTCG AGACATCATG 2520
CGAGACTCGA ACTACATCTC TAAAGGCAGC ACCTTCCTGC CCCTGAAGTG GATGGCCCCG 2580
GAGAGCATCT TCAACAGCCT TTACACCACT TTGAGCGACG TGTGGTCCTT TGGGATCCTC 2640
CTCTGGGAGA TCTTCACCTT GGGTGGCACC CCTTACCCAG AGCTGCCCAT GAATGAGCAG 2700
TTCTACAATG CCATCAAGCG GGGCTACCGC ATGGCGCAGC CCGCTCATGC CTCCGATGAG 2760
ATCTATGAGA TCATGCAGAA GTGCTGGGAA GAGAAGTTTG AGATCCGGCC TCCCTTCTCC 2820
CAGCTGGTGC TGCTTCTGGA GAGACTGCTG GGTGAGGGGT ACAAAAAGAA GTACCAGCAG 2880
GTGGATGAGG AGTTTCTGAG GAGCGACCAC CCAGCCATCC TTCGGTCCCA AGCCCGCTTG 2940
CCTGGGTTCC ATGGCCTCCG GTCTCCCCTG GACACCAGCT CTGTCCTCTA CACTGCCGTA 3000
CAGCCCAATG AGGGTGACAA TGACTATATC ATCCCCCTGC CTGACCCCAA ACCTGAGGTT 3060
GCTGAGGAGG GCCCACTGGA GGGCTCCCCC AGCCTTGCCA GCTCCACCCT GAATGAAGCC 3120
AACACTTCCT CTACCATCTC CTGTGACAGC CCCCTGGACC CTCAAGAGGA GCCAGACCCA 3180
GAGCCCCCGG CAGAGCCAGA GCCGGAGTTG GAGCAACCTC CGGATTCAGG CTGTCCCAGG 3240
CCCCAGGTCG AAGTGGAGGA CAGCTTCCTG 3270
Domain Profile
S: 1     lelGkvlGsGafGkvveatayGlsksdavlkvavkmlkstarssekealmselkilshlG  60
         l+lG++lGsGafG+vveata+Gl++s+a++kvavkmlkstarssek+almselki+shlG
Q: 588   LVLGRTLGSGAFGQVVEATAHGLGHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLG  647
         78**********************************************************
S: 61    ehenivnllGactkgGpiyviteyccyGdllnylrrkresflkkslekkkekeeeldska  120
         +h+n+vnllGactkgGpiy+iteyc+yGdl++yl+r++++fl+++++k+++++ el+s++
Q: 648   PHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHTFLQHHSDKHRPPSIELYSNT  707
         ************************************************************
S: 121   lladkslrsksslssesseeyvdlkkd................vsdvssskadklasekk  164
         l+++  l s +sls es++ y+d++kd                ++d++ss++++++++++
Q: 708   LPVGLPLPSPVSLSGESDGGYMDMSKDesvdyvpmldmkgdikYADIESSNYMAPYDNYV  767
         ************************************************************
S: 165   ksalerevkaaleeedsevleledllsfsyqvakGmeflaskncvhrdlaarnvllteGk  224
          sa er+++a+l++e s vl+++dl+ fsyqva+Gmeflaskncvhrdlaarnvl++eGk
Q: 768   PSAPERTYRATLINE-SPVLSYTDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGK  826
         **************9.9*******************************************
S: 225   vvkicdfGlardimkdsnyvvkGnarlpvkwmapesifdslytvksdvwsyGillweifs  284
         +vkicdfGlardim+dsny++kG+++lp+kwmapesif+slyt+ sdvws+Gillweif+
Q: 827   LVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFT  886
         ************************************************************
S: 285   lGstpypgllvdskfyklikeGyrmaqpayateeiyeimqkcweaepekrpsfkqlvell  344
         lG+tpyp+l+++++fy++ik+Gyrmaqpa+a++eiyeimqkcwe+++e rp+f+qlv ll
Q: 887   LGGTPYPELPMNEQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLVLLL  946
         ********************************************************9986
Domain Sequence
(FASTA)
LVLGRTLGSG AFGQVVEATA HGLGHSQATM KVAVKMLKST ARSSEKQALM SELKIMSHLG 60
PHLNVVNLLG ACTKGGPIYI ITEYCRYGDL VDYLHRNKHT FLQHHSDKHR PPSIELYSNT 120
LPVGLPLPSP VSLSGESDGG YMDMSKDESV DYVPMLDMKG DIKYADIESS NYMAPYDNYV 180
PSAPERTYRA TLINESPVLS YTDLVGFSYQ VANGMEFLAS KNCVHRDLAA RNVLICEGKL 240
VKICDFGLAR DIMRDSNYIS KGSTFLPLKW MAPESIFNSL YTTLSDVWSF GILLWEIFTL 300
GGTPYPELPM NEQFYNAIKR GYRMAQPAHA SDEIYEIMQK CWEEKFEIRP PFSQLVLLL 359
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00377
EKS-ANC-00390
EKS-BOT-00403
EKS-CAJ-00406
EKS-CAF-00403
EKS-DAR-00792
EKS-EQC-00395
EKS-FEC-00387
EKS-GAG-00340
EKS-GAA-00491
EKS-GOG-00395
EKS-HOS-00408
EKS-ICT-00382
EKS-LAC-00418
EKS-LOA-00411
EKS-MAM-00401
EKS-MEG-00334
EKS-MOD-00394
EKS-MUM-00434
EKS-MUP-00396
EKS-MYL-00398
EKS-NOL-00367
EKS-OCP-00083
EKS-ORN-00513
EKS-ORA-00353
EKS-ORC-00377
EKS-ORL-00471
EKS-OTG-00404
EKS-PES-00358
EKS-POA-00393
EKS-RAN-00417
EKS-SAH-00371
EKS-SUS-00358
EKS-TAG-00472
EKS-TAR-00509
EKS-TEN-00510
EKS-XET-00513
EKS-XIM-00505
Gene Ontology
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0005021; F:vascular endothelial growth factor-activated receptor activity
GO:0048010; P:vascular endothelial growth factor receptor signaling pathway
GO:0038084; P:vascular endothelial growth factor signaling pathway
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003599; Ig_sub.
IPR003598; Ig_sub2.
IPR013151; Immunoglobulin.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016243; Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824; Tyr_kinase_rcpt_3_CS.
IPR009134; Tyr_kinase_VEGFR_rcpt_N.
Pfam
PF07679; I-set; 1.
PF00047; ig; 1.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00409; IG; 2.
SM00408; IGc2; 1.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 3.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00240; RECEPTOR_TYR_KIN_III; 1.
Prints
PR01832; VEGFRECEPTOR.
Created Date20-Feb-2013